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Topic:Veterinary Research

Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Partitioning of total pulmonary resistance in horses.
American journal of veterinary research    July 1, 1995   Volume 56, Issue 7 924-929 
Lavoie JP, Pascoe JR, Kupershoek CJ.The partitioning of total pulmonary resistance (RL) into upper airway resistance and lower airway resistance (RI) was studied in 8 Thoroughbred geldings. In addition, the phase shift and amplitude distortion of 3 catheters used for pressure measurements in this study were evaluated under static and dynamic conditions. Flow rate was obtained from a heated pneumotachograph attached to a tight-fitting mask placed over the nose. Electronic integration of the flow signal gave tidal volume. Transpulmonary pressure (PL) was obtained from calculation of the difference between the esophageal balloon ca...
Comparative study of sensitive and vegetative innervation of external and internal anal sphincter muscles in different mammals. Panu R, Bo Minelli L, Sanna L, Acone F, Zedda M, Gazza F, Palmieri G.Proprioceptive innervation of the external anal sphincter muscle and the organization of the vegetative and sensitive nerve components of the internal and sphincter muscle have been studied in different mammals. The findings of typical muscle spindles in the external anal sphincter muscle were constant in the pig, frequent in the goat and cow, rare in the sheep and horse and absent in the roe and rabbit. In the pig, muscle spindles were observed in the entire extension of the muscle, while in the sheep, goat, cow and horse, the receptors were found only in the cranial portion of the muscle. In...
Needle aspiration lung biopsy: reevaluation of the blood patch technique in an equine model.
Radiology    July 1, 1995   Volume 196, Issue 1 183-186 doi: 10.1148/radiology.196.1.7784564
Moore EH, Shelton DK, Wisner ER, Richardson ML, Bishop DM, Brock JM.To reexamine the blood patch technique in a laboratory model of lung biopsy free of confounding clinical variables. Methods: An equine model of lung biopsy was developed with an excised lobe connected to an insufflation bulb and pressure monitor. Patched and control unpatched punctures were made in the lung surface, and the pressure within the lung was raised to the maximum achievable. Whether air leakage from the puncture sites could be induced was determined and, if so, at what pressure it occurred. Results: At statistical analysis with the Kaplan-Meier test and the Cox proportional hazards ...
Pathology of equine respiratory disease occurring in association with transport.
Journal of comparative pathology    July 1, 1995   Volume 113, Issue 1 29-43 doi: 10.1016/s0021-9975(05)80066-0
Oikawa M, Takagi S, Anzai R, Yoshikawa H, Yoshikawa T.Eight young thoroughbred horses, taken 1858 km by road (travelling time, 41 h), were examined to assess the pathological nature of respiratory disease associated with transport. Three of the horses showed clinical abnormalities including pyrexia, coughing, leucocytosis and neutrophilia after the first 20 h of transportation. Endoscopical examination of the trachea revealed exacerbation of airway inflammation as a result of transport in two of the three affected horses. A consistent finding in the affected horses was focal serous neutrophilic pneumonia affecting the cranio-ventral portion of th...
Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus.
Journal of virological methods    July 1, 1995   Volume 54, Issue 1 1-13 doi: 10.1016/0166-0934(95)00020-u
Chirnside ED, Francis PM, de Vries AA, Sinclair R, Mumford JA.A recombinant glutathione-S-transferase fusion protein expressing amino acids 55-98 of equine arteritis virus (EAV) GL (rGL 55-98) was tested in an ELISA for its ability to detect serum antibodies to EAV. Host antibodies induced following EAV infection bound the recombinant antigen by ELISA. The ELISA specificity and sensitivity were determined with a panel of equine sera including postinfection and postvaccination samples. A good correlation existed between EAV neutralizing antibody titers and ELISA absorbance values (r = 0.827). The sensitivity and specificity of the ELISA were 99.6 and 90.1...
Monoclonal equine IgM and IgG immunoglobulins.
Veterinary immunology and immunopathology    July 1, 1995   Volume 47, Issue 1-2 1-12 doi: 10.1016/0165-2427(94)05381-2
Wagner B, Radbruch A, Richards C, Leibold W.In order to define equine immunoglobulins (Igs) and to produce monoclonal reference Igs we fused equine peripheral blood mononuclear cells with X63-Ag8.653 non Ig producing murine myeloma cells. A total of 29 equine Ig producing equi-murine heterohybridomas were obtained, of which ten expressed equine Ig for more than 3 months. One of these heterohybridoma lines produced monoclonal IgM, an equine isotype which has not been available in monoclonal form before. Four lines secreted equine IgG of two distinct Ig heavy chain types as assessed by the molecular weight (MW), while the remaining five l...
Effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics in neonatal foals.
Journal of the American Veterinary Medical Association    July 1, 1995   Volume 207, Issue 1 71-73 
Kasper CA, Clayton HM, Wright AK, Skuba EV, Petrie L.Thirteen clinically normal Belgian-type foals were used to study the effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics. Seven foals (treatment group) received 2 doses of oxytetracycline (3 g, IV). The first dose was given when foals were 4 days old; the second dose was given 24 hours later. Six foals (control group) received 2 doses of saline (0.9% NaCl) solution (15 ml, IV) at equivalent time periods. All foals were videotaped at a walk twice: immediately prior to the first treatment and 24 hours after the second treatment. The tapes were digitized, and metacarp...
Comparison of the anti-inflammatory actions of flunixin and ketoprofen in horses applying PK/PD modelling.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 247-256 doi: 10.1111/j.2042-3306.1995.tb03073.x
Landoni MF, Lees P.A comparative study in horses of the pharmacokinetics (PK) and pharmacodynamics (PD) of 2 extensively used nonsteroidal anti-inflammatory drugs (NSAIDs), flunixin (FXN) and ketoprofen (KTP), was carried out applying PK/PD modelling. To evaluate the anti-inflammatory properties of these drugs a model of acute inflammation, comprising surgically implanted subcutaneous tissue cages stimulated by intracaveal injection of carrageenan, was used. FXN elimination half-life (T1/2 beta) in plasma was 3.37 +/- 1.09 h. However, in exudate a much longer T1/2 beta was obtained (15.99 +/- 3.80 h). Apparent v...
Changes in breathing pattern in the normal horse at rest up to age one year.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 265-274 doi: 10.1111/j.2042-3306.1995.tb03075.x
Koterba AM, Wozniak JA, Kosch PC.Changes in pattern of airflow, sequence of respiratory muscle activation and generated pressures were measured serially in a group of foals during the first year post partum, in order to describe the maturation of the equine breathing pattern. In neonatal foals, inspiration and expiration were both primarily active and airflow pattern was essentially monophasic. By age 1 year, foals displayed essentially the same breathing pattern previously described in adult horses, utilising a combination of active and passive inspiration and expiration to breathe around, rather than from, the relaxation vo...
Critical thinking: radiographic misdiagnoses in horses.
The Canadian veterinary journal = La revue veterinaire canadienne    July 1, 1995   Volume 36, Issue 7 442-443 
Farrow CS.No abstract available
Equine morbillivirus pneumonia: susceptibility of laboratory animals to the virus.
Australian veterinary journal    July 1, 1995   Volume 72, Issue 7 278-279 doi: 10.1111/j.1751-0813.1995.tb03549.x
Westbury HA, Hooper PT, Selleck PW, Murray PK.No abstract available
Evaluation of tissue adhesive to contain axonal regeneration in horses.
Veterinary surgery : VS    July 1, 1995   Volume 24, Issue 4 308-314 doi: 10.1111/j.1532-950x.1995.tb01335.x
Turner AS, Trotter GW, Powers BE.Bilateral palmar and plantar digital neurectomies were completed in 10 horses (a total of 80 neurectomies) using one of three methods: (1) simple transection (guillotine method); (2) epineural capping; (3) n-butyl cyanoacrylate injected into the epineural sheath to act as a nerve sealant. Horses were regularly evaluated clinically for tenderness in and around the surgical site, as well as skin sensation at the coronary band in the heel region, during the 12-week course of the study. None of the surgical sites exhibited any signs of drainage or infection. Horses were then euthanatized, the nerv...
Ventilatory and timing parameters in normal horses at rest up to age one year.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 257-264 doi: 10.1111/j.2042-3306.1995.tb03074.x
Koterba AM, Wozniak JA, Kosch PC.The purpose of the study was to document the developmental changes in the ventilatory and timing parameters associated with quiet breathing at rest in awake, standing horses during the first year post partum. Tidal volume (VT), breathing frequency, airflow, mechanical timing intervals and minute ventilation (VE) were measured serially in foals age 24 h-1 year. In the growing foal, VE increased due to a progressive rise in VT, in spite of a pronounced decrease in respiratory frequency. When normalised to body weight (bwt), VE/kg declined with maturation in a curvilinear fashion, from mean +/- s...
99Tcm-HMPAO labelled leucocytes and their biodistribution in the horse: a preliminary investigation.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 313-315 doi: 10.1111/j.2042-3306.1995.tb03083.x
Butson RJ, Webbon PM, Fairbairn SM.No abstract available
XX male pseudohermaphroditism in a horse.
Journal of the American Veterinary Medical Association    July 1, 1995   Volume 207, Issue 1 77-79 
Milliken JE, Paccamonti DL, Shoemaker S, Green WH.A pseudohermaphrodite horse with aggressive stallion-like behavior and ambiguous external genitalia was gonadectomized. The hypoplastic gonads removed from the abdomen were confirmed by histologic examination to be testes. Examination of blood and fibroblasts revealed a 64,XX karyotype.
Clinical features of the 1992 outbreak of equine viral arteritis in Spain.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 301-304 doi: 10.1111/j.2042-3306.1995.tb03081.x
Monreal L, Villatoro AJ, Hooghuis H, Ros I, Timoney PJ.During 1992, a widespread outbreak of Equine viral arteritis (EVA) occurred at a riding establishment near Barcelona, Spain. A total of 31 out of 186 horses on the premises displayed clinical signs, most frequently, fever, depression, mild ventral and limb oedema and a vesicular-erosive stomatitis, with hypersalivation, petechiations and small ulcerations. Affected horses developed illness of varying severity with only a few exhibiting a severe form of the disease and no mortality was recorded. Haematological and blood biochemical examination the most severely affected horses revealed a thromb...
Resolution of a left ureteral stone using electrohydraulic lithotripsy in a thoroughbred colt.
Journal of veterinary internal medicine    July 1, 1995   Volume 9, Issue 4 280-282 doi: 10.1111/j.1939-1676.1995.tb01081.x
Rodger LD, Carlson GP, Moran ME, Yarbrough TB, Pascoe JR, Reynolds JA.A 3-year-old Thoroughbred colt was presented for evaluation of azotemia and anorexia. Physical examination revealed a ureterolith in the left ureter, approximately 10 cm from the bladder, which was thought to obstruct urine flow by approximately 90% when viewed cystoscopically. Ultrasonographic examination of both kidneys revealed indistinct corticomedullary junctions, and the right kidney was more hyperechoic. A percutaneous biopsy of the right kidney revealed chronic interstitial nephritis with marked interstitial medullary fibrosis. Medical therapy consisting of IV fluids, sodium chloride P...
The morphology and pathology of Besnoitia sp. in reindeer (Rangifer tarandus tarandus).
Journal of wildlife diseases    July 1, 1995   Volume 31, Issue 3 319-326 doi: 10.7589/0090-3558-31.3.319
Ayroud M, Leighton FA, Tessaro SV.Four of five reindeer (Rangifer tarandus tarandus) obtained from a Besnoitia sp.- infected herd at the Assiniboine Park Zoo in Winnipeg, Manitoba, Canada, in October 1989, had evidence of mild dermatitis over the articular surfaces of carpal and tarsal joints. Cysts of Besnoitia sp., either surrounded by inflammatory reactions or without evident host response, were present within the dermis, submucosa of the nasal turbinates, periosteum, tendons, testes and hooves. The light microscopic and histochemical features of Besnoitia sp. from reindeer were indistinguishable from those of other Besnoit...
Assessment of glycosaminoglycan concentration in equine synovial fluid as a marker of joint disease. Palmer JL, Bertone AL, McClain H.A modification of a colorimetric assay was used to determine synovial fluid total and individual sulphated-glycosaminoglycan concentration in various clinical presentations of joint disease in horses. Concentrations of synovial fluid and serum sulphated-glycosaminoglycan (GAG) were measured by the 1,9-dimethylmethylene blue (DMMB) dye assay in normal horses (n = 49), horses with acute (n = 26) or chronic (n = 27) joint disease (defined by clinical, radiographic, and clinicopathological parameters), and horses with cartilaginous lesions at diagnostic arthroscopy, but with normal radiographs and...
Contact area and static pressure profile at the plate-bone interface in the nonluted and luted bone plate.
Veterinary surgery : VS    July 1, 1995   Volume 24, Issue 4 299-307 doi: 10.1111/j.1532-950x.1995.tb01334.x
Staller GS, Richardson DW, Nunamaker DM, Provost M.Contact area and pressure between 6-hole broad dynamic compression plates and 20 pairs of equine third metatarsal bones were measured using nonluted and luted plating techniques. Pressure-sensitive film (pressure ranges 10 to 50 MPa and 50 to 130 MPa) was used as the static pressure transducer. Nonluted and one of two luting techniques were tested on each pair of bones; each luting technique was tested on 20 bones. Quantitative determinations of contact area and pressure were made using computerized image processing techniques. Mean (+/- SD) total contact area for nonluted plates was 18.49% +/...
Practical implications of pharmacokinetic and pharmacodynamic (PK/PD) modelling of drug dose regimens.
Equine veterinary journal    July 1, 1995   Volume 27, Issue 4 245-246 doi: 10.1111/j.2042-3306.1995.tb03071.x
Baggot JD.No abstract available
A mouse model for testing the pathogenicity of equine herpes virus-1 strains.
Journal of virological methods    July 1, 1995   Volume 54, Issue 1 39-49 doi: 10.1016/0166-0934(95)00024-o
van Woensel PA, Goovaerts D, Markx D, Visser N.A mouse model was developed for testing the pathogenicity of equine herpes virus-1 (EHV-1) strains. The model was validated with EHV-1 strains that are known to be of a low or high pathogenicity in horses. From all parameters tested, the safety index, which was calculated from the body weights of the mice after infection, proved to be the best predictive parameter. When this parameter was used, good and reliable correlations were found with the pathogenicity of the EHV-1 strains in horses. This method enabled the differentiation between the two experimental EHV-1 strains whose genetic backgrou...
Hemicastration of thoroughbreds.
The Veterinary record    June 24, 1995   Volume 136, Issue 25 643-644 doi: 10.1136/vr.136.25.643
Green P.No abstract available
Infection of humans and horses by a newly described morbillivirus.
The Medical journal of Australia    June 19, 1995   Volume 162, Issue 12 642-645 doi: 10.5694/j.1326-5377.1995.tb126050.x
Selvey LA, Wells RM, McCormack JG, Ansford AJ, Murray K, Rogers RJ, Lavercombe PS, Selleck P, Sheridan JW.To describe the clinical and epidemiological features of an outbreak of a viral infection affecting humans and horses. Methods: Stables in Hendra, a suburb of Brisbane. Methods: Affected horses and humans, and at-risk human contacts. Results: A pregnant mare died two days after arrival from a paddock elsewhere in Brisbane. Eight to 11 days later, illness (depression, anorexia, fever, dyspnoea, ataxia, tachycardia, tachypnoea and nasal discharge) was reported among 17 other horses from the same or an adjoining stable. Fourteen horses died or were put down. Five and six days after the index mare...
Application of an equine herpesvirus 1 (EHV1) type-specific ELISA to the management of an outbreak of EHV1 abortion.
The Veterinary record    June 10, 1995   Volume 136, Issue 23 579-581 doi: 10.1136/vr.136.23.579
Drummer HE, Reynolds A, Studdert MJ, MacPherson CM, Crabb BS.Sera from 33 Australian thoroughbred mares were tested during an outbreak of equine herpesvirus 1 (EHV1) abortion with an enzyme-linked immunosorbant assay (ELISA) for the presence of EHV1-specific antibodies. The ELISA used a recombinant EHV1 antigen derived from glycoprotein G (gG) and distinguished antibodies to EHV1 from those of the antigenically related and widespread herpesvirus EHV4. Sera were obtained from most of the mares on three occasions, three, 13 and 67 days after the first abortion. Mares which were negative in the ELISA were kept separate from mares which were positive. A sec...
The DNA sequence of equine herpesvirus 2.
Journal of molecular biology    June 9, 1995   Volume 249, Issue 3 520-528 doi: 10.1006/jmbi.1995.0314
Telford EA, Watson MS, Aird HC, Perry J, Davison AJ.The complete DNA sequence of equine herpesvirus 2 (EHV-2) strain 86/67 was determined. The genome is 184,427 bp in size and has a base composition of 57.5% G + C. Unusually for a herpesvirus, about a third of the sequence distributed in several large blocks appears not to encode proteins. The 79 open reading frames that were identified as probably polypeptide-coding are predicted to encode 77 distinct proteins. Amino acid sequence comparisons confirmed that EHV-2 is a gamma-herpesvirus that is genetically collinear with herpesvirus saimiri (HVS; a gamma 2-herpesvirus) and Epstein-Barr virus (E...
Emergence of a new epidemic/epizootic Venezuelan equine encephalitis virus in South America.
Proceedings of the National Academy of Sciences of the United States of America    June 6, 1995   Volume 92, Issue 12 5278-5281 doi: 10.1073/pnas.92.12.5278
Rico-Hesse R, Weaver SC, de Siger J, Medina G, Salas RA.One of the most important questions in arbovirology concerns the origin of epidemic Venezuelan equine encephalitis (VEE) viruses; these viruses caused periodic, extensive epidemics/epizootics in the Americas from 1938-1973 (reaching the United States in 1971) but had recently been presumed extinct. We have documented the 1992 emergence of a new epidemic/epizootic VEE virus in Venezuela. Phylogenetic analysis of strains isolated during two outbreaks indicated that the new epidemic/epizootic virus(es) evolved recently from an enzootic VEE virus in northern South America. These results suggest co...
Electrocardiographic values in Spanish-bred horses of different ages.
Australian veterinary journal    June 1, 1995   Volume 72, Issue 6 225-226 doi: 10.1111/j.1751-0813.1995.tb03526.x
Ayala I, Montes A, Bernal LJ, Sandoval JA, Gutierrez C.The duration of electrocardiograph wave forms and intervals were determined in 179 Spanish-bred (Andalusian) horses aged from 1 month to 17 years. The values were compared with those of other breeds, and the relationship between electrocardiographic data and age was examined. High correlation coefficients were found between PR, ST and QT intervals and the age of the horses, and an inverted relation between heart rate and age was found. A multiple range analysis was made and the results suggest that significant changes in duration values and heart rate occurred at the age of 6 months and in the...
At least four MHC class I genes are transcribed in the horse: phylogenetic analysis suggests an unusual evolutionary history for the MHC in this species.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics    June 1, 1995   Volume 22, Issue 3 249-260 doi: 10.1111/j.1744-313x.1995.tb00239.x
Ellis SA, Martin AJ, Holmes EC, Morrison WI.Nineteen horse MHC class I specificities have been serologically identified previously at a single locus (ELA-A), and two other specificities appear to be coded at other loci. Biochemical studies indicate that there are at least two expressed loci. In order to establish the number of transcribed horse MHC class I genes, we made a cDNA library from a heterozygous animal (ELA-A3/A7), and screened for positive clones using a bovine class I probe. More than 200 class I clones were isolated in this way, and so far seven unique full length sequences have been identified. All of the sequences are pre...
Extensive mtDNA diversity in horses revealed by PCR-SSCP analysis.
Animal genetics    June 1, 1995   Volume 26, Issue 3 193-196 doi: 10.1111/j.1365-2052.1995.tb03162.x
Marklund S, Chaudhary R, Marklund L, Sandberg K, Andersson L.The hypervariable D-loop region of mitochondrial DNA (mtDNA) was amplified with the polymerase chain reaction using total horse DNA samples. Analysis of single strand conformation polymorphism (SSCP) of denatured amplification products was carried out by native polyacrylamide (8%) gel electrophoresis followed by silver staining. As many as 15 distinct SSCP variants were revealed when screening a total of 78 maternally unrelated horses representing five different breeds. All breeds showed a high degree of polymorphism and the estimated probability (PImt) that two maternally unrelated individual...