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Animals : an open access journal from MDPI2024; 14(23); doi: 10.3390/ani14233385

Nutraceutical Supplement Mitigates Insulin Resistance in Horses with a History of Insulin Dysregulation During a Challenge with a High-Starch Diet.

Abstract: Insulin dysregulation (ID) is associated with an increased risk of laminitis which often necessitates the need for clinical intervention. To test the contention that the prophylactic supplementation of nutraceuticals could mitigate ID in susceptible horses, 16 mature horses with a history of ID were supplemented with either the placebo (n = 8) or nutraceutical (n = 8) once daily. Horses were housed in dry lots with ad libitum access to grass hay and fed a concentrate twice daily to provide 0.5 g starch/kg BW/meal. A combined glucose-insulin tolerance test was performed on all horses before and after 4 weeks of treatment. Nutraceutical-supplemented horses had 61% greater (p = 0.05) glucose clearance rates compared to the placebo group. This resulted in a shorter time in the positive phase of glucose clearance (p = 0.03) for the nutraceutical group compared to the placebo group. Horses receiving the nutraceutical had lower (p = 0.003) insulin concentrations at 75 min and lower (p = 0.04) glucose concentrations at 45 min compared to the placebo. Prophylactic supplementation with nutraceuticals resulted in greater glucose clearance rates during a starch challenge, indicating that nutraceuticals can mitigate ID in susceptible horses consuming an excess of non-structural carbohydrate.
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Publication Date: 2024-11-25 PubMed ID: 39682351PubMed Central: PMC11640219DOI: 10.3390/ani14233385Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study investigates the effects of a nutraceutical supplement on insulin regulation in horses known to have insulin dysregulation. The study found that horses supplemented with the nutraceutical demonstrated greater glucose clearance rates, thus suggesting that nutraceutical use could help manage insulin-related health issues in these animals.

Study Design

  • The experiment involved 16 mature horses that had a history of insulin dysregulation. These horses were divided into two groups of eight – one group receiving the nutraceutical and the other group given a placebo. All horses were housed in dry lots and had unrestricted access to grass hay. They were also given a concentrated feed twice daily.
  • A combined glucose-insulin tolerance test was performed on all horses before the experiment (baseline) and after four weeks of treatment to measure the effects of the nutraceutical.

Key Findings

  • The results of the glucose-insulin tolerance tests showed that horses supplemented with the nutraceutical had significantly higher glucose clearance rates (61%) compared to those given the placebo. This implied that the nutraceutical helped these horses remove glucose from their bloodstream more efficiently.
  • The time taken for glucose clearance in the positive phase was significantly shorter for the nutraceutical group compared to the placebo group.
  • Nutraceutical-supplemented horses also recorded lower insulin concentrations at the 75-minute mark and reduced glucose concentrations at the 45-minute mark compared to the placebo group.

Significance and Implications

  • The observed improvements in insulin regulation suggest that nutraceutical supplements could mitigate insulin dysregulation in horses. This finding is particularly significant because insulin dysregulation is associated with an elevated risk of laminitis, which can require clinical intervention.
  • The sprinkling of a daily dose of nutraceuticals into the diet of horses that are consuming an excess of non-structural carbohydrates could be a useful strategy to enhance their glucose clearance capacity and overall insulin regulation. This hints towards a potential non-invasive and practical approach towards the management and prevention of insulin-related health problems in susceptible horses.

Cite This Article

APA
Loos C, Castelein A, Vanzant E, Adam E, McLeod KR. (2024). Nutraceutical Supplement Mitigates Insulin Resistance in Horses with a History of Insulin Dysregulation During a Challenge with a High-Starch Diet. Animals (Basel), 14(23). https://doi.org/10.3390/ani14233385

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 23

Researcher Affiliations

Loos, Caroline
  • Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.
Castelein, Annette
  • Nutrition Department, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands.
Vanzant, Eric
  • Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.
Adam, Emma
  • Gluck Equine Research Center, University of Kentucky, Lexington, KY 40503, USA.
McLeod, Kyle R
  • Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.

Grant Funding

  • 0001 / Cooperative Research Farms

Conflict of Interest Statement

Cooperative Research Farms provided the nutraceutical supplement used in this study. The funder was not involved in the collection, analysis, or interpretation of the data or in the decision to submit it for publication. The other authors declare no conflicts of interest.

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