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Topic:Disease Management

Disease management in horses encompasses the strategies and practices employed to prevent, control, and treat diseases affecting equine populations. This field involves understanding the etiology, transmission, and clinical presentation of various equine diseases, as well as implementing biosecurity measures and therapeutic interventions. Common diseases in horses include equine influenza, strangles, and equine herpesvirus. Effective disease management relies on accurate diagnosis, vaccination protocols, and the use of antimicrobials and other treatments. This page compiles peer-reviewed research studies and scholarly articles that explore the methodologies, challenges, and advancements in managing diseases in equine health.
Clarifying the role of maples in atypical myopathy.
Equine veterinary journal    February 20, 2014   Volume 46, Issue 2 135-136 doi: 10.1111/evj.12176
Gillman JH, Hegeman AD, Sharp RG.No abstract available
Antimicrobial use in foals: Do we need to change how we think?
Equine veterinary journal    February 20, 2014   Volume 46, Issue 2 137-138 doi: 10.1111/evj.12178
Haggett EF.No abstract available
Standing equine surgery of the upper respiratory tract.
The Veterinary clinics of North America. Equine practice    February 19, 2014   Volume 30, Issue 1 111-141 doi: 10.1016/j.cveq.2013.11.009
Cramp PA, Prange T, Nickels FA.The purpose of this article is to review the literature and personal experiences of equine surgeons so as to describe procedures that can be performed in the standing sedated horse to alleviate conditions that result in upper respiratory tract obstruction. Upper respiratory tract surgery requires attention to detail, meticulous planning, and careful dissection and execution with little room for error. This article describes a selection of standing upper airway procedures, the indications for and possible complications of these surgeries, and advantages and disadvantages of a particular method....
The Equine PeptideAtlas: a resource for developing proteomics-based veterinary research.
Proteomics    February 16, 2014   Volume 14, Issue 6 763-773 doi: 10.1002/pmic.201300398
Bundgaard L, Jacobsen S, Sørensen MA, Sun Z, Deutsch EW, Moritz RL, Bendixen E.Progress in MS-based methods for veterinary research and diagnostics is lagging behind compared to the human research, and proteome data of domestic animals is still not well represented in open source data repositories. This is particularly true for the equine species. Here we present a first Equine PeptideAtlas encompassing high-resolution tandem MS analyses of 51 samples representing a selection of equine tissues and body fluids from healthy and diseased animals. The raw data were processed through the Trans-Proteomic Pipeline to yield high quality identification of proteins and peptides. T...
Molecular characterization of the Babesia caballi rap-1 gene and epidemiological survey in horses in Israel.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases    February 10, 2014   Volume 23 115-120 doi: 10.1016/j.meegid.2014.01.033
Rapoport A, Aharonson-Raz K, Berlin D, Tal S, Gottlieb Y, Klement E, Steinman A.Equine piroplasmosis imposes great concerns for the equine industry regarding international horse movement, and therefore requires reliable diagnostic tools. Recent studies from South Africa and Jordan, including a preliminary study in Israel, reported extremely low seroprevalence to Babesia caballi (B. caballi) (0-1%) using the acceptable rhoptry-associated protein-1 (RAP-1) cELISA. In accordance with the study from South Africa demonstrating a significant heterogeneity in the rap-1 gene sequence of South African B. caballi isolates, the objectives of this study were to phylogenetically chara...
Treatment of nonhealing corneal ulcers in 60 horses with diamond burr debridement (2010-2013).
Veterinary ophthalmology    February 10, 2014   Volume 17 Suppl 1 76-81 doi: 10.1111/vop.12148
Lassaline-Utter M, Cutler TJ, Michau TM, Nunnery CM.To review the signalment, clinical characteristics, and outcome of horses with nonhealing corneal ulcers treated with diamond burr debridement (DBD); and to evaluate the role of ulcer duration, size and location, and bandage contact lens (BCL) placement on healing. Methods: From January 2012-April 2013, 60 horses were diagnosed with ulcers classified as nonhealing based on the presence of raised epithelial margins and duration of at least 7 days. Methods: Retrospective record review. Results: Average age of included horses was 14.68 years, SD 8.17 years. There were three times as many males (4...
The threat of midge-borne equine disease: investigation of Culicoides species on UK equine premises.
The Veterinary record    February 6, 2014   Volume 174, Issue 12 301 doi: 10.1136/vr.102151
Robin M, Archer D, Garros C, Gardès L, Baylis M.There are concerns that outbreaks of exotic or novel vector-borne viral diseases will increasingly occur within northern Europe and the UK in the future. African horse sickness (AHS) is a viral disease of equids that is transmitted by Culicoides and is associated with up to 95 per cent mortality. AHS has never occurred in the UK; however, it has been suggested that appropriate Culicoides species and climatic conditions are present in northern Europe to support an outbreak. No data are currently available regarding the Culicoides species present on UK equine properties. This study demonstrates ...
[Helminth control in the adult horse: the need for a re-orientation].
Schweizer Archiv fur Tierheilkunde    January 28, 2014   Volume 156, Issue 2 61-70 doi: 10.1024/0036-7281/a000552
Hertzberg H, Schwarzwald CC, Grimm F, Frey CF, Gottstein B, Gerber V.The epidemiological situation of strongyle infections in adult horses in Switzerland is characterized by a strong dominance of small strongyles (Cyathostominae) and an overall low level of egg shedding in the faeces. The prevailing attitude towards anthelmintic therapy considers neither husbandry conditions nor pasture hygiene measures. Instead, calendar-based routine medication, comprising usually 3 to 4 annual treatments, is the typical strategy. Such an approach, however, often results in an excessive administration of anthelmintics. With respect to the continuous spread of drug resistant c...
The effectiveness of faecal removal methods of pasture management to control the cyathostomin burden of donkeys.
Parasites & vectors    January 24, 2014   Volume 7 48 doi: 10.1186/1756-3305-7-48
Corbett CJ, Love S, Moore A, Burden FA, Matthews JB, Denwood MJ.The level of anthelmintic resistance within some cyathostomin parasite populations has increased to the level where sole reliance on anthelmintic-based control protocols is not possible. Management-based nematode control methods, including removal of faeces from pasture, are widely recommended for use in association with a reduction in anthelmintic use to reduce selection pressure for drug resistance; however, very little work has been performed to quantitatively assess the effectiveness of such methods. Methods: We analysed data obtained from 345 donkeys at The Donkey Sanctuary (Devon, UK), m...
A chromosomal region on ECA13 is associated with maxillary prognathism in horses.
PloS one    January 21, 2014   Volume 9, Issue 1 e86607 doi: 10.1371/journal.pone.0086607
Signer-Hasler H, Neuditschko M, Koch C, Froidevaux S, Flury C, Burger D, Leeb T, Rieder S.Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in breeding programs. We performed a case-control analysis for maxillary prognathism in horses using 96 cases and 763 controls. All horses had been previously genotyped with a commercially available 50 k SNP array. We analyzed the data with a mixe...
From the pens to the field: real-world wildlife contraception.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians    January 21, 2014   Volume 44, Issue 4 Suppl S102-S110 doi: 10.1638/1042-7260-44.4S.S102
Turner JW, Rutberg AT.There are only two nonlethal approaches with which to manage wildlife populations: remove excess individuals or decrease reproductive rates. In the case of wild horse management, the latter has already been shown to be a more humane and less costly approach. Contraception has been known for many years to be effective in wild horses with regard to both fertility and population alteration. Field testing under real-world management situations is a critical aspect of wildlife contraception assessment. Field testing also requires documentation to justify eventual large-scale use of fertility contro...
Anthelmintic resistance in important parasites of horses: does it really matter?
Veterinary parasitology    January 15, 2014   Volume 201, Issue 1-2 1-8 doi: 10.1016/j.vetpar.2014.01.004
Peregrine AS, Molento MB, Kaplan RM, Nielsen MK.Parascaris equorum and cyathostomins are currently considered the most important parasites of horses and have traditionally been controlled with anthelmintics belonging to three drug classes: benzimidazoles, the tetrahydropyrimidine pyrantel, and macrocyclic lactones. Unfortunately, resistance to benzimidazoles, and to a lesser extent pyrantel, is widespread in cyathostomins around the world. Furthermore, resistance to macrocyclic lactones appears to be in the early stages of development in cyathostomins in multiple locations. In contrast, P. equorum populations have remained susceptible to th...
Nonthyroidal illness syndrome in adult horses.
Journal of veterinary internal medicine    January 13, 2014   Volume 28, Issue 2 609-617 doi: 10.1111/jvim.12274
Hilderbran AC, Breuhaus BA, Refsal KR.This study was performed to determine whether sick horses have thyroid hormone (TH) alterations similar to those observed in nonthyroidal illness syndrome in other species. Objective: Horses suffering from systemic diseases have decreased THs and inappropriately low thyroid-stimulating hormone (TSH). Methods: Seventy-one clinically normal horses; 380 hospitalized horses. Methods: Total thyroxine (TT4), free thyroxine by equilibrium dialysis (fT4D), total triiodothyronine (TT3), free triiodothyronine (fT3), and TSH were measured in normal and hospitalized horses. Disease severity was categorize...
Long-term survival in horses with strangulating obstruction of the small intestine managed without resection.
Equine veterinary journal    January 7, 2014   Volume 46, Issue 6 711-717 doi: 10.1111/evj.12216
Freeman DE, Schaeffer DJ, Cleary OB.Although many studies have described results after small intestinal resection and anastomosis in horses, few have described the outcome in horses with strangulating lesions managed without resection. Objective: To examine short- and long-term recoveries in horses with strangulated small intestine that was judged to be viable during surgery and not resected. Methods: Retrospective analysis of case records. Methods: Data were reviewed from all cases (35 horses) with colic caused by small intestinal strangulation that underwent surgery between 1996 and 2011 at 2 university hospitals and that were...
Extensive rostral mandibulectomy for treatment of ameloblastoma in a horse.
Veterinary surgery : VS    January 6, 2014   Volume 43, Issue 2 222-226 doi: 10.1111/j.1532-950X.2014.12110.x
Mendez-Angulo JL, Tatarniuk DM, Ruiz I, Ernst N.To report long-term outcome in a mare that had extensive rostral mandibulectomy to remove an ameloblastoma. Methods: Clinical report. Methods: A 21-year-old mare. Methods: An ameloblastoma, located in the rostral aspect of the mandible, was removed by complete en-bloc resection of the tumor, removing most of the mandibular symphysis. Results: The day after surgery, the remaining mandibular symphysis (<5 mm) fractured causing marked instability of the hemi-mandibles. Partial wound dehiscence occurred 5 days after surgery; however, the mare was able to eat well and the incision healed within 2...
Anesthesia and analgesia for standing equine surgery.
The Veterinary clinics of North America. Equine practice    December 31, 2013   Volume 30, Issue 1 1-17 doi: 10.1016/j.cveq.2013.11.008
Vigani A, Garcia-Pereira FL.Morbidity and mortality rate in equine anesthesia is still unacceptably high. Thus it is critical contemplating whether the benefit of general anesthesia for a specific patient and procedure outweighs the risks. Sedative protocols that would allow performing diagnostic and surgical procedures with the patient remaining standing would therefore be ideal. Infusion of short-acting agents allows to rapidly achieve a titratable steady state of sedation. Supplementing sedatives and tranquilizers with systemic analgesic or regional anesthetic techniques (i.e. epidurals) facilitates standing surgical ...
The management of anthelmintic resistance in grazing ruminants in Australasia–strategies and experiences.
Veterinary parasitology    December 31, 2013   Volume 204, Issue 1-2 44-54 doi: 10.1016/j.vetpar.2013.12.022
Leathwick DM, Besier RB.In many countries the presence of anthelmintic resistance in nematodes of small ruminants, and in some cases also in those infecting cattle and horses, has become the status quo rather than the exception. It is clear that consideration of anthelmintic resistance, and its management, should be an integral component of anthelmintic use regardless of country or host species. Many years of research into understanding the development and management of anthelmintic resistance in nematodes of small ruminants has resulted in an array of strategies for minimising selection for resistance and for dealin...
Anthelmintic resistance in equine parasites–current evidence and knowledge gaps.
Veterinary parasitology    December 31, 2013   Volume 204, Issue 1-2 55-63 doi: 10.1016/j.vetpar.2013.11.030
Nielsen MK, Reinemeyer CR, Donecker JM, Leathwick DM, Marchiondo AA, Kaplan RM.Anthelmintic resistance is becoming increasingly prevalent among equine nematode parasites. The first reports documenting resistance were published in the 1960s, just a short time after introduction of the first modern anthelmintics phenothiazine and thiabendazole. Several factors are known to influence development of resistance, but evidence specific to equine parasites is limited. Most current knowledge and applications have been extrapolated from research with trichostrongylid parasites of sheep. The number of cyathostomin species co-infecting horses adds to the complexity of investigating ...
Comparing the genetic diversity of ORF30 of Australian isolates of 3 equid alphaherpesviruses.
Veterinary microbiology    December 25, 2013   Volume 169, Issue 1-2 50-57 doi: 10.1016/j.vetmic.2013.12.007
Cuxson JL, Hartley CA, Ficorilli NP, Symes SJ, Devlin JM, Gilkerson JR.A single nucleotide polymorphism (SNP) has been previously associated with EHV-1 neurological disease in several countries around the world. This disease is very uncommon in Australia and little information is available about the presence of this SNP in Australian EHV-1 isolates. The ORF30 sequence of 66 Australian EHV-1 isolates was determined and the genotype was compared to the disease manifestation of the case from which the virus was isolated. Of the 66 isolates, 61 were from cases of abortion and 5 were cases associated with equine herpesvirus myeloencephalopathy (EHM). There was no asso...
The future of helminth control in horses.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 10-11 doi: 10.1111/evj.12200
Matthews JB.No abstract available
Current status and future directions: equine pituitary pars intermedia dysfunction and equine metabolic syndrome.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 99-102 doi: 10.1111/evj.12194
Sojka-Kritchevsky JE, Johnson PJ.No abstract available
EVE and EVJ online collection of equine endocrinology: recent and future directions; a great start, but still a long way to go.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 97-98 doi: 10.1111/evj.12217
Marr CM, Mair TS.No abstract available
The dilemmas of medicine selection for equine veterinarians.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 15-16 doi: 10.1111/evj.12195
Chandler KJ, Sutton DG.No abstract available
Response to Stancampiano et al. (2013), Letter to the Editor.
Veterinary parasitology    December 14, 2013   Volume 200, Issue 1-2 229-230 doi: 10.1016/j.vetpar.2013.12.006
Lichtenfels JR, Kharchenko VA.No abstract available
Applying Bayesian network modelling to understand the links between on-farm biosecurity practice during the 2007 equine influenza outbreak and horse managers’ perceptions of a subsequent outbreak.
Preventive veterinary medicine    December 14, 2013   Volume 116, Issue 3 243-251 doi: 10.1016/j.prevetmed.2013.11.015
Firestone SM, Lewis FI, Schemann K, Ward MP, Toribio JA, Taylor MR, Dhand NK.Australia experienced its first ever outbreak of equine influenza in August 2007. Horses on 9359 premises were infected over a period of 5 months before the disease was successfully eradicated through the combination of horse movement controls, on-farm biosecurity and vaccination. In a previous premises-level case-control study of the 2007 equine influenza outbreak in Australia, the protective effect of several variables representing on-farm biosecurity practices were identified. Separately, factors associated with horse managers' perceptions of the effectiveness of biosecurity measures have b...
In vitro reproduction of the life cycle of Pythium insidiosum from kunkers’ equine and their role in the epidemiology of pythiosis.
Mycopathologia    December 11, 2013   Volume 177, Issue 1-2 123-127 doi: 10.1007/s11046-013-9720-6
Fonseca AO, Botton Sde A, Nogueira CE, Corrêa BF, Silveira Jde S, de Azevedo MI, Maroneze BP, Santurio JM, Pereira DI.Pythium insidiosum is an important pathogen of mammals' species, including humans. Equine is the main species affected by this oomycete. P. insidiosum requires an aquatic environment to develop its life cycle, and the susceptible hosts are contaminated when they contact the microorganism in swampy areas. The equine pythiosis is characterized by the formation of irregular masses within the cutaneous lesions, called kunkers, which easily detach from the lesion. From these structures, it is possible to isolate P. insidiosum in pure cultures. The present study aimed to reproduce in vitro the life ...
Faecal worm egg count analysis for targeting anthelmintic treatment in horses: points to consider.
Equine veterinary journal    December 10, 2013   Volume 46, Issue 2 139-145 doi: 10.1111/evj.12199
Lester HE, Matthews JB.Equine gastrointestinal nematodes are ubiquitous; in horses that graze contaminated pasture and that are not treated appropriately, large numbers of worms can accumulate, which can lead to serious clinical disease. Nematode control has traditionally followed interval treatment regimens, which involve regular anthelmintic administration to all horses based on the strongyle egg reappearance periods of each drug, usually defined around the time of licensing. Interval treatment programmes have resulted in substantial reductions in large strongyle disease, but have made major contributions to the d...
Three-dimensional anatomy of equine incisors: tooth length, enamel cover and age related changes.
BMC veterinary research    December 9, 2013   Volume 9 249 doi: 10.1186/1746-6148-9-249
Schrock P, Lüpke M, Seifert H, Staszyk C.Equine incisors are subjected to continuous occlusal wear causing multiple, age related changes of the extragingival crown. It is assumed that the occlusal wear is compensated by continued tooth elongation at the apical ends of the teeth. In this study, μCT-datasets offered the opportunity to analyze the three-dimensional appearance of the extra- and intraalveolar parts of the enamel containing dental crown as well as of the enamel-free dental root. Multiple morphometric measurements elucidated age related, morphological changes within the intraalveolar part of the incisors. Results: Equine i...
Comparison of two sampling and culture systems for detection of Salmonella enterica in the environment of a large animal hospital.
Equine veterinary journal    December 5, 2013   Volume 46, Issue 4 499-502 doi: 10.1111/evj.12193
Ruple-Czerniak A, Bolte DS, Burgess BA, Morley PS.Nosocomial salmonellosis is an important problem in veterinary hospitals that treat horses and other large animals. Detection and mitigation of outbreaks and prevention of healthcare-associated infections often require detection of Salmonella enterica in the hospital environment. Objective: To compare 2 previously published methods for detecting environmental contamination with S. enterica in a large animal veterinary teaching hospital. Methods: Hospital-based comparison of environmental sampling techniques. Methods: A total of 100 pairs of environmental samples were collected from stalls us...
Factors associated with survival in 148 recumbent horses.
Equine veterinary journal    December 5, 2013   Volume 46, Issue 5 575-578 doi: 10.1111/evj.12147
Winfield LS, Kass PH, Magdesian KG, Madigan JE, Aleman M, Pusterla N.There are currently few data available on the prognosis and outcome of recumbent horses. Objective: To investigate the outcome of hospitalised horses that had been recumbent in the field or hospital and factors affecting their survival within the first 3 days of hospitalisation and survival after 3 days to hospital discharge. Methods: Retrospective analysis of clinical records. Methods: Records of 148 horses admitted to the William R. Pritchard Veterinary Medical Teaching Hospital, University of California Davis from January 1995 to December 2010 with a history of recumbency or horses that bec...
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