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Topic:Disease

The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse.
Journal of veterinary internal medicine    March 14, 2017   Volume 31, Issue 3 884-889 doi: 10.1111/jvim.14682
Luethy D, Slack J, Kraus MS, Gelzer AR, Habecker P, Johnson AL.Third-degree atrioventricular block (AVB) and primary inflammatory myocarditis are uncommon findings in horses. The horse of this report presented for collapse at rest and was found to have multiple cardiac arrhythmias, most notably 3rd-degree AVB. The horse was subsequently diagnosed with eosinophilic myocarditis on necropsy, a rare form of myocarditis not previously reported in horses. Despite extensive testing, an etiologic agent could not be identified, illustrating the difficulty in identifying a specific cause of myocarditis in horses.
Occurrence and Genetic Characteristics of Cryptosporidium hominis and Cryptosporidium andersoni in Horses from Southwestern China.
The Journal of eukaryotic microbiology    March 8, 2017   Volume 64, Issue 5 716-720 doi: 10.1111/jeu.12399
Deng L, Li W, Zhong Z, Gong C, Cao X, Song Y, Wang W, Huang X, Liu X, Hu Y, Fu H, He M, Wang Y, Zhang Y, Wu K, Peng G.A total of 333 fecal specimens from horses in southwestern China were genotyped based on analysis of the small subunit rRNA (SSU rRNA) gene. Cryptosporidium hominis and Cryptosporidium andersoni were identified in 2 and 4 stool specimens, respectively. The identification of C. hominis was confirmed by sequence analysis of the 70-kDa heat shock protein (HSP70) and oocyst wall protein (COWP) genes. Subtyping analysis of the 60-kDa glycoprotein (GP60) gene sequence of C. hominis revealed a new rare subtype Id, named IdA15; only three Id isolates have been reported in humans to date. Multilocus ...
Immune protection against reinfection with nonprimate hepacivirus.
Proceedings of the National Academy of Sciences of the United States of America    March 8, 2017   Volume 114, Issue 12 E2430-E2439 doi: 10.1073/pnas.1619380114
Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P....Hepatitis C virus (HCV) displays a restricted host species tropism and only humans and chimpanzees are susceptible to infection. A robust immunocompetent animal model is still lacking, hampering mechanistic analysis of virus pathogenesis, immune control, and prophylactic vaccine development. The closest homolog of HCV is the equine nonprimate hepacivirus (NPHV), which shares similar features with HCV and thus represents an animal model to study hepacivirus infections in their natural hosts. We aimed to dissect equine immune responses after experimental NPHV infection and conducted challenge ex...
Treatment of supraventricular tachycardia in a horse.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)    March 7, 2017   Volume 27, Issue 3 362-368 doi: 10.1111/vec.12591
Whelchel DD, Tennent-Brown BS, Coleman AE, Rapoport GS, Blas-Machado U, Maisenbacher HW, Credille BC, Giguère S.To describe the treatment of persistent supraventricular tachycardia (SVT) in a young horse in endurance training. Methods: A 6-year-old Arab gelding in endurance training presented for a dysrhythmia and decreased performance. SVT was diagnosed and conversion to a normal sinus rhythm was achieved following administration of a constant rate infusion of amiodarone. However, reversion to SVT occurred shortly after initiation of ridden exercise. A second attempt to convert the dysrhythmia with amiodarone failed, but normal sinus rhythm was achieved with transvenous electrical cardioversion (TVEC)....
Alterations in Intestinal Permeability: The Role of the “Leaky Gut” in Health and Disease.
Journal of equine veterinary science    March 7, 2017   Volume 52 10-22 doi: 10.1016/j.jevs.2017.02.009
Stewart AS, Pratt-Phillips S, Gonzalez LM.All species, including horses, suffer from alterations that increase intestinal permeability. These alterations, also known as "leaky gut," may lead to severe disease as the normal intestinal barrier becomes compromised and can no longer protect against harmful luminal contents including microbial toxins and pathogens. Leaky gut results from a variety of conditions including physical stressors, decreased blood flow to the intestine, inflammatory disease, and pathogenic infections, among others. Several testing methods exist to diagnose these alterations in both a clinical and research setting....
Equine herpesvirus type 1 induces both neurological and respiratory disease in Syrian hamsters.
Veterinary microbiology    March 7, 2017   Volume 203 117-124 doi: 10.1016/j.vetmic.2017.03.007
Mesquita LP, Arévalo AF, Zanatto DA, Miyashiro SI, Cunha EMS, de Souza MDCC, Villalobos EMC, Mori CMC, Maiorka PC, Mori E.The equine herpesvirus type 1 (EHV-1) is an important cause of myeloencephalopathy and respiratory disease in horses. Animal models for EHV-1 infection have been specially developed using mice and Syrian hamsters (Mesocricetus auratus). However, few studies have attempted to evaluate the pathogenesis of EHV-1 infection in the central nervous system (CNS) and respiratory system of hamsters. Therefore, the aim of this study was to evaluate the pathogenesis of four Brazilian EHV-1 strains within the CNS and lungs of Syrian hamsters. Hamsters intranasally infected with A4/72, A9/92, A3/97, and Iso...
Isolation and molecular characterisation of Halicephalobus gingivalis in the brain of a horse in Piedmont, Italy.
Parasites & vectors    March 7, 2017   Volume 10, Issue 1 135 doi: 10.1186/s13071-017-2070-3
Pintore MD, Cerutti F, D'Angelo A, Corona C, Gazzuola P, Masoero L, Colombo C, Bona R, Cantile C, Peletto S, Casalone C, Iulini B.A fatal case of meningoencephalitis was reported in a 13-year-old Koninklijk Warmbloed Paard Nederland stallion, suspected of West Nile virus (WNV) infection, in the Piedmont region of Italy. Clinical signs included right head tilt and circling, depression alternated with excitability, fever and lateral strabismus. Combined treatment consisting of dimethylsulfoxide, dexamethasone, sulphonamides and sedative was administered, but because of the poor conditions the horse was euthanatized and submitted for necropsy. At post-mortem examination no skin lesions were observed, all organs appeared nor...
Highlights of recent clinically relevant papers.
Equine veterinary education    March 5, 2017   Volume 29, Issue 4 178-179 doi: 10.1111/eve.12743
Wright S.No abstract available
Localization of the 5-hydroxytryptamine 4 receptor in equine enteric neurons and extrinsic sensory fibers.
Neurogastroenterology and motility    March 3, 2017   Volume 29, Issue 7 doi: 10.1111/nmo.13045
Giancola F, Rambaldi AM, Bianco F, Iusco S, Romagnoli N, Tagliavia C, Bombardi C, Clavenzani P, De Giorgio R, Chiocchetti R.Serotonin plays a pivotal role in regulating gut motility, visceral sensitivity, and fluid secretion via specific receptors. Among these receptors, 5-HT exerts a prominent control on gut motor function. Although the prokinetic effect exerted by 5-HT agonists is well known, the cellular sites of 5-HT expression remain poorly understood in large mammals, e.g., horses. In this study, we evaluated the distribution of 5-HT in the horse intestine and in foals with enteric aganglionosis, reminiscent of human Hirschsprung's disease. Methods: The intestine and spinal ganglia were obtained from three he...
Treatment of chronic sinusitis in a horse with systemic and intra-sinus antimicrobials.
The Canadian veterinary journal = La revue veterinaire canadienne    March 2, 2017   Volume 58, Issue 3 289-292 
Gordon DL, Radtke CL.A 12-year-old Norwegian Fjord gelding was diagnosed with paranasal sinusitis as a post-operative complication of tooth repulsion surgery. The infection with inspissated purulent material persisted despite sinus trephination and lavage, and systemic antimicrobial therapy. Resolution occurred following infusion of a gelatin/penicillin mixture into the right rostral and caudal maxillary sinus. Une sinusite paranasale a été diagnostiquée chez un hongre Fjord âgé de 12 ans comme complication postopératoire d’une chirurgie pour la répulsion d’une dent. L’infection avec du matériel pur...
Efficacy of a morantel-abamectin combination for the treatment of resistant ascarids in foals.
Australian veterinary journal    February 28, 2017   Volume 95, Issue 3 85-88 doi: 10.1111/avj.12559
Wilkes E, McConaghy FF, Thompson RL, Dawson K, Sangster NC, Hughes KJ.This study was performed to investigate the efficacy of a morantel-abamectin combination for the treatment of macrocyclic lactone (ML)-resistant Parascaris spp. infections in foals. Methods: Foals on five properties with a Parascaris faecal egg count (FEC) > 50 eggs per gram were used to estimate the FEC reduction (FECR) and efficacy of the anthelmintic combination. Conclusions: On all properties, resistance to ivermectin and abamectin was present and the Parascaris FECR in foals administered the morantel-abamectin combination was > 99%, indicating that this combination effective...
Parasites of domestic and wild animals in South Africa. L. Ixodid ticks infesting horses and donkeys.
The Onderstepoort journal of veterinary research    February 28, 2017   Volume 84, Issue 1 e1-e6 doi: 10.4102/ojvr.v84i1.1302
Horak IG, Heyne H, Halajian A, Booysen S, Smit WJ.The aim of the study was to determine the species spectrum of ixodid ticks that infest horses and donkeys in South Africa and to identify those species that act as vectors of disease to domestic livestock. Ticks were collected opportunistically from 391 horses countrywide by their owners or grooms, or by veterinary students and staff at the Faculty of Veterinary Science, University of Pretoria. Ticks were also collected from 76 donkeys in Limpopo Province, 2 in Gauteng Province and 1 in North West province. All the ticks were identified by means of a stereoscopic microscope. Horses were infest...
CCL2 and CCL5 driven attraction of CD172a+ monocytic cells during an equine herpesvirus type 1 (EHV-1) infection in equine nasal mucosa and the impact of two migration inhibitors, rosiglitazone (RSG) and quinacrine (QC).
Veterinary research    February 27, 2017   Volume 48, Issue 1 14 doi: 10.1186/s13567-017-0419-4
Zhao J, Poelaert KCK, Van Cleemput J, Nauwynck HJ.Equine herpesvirus type 1 (EHV-1) causes respiratory disease, abortion and neurological disorders in horses. Besides epithelial cells, CD172a monocytic cells become infected with EHV-1 in the respiratory mucosa and transport the virus from the apical side of the epithelium to the lamina propria en route to the lymph and blood circulation. Whether CD172a monocytic cells are specifically recruited to the infection sites in order to pick up virus is unknown. In our study, equine nasal mucosa explants were inoculated with EHV-1 neurological strains 03P37 and 95P105 or the non-neurological strains ...
Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).
Journal of proteomics    February 24, 2017   Volume 158 62-72 doi: 10.1016/j.jprot.2017.02.015
Segura Á, Herrera M, Reta Mares F, Jaime C, Sánchez A, Vargas M, Villalta M, Gómez A, Gutiérrez JM, León G.The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic properties. This venom is composed of 68% Zn2+-dependent metalloproteinases (SVMPs), 14% phospholipases A2 (PLA2s), 11% serine proteinases, 4% SVMPs-inhibitor tripeptides (SVMP-ITs), 2% bradykinin-potentiating peptides (BPPs), 0.6% cysteine-rich secretory proteins (CRISPs), and 0.2% l-amino acid oxidases (LAAOs). SVMPs present in the venom are responsible for azocasein hydrolysis and hemorrhagic activity, but their contribution to the lethal...
Volumetric capnography to diagnose venous air embolism in an anaesthetised horse.
Veterinary anaesthesia and analgesia    February 23, 2017   Volume 44, Issue 1 189-190 doi: 10.1111/vaa.12383
Sacks M, Mosing M.No abstract available
A case of airway obstruction caused by probable nasotracheal tube cuff herniation in a horse.
Veterinary anaesthesia and analgesia    February 23, 2017   Volume 44, Issue 1 191-192 doi: 10.1111/vaa.12401
Richardson E, McMillan M.No abstract available
Genomics and genetics: A daily double for the horse industry.
Equine veterinary journal    February 22, 2017   Volume 49, Issue 3 260-262 doi: 10.1111/evj.12668
Rothschild MF.No abstract available
Gingival Fibrosarcoma in a Horse.
Journal of veterinary dentistry    February 22, 2017   Volume 33, Issue 4 243-248 doi: 10.1177/0898756417690845
Horbal A, Dixon PM.A 4-year-old thoroughbred cross mare was referred to the University of Edinburgh Veterinary School Equine Hospital for treatment of a soft tissue tumor on the buccal gingival margin of the rostral right maxillary cheek teeth. The lesion was initially surgically excised and diagnosed as a fibrosarcoma via histopathology. Adjunctive treatment with intralesional cisplatin chemotherapy was begun. The tumor recurred and was repeatedly treated with intralesional cisplatin injections and additional surgical resection over the course of 14 weeks. Despite the initial poor response to treatment, no furt...
Encysted cyathostomin larvae in foals – progression of stages and the effect of seasonality.
Veterinary parasitology    February 20, 2017   Volume 236 108-112 doi: 10.1016/j.vetpar.2017.02.013
Nielsen MK, Lyons ET.Cyathostomins (small strongyles) are ubiquitous in grazing horses and are known pathogens as cause of larval cyathostominosis. As part of their life cycle, cyathostomin larvae invade the mucosal walls of the large intestines and undergo encystment. Newly ingested third stage larvae are known to undergo arrested development and this can lead to an accumulation of encysted burdens over the course of a grazing season. It is believed that the host immune system plays a significant role in triggering this arrestment. Little is known about the development and progression of larval stages in foals th...
Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.
Journal of veterinary internal medicine    February 16, 2017   Volume 31, Issue 2 582-592 doi: 10.1111/jvim.14670
Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S.Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objective: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. Methods: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. Methods: Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. ...
Multilocus sequence typing identifies an avian-like Chlamydia psittaci strain involved in equine placentitis and associated with subsequent human psittacosis.
Emerging microbes & infections    February 15, 2017   Volume 6, Issue 2 e7 doi: 10.1038/emi.2016.135
Jelocnik M, Branley J, Heller J, Raidal S, Alderson S, Galea F, Gabor M, Polkinghorne A.No abstract available
Use of Renal Replacement Therapy in a Neonatal Foal with Postresuscitation Acute Renal Failure.
Journal of veterinary internal medicine    February 12, 2017   Volume 31, Issue 2 593-597 doi: 10.1111/jvim.14665
Wong DM, Ruby RE, Eatroff A, Yaeger MJ.A newborn foal was presented because it was unresponsive and in cardiopulmonary arrest. Aggressive cardiopulmonary cerebral resuscitation was administered to the foal, which revived the foal; however, acute renal failure developed. Fluid retention and azotemia occurred although the foal was alert and able to suckle. A 6-hour renal replacement therapy session using hemodiafiltration and a continuous renal replacement therapy machine was administered to the foal at 3 days of age which lowered the foal's azotemia and facilitated removal of some of the excess body fluid. Despite therapy, the foal ...
Corrigendum: Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation.
Frontiers in veterinary science    February 10, 2017   Volume 4 10 doi: 10.3389/fvets.2017.00010
Stokol T, Serpa PB, Zahid MN, Brooks MB.[This corrects the article on p. 99 in vol. 3, PMID: 27909693.].
Science-in-brief: Streptococcus zooepidemicus: a versatile opportunistic pathogen that hedges its bets in horses.
Equine veterinary journal    February 9, 2017   Volume 49, Issue 2 146-148 doi: 10.1111/evj.12658
Waller AS.No abstract available
Strangles: A modern clinical view from the 17th century.
Equine veterinary journal    February 9, 2017   Volume 49, Issue 2 141-145 doi: 10.1111/evj.12659
Paillot R, Lopez-Alvarez MR, Newton JR, Waller AS.No abstract available
Genetic parameters of insect bite hypersensitivity in the Old Grey Kladruber horse.
Journal of animal science    February 9, 2017   Volume 95, Issue 1 53-58 doi: 10.2527/jas.2016.0745
Citek J, Vostry L, Vostra-Vydrova H, Brzakova M, Prantlova V.The objective of this study was to assess the genetic parameters of insect bite hypersensitivity (IBH) in the Old Grey Kladruber horse, an original Czech warmblood horse breed. Insect bite hypersensitivity is a recurrent allergic skin disease affecting horses worldwide. Its etiology is multifactorial. The defect is genetically controlled, and the starting impulse is a bite by midges of the spp. and less frequently spp. Knowledge about the associated genes is limited. Horses were kept by the National Stud in Kladruby (1,146 measurements) and by 10 private breeders (63 measurements). The horses ...
Cleaning with a wet sterile gauze significantly reduces contamination of sutures, instruments, and surgical gloves in an ex-vivo pelvic flexure enterotomy model in horses. Giusto G, Tramuta C, Caramello V, Comino F, Nebbia P, Robino P, Singer E, Grego E, Gandini M.The objective of this study was to investigate whether cleaning surgical materials used to close pelvic flexure enterotomies with a wet sterile gauze will reduce contamination and whether the use of a full thickness appositional suture pattern (F) or a partial thickness inverting (or Cushing) suture pattern (C) would make a difference in the level of contamination. Large colon specimens were assigned to group F or C and divided into subgroups N and G. In group G, a wet sterile gauze was passed over the suture material, another over the instruments, and another over the gloves. In group N, no t...
Preliminary study of ectoparasites of horses in the western highlands of Cameroon.
Veterinary medicine and science    February 2, 2017   Volume 3, Issue 2 63-70 doi: 10.1002/vms3.56
Payne VK, Mbafor FL, Wabo Pone J, Tchoumboué J.To evaluate the prevalence of infestation of ectoparasites of horses, a total of 894 horses (367 males and 527 females), aged 1-7 years old were examined. Horses were groomed for collection of ectoparasites. Out of the horses examined, 164 came from Fundong, 80 from Acha, 30 from Fongo-Tongo, 30 from Fokoue and 17 from Dschang, all of which were infested with ectoparasites. Five hundred and seventy-three (573) horses came from Banso and 99.48% were infested by ectoparasites. From the results obtained, three species of hard ticks ( and ) and one species of biting lice () were identified. (66%...
Efficacy of two extra-label anthelmintic formulations against equine strongyles in Cuba.
Veterinary parasitology, regional studies and reports    February 1, 2017   Volume 8 39-42 doi: 10.1016/j.vprsr.2017.01.010
Salas-Romero J, Gomez-Cabrera K, Molento MB, Lyons ET, Delgado A, González L, Arenal A, Nielsen MK.Equine cyathostomin parasites are ubiquitous in grazing horses and have been shown to cause severe inflammatory disease in the large intestine of horses. Decades of intensive anthelmintic therapy have led to widespread anthelmintic resistance in cyathostomins across the world. In Cuba, no anthelmintic products are formulated and sold for equine usage and little is known about anthelmintic efficacy of ruminant and swine formulations used. A strongyle fecal egg count reduction test was used to assess the efficacy of a liquid formulation of ivermectin labelled for use in swine, ruminants and carn...
A brief and critical review on hydrofluorosis in diverse species of domestic animals in India.
Environmental geochemistry and health    January 31, 2017   Volume 40, Issue 1 99-114 doi: 10.1007/s10653-017-9913-x
Choubisa SL.India is one of the fluoride-endemic countries where the maximum numbers of ground or drinking water sources are naturally fluoridated. In India, a total of 23, out of 36 states and union territories have drinking water contaminated with fluoride in varying concentration. In the present scenario, especially in rural India, besides the surface waters (perennial ponds, dams, rivers, etc.), bore wells and hand pumps are the principal drinking water sources for domestic animals such as cattle (Bos taurus), water buffaloes (Bubalus bubalis), sheep (Ovis aries), goats (Capra hircus), horses (Equus c...
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