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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Neutrophil extracellular traps formation by bacteria causing endometritis in the mare.
Journal of reproductive immunology    August 27, 2014   Volume 106 41-49 doi: 10.1016/j.jri.2014.08.003
Rebordão MR, Carneiro C, Alexandre-Pires G, Brito P, Pereira C, Nunes T, Galvão A, Leitão A, Vilela C, Ferreira-Dias G.Besides the classical functions, neutrophils (PMNs) are able to release DNA in response to infectious stimuli, forming neutrophil extracellular traps (NETs) and killing pathogens. The pathogenesis of endometritis in the mare is not completely understood. The aim was to evaluate the in vitro capacity of equine PMNs to secrete NETs by chemical activation, or stimulated with Streptococcus equi subspecies zooepidemicus (Szoo), Escherichia coli (Ecoli) or Staphylococcus capitis (Scap) strains obtained from mares with endometritis. Ex vivo endometrial mucus from mares with bacterial endometritis wer...
Antiviral potency and functional analysis of tetherin orthologues encoded by horse and donkey.
Virology journal    August 27, 2014   Volume 11 151 doi: 10.1186/1743-422X-11-151
Yin X, Guo M, Gu Q, Wu X, Wei P, Wang X.Tetherin is an interferon-inducible host cell factor that blocks the viral particle release of the enveloped viruses. Most knowledge regarding the interaction between tetherin and viruses has been obtained using the primate lentiviral system. However, much less is known about the functional roles of tetherin on other lentiviruses. Equine infectious anemia virus (EIAV) is an important macrophage-tropic lentivirus that has been widely used as a practical model for investigating the evolution of the host-virus relationship. The host range of EIAV is reported to include all members of the Equidae ...
Effect of endotoxin on leukocyte activation and migration into laminar tissue of isolated perfused equine limbs.
American journal of veterinary research    August 27, 2014   Volume 75, Issue 9 842-850 doi: 10.2460/ajvr.75.9.842
Patan-Zugaj B, Gauff FC, Plendl J, Licka TF.To investigate effects of endotoxin on leukocyte activation and infiltration of the laminar tissue in isolated perfused equine limbs. Methods: 10 right forelimbs and 3 left forelimbs collected from 10 healthy adult horses after slaughter at a licensed abattoir. procedures: Isolated right forelimbs were randomly assigned to 2 groups (5 forelimbs/group): perfusion of the distal portion for 10 hours with 80 ng of endotoxin/L and perfusion under the same conditions without endotoxin. After perfusion, samples for immunohistochemical detection of leukocytes (by use of antibodies against calprotectin...
Use of an inertial measurement unit to assess the effect of forelimb lameness on three-dimensional hoof orientation in horses at a walk and trot.
American journal of veterinary research    August 27, 2014   Volume 75, Issue 9 800-808 doi: 10.2460/ajvr.75.9.800
Moorman VJ, Reiser RF, Mahaffey CA, Peterson ML, McIlwraith CW, Kawcak CE.To determine intralimb orientation changes with an inertial measurement unit (IMU) in hooves of horses at a walk and trot after induction of weight-bearing single forelimb lameness and to determine whether hoof orientations are similar to baseline values following perineural anesthesia. Methods: 6 clinically normal horses. Methods: 3-D hoof orientations were determined with an IMU mounted on the right forelimb hoof during baseline conditions, during 3 grades of lameness (induced by application of pressure to the sole), and after perineural anesthesia. Linear acceleration profiles were used to ...
Evaluation of chitosan-GP hydrogel biocompatibility in osteochondral defects: an experimental approach.
BMC veterinary research    August 27, 2014   Volume 10 197 doi: 10.1186/s12917-014-0197-4
Martins EA, Michelacci YM, Baccarin RY, Cogliati B, Silva LC.Articular cartilage, because of its avascular nature, has little capacity for spontaneous healing, and tissue engineering approaches, employing different biomaterials and cells, are under development. Among the investigated biomaterials are the chitosan-based hydrogels. Although thoroughly studied in other mammalian species, studies are scarce in equines. So, the aim of the present study was to investigate the biocompatibility of chitosan-GP in horse joints submitted to high mechanical loads. Results: An osteochondral defect was created by arthroscopy in the medial surface of lateral trochlea ...
Membrane vesicles mediate pro-angiogenic activity of equine adipose-derived mesenchymal stromal cells.
Veterinary journal (London, England : 1997)    August 26, 2014   Volume 202, Issue 2 361-366 doi: 10.1016/j.tvjl.2014.08.021
Pascucci L, Alessandri G, Dall'Aglio C, Mercati F, Coliolo P, Bazzucchi C, Dante S, Petrini S, Curina G, Ceccarelli P.Multipotent mesenchymal stromal cells (MSCs) have attracted a great deal of interest, due to several distinctive features, including the ability to migrate to damaged tissue and to participate in tissue regeneration. There is increasing evidence that membrane vesicles (MVs), comprising exosomes and shedding vesicles, represent a key component, responsible for many of the paracrine effects of MSCs. The aim of the present study was to establish whether equine adipose-derived MSCs (E-AdMSCs) produce MVs that are capable of influencing angiogenesis, a key step in tissue regeneration. A morphologic...
Immunogenicity of intensively decellularized equine carotid arteries is conferred by the extracellular matrix protein collagen type VI.
PloS one    August 26, 2014   Volume 9, Issue 8 e105964 doi: 10.1371/journal.pone.0105964
Boeer U, Buettner FF, Klingenberg M, Antonopoulos GC, Meyer H, Haverich A, Wilhelmi M.The limited biocompatibility of decellularized scaffolds is an ongoing challenge in tissue engineering. Here, we demonstrate the residual immunogenicity of an extensively decellularized equine carotid artery (dEAC(intens)) and identify the involved immunogenic components. EAC were submitted to an elaborated intensified decellularization protocol with SDS/sodium desoxycholate for 72 h using increased processing volumes (dEAC(intens)), and compared to dEAC(ord) prepared by an ordinary protocol (40 h, normal volumes). Matrix integrity was checked via correlative volumetric visualization which rev...
Haplotype diversity in the equine myostatin gene with focus on variants associated with race distance propensity and muscle fiber type proportions.
Animal genetics    August 26, 2014   Volume 45, Issue 6 827-835 doi: 10.1111/age.12205
Petersen JL, Valberg SJ, Mickelson JR, McCue ME.Two variants in the equine myostatin gene (MSTN), including a T/C SNP in the first intron and a 227-bp SINE insertion in the promoter, are associated with muscle fiber type proportions in the Quarter Horse (QH) and with the prediction of race distance propensity in the Thoroughbred (TB). Genotypes from these loci, along with 18 additional variants surrounding MSTN, were examined in 301 horses of 14 breeds to evaluate haplotype relationships and diversity. The C allele of intron 1 was found in 12 of 14 breeds at a frequency of 0.27; the SINE was observed in five breeds, but common in only the T...
Clinical follow-up of horses treated with allogeneic equine mesenchymal stem cells derived from umbilical cord blood for different tendon and ligament disorders.
The veterinary quarterly    August 26, 2014   Volume 34, Issue 2 92-97 doi: 10.1080/01652176.2014.949390
Mesenchymal stem cells (MSCs) offer promise as therapeutic aids in the repair of tendon and ligament disorders in sport horses. Equine allogeneic MSCs derived from umbilical cord blood (eUCB-MSCs) can be obtained in a minimally invasive fashion with successful propagation of MSCs. Objective: The objective of this study was to determine the applicability and therapeutic effect of eUCB-MSCs on tendinitis of the superficial digital flexor tendon, desmitis of the suspensory ligament, tendinitis of the deep digital flexor tendon, and desmitis of the inferior check ligament in clinical cases. Method...
Diagnostic imaging in veterinary dental practice. Supernumerary molars in a horse.
Journal of the American Veterinary Medical Association    August 26, 2014   Volume 245, Issue 5 493-496 doi: 10.2460/javma.245.5.493
Henry TJ, Young AC.No abstract available
Comparison of equine articular cartilage thickness in various joints.
Connective tissue research    August 26, 2014   Volume 55, Issue 5-6 339-347 doi: 10.3109/03008207.2014.949698
Lee H, Kirkland WG, Whitmore RN, Theis KM, Young HE, Richardson AJ, Jackson RL, Hanson RR.Thicknesses of fresh equine articular cartilage surfaces from the fetlock, carpal and stifle joints were measured employing a needle probe test. Methods: Eighty-seven samples used in measurement were cultivated from fetlock, carpal and stifle joints of 12 deceased within 4 h of death. After approximately three minutes of exposure to air during dissection, all cartilage samples were preserved in a saline solution to keep the articular cartilage hydrated for testing. The thickness was measured on five different spots on the same sample. The thicknesses of the fetlock, carpus and stifle were co...
Effects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alveolar concentrations in horses.
Veterinary journal (London, England : 1997)    August 25, 2014   Volume 202, Issue 2 329-333 doi: 10.1016/j.tvjl.2014.08.007
Villalba M, Santiago I, Gómez de Segura IA.The aim of this investigation was to determine the isoflurane-sparing effect and impact on arterial blood pressure and anaesthetic recovery of a constant rate infusion of medetomidine-propofol in horses. In a prospective, crossover, randomised study, six healthy horses (mean ± SD age, 13.7 ± 7.7 years; weight, 433 ± 51 kg) were anaesthetised twice with isoflurane and were randomly assigned to receive one of two treatments on each occasion, at least 2 weeks apart. The first treatment was saline (CTL group) and the second a medetomidine-propofol infusion (MP group; 1.25 µg/kg...
Lunar cycles at mating do not influence sex ratio at birth in horses.
Chronobiology international    August 25, 2014   Volume 32, Issue 1 43-47 doi: 10.3109/07420528.2014.950738
Aguilar JJ, Cuervo-Arango J, Santa Juliana L.It is scientifically demonstrated that lunar cycles have important effects on several biological events. Controversy exists about the lunar influence on human and animal parturition. In addition, in the horse industry, especially in Polo Horse breeders of Argentina and around the world there is a higher demand for female offspring than for males. The objective of this study was to determine whether there is a significant association between the lunar phase at the time of mating and the sex ratio at birth in horses. The Argentinean Stud Book provided information related to all matings registere...
Immunogenicity of an electron beam inactivated Rhodococcus equi vaccine in neonatal foals.
PloS one    August 25, 2014   Volume 9, Issue 8 e105367 doi: 10.1371/journal.pone.0105367
Bordin AI, Pillai SD, Brake C, Bagley KB, Bourquin JR, Coleman M, Oliveira FN, Mwangi W, McMurray DN, Love CC, Felippe MJ, Cohen ND.Rhodococcus equi is an important pathogen of foals that causes severe pneumonia. To date, there is no licensed vaccine effective against R. equi pneumonia of foals. The objectives of our study were to develop an electron beam (eBeam) inactivated vaccine against R. equi and evaluate its immunogenicity. A dose of eBeam irradiation that inactivated replication of R. equi while maintaining outer cell wall integrity was identified. Enteral administration of eBeam inactivated R. equi increased interferon-γ production by peripheral blood mononuclear cells in response to stimulation with virulent R. ...
Effects of two field continuous incremental tests on cardiorespiratory responses in Standardbred trotters.
Journal of animal physiology and animal nutrition    August 25, 2014   Volume 99, Issue 2 244-250 doi: 10.1111/jpn.12242
Fortier J, Goachet AG, Julliand V, Deley G.In humans, cardiorespiratory responses are widely evaluated from field incremental exercise tests. On the contrary, equine exercise physiology faces a huge lack of oxygen consumption measurements (VO2) in field conditions due to technical concerns. The aim of this study was to test the effects of two incremental continuous field tests on cardiorespiratory responses in Standardbred trotters. The two protocols were realized at trot and ended when horses galloped. The tests started at 4.2 m/s (T1) and 6.4 m/s (T2), with speed increments of 1.4 m/s every 3 min for T1 and 0.8 m/s every 2 min for T2...
What is your diagnosis? Guttural pouch lesion in a horse. Fungal infection with probable spore formation.
Veterinary clinical pathology    August 25, 2014   Volume 43, Issue 4 607-608 doi: 10.1111/vcp.12187
Flatland B, Bemis DA, Cocquyt CM.No abstract available
A missense mutation in melanocortin 1 receptor is associated with the red coat colour in donkeys.
Animal genetics    August 25, 2014   Volume 45, Issue 6 878-880 doi: 10.1111/age.12207
Abitbol M, Legrand R, Tiret L.The seven donkey breeds recognised by the French studbook are characterised by few coat colours: black, bay and grey. Normand bay donkeys seldom give birth to red foals, a colour more commonly seen and recognised in American miniature donkeys. Red resembles the equine chestnut colour, previously attributed to a mutation in the melanocortin 1 receptor gene (MC1R). We used a panel of 124 donkeys to identify a recessive missense c.629T>C variant in MC1R that showed a perfect association with the red coat colour. This variant leads to a methionine to threonine substitution at position 210 in th...
Prevalence of patent Strongyloides westeri infections in Thoroughbred foals in 2014.
Parasitology research    August 23, 2014   Volume 113, Issue 11 4163-4164 doi: 10.1007/s00436-014-4088-1
Lyons ET, Tolliver SC.The prevalence of patent Strongyloides westeri infections was determined by examination for eggs in fecal samples collected from 513 Thoroughbred (TB) foals between February 25 and June 3, 2014. The study was conducted with 244 colts and 269 fillies from 11 well-managed farms in Central Kentucky. Foals ranged from 17 to 117 days of age and had never been dewormed. The mean prevalence of patent S. westeri infection was 30% (156/513 foals). This prevalence was substantially greater than historical reports from the same sampling area during the late 1990s and early 2000s. It is hypothesized that ...
Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised, blinded, clinical study.
BMC veterinary research    August 23, 2014   Volume 10 180 doi: 10.1186/s12917-014-0180-0
Sykes BW, Sykes KM, Hallowell GD.Interest in Equine Gastric Ulcer Syndrome (EGUS) has recently increased in part due to a growing awareness of the differences between squamous and glandular disease. The pathophysiology and epidemiology of squamous and glandular disease are different and recently it has been shown that the response of glandular gastric ulceration to monotherapy with omeprazole is poor. Given these differences it has been recommended that specific treatment guidelines be formulated for equine glandular disease and that adjunctive therapies be investigated. Along these lines it has been suggested that the additi...
Comparative analysis of LTR and structural genes in an equine infectious anemia virus strain isolated from a feral horse in Japan.
Archives of virology    August 23, 2014   Volume 159, Issue 12 3413-3420 doi: 10.1007/s00705-014-2206-0
Dong J, Cook FR, Haga T, Horii Y, Norimine J, Misawa N, Goto Y, Zhu W.Although equine infectious anemia virus (EIAV) poses a major threat to the equine industry worldwide, the molecular epidemiology of this virus is poorly understood. Recently, an EIAV strain (EIAVMiyazaki2011-A) representing a new monophyletic group was discovered in feral horses in southern Japan. In the present study, the EIAVMiyazaki2011-A proviral genome is compared with evolutionarily divergent EIAV isolates to investigate conservation of functional elements or motifs within the long terminal repeats (LTRs) and structural genes. This analysis represents a significant step forward in increa...
A pre- and post-intervention study of infection control in equine hospitals in Sweden.
Acta veterinaria Scandinavica    August 22, 2014   Volume 56, Issue 1 52 doi: 10.1186/s13028-014-0052-4
Bergström K, Grönlund U.Detection of nosocomial methicillin-resistant Staphylococcus aureus infections in horses in Sweden has increased attention on infection control (IC) in equine hospitals. This study established baseline data on IC programmes within such settings, evaluated compliance with some IC procedures before and after an education intervention, and examined barriers to compliance.The study was carried out between 2008 and 2011 in four Swedish equine hospitals. Data on current IC of each hospital, purchase data on hand sanitisers and disposable gloves per patient, and direct observations of compliance with...
Airway wall eosinophilia is not a feature of equine heaves.
Veterinary journal (London, England : 1997)    August 22, 2014   Volume 202, Issue 2 387-389 doi: 10.1016/j.tvjl.2014.08.020
Dubuc J, Lavoie JP.The objective of this study was to determine whether eosinophils infiltrate the airway wall of horses with heaves. Eosinophils were evaluated using paraffin embedded lung tissues from six heaves-affected horses in crisis and six aged-matched controls. Slides were stained using Luna's method and eosinophils enumerated using histomorphometric techniques. Total eosinophil counts (expressed per mm(2) of basement membrane) were significantly higher in the airways of controls horses than in horses with heaves. Intraluminal, intraepithelial, and airway smooth muscle eosinophils counts were also incre...
Report of the International Equine Influenza Roundtable Expert Meeting at Le Touquet, Normandy, February 2013.
Equine veterinary journal    August 21, 2014   Volume 46, Issue 6 645-650 doi: 10.1111/evj.12302
Slater J, Borchers K, Chambers T, Cullinane A, Duggan V, Elton D, Legrand L, Paillot R, Fortier G.No abstract available
Outcomes following liver trauma in equestrian accidents.
Journal of trauma management & outcomes    August 21, 2014   Volume 8 13 doi: 10.1186/1752-2897-8-13
Balakrishnan A, Abbadi R, Oakland K, Jamdar S, Harper SJ, Jamieson NV, Huguet EL, Jah A, Praseedom RK.Equestrian sports are common outdoor activities that may carry a risk of liver injury. Due to the relative infrequency of equestrian accidents the injury patterns and outcomes associated with liver trauma in these patients have not been well characterized. Methods: We examined our experience of the management of equestrian liver trauma in our regional hepatopancreaticobiliary unit at a tertiary referral center. The medical records of patients who sustained liver trauma secondary to equestrian activities were analysed for parameters such as demographic data, liver function tests, patterns of in...
Systemic mycobacteriosis in an aborted thoroughbred fetus in Japan.
The Journal of veterinary medical science    August 21, 2014   Volume 76, Issue 12 1617-1621 doi: 10.1292/jvms.14-0276
Sano Y, Matsuda K, Osaki K, Miyasho T, Tsuda T, Taniyama H.A male Thoroughbred fetus was aborted on day 251 of pregnancy. Gross and histological examinations detected systemic granulomatous lesions in many superficial and visceral lymph nodes and organs including the liver, tonsils, lungs, thymus, spleen, right thyroid gland and gastrointestinal tract, and suppurative placentitis, pyogranulomatous amnionitis and intralesional acid-fast bacilli were also detected. An examination of the DNA base sequence of the β subunit of RNA polymerase demonstrated that Mycobacterium avium strain 104 had infected several organs. To the best of our knowledge, this is...
Morphology, Morphometry and Spatial Distribution of Secondary Osteons in Equine Femur.
Anatomia, histologia, embryologia    August 21, 2014   Volume 44, Issue 5 328-332 doi: 10.1111/ahe.12141
Zedda M, Lepore G, Biggio GP, Gadau S, Mura E, Farina V.A high number of differences exist in bone histological features depending on the species, breed, age and bone. Moreover, osteon distribution may vary in the different sides of a bone as a consequence of different biomechanical strains. The aim of this work was to study the distribution and morphology of osteons in different sides of the equine femoral diaphysis with the attempt to correlate them to the main strains operating on them. The following parameters of secondary osteons and Haversian canals were measured in the transverse sections of diaphyses: perimeter, area, minimum and maximum di...
Experimental inoculation of equine coronavirus into Japanese draft horses.
Archives of virology    August 20, 2014   Volume 159, Issue 12 3329-3334 doi: 10.1007/s00705-014-2205-1
Nemoto M, Oue Y, Morita Y, Kanno T, Kinoshita Y, Niwa H, Ueno T, Katayama Y, Bannai H, Tsujimura K, Yamanaka T, Kondo T.Recently, outbreaks associated with equine coronavirus (ECoV) have occurred in Japan and the United States. While ECoV is likely to be pathogenic to horses, it has not been shown that experimental inoculation of horses with ECoV produces clinical signs of disease. In this study, we inoculated three Japanese draft horses with an ECoV-positive diarrheic fecal sample to confirm infection after inoculation and to investigate the clinical course and virus shedding patterns of ECoV. Virus neutralization tests showed that all three horses became infected with ECoV. Two of the three horses developed c...
Comparison of the Effect of Heterologous and Homologous Seminal Plasma on Motility and Chromatin Integrity of Stallion Spermatozoa Selected by Single Layer Centrifugation.
Journal of veterinary medicine    August 20, 2014   Volume 2014 325451 doi: 10.1155/2014/325451
Morrell JM, Johannisson A.The effect on sperm motility and chromatin integrity of adding homologous or heterologous equine seminal plasma (SP) to fresh stallion spermatozoa selected by single layer centrifugation (SLC) was studied. No statistical difference in mean progressive motility was seen after adding SP at time 0 h, although there were differences for individual stallions. The proportion of spermatozoa with high velocity was increased compared to untreated SLC-selected spermatozoa (P < 0.05), with significant differences between individuals (P < 0.01). When the SLC samples were stored for 24 h before a...
Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals.
Veterinary journal (London, England : 1997)    August 19, 2014   Volume 202, Issue 2 384-386 doi: 10.1016/j.tvjl.2014.08.013
Fouché N, Graubner C, Howard J.Various assays have been used as an aid to diagnose failure of passive transfer (FPT) of immunoglobulins in neonatal foals, but often lack sensitivity as screening tests, or are time consuming to perform and impractical as confirmatory tests. The aim of the present study was to evaluate whether measurement of serum total globulins (TG; i.e. total protein minus albumin) can be used to estimate the electrophoretic gamma globulin (EGG) fraction in hospitalised neonatal foals with suspected FPT. Sample data from 56 foals were evaluated retrospectively. The coefficient of rank correlation was 0.84....
Magnetic resonance imaging characteristics of equine head disorders: 84 cases (2000-2013). Manso-Díaz G, Dyson SJ, Dennis R, García-López JM, Biggi M, García-Real MI, San Román F, Taeymans O.The equine head is an anatomically complex area, therefore advanced tomographic imaging techniques, such as computed tomography or magnetic resonance imaging (MRI), are often required for diagnosis and treatment planning. The purpose of this multicenter retrospective study was to describe MRI characteristics for a large sample of horses with head disorders. Horses imaged over a period of 13 years were recruited. Eighty-four horses met the inclusion criteria, having neurological (n = 65), sinonasal (n = 14), and soft tissue (n = 5) disorders. Magnetic resonance imaging accurately depicted the a...