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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia.
Virology    September 18, 2009   Volume 394, Issue 2 298-310 doi: 10.1016/j.virol.2009.08.032
Attoui H, Mendez-Lopez MR, Rao S, Hurtado-Alendes A, Lizaraso-Caparo F, Mohd Jaafar F, Samuel AR, Belhouchet M, Pritchard LI, Melville L, Weir RP....During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, 78% fatality) belongs to a new species the Peruvian horse sickness virus (PHSV), within the genus Orbivirus, family Reoviridae. This represents the first isolation of PHSV, which was subsequently also isolated during 1999, from diseased horses in the Northern Territory of Australia (Elsey virus, ELSV). Serological and molecular studies showed that PHSV and ELSV are very s...
A whole-genome scan for recurrent airway obstruction in Warmblood sport horses indicates two positional candidate regions.
Mammalian genome : official journal of the International Mammalian Genome Society    September 18, 2009   Volume 20, Issue 8 504-515 doi: 10.1007/s00335-009-9214-5
Swinburne JE, Bogle H, Klukowska-Rötzler J, Drögemüller M, Leeb T, Temperton E, Dolf G, Gerber V.Recurrent airway obstruction (RAO), or heaves, is a naturally occurring asthma-like disease that is related to sensitisation and exposure to mouldy hay and has a familial basis with a complex mode of inheritance. A genome-wide scanning approach using two half-sibling families was taken in order to locate the chromosome regions that contribute to the inherited component of this condition in these families. Initially, a panel of 250 microsatellite markers, which were chosen as a well-spaced, polymorphic selection covering the 31 equine autosomes, was used to genotype the two half-sibling familie...
Pharmacokinetics of the injectable formulation of methadone hydrochloride administered orally in horses.
Journal of veterinary pharmacology and therapeutics    September 17, 2009   Volume 32, Issue 5 492-497 doi: 10.1111/j.1365-2885.2009.01071.x
Linardi RL, Stokes AM, Barker SA, Short C, Hosgood G, Natalini CC.Methadone hydrochloride is a synthetic mu-opioid receptor agonist with potent analgesic properties. Oral methadone has been successfully used in human medicine and may overcome some limitations of other analgesics in equine species for producing analgesia with minimal adverse effects. However, there are no studies describing the pharmacokinetics (PK) of oral opioids in horses. The aim of this study was to describe the PK of orally administered methadone (0.1, 0.2 and 0.4 mg/kg) and physical effects in 12 healthy adult horses. Serum methadone concentrations were measured by gas chromatography/m...
Use of quantitative real-time PCR for the detection of Salmonella spp. in fecal samples from horses at a veterinary teaching hospital.
Veterinary journal (London, England : 1997)    September 17, 2009   Volume 186, Issue 2 252-255 doi: 10.1016/j.tvjl.2009.08.022
Pusterla N, Byrne BA, Hodzic E, Mapes S, Jang SS, Magdesian KG.A quantitative real-time (RT)-PCR assay was developed to detect Salmonella spp. in the feces of 911 equine species admitted to a veterinary hospital. Fresh feces and feces enriched for 24h in selenite broth were assessed by conventional culture and by RT-PCR targeting the Salmonella invA gene. The detection limit for the RT-PCR assay was 3 and 10 organisms, respectively, when spiked samples were purified from selenite broth and feces. The analytical specificity was 100% based on the detection of a panel of 40 salmonella serotypes from five serogroups and the lack of cross-reactivity with non-r...
Equine gammaherpesviruses: pathogenesis, epidemiology and diagnosis.
Veterinary journal (London, England : 1997)    September 17, 2009   Volume 186, Issue 2 148-156 doi: 10.1016/j.tvjl.2009.08.017
Fortier G, van Erck E, Pronost S, Lekeux P, Thiry E.Equine gammaherpesviruses (γEHV) have been widely studied over the past 45 years and many isolates have been characterised. Despite this, the diagnosis of γEHV infection remains difficult to establish as its clinical manifestations lack specificity, ranging from mild respiratory signs in a small number of animals to outbreaks in large groups of young horses. This review focuses on the epidemiology, pathogenesis, clinical manifestations and diagnosis of equine herpesvirus (EHV)-2 and -5 infections, as well as on the genetic variation of these viruses. Study of these variations has resulted in...
Effects of blood contamination on peritoneal D-dimer concentration in horses with colic.
Journal of veterinary internal medicine    September 16, 2009   Volume 23, Issue 6 1232-1238 doi: 10.1111/j.1939-1676.2009.0381.x
Delgado MA, Monreal L, Armengou L, Segura D, Ríos J.Peritoneal D-Dimer concentration can be determined to assess peritoneal fibrinolysis activity in horses with gastrointestinal disorders. However, blood contamination of peritoneal fluid may occur during collection and could alter peritoneal D-Dimer concentration. Objective: Blood contamination in peritoneal fluid does not affect interpretation of peritoneal D-Dimer concentration in horses with colic. Methods: Thirty-four horses with colic and 4 healthy horses. Methods: Peritoneal fluid and blood samples were simultaneously collected upon admission. Then, peritoneal fluid was serially contamina...
Multimodal treatment of recurrent sinonasal cryptococcal granulomas in a horse.
Journal of the American Veterinary Medical Association    September 16, 2009   Volume 235, Issue 6 723-730 doi: 10.2460/javma.235.6.723
Stewart AJ, Salazar T, Waldridge BM, Schumacher J, Welles EG, Hanson RR, Sartin EA, Lenz SD, Holland M, Beard DM.A 7-year-old 509-kg (1,120-lb) Tennessee Walking Horse mare was evaluated because of bilateral mucosanguinous nasal discharge, intermittent right-sided epistaxis, and worsening dyspnea of 9 months' duration. Results: Multiple masses in the nasopharynx were detected via endoscopic and radiographic examinations. Cytologic and histologic examinations of biopsy specimens of 1 mass revealed round yeasts with thick nonstaining capsules and occasional narrow-based budding that resembled cryptococcal organisms. Results: Oral administration of fluconazole and organic ethylenediamine dihydriodide and in...
Evaluation of plasma ACTH, alpha-melanocyte-stimulating hormone, and insulin concentrations during various photoperiods in clinically normal horses and ponies and those with pituitary pars intermedia dysfunction.
Journal of the American Veterinary Medical Association    September 16, 2009   Volume 235, Issue 6 715-722 doi: 10.2460/javma.235.6.715
Beech J, Boston RC, McFarlane D, Lindborg S.To measure plasma ACTH, alpha-melanocyte-stimulating hormone (aloha-MSH), and insulin concentrations during various photoperiods between February and October in horses and ponies with and without pituitary pars intermedia dysfunction (PPID). Methods: Cohort study. Methods: 13 clinically normal (control) ponies, 14 clinically normal (control) horses, 7 ponies with PPID, and 8 horses with PPID. Methods: Blood samples were collected from February through October during 8 photoperiods: 1, February 13 through March 2; 2, April 4 through 6; 3, June 19 through 22; 4, August 6 through 7; 5, August 14 ...
Plasma and pulmonary fluid endothelin in horses with seasonal recurrent airway obstruction.
Journal of veterinary internal medicine    September 16, 2009   Volume 23, Issue 6 1239-1246 doi: 10.1111/j.1939-1676.2009.0385.x
Costa LR, Eades SC, Venugopal CS, Moore RM.Summer pasture-associated recurrent airway obstruction (SPA-RAO), a seasonal airway obstructive disease of horses, is characterized by clinical exacerbation after exposure to pasture during warm months of the year. Endothelin (ET)-1, potent bronchoconstrictor, mitogen, secretagogue, and proinflammatory mediator, has been implicated in the pathogenesis of asthma and equine heaves. Objective: Immunoreactive ET-1 concentrations increase during clinical exacerbation and return to basal values during periods of disease remission. Methods: Twelve horses, 6 affected with SPA-RAO and 6 nonaffected. Me...
Iris abscesses with and without intralenticular fungal invasion in the horse.
Veterinary ophthalmology    September 16, 2009   Volume 12, Issue 5 306-312 doi: 10.1111/j.1463-5224.2009.00718.x
Brooks DE, Taylor DP, Plummer CE, Quinn R, Kallberg ME, Sheppard B, Barrie KP, Blackwood SE, Nunnery CM, Ben-Shlomo G, Clark CJ, Woodworth AA.To describe clinical and histologic findings in horses with iris abscesses. Design Retrospective medical records study. Methods: Medical records of horses that had iris abscesses at the University of Florida Veterinary Medical Center, Peterson & Smith Equine Hospital, and Veterinary Eye Specialists of London, Ontario, from 2005 to 2008 were reviewed. Methods: Data collected from the medical records included signalment, clinical and histologic descriptions of ocular lesions, therapy, complications, and visual outcomes. Results: The medical records of two Quarterhorses, one pony, one warmblood, ...
In vitro susceptibility patterns of Aspergillus and Fusarium species isolated from equine ulcerative keratomycosis cases in the midwestern and southern United States with inclusion of the new antifungal agent voriconazole.
Veterinary ophthalmology    September 16, 2009   Volume 12, Issue 5 318-324 doi: 10.1111/j.1463-5224.2009.00721.x
Pearce JW, Giuliano EA, Moore CP.To evaluate and compare the in vitro susceptibility of Aspergillus and Fusarium spp. isolated from horses with ulcerative keratomycosis, address regional differences in equine keratomycosis isolates, and provide susceptibility data to update prior studies. Methods: Fourteen horses with ulcerative keratomycosis. Methods: Banked fungal isolates from equine corneal ulcers (eight Aspergillus spp. and six Fusarium spp.) were identified at The University of Texas Health Science Center at San Antonio. In vitro minimum inhibitory concentration and susceptibility to natamycin, fluconazole, itraconazole...
Partial resection of the plica salpingopharyngeus for the treatment of three foals with bilateral tympany of the auditory tube diverticulum (guttural pouch).
Journal of the American Veterinary Medical Association    September 16, 2009   Volume 235, Issue 6 731-733 doi: 10.2460/javma.235.6.731
Sparks HD, Stick JA, Brakenhoff JE, Cramp PA, Spirito MA.3 foals were referred for treatment of tympany of the auditory tube diverticulum (guttural pouch). Results: Bilateral guttural pouch tympany was diagnosed in all 3 foals on the basis of clinical signs and results of radiographic and endoscopic evaluations and gutturocentesis. In each foal, previous medical or surgical interventions or both had failed to correct the problem. Results: Bilateral surgical resection of the plica salpingopharyngeus was performed. Follow-up telephone interviews with owners 8 months to 3 years after surgery revealed that long-term resolution of the tympany had been ac...
Occurrence of Leishmania sp. in cutaneous lesions of horses in Central Europe.
Veterinary parasitology    September 15, 2009   Volume 166, Issue 3-4 346-351 doi: 10.1016/j.vetpar.2009.09.001
Müller N, Welle M, Lobsiger L, Stoffel MH, Boghenbor KK, Hilbe M, Gottstein B, Frey CF, Geyer C, von Bomhard W.The present report describes a novel etiological agent of cutaneous leishmaniasis in horses that, at least for some cases, sporadically appeared as autochthonous infections in geographically distant regions of Germany and Switzerland. The infection was initially diagnosed upon clinical and immunohistological findings. Subsequent comparative sequence analysis of diagnostic PCR products from the internal transcribed spacer 1 (ITS1) of ssrRNA classified the respective isolates as neither Old World nor New World Leishmania species. However, four isolates subjected to molecular analyses all exhibit...
Association of Stenotrophomonas maltophilia infection with lower airway disease in the horse: a retrospective case series.
Veterinary journal (London, England : 1997)    September 15, 2009   Volume 186, Issue 3 358-363 doi: 10.1016/j.tvjl.2009.08.026
Winther L, Andersen RM, Baptiste KE, Aalbæk B, Guardabassi L.Stenotrophomonas maltophilia is being reported with increasing frequency as a human nosocomial pathogen, especially among immuno-compromised patients. To the authors' knowledge, this pathogen has not previously been associated with lower airway disease in the horse. In this paper the clinical findings, laboratory diagnosis and response to treatment of seven cases of respiratory infection with S. maltophilia in horses, presented at three equine referral hospitals in Denmark in 2007, are described. In all cases there was a clinical history of chronic coughing and abundant mucopurulent exudate wa...
Transcriptional profiling differences for articular cartilage and repair tissue in equine joint surface lesions.
BMC medical genomics    September 14, 2009   Volume 2 60 doi: 10.1186/1755-8794-2-60
Mienaltowski MJ, Huang L, Frisbie DD, McIlwraith CW, Stromberg AJ, Bathke AC, Macleod JN.Full-thickness articular cartilage lesions that reach to the subchondral bone yet are restricted to the chondral compartment usually fill with a fibrocartilage-like repair tissue which is structurally and biomechanically compromised relative to normal articular cartilage. The objective of this study was to evaluate transcriptional differences between chondrocytes of normal articular cartilage and repair tissue cells four months post-microfracture. Methods: Bilateral one-cm2 full-thickness defects were made in the articular surface of both distal femurs of four adult horses followed by subchond...
Comparison of pressure plate and force plate gait kinetics in sound Warmbloods at walk and trot.
Veterinary journal (London, England : 1997)    September 13, 2009   Volume 186, Issue 3 347-351 doi: 10.1016/j.tvjl.2009.08.024
Oosterlinck M, Pille F, Huppes T, Gasthuys F, Back W.Modern pressure plates (PP) could be an alternative to traditional force plates (FP) for quantitative equine gait analysis, thereby providing the clinician with objective data on the horse's gait while unravelling the loading of different regions of the hoof during the stance phase. The aim of this study was to determine whether a stand-alone PP allows reliable measurement of gait kinetics, compared to simultaneously recorded FP variables. Six sound Warmblood horses were walked and trotted over a combined PP and FP system for collection of a set of five valid kinetic measurements for each fore...
Concentrations of 15-ketodihydro-PGF2alpha, cortisol, and progesterone in the plasma of healthy and pathologic newborn foals.
Theriogenology    September 12, 2009   Volume 72, Issue 8 1032-1040 doi: 10.1016/j.theriogenology.2009.06.015
Panzani S, Villani M, McGladdery A, Magri M, Kindahl H, Galeati G, Martino PA, Veronesi MC.Information regarding the plasma hormone profiles of prostaglandins (PGs), cortisol (C), and progesterone (P4) during pathologic processes in newborn foals is scarce. The aim of this study was to determine the plasma concentrations of these hormones in diseased foals (n=40) and healthy at-term foals (n=24) (Equus caballus) during the first 2 weeks of life. Blood samples were collected daily, before any treatment with nonsteroidal drugs in diseased foals, and plasma was analyzed by radioimmunoassay. 15-Ketodihydro-PGF(2alpha) (PGM) was consistently higher in diseased foals than in healthy foals...
Heat, humidity and horse welfare in the Olympic Games: learning from history.
Veterinary journal (London, England : 1997)    September 12, 2009   Volume 182, Issue 3 373-374 doi: 10.1016/j.tvjl.2009.08.025
Marlin D.No abstract available
Effect of ketamine on the limb withdrawal reflex evoked by transcutaneous electrical stimulation in ponies anaesthetised with isoflurane.
Veterinary journal (London, England : 1997)    September 12, 2009   Volume 186, Issue 3 304-311 doi: 10.1016/j.tvjl.2009.08.018
Levionnois OL, Menge M, Thormann W, Mevissen M, Spadavecchia C.The purpose of this study was to evaluate the anti-nociceptive activity of ketamine and isoflurane in horses using a limb withdrawal reflex (WR) model. Single and repeated stimulations were applied to the digital nerve of the left forelimb in ponies anaesthetised with isoflurane before, during and after intravenous administration of racemic ketamine. Surface electromyographic activity was recorded from the deltoid muscle. Higher stimulation intensity was required to evoke a reflex during ketamine administration. Furthermore, the amplitudes of response to stimulations were significantly and dos...
The equine influenza epidemic in Australia: spatial and temporal descriptive analyses of a large propagating epidemic.
Preventive veterinary medicine    September 12, 2009   Volume 92, Issue 1-2 60-70 doi: 10.1016/j.prevetmed.2009.08.006
Cowled B, Ward MP, Hamilton S, Garner G.Australia experienced a large outbreak of equine influenza in August 2007. Nearly 10000 premises were infected during the epidemic. We used spatial and temporal analytical techniques to describe the epidemic, to quantify important descriptors of the epidemic, and to generate hypotheses about how the epidemic progressed and which control tools assisted in eradication. Spatio-temporal epidemic curves revealed three phases in the epidemic: dispersal, local spread and disease fade out. Spatial dispersal of infection rapidly declined immediately after national movement restrictions were introduced....
Equine encephalosis virus in Israel.
Transboundary and emerging diseases    September 12, 2009   Volume 56, Issue 8 291 doi: 10.1111/j.1865-1682.2009.01087_1.x
Mildenberg Z, Westcott D, Bellaiche M, Dastjerdi A, Steinbach F, Drew T.No abstract available
Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction.
Journal of veterinary internal medicine    September 11, 2009   Volume 23, Issue 6 1247-1253 doi: 10.1111/j.1939-1676.2009.0382.x
Robinson NE, Berney C, Behan A, Derksen FJ.Efficacy of inhaled fluticasone propionate (FP) for management of recurrent airway obstruction (RAO) has only been evaluated after several weeks' treatment. Objective: To compare efficacy of (1) 3-day treatments with FP to dexamethasone (DEX) for management of RAO; and (2) FP and DEX to no treatment in prevention of acute RAO exacerbations. Methods: Nine RAO affected horses. Methods: Crossover studies in RAO-affected horses compared (a) 3-day treatment of RAO exacerbation with FP (3 and 6 mg q12h) and DEX (0.1 mg/kg q24h) and (b) FP (6 mg q12h) and DEX (0.1 mg/kg q24h) to no treatment for prev...
Neuroaxonal dystrophy associated with cerebellar dysfunction in a 5-month-old Pony of the Americas colt.
Journal of veterinary internal medicine    September 11, 2009   Volume 23, Issue 6 1303-1306 doi: 10.1111/j.1939-1676.2009.0379.x
Brosnahan MM, Holbrook TC, Ritchey JW.No abstract available
Infectious agents detected in the feces of diarrheic foals: a retrospective study of 233 cases (2003-2008).
Journal of veterinary internal medicine    September 11, 2009   Volume 23, Issue 6 1254-1260 doi: 10.1111/j.1939-1676.2009.0383.x
Frederick J, Giguère S, Sanchez LC.Diarrhea is common in foals but there are no studies investigating the relative prevalence of common infectious agents in a population of hospitalized diarrheic foals. Objective: To determine the frequency of detection of infectious agents in a population of hospitalized foals with diarrhea and to determine if detection of specific pathogens is associated with age, outcome, or clinicopathologic data. Methods: Two hundred and thirty-three foals < or = 10 months of age with diarrhea examined at a referral institution. Methods: Retrospective case series. Each foal was examined for Salmonella s...
Assessment of prothrombin time, activated partial thromboplastin time, and fibrinogen concentration on equine plasma samples following different storage conditions. Casella S, Giannetto C, Fazio F, Giudice E, Piccione G.The aim of the present study was to assess the effect of different storage conditions on prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen concentration in clinical samples from healthy horses. A total of 100 healthy horses of varying breeds and gender, ranging in age from 4 to 18 years, with a mean body weight of 480 +/- 70 kg, were used. Blood was collected by jugular venipuncture, and a hemochrome-cytometric examination was conducted on all samples. All blood samples were centrifuged and divided into 4 different aliquots to assess clotting parameters by mea...
Multiple maternal origins of native modern and ancient horse populations in China.
Animal genetics    September 10, 2009   Volume 40, Issue 6 933-944 doi: 10.1111/j.1365-2052.2009.01950.x
Lei CZ, Su R, Bower MA, Edwards CJ, Wang XB, Weining S, Liu L, Xie WM, Li F, Liu RY, Zhang YS, Zhang CM, Chen H.To obtain more knowledge of the origin and genetic diversity of domestic horses in China, this study provides a comprehensive analysis of mitochondrial DNA (mtDNA) D-loop sequence diversity from nine horse breeds in China in conjunction with ancient DNA data and evidence from archaeological and historical records. A 247-bp mitochondrial D-loop sequence from 182 modern samples revealed a total of 70 haplotypes with a high level of genetic diversity. Seven major mtDNA haplogroups (A-G) and 16 clusters were identified for the 182 Chinese modern horses. In the present study, nine 247-bp mitochondr...
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Journal of comparative pathology    September 9, 2009   Volume 142, Issue 1 61-73 doi: 10.1016/j.jcpa.2009.07.007
Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, Mattutino G, Torre C, Schiffer D, Catalano D, Valenza F, Guarda F, Pumarola M.Many age-related changes are described in the nervous system of different species, but detailed studies of brain lesions in ageing horses are lacking. The aim of the present study was to systematically characterize lesions in the brains of 60 horses aged from 7 to 23 years. No gross changes were present in any brain. Microscopically, spongiform changes, lipofuscin storage, corpora amylacea, gliosis and satellitosis were common, together with axonal and neuronal swellings. The most important findings were the presence of pseudocalcium-calcium (pCa-Ca) deposits and arterial wall degeneration. Sc...
Concentrations of dust and endotoxin in equine stabling.
The Veterinary record    September 8, 2009   Volume 165, Issue 10 293-295 doi: 10.1136/vr.165.10.293
Whittaker AG, Hughes KJ, Parkin TD, Love S.No abstract available
Regional limb perfusion with erythromycin for treatment of septic physitis and arthritis caused by Rhodococcus equi.
The Veterinary record    September 8, 2009   Volume 165, Issue 10 291-292 doi: 10.1136/vr.165.10.291
Kelmer G, Hayes ME.No abstract available
Purification and partial characterization of proteinase inhibitors of equine seminal plasma.
Reproductive biology    September 8, 2009   Volume 9, Issue 2 151-160 doi: 10.1016/s1642-431x(12)60023-0
Vasconcelos AB, Santos AM, Oliveira JS, Lagares Mde A, Santoro MM.The aims of the study were: 1/ to isolate and identify equine seminal plasma proteinase inhibitors, 2/ to evaluate their inhibitory potential, and 3/ to test a correlation between protein concentration in seminal plasma supernatant (obtained after precipitation with 36% ammonium sulfate) and stallion sexual maturity. Seminal plasma proteins obtained from six stallions were chromatographed in a Superose 12 (FPLC system) column followed by C(18) HPLC reverse-phase. Inhibition of trypsin amidase activity was evaluated in the collected fractions. Active proteins with a molecular mass of 6.3-7.0 KD...