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Topic:Horse Racing

Horse racing is a competitive equestrian sport involving horses ridden by jockeys over set distances, often on flat tracks or over obstacles. It is characterized by a variety of race types, including thoroughbred, harness, and steeplechase, each with distinct rules and traditions. The sport emphasizes speed, stamina, and strategy, with races typically categorized by distance, surface type, and horse age or breed. Horse racing plays a significant role in the equine industry, influencing breeding, training, and veterinary care practices. This page compiles peer-reviewed research studies and scholarly articles that explore the physiological demands, training methodologies, and health considerations associated with horse racing.
Plasma concentrations of testosterone and nandrolone in racing and nonracing intact male horses.
Journal of veterinary pharmacology and therapeutics    April 12, 2011   Volume 35, Issue 2 132-138 doi: 10.1111/j.1365-2885.2011.01295.x
Soma LR, Uboh CE, You Y, Guan F, McDonnell S.Pennsylvania (PA) State Racing Commissions regulate the endogenous androgenic steroid, testosterone (TES), in racing intact males (RIM) by quantification of TES in post-race samples. Post-race plasma samples (2209) collected between March 2008 and November 2010 were analyzed for TES, nandrolone (NAN), and other anabolic steroids (ABS). Of the 2209 plasma samples, 2098 had quantifiable TES ≥ 25 pg/mL. Plasma (mean ± SD) concentrations of TES and NAN in RIM were 329.2 ± 266.4 and 96.0 ± 67.8 pg/mL, respectively. Only 64.6% of RIM had quantifiable concentration of NAN, and there was no relat...
Tracing outbreaks of Streptococcus equi infection (strangles) in horses using sequence variation in the seM gene and pulsed-field gel electrophoresis.
Veterinary microbiology    March 30, 2011   Volume 153, Issue 1-2 144-149 doi: 10.1016/j.vetmic.2011.03.027
Lindahl S, Söderlund R, Frosth S, Pringle J, Båverud V, Aspán A.Strangles is a serious respiratory disease in horses caused by Streptococcus equi subspecies equi (S. equi). Transmission of the disease occurs by direct contact with an infected horse or contaminated equipment. Genetically, S. equi strains are highly homogenous and differentiation of strains has proven difficult. However, the S. equi M-protein SeM contains a variable N-terminal region and has been proposed as a target gene to distinguish between different strains of S. equi and determine the source of an outbreak. In this study, strains of S. equi (n=60) from 32 strangles outbreaks in Sweden ...
Racetrack surfaces just one factor in horse racing fatalities.
Journal of the American Veterinary Medical Association    March 18, 2011   Volume 238, Issue 5 550-551 
Larkin M.No abstract available
Easy stereoselective synthesis of 5α-estrane-3β,17α-diol, the major metabolite of nandrolone in the horse.
Steroids    March 16, 2011   Volume 76, Issue 7 667-668 doi: 10.1016/j.steroids.2011.03.004
Balssa F, Fischer M, Bonnaire Y.5α-Estrane-3β,17α-diol is the major metabolite of nandrolone in horse urine. The presence of 5α-estrane-3β,17α-diol in female and gelding urines is prohibited by Racing Rules and its natural presence in male urine led regulation authorities to establish a concentration threshold of 45 ng/mL. This paper describes a rapid, simple and stereoselective synthesis of 5α-estrane-3β,17α-diol, providing horseracing laboratories with an essential reference material for their antidoping performance.
Physical, behavioral, endocrinologic, and cytogenetic evaluation of two Standardbred racehorses competing as mares with an intersex condition and high postrace serum testosterone concentrations.
Journal of the American Veterinary Medical Association    March 16, 2011   Volume 238, Issue 6 751-754 doi: 10.2460/javma.238.6.751
Knobbe MG, Maenhoudt C, Turner RM, McDonnell SM.2 Standardbred racehorses that had been winning races while competing as mares underwent postrace drug testing and had serum testosterone concentrations above the acceptable limit for female racehorses. Results: Initial physical examinations by the referring veterinarian revealed ambiguous external genitalia and suspected intra-abdominally located testes leading to a preliminary diagnosis of male pseudohermaphroditism. Horses were referred for further evaluation of sex. Physical examination of the external genitalia confirmed the findings of the referring veterinarian. Transrectal palpation an...
Descriptive epidemiology of joint injuries in Thoroughbred racehorses in training.
Equine veterinary journal    March 15, 2011   Volume 44, Issue 1 13-19 doi: 10.1111/j.2042-3306.2010.00352.x
Reed SR, Jackson BF, Mc Ilwraith CW, Wright IM, Pilsworth R, Knapp S, Wood JL, Price JS, Verheyen KL.No large scale epidemiological studies have previously quantified the occurrence of carpal, metacarpo- and metatarsophalangeal (MCP/MTP) joint injuries in Thoroughbred racehorses. Objective: To develop an objective classification system for carpal and MCP/MTP joint injuries and estimate the incidence of these injuries in young Thoroughbreds in flat race training. Methods: In a prospective cohort study, data on daily exercise and veterinary-diagnosed carpal and MCP/MTP joint injuries were collected from Thoroughbreds monitored since starting training as yearlings, for up to 2 years. Cases were ...
Particle mapping in stables at an American Thoroughbred racetrack.
Equine veterinary journal    March 4, 2011   Volume 43, Issue 5 599-607 doi: 10.1111/j.2042-3306.2010.00331.x
Millerick-May ML, Karmaus W, Derksen FJ, Berthold B, Holcombe SJ, Robinson NE.Airway inflammation and mucus in the trachea are common in racehorses. Fine airborne particles can initiate and coarse particles can worsen airway inflammation in man and in animal models of airway disease. The regional and seasonal distribution of particles of different sizes has never been investigated in American racing stables. Objective: To determine the regional and seasonal concentration and number of airborne particles of different sizes in racing stables. Methods: Direct reading instruments were used to determine the mass concentration and numbers of particles 3 times daily (early mor...
Effects of racing on equine fertility.
Animal reproduction science    February 13, 2011   Volume 124, Issue 1-2 73-84 doi: 10.1016/j.anireprosci.2011.02.010
Sairanen J, Katila T, Virtala AM, Ojala M.Racing and fertility are connected with each other in many ways. Stress and increased body temperature induced by racing may have negative effects on fertility, but on the other hand, high quality nutrition and management of racing horses may have positive effects. Fertility may also be genetically associated with racing performance. The analysed data consisted of Finnish mating records of Standardbreds (n=33,679) and Finnhorses (n=32,731), from 1991 to 2005, and the harness racing records of both mares and stallions. Fertility was measured by foaling outcome, and racing performance was measur...
Racing towards the genes for speed.
Veterinary journal (London, England : 1997)    February 9, 2011   Volume 190, Issue 1 5-6 doi: 10.1016/j.tvjl.2011.01.002
Hamilton NA, Raadsma HW.No abstract available
The effect of age on thoroughbred racing performance.
Journal of equine science    January 29, 2011   Volume 21, Issue 4 73-78 doi: 10.1294/jes.21.73
Gramm M, Marksteiner R.Using a dataset of 274 male Thoroughbred racehorses in the United States, we study the effect of age on racing performance. Beyer speed figures, which are uniform measures of racing performance across distance and racing surface, are utilized in this study. A system of equations is estimated to determine quadratic improvement and decline in racing performance. We find that a typical horse's peak racing age is 4.45 years. The rate of improvement from age 2 to 4 1/2 is greater than the rate of decline after age 4 1/2. A typical horse will improve by 10 (horse) lengths in sprints (less than 1 mil...
The effect of age on thoroughbred racing performance.
Journal of equine science    January 29, 2011   Volume 21, Issue 4 73-78 doi: 10.1294/jes.21.73
Gramm M, Marksteiner R.Using a dataset of 274 male Thoroughbred racehorses in the United States, we study the effect of age on racing performance. Beyer speed figures, which are uniform measures of racing performance across distance and racing surface, are utilized in this study. A system of equations is estimated to determine quadratic improvement and decline in racing performance. We find that a typical horse's peak racing age is 4.45 years. The rate of improvement from age 2 to 4 1/2 is greater than the rate of decline after age 4 1/2. A typical horse will improve by 10 (horse) lengths in sprints (less than 1 mil...
An investigation of racing performance and whip use by jockeys in thoroughbred races.
PloS one    January 27, 2011   Volume 6, Issue 1 e15622 doi: 10.1371/journal.pone.0015622
Evans D, McGreevy P.Concerns have been expressed concerning animal-welfare issues associated with whip use during Thoroughbred races. However, there have been no studies of relationships between performance and use of whips in Thoroughbred racing. Our aim was to describe whip use and the horses' performance during races, and to investigate associations between whip use and racing performance. Under the Australian Racing Board (ARB) rules, only horses that are in contention can be whipped, so we expected that whippings would be associated with superior performance, and those superior performances would be explaine...
Pharmacokinetics of yohimbine following intravenous administration to horses.
Journal of veterinary pharmacology and therapeutics    January 12, 2011   Volume 34, Issue 1 58-63 doi: 10.1111/j.1365-2885.2010.01194.x
Dimaio Knych HK, Steffey EP, Deuel JL, Shepard RA, Stanley SD.Yohimbine is an alpha 2 adrenergic receptor antagonist used most commonly in veterinary medicine to reverse the effects of the alpha 2 receptor agonists, xylazine and detomidine. Most notably, yohimbine has been shown to counteract the CNS depressant effects of alpha 2 receptor agonists in a number of species. The recent identification of a yohimbine positive urine sample collected from a horse racing in California has led to the investigation of the pharmacokinetics of this compound. Eight healthy adult horses received a single intravenous dose of 0.12 mg/kg yohimbine. Blood samples were co...
Electrosurgical tenoscopic desmotomy of the accessory ligament of the superficial digital flexor muscle (proximal check ligament) in horses.
Veterinary surgery : VS    December 23, 2010   Volume 40, Issue 1 46-53 doi: 10.1111/j.1532-950X.2010.00770.x
David F, Laverty S, Marcoux M, Szoke M, Celeste C.To report a tenoscopic technique using monopolar electrosurgery to transect the accessory ligament of superficial digital flexor muscle (AL-SDFM) and outcome in 33 horses. Methods: Case series. Methods: Horses (n=33). Methods: Medical files and surgery video recordings of horses that had AL-SDFM desmotomy performed by tenoscopy with monopolar electrosurgical electrodes were reviewed. Results: Of 33 horses, 24 were Standardbred racehorses with surgery performed bilaterally for superficial digital flexor tendonitis and 9 horses had flexural deformity. Severe (n=6) and mild (6) intrathecal hemorr...
Racing and sales performance after unilateral or bilateral single transphyseal screw insertion for varus angular limb deformities of the carpus in 53 thoroughbreds.
Veterinary surgery : VS    December 23, 2010   Volume 40, Issue 1 124-128 doi: 10.1111/j.1532-950X.2010.00769.x
Baker WT, Slone DE, Lynch TM, Johnson CR, Baker WA.To evaluate the racing and sales performance of Thoroughbred horses with varus angular limb deformities of the carpus treated by unilateral or bilateral single transphyseal screw (STS) placement. Methods: Case series. Methods: Thoroughbred horses (n=53). Methods: Medical records (January 1, 2005-December 31, 2006) of yearling Thoroughbreds treated for carpal angular limb deformity by transphyseal screw insertion in the distal aspect of the radius were reviewed. Retrieved data were sex, surgery, and screw removal dates, surgical site, appearance, limb(s) affected, type of angular limb deformity...
Predictors of race-day jockey falls in jumps racing in Australia.
Accident; analysis and prevention    December 9, 2010   Volume 43, Issue 3 840-847 doi: 10.1016/j.aap.2010.11.003
Hitchens P, Blizzard L, Jones G, Day L, Fell J.Thoroughbred jumps racing jockeys have a fall rate greater than their flat racing counterparts. Previous studies have focused on factors that contribute to falls by horses but, to date, there has not been a study of risk factors for falls to jockeys in jumps races. Data on race-day falls were extracted from stipendiary stewards reports lodged with Principal Racing Authorities following each race meeting. Denominator data were provided by Racing Information Services Australia on races conducted from August 2002 until July 2009. Univariable and multivariable analyses, estimating incidence rate r...
Grip and limb force limits to turning performance in competition horses.
Proceedings. Biological sciences    December 8, 2010   Volume 278, Issue 1715 2105-2111 doi: 10.1098/rspb.2010.2395
Tan H, Wilson AM.Manoeuverability is a key requirement for successful terrestrial locomotion, especially on variable terrain, and is a deciding factor in predator-prey interaction. Compared with straight-line running, bend running requires additional leg force to generate centripetal acceleration. In humans, this results in a reduction in maximum speed during bend running and a published model assuming maximum limb force as a constraint accurately predicts how much a sprinter must slow down on a bend given his maximum straight-line speed. In contrast, greyhounds do not slow down or change stride parameters dur...
Equine influenza virus: a jumping virus that races with Thoroughbred horses and greyhounds.
Veterinary journal (London, England : 1997)    November 30, 2010   Volume 189, Issue 1 3-4 doi: 10.1016/j.tvjl.2010.10.023
Murcia PR, Wood JL.No abstract available
Use of in vitro technologies to study phase II conjugation in equine sports drug surveillance.
Bioanalysis    November 30, 2010   Volume 2, Issue 12 1971-1988 doi: 10.4155/bio.10.135
Taylor P, Scarth JP, Hillyer LL.Within equine drug surveillance, there is significant interest in analyzing intact phase II conjugates of drugs in urine, but progress has been limited by a lack of reference material. Methods: In this study, in vitro techniques using equine liver fractions were employed to produce glucuronide and sulfate conjugates of stanozolol, 16β-hydroxystanozolol and nandrolone, the glucuronide conjugate of morphine and the glutathione metabolite of chlordinitrobenzene for the first time in equine sports drug surveillance. Results: The glucuronide conjugate of the synthetic progestagen altrenogest was a...
Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance.
Animal genetics    November 26, 2010   Volume 41 Suppl 2 56-63 doi: 10.1111/j.1365-2052.2010.02104.x
Hill EW, Gu J, McGivney BA, MacHugh DE.Athletic performance is influenced by a complex interplay among the environment and a suite of genes, which contributes to system-wide structure and function. In a panel of elite and non-elite Thoroughbred horses (n=148), we genotyped 68 SNPs in 17 putative exercise-relevant genes chosen from a genome scan for selection. We performed a series of case-control and quantitative association tests for relationships with racecourse performance. Thirteen SNPs in nine genes were significantly (P<0.05) associated with a performance phenotype. We selected five SNPs in four genes (ACSS1, ACN9, COX4I1,...
Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA.
Animal genetics    November 26, 2010   Volume 41 Suppl 2 154-158 doi: 10.1111/j.1365-2052.2010.02126.x
Binns MM, Boehler DA, Lambert DH.One hundred and eighty-nine Thoroughbred horses that had won Graded Stakes races in North America were genotyped with the Illumina Equine SNP50 bead chip. Association tests using PLINK to determine whether any SNPs were associated with optimum racing distance (7 furlongs and under compared to 8-10 furlongs) identified a locus on ECA18 that was statistically significant (-log 10 EMP2=1.63) at the genome-wide level following permutation analysis (10,000 permutations). Bioinformatic analysis revealed that the two ECA18 SNPs with the highest statistical significance spanned the MSTN (myostatin) lo...
A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene.
Animal genetics    November 26, 2010   Volume 41 Suppl 2 28-35 doi: 10.1111/j.1365-2052.2010.02095.x
Tozaki T, Miyake T, Kakoi H, Gawahara H, Sugita S, Hasegawa T, Ishida N, Hirota K, Nakano Y.Using 1400 microsatellites, a genome-wide association study (GWAS) was performed to identify genomic regions associated with lifetime earnings and performance ranks, as determined by the Japan Racing Association (JRA). The minimum heritability (h(2) ) was estimated at 7-8% based on the quantitative trait model, suggesting that the racing performance is heritable. Following GWAS with microsatellites, fine mapping led to identification of three SNPs on ECA18, namely, g.65809482T>C (P=1.05E-18), g.65868604G>T (P=6.47E-17), and g.66539967A>G (P=3.35E-14) associated with these performance ...
Metabolism of anabolic steroids and their relevance to drug detection in horseracing.
Bioanalysis    November 19, 2010   Volume 2, Issue 6 1085-1107 doi: 10.4155/bio.10.57
Teale P, Houghton E.The fight against doping in sport using analytical chemistry is a mature area with a history of approximately 100 years in horseracing. In common with human sport, anabolic/androgenic steroids (AASs) are an important group of potential doping agents. Particular issues with their detection are extensive metabolism including both phase I and phase II. A number of the common AASs are also endogenous to the equine. A further issue is the large number of synthetic steroids produced as pharmaceutical products or as 'designer' drugs intended to avoid detection or for the human supplement market. An u...
Confirmatory analysis of continuous erythropoietin receptor activator and erythropoietin analogues in equine plasma by LC-MS for doping control.
Analytical chemistry    October 14, 2010   Volume 82, Issue 21 9074-9081 doi: 10.1021/ac102031w
Guan F, Uboh CE, Soma LR, Maylin G, Jiang Z, Chen J.Continuous erythropoietin receptor activator (CERA) is the third generation of recombinant human erythropoietin (rhEPO) medication that retains the effect of promoting red blood cell production but has longer duration of action in the body. CERA, rhEPO, and darbepoetin alpha (DPO) can be misused to enhance performance in both human and equine athletes. To deter such misuse, a very selective and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has now been developed for identification of CERA, rhEPO, and DPO in equine plasma. The method employs a new signature tryptic...
A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses.
BMC genomics    October 11, 2010   Volume 11 552 doi: 10.1186/1471-2164-11-552
Hill EW, McGivney BA, Gu J, Whiston R, Machugh DE.Thoroughbred horses have been selected for traits contributing to speed and stamina for centuries. It is widely recognized that inherited variation in physical and physiological characteristics is responsible for variation in individual aptitude for race distance, and that muscle phenotypes in particular are important. Results: A genome-wide SNP-association study for optimum racing distance was performed using the EquineSNP50 Bead Chip genotyping array in a cohort of n = 118 elite Thoroughbred racehorses divergent for race distance aptitude. In a cohort-based association test we evaluated geno...
Analysis of the subchondral microarchitecture of the distopalmar aspect of the third metacarpal bone in racing Thoroughbreds.
American journal of veterinary research    October 6, 2010   Volume 71, Issue 10 1148-1153 doi: 10.2460/ajvr.71.10.1148
Rubio-Martínez LM, Cruz AM, Inglis D, Hurtig MB.To determine the anisotropic characteristics of the microarchitecture of the subchondral bone (SCB) plate and trabecular bone (TBB) of the distopalmar aspect of the metacarpal condyles in horses with different stages of SCB disease. Methods: 12 third metacarpal bone pairs from racing Thoroughbreds euthanized for diverse reasons. Methods: Both metacarpi were collected from horses with SCB changes that were mild (sclerosis and focal radiolucencies; n=6) or severe (multifocal radiolucencies and articular surface defects; 6). Sample blocks of SCB plate and TBB were collected from the distopalmar a...
Thromboelastometric profiles of horses affected by exercise-induced pulmonary hemorrhages.
Veterinary medicine international    September 30, 2010   Volume 2010 945789 doi: 10.4061/2010/945789
Giordano A, Meazza C, Salvadori M, Paltrinieri S.Exercise-induced pulmonary hemorrhage (EIPH) commonly occurs in race horses. Thromboelastometry (TEM) investigates the whole hemostatic process by evaluating the viscoelastic properties of the blood clot from its formation to fibrinolysis. The aim of this study was to assess whether horses with EIPH have abnormal thromboelastometric profiles. Intrinsic and extrinsic pathways, fibrinogen activity and fibrinolysis were investigated by TEM before and after the race in negative controls and in horses on which EIPH was confirmed by bronchoscopy. Compared with controls, horses with EIPH had an incre...
The use of in vitro technologies coupled with high resolution accurate mass LC-MS for studying drug metabolism in equine drug surveillance.
Drug testing and analysis    September 30, 2010   Volume 2, Issue 1 1-10 doi: 10.1002/dta.88
Scarth JP, Spencer HA, Timbers SE, Hudson SC, Hillyer LL.The detection of drug abuse in horseracing often requires knowledge of drug metabolism, especially if urine is the matrix of choice. In this study, equine liver/lung microsomes/S9 tissue fractions were used to study the phase I metabolism of eight drugs of relevance to equine drug surveillance (acepromazine, azaperone, celecoxib, fentanyl, fluphenazine, mepivacaine, methylphenidate and tripelennamine). In vitro samples were analyzed qualitatively alongside samples originating from in vivo administrations using LC-MS on a high resolution accurate mass Thermo Orbitrap Discovery instrument and by...
Simultaneous separation and confirmation of amphetamine and related drugs in equine plasma by non-aqueous capillary-electrophoresis-tandem mass spectrometry.
Drug testing and analysis    September 30, 2010   Volume 2, Issue 2 70-81 doi: 10.1002/dta.102
Li XQ, Uboh CE, Soma LR, Guan FY, You YW, Kahler MC, Judy JA, Liu Y, Chen JW.A non-aqueous capillary electrophoresis-mass spectrometry (NACE-MS) method was developed for simultaneous separation and identification of 12 amphetamine and related compounds in equine plasma. Analytes were recovered from plasma by liquid-liquid extraction using methyl tertiary butyl ether (MTBE). A bare fused-silica capillary was used for separation of the analytes. Addition of sheath liquid to the capillary effluent allowed the detection of the analytes by positive electrospray ionization mass spectrometry using full scan data acquisition. The limit of detection (LOD) for the target analyte...
Detection and confirmation of 60 anabolic and androgenic steroids in equine plasma by liquid chromatography-tandem mass spectrometry with instant library searching.
Drug testing and analysis    September 28, 2010   Volume 3, Issue 1 54-67 doi: 10.1002/dta.168
Liu Y, Uboh CE, Soma LR, Li X, Guan F, You Y, Rudy JA, Chen JW.In 2008, Pennsylvania (PA) became the first State in the USA to ban and enforce the ban on the use of anabolic and androgenic steroids (AAS) in equine athletes by using plasma for analysis. To enforce the ban, a rapid and high-throughput method for analysis of 60 AAS in equine plasma was developed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Analytes were recovered from plasma by liquid-liquid extraction (LLE) using methyl tert-butyl ether, separated on a reversed-phase C₁₈ column and analyzed by electrospray ionization mass spectrometry. Multiple-reaction monitoring (MRM)...
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