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Topic:Standardbred Horses

Standardbred horses are a breed known for their performance in harness racing, characterized by their ability to trot or pace at high speeds. This breed is distinguished by its well-muscled build, strong legs, and calm temperament. Standardbreds are primarily used in racing but are also versatile in other equestrian activities, including riding and driving. Their genetic lineage can be traced back to the late 18th century, with the establishment of the breed registry in the United States. This page compiles peer-reviewed research studies and scholarly articles that explore the genetics, physiology, and performance characteristics of Standardbred horses, as well as their management and health considerations in various equine disciplines.
Multiple rib fracture in a neonatal foal using a nylon strand suture repair technique.
Veterinary surgery : VS    October 11, 2005   Volume 34, Issue 4 399-404 doi: 10.1111/j.1532-950X.2005.00061.x
Kraus BM, Richardson DW, Sheridan G, Wilkins PA.To report rib fracture repair using the Securos Cranial Cruciate Ligament Repair System (SCCLRS; Securos Veterinary Orthopedics, Charlton, MA) in a neonatal foal. Methods: Case report. Methods: A 1-day-old Standardbred foal with fracture of left ribs 2-9. Methods: Four days after admission the foal was anesthetized and rib fractures were repaired using open reduction and the SCCLRS. Results: Rib fractures were successfully stabilized and the foal was discharged 7 days postoperatively without further complications. Conclusions: The SCCLRS provided a straightforward, effective method of rib frac...
Incomplete sagittal fracture of the talus in 11 racehorses: outcome.
Equine veterinary journal    September 17, 2005   Volume 37, Issue 5 457-461 doi: 10.2746/042516405774480030
Davidson EJ, Ross MW, Parente EJ.Little information exists regarding talus fractures in the horse and there have been no previously published case series of racehorses diagnosed with incomplete sagittal fracture of the talus. Objective: To describe the diagnosis, treatment and post injury performance of horses with incomplete sagittal fracture of the talus. Methods: Medical records of 11 racehorses (8 Standardbreds and 3 Thoroughbreds) admitted between January 1992 and January 1999 were reviewed. Subject details, anamnesis, results of lameness examination, radiographs and nuclear scintigraphic findings were evaluated. Racing ...
Diurnal variation of ghrelin, leptin, and adiponectin in Standardbred mares.
Journal of animal science    September 15, 2005   Volume 83, Issue 10 2365-2371 doi: 10.2527/2005.83102365x
Gordon ME, McKeever KH.Twelve Standardbred mares underwent blood sampling for 24 h to test the hypothesis that there is diurnal variation of humoral mediators of peripheral energy balance including active ghrelin, adiponectin, leptin, glucose, insulin, and cortisol. The experiment was conducted under acclimated conditions. Grass hay and pelleted grain were provided at 0730 and 1530. Plasma concentrations of active ghrelin and leptin concentrations both peaked (47.3 +/- 6.5 pg/ mL and 5.9 +/- 1.1 ng/mL, respectively; P < 0.05) at 1550, 20 min after feeding. Active ghrelin decreased (P 0.05) after the morning feed...
Oxygen radical absorbance capacity (ORAC) and exercise-induced oxidative stress in trotters.
European journal of applied physiology    August 31, 2005   Volume 95, Issue 5-6 550-556 doi: 10.1007/s00421-005-0034-3
Kinnunen S, Hyyppä S, Lehmuskero A, Oksala N, Mäenpää P, Hänninen O, Atalay M.Strenuous exercise is a potent inducer of oxidative stress, which has been suggested to be associated with disturbances in muscle homeostasis, fatigue and injury. There is no comprehensive or uniform view of the antioxidant status in horses. We have previously shown that moderate exercise induces protein oxidation in trotters. The aim of this study was to measure the antioxidative capacity of the horse in relation to different antioxidant components and oxidative stress markers after a single bout of moderate exercise to elucidate the mechanisms of antioxidant protection in horses. Eight clini...
Respiratory mechanics in Standardbred horses with sub-clinical inflammatory airway disease and poor athletic performance.
Veterinary journal (London, England : 1997)    August 29, 2005   Volume 173, Issue 1 144-150 doi: 10.1016/j.tvjl.2005.07.020
Pirrone F, Albertini M, Clement MG, Lafortuna CL.The aim of this study was to investigate and quantify respiratory mechanical dysfunctions in Standardbred horses with both poor performance and bronchoalveolar lavage fluid cytology characteristic of inflammatory airway disease (IAD). A control group of healthy Standardbred horses was compared. Respiratory mechanics and breathing pattern were examined at rest and during hyperventilation induced using a rebreathing method. At rest, respiratory mechanics and breathing pattern were superimposable in both groups. In IAD horses, rebreathing increased ventilation, with larger tidal volumes and lower...
Effects of recombinant equine growth hormone on in vitro biomechanical properties of the superficial digital flexor tendon of Standardbred yearlings in training.
Veterinary surgery : VS    August 24, 2005   Volume 34, Issue 3 253-259 doi: 10.1111/j.1532-950X.2005.00038.x
Gerard MP, Hodgson DR, Rose RJ, Walsh WR.To determine whether recombinant equine growth hormone (rEGH) would alter the in vitro biomechanical properties of the forelimb superficial digital flexor tendon (SDFT) in exercising young Standardbred horses. Methods: Randomized complete block design. Methods: Twelve Standardbred yearlings. Methods: Horses were trained for 12 weeks on a high-speed treadmill (10% positive incline). rEGH was administered intramuscularly (IM) daily (10 microg/kg during week 4; 20 microg/kg for weeks 5-9) to 6 horses (treated group), whereas 6 horses (control group) were administered an equivalent daily volume of...
Laser vocal cordectomy fails to effectively reduce respiratory noise in horses with laryngeal hemiplegia.
Veterinary surgery : VS    August 24, 2005   Volume 34, Issue 3 247-252 doi: 10.1111/j.1532-950X.2005.00037.x
Brown JA, Derksen FJ, Stick JA, Hartmann WM, Robinson NE.To report the effect of unilateral laser vocal cordectomy on respiratory noise and airway function in horses with experimentally induced laryngeal hemiplegia (LH). Methods: Experimental study. Methods: Six Standardbred horses without upper airway abnormalities at rest or during high-speed treadmill exercise. Methods: Respiratory sounds and inspiratory trans-upper airway pressure (P(Ui)) were measured before (baseline) and 14 days after induction of LH by left recurrent laryngeal neurectomy, and again 30, 60, 90, and 120 days after endoscopically assisted laser cordectomy of the left vocal cord...
Sudden death due to thoracic lymphoma in a standardbred racing horse.
The Canadian veterinary journal = La revue veterinaire canadienne    July 29, 2005   Volume 46, Issue 6 528-529 
Lawn K.During training, a 6-year-old standardbred gelding collapsed, exhibiting severe epistaxis and agonal breathing and was euthanized. The horse had a recent history of poor performance, lethargy, and unilateral eyelid swelling with serous ocular discharge. Postmortem and histopathologic examination findings revealed thoracic lymphosarcoma and concurrent exercise-induced pulmonary hemorrhage. Résumé — Mort subite d’un cheval de course de race standardbred causée par un lymphome thoracique. En cours d’entraînement, un standardbred hongre âgé de 6 ans s’est effondré, présentant des s...
Endoscopic observations on laryngeal symmetry and movements in young racing horses.
New Zealand veterinary journal    July 21, 2005   Volume 45, Issue 5 188-192 doi: 10.1080/00480169.1997.36024
Anderson BH, Kannegieter NJ, Goulden BE.An endoscopic survey of young race horses was performed to examine the prevalence and character of laryngeal movements during quiet respiration. The main aim was to determine whether those arytenoid movements which could possibly reflect the efficiency of left dorsal cricoarytenoid muscle function changed over a period of time. Of the 452 horses examined, 439 were Thoroughbreds and 23 were Standardbreds, 250 were less than 2 years of age (6-21 months), and 202 were 2 years old. One hundred and nine of these horses were examined again 16 months later. Arytenoid movements were given one of four ...
Pathophysiology and diagnosis of third carpal bone disease in horses: a review.
New Zealand veterinary journal    July 21, 2005   Volume 50, Issue 1 2-8 doi: 10.1080/00480169.2002.36241
Secombe CJ, Firth EC, Perkins NR, Anderson BH.Third carpal bone (C3) disease is a significant cause of lameness in Standardbred and Thoroughbred horses. The bone density of C3 increases as a result of exercise, reducing the compliance of the bone and predisposing it to injury. Currently, the most widely used method of diagnosis is subjective radiography using the tangential view. Radiographically, increases in bone mineral density (BMD) appear as sclerosis but it is not known at what point increases in sclerosis indicate the onset of disease or increased risk of C3 fracture. A quantitative assessment of the BMD of C3 in horses would impro...
Scrutiny of antimicrobial use in racing horses with allergic small airway inflammatory disease.
The Canadian veterinary journal = La revue veterinaire canadienne    July 16, 2005   Volume 46, Issue 5 438-439 
Weese JS, Sabino C.Antimicrobials had been administered to 38/55 (69%) racing standardbred and Thoroughbred horses with poor performance, subsequently diagnosed with nonseptic inflammatory airway disease. Horses with cough were more commonly treated (P = 0.02). In almost all cases, no clinical signs suggested that bacterial infection was present. Inappropriate use of antimicrobials was common. Des antimicrobiens ont été administrés à 38/55 (69 %) chevaux standardbreds et chevaux pursang affichant une piètre performance, diagnostiqués par la suite avec une maladie inflammatoire aseptique des voies respirat...
Adiponectin and leptin are related to fat mass in horses.
Veterinary journal (London, England : 1997)    June 29, 2005   Volume 172, Issue 3 460-465 doi: 10.1016/j.tvjl.2005.05.002
Kearns CF, McKeever KH, Roegner V, Brady SM, Malinowski K.Plasma concentrations of adiponectin and leptin were measured in 23 mature Standardbred mares (age: 10+/-3 years) and 12 weanling fillies (10 Quarter Horse/Belgian crossbreds and two Quarter Horses; aged: 4+/-3 months) to test the hypothesis that adipocytokines are proportional to adiposity in horses. Rump fat thickness was measured using B-mode ultrasound and percent body fat (% fat) calculated using a published formula for the estimation of fatness in horses. Plasma adiponectin and leptin were determined using radioimmunoassay. In the absence of purified equine adiponectin or leptin, results...
Changes over time in echocardiographic measurements in young Standardbred racehorses undergoing training and racing and association with racing performance.
Journal of the American Veterinary Medical Association    June 7, 2005   Volume 226, Issue 11 1881-1887 doi: 10.2460/javma.2005.226.1881
Buhl R, Ersbøll AK, Eriksen L, Koch J.To evaluate changes over time in echocardiographic measurements in young Standardbred racehorses undergoing training and racing and determine whether there was any relationship between cardiac dimensions and racing performance. Methods: Longitudinal observational study. Methods: 103 horses. Methods: 2-dimensional and M-mode echocardiography was performed 4 times at 6-month intervals. Results: Significant cardiac enlargement took place during the study period as indicated by increases in left ventricular internal diameter in diastole (LVIDd), estimated left ventricular muscle mass (LV mass), an...
Comparison of thermal dilution and electrical impedance dilution methods for measurement of cardiac output in standing and exercising horses.
American journal of veterinary research    June 7, 2005   Volume 66, Issue 5 878-884 doi: 10.2460/ajvr.2005.66.878
Wilkins PA, Boston RC, Gleed RD, Dobson A.To compare cardiac output measured in the pulmonary artery and a carotid artery by use of thermal and electrical impedance dilution. Animals-7 fit, clinically normal Standardbreds between 2 and 5 years of age. Methods: Transient changes in electrical impedance and temperature of blood were induced by bolus injections of ice-cold saline hypertonic (6% and 9% NaCl) solutions. Cardiac output was calculated by applying Stewart-Hamilton principles to the indicator dilution transients. Measurements were made during sequential exercise episodes on a level treadmill over approximately an 8-fold range ...
Prevalence and risk factors associated with outcome of surgical removal of pedunculated lipomas in horses: 102 cases (1987-2002).
Journal of the American Veterinary Medical Association    May 11, 2005   Volume 226, Issue 9 1529-1537 doi: 10.2460/javma.2005.226.1529
Garcia-Seco E, Wilson DA, Kramer J, Keegan KG, Branson KR, Johnson PJ, Tyler JW.To determine the prevalence of pedunculated lipomas and identify risk factors affecting postoperative complications and survival in horses at a veterinary teaching hospital undergoing surgery for colic caused by pedunculated lipomas. Methods: Retrospective study. Methods: 102 horses with a diagnosis of pedunculated lipoma. Methods: Age, breed, weight, and sex of horses with pedunculated lipomas were compared with the total equine hospital population and the population of horses admitted for abdominal surgery during the same period. Follow-up information was obtained by reevaluation or contact ...
Comparison of two techniques for injection of the podotrochlear bursa in horses.
Journal of the American Veterinary Medical Association    May 11, 2005   Volume 226, Issue 9 1524-1528 doi: 10.2460/javma.2005.226.1524
Piccot-Crézollet C, Cauvin ER, Lepage OM.To compare accuracy of 2 methods for injection of the podotrochlear bursa in horses. Methods: Observational study. Methods: 17 French Standardbreds. Methods: In each horse, contrast medium was injected into the podotrochlear bursa of 1 foot by use of a distal palmar approach with the needle inserted parallel to the sole (DPPS) and into the podotrochlear bursa of the other foot by use of a distal palmar approach to the navicular position (DPNP). Podotrochlear bursa injection was evaluated by means of radiographic examination in all horses and postmortem examination in 6. Results: Contrast mediu...
The opioid haemorphin-7 in horses during low-speed and high-speed treadmill exercise to fatigue.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    May 11, 2005   Volume 52, Issue 4 162-165 doi: 10.1111/j.1439-0442.2005.00712.x
Collinder E, Nyberg F, Sanderson-Nydahl K, Gottlieb-Vedi M, Lindholm A.The opioid neuropeptide haemorphin-7 was measured, by immunoreactivity, in Standardbred horses during low-speed (7 m/s) and high-speed (10 m/s) endurance exercises, lasting 49-58 and 12-16 min respectively. In parallel, heart rate, muscle temperature and plasma lactate concentrations were measured. The profile of the low-speed exercise showed significantly increased heart rate after 10 min [154 beats per minute (bpm)]. After the exercise, muscle temperature (42.1 degrees C) and plasma lactate (4.8 mmol/l) were significantly increased. The profile of the high-speed exercise was comparatively ch...
Electroencephalographic and cardiovascular variables as nociceptive indicators in isoflurane-anaesthetized horses.
Veterinary anaesthesia and analgesia    May 10, 2005   Volume 32, Issue 3 128-135 doi: 10.1111/j.1467-2995.2005.00194.x
Haga HA, Dolvik NI.To evaluate Fourier-transformed electroencephalographic (EEG) variables, mean arterial blood pressure (MAP) and pulse rate as nociceptive indicators in isoflurane-anaesthetized horses. Methods: Five standardbred and three Norwegian cold-blooded trotter stallions undergoing castration, aged 2-4 years, mass 378-538 kg. Methods: All horses received intravenous (IV) detomidine (10 microg kg(-1) IV) and butorphanol (0.01 mg kg(-1) IV). Additional detomidine (4 microg kg(-1) IV) was administered in the induction area. Anaesthesia was induced with ketamine (2.5 mg kg(-1) IV) and diazepam (40 microg k...
Relationships between physiological variables and race performance in French standardbred trotters.
The Veterinary record    March 26, 2005   Volume 156, Issue 11 339-342 doi: 10.1136/vr.156.11.339
Leleu C, Cotrel C, Courouce-Malblanc A.The relationships between V4 (the velocity for a blood lactate concentration of 4 mmol/litre) and V200 (the velocity for a heart rate of 200 bpm) and the performance indices of 223 healthy French trotters were analysed. They were divided into four age groups of three, four, five and six years and over, and into three performance groups (good, intermediate and poor performers) defined by the index of trot (ITR), an annual index of performance calculated by the national stud. V4 and V200 were assessed during the performance of a three-step standardised field exercise test, and four performance i...
Surgical and nonsurgical management of sagittal slab fractures of the third carpal bone in racehorses: 32 cases (1991-2001).
Journal of the American Veterinary Medical Association    March 25, 2005   Volume 226, Issue 6 945-950 doi: 10.2460/javma.2005.226.945
Kraus BM, Ross MW, Boston RC.To compare results (ie, return to racing and earnings per race start) of surgical versus nonsurgical management of sagittal slab fractures of the third carpal bone in racehorses. Methods: Retrospective study. Methods: 32 racehorses (19 Thoroughbreds, 11 Standardbreds, and 2 Arabians). Methods: Medical records and radiographs were reviewed to obtain information regarding signalment and treatment. Follow-up information was obtained from race records. Robust regression analysis was performed to evaluate earnings per start in horses that raced at least once before and after injury. Results: 22 (69...
Effects of draught load exercise and training on calcium homeostasis in horses.
Journal of animal physiology and animal nutrition    March 25, 2005   Volume 89, Issue 3-6 134-139 doi: 10.1111/j.1439-0396.2005.00533.x
Vervuert I, Coenen M, Zamhöfer J.This study was conducted to investigate the effects of draught load exercise on calcium (Ca) homeostasis in young horses. Five 2-year-old untrained Standardbred horses were studied in a 4-month training programme. All exercise workouts were performed on a treadmill at a 6% incline and with a constant draught load of 40 kg (0.44 kN). The training programme started with a standardized exercise test (SET 1; six incremental steps of 5 min duration each, first step 1.38 m/s, stepwise increase by 0.56 m/s). A training programme was then initiated which consisted of low-speed exercise sessions (LSE; ...
Equine viral arteritis control scheme: a brief review with emphasis on laboratory aspects of the scheme in New Zealand.
New Zealand veterinary journal    March 16, 2005   Volume 52, Issue 2 82-84 doi: 10.1080/00480169.2004.36409
Horner GW.To review laboratory aspects of the equine viral arteritis (EVA) control scheme in New Zealand between 1989 and 2002. Methods: The optimisation and performance of the virus neutralisation test (VNT) for equine arteritis virus (EAV) antibody, and the cell culture test to detect EAV in semen were analysed. Laboratory data and control scheme results were reviewed. Results: Using optimised tests, it has been shown that antibody prevalence in Standardbred horses has steadily declined from 54% to <20%. Prevalences in Thoroughbred horses have remained at a low level of around 3%. The number of hor...
Statistical analysis of some factors affecting the number of horse births in France.
Reproduction, nutrition, development    March 15, 2005   Volume 44, Issue 6 583-595 doi: 10.1051/rnd:2004055
Langlois B, Blouin C.Declarations of matings (535,746) and 308,549 consecutive declarations of birth from 1989 to 1999 were analysed by logistic regression in order to determine the effects of year, breed and age of parents on numerical productivity (the number of foals declared per mated mare per year). For the years 1994 to 1999, the status of the mare, type of mating and month of first mating, were also available. The effect of inbreeding and, for warm-blooded horses, the effect of the level of performances or the effect of the level of breeding value estimation were also analysed. The main results are the foll...
Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses.
Veterinary anaesthesia and analgesia    March 15, 2005   Volume 32, Issue 2 83-93 doi: 10.1111/j.1467-2995.2004.00178.x
Marntell S, Nyman G, Funkquist P, Hedenstierna G.To study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletamine-zolazepam anaesthesia in horses. Methods: Six (four males and two females) healthy Standardbred trotters aged 3-12 years; mass 423-520 kg. Methods: Randomized, cross-over, experimental study. Methods: Horses were anaesthetized on two occasions (with a minimum interval of 1 week) with intravenous (IV) tiletamine-zolazepam (Z; 1.4 mg kg(-1)) after pre-anaesthetic medication with IV romifidine (R; 0.1 mg kg(-1...
Blood-oxygen binding in healthy Standardbred horses.
Veterinary journal (London, England : 1997)    February 25, 2005   Volume 169, Issue 2 251-256 doi: 10.1016/j.tvjl.2004.01.025
Cambier C, Di Passio N, Clerbaux T, Amory H, Marville V, Detry B, Frans A, Gustin P.The purpose of this study was to determine the effect of regulating factors on the oxygen equilibrium curve (OEC) under standard conditions and then to calculate the oxygen extraction between arterial and jugular venous blood in healthy Standardbred horses. The results were compared to those previously obtained in humans and cattle, using the same experimental method. The partial oxygen pressure at 50% saturation of haemoglobin, measured under standard conditions (standard P50), was 24.8+/-2.0 (SD of mean) mmHg. This value was similar to the cattle standard P50 (25.0+/-1.4 mmHg, SD of mean) bu...
Whole blood, plasma viscosity, and erythrocyte aggregation as a determining factor of competitiveness in standard bred trotters.
Clinical hemorheology and microcirculation    January 25, 2005   Volume 32, Issue 1 31-41 
Stoiber B, Zach C, Izay B, Windberger U.In situations where capillary perfusion in skeletal muscles is limited, changes in blood flow play an important role. Especially alterations in intrinsic erythrocyte factors like red cell aggregation and deformability would increase blood flow resistance. In our study we investigated whether whole blood and plasma viscosity influence exercise tolerance during submaximal training and whether a difference can be realized between trained and untrained standardbred trotters. Venous blood from 42 healthy adult trotters (20 horses at the beginning of their training and 22 well trained horses) was in...
Relationships between fore- and hindlimb ground reaction force and hoof deceleration patterns in trotting horses.
Equine veterinary journal    January 20, 2005   Volume 36, Issue 8 737-742 doi: 10.2746/0425164044848136
Gustås P, Johnston C, Roepstorff L, Drevemo S, Lanshammar H.The transmission of shockwaves following hoof impact is proposed to be one major source of stress to the limb. In the forelimb, there are indications that the period of horizontal deceleration of the hoof is related to the attenuation of shockwaves. In the hindlimb, information about the hoof deceleration has been lacking. Objective: To compare hoof deceleration patterns between the fore- and hindlimbs. Methods: Seven Standardbreds were trotted by hand over a force plate covered with sand, with triaxial accelerometers mounted on the fore and hind hooves. Variables representative of deceleratio...
Dynamic pressure measurements for the detailed study of hoof balance: the effect of trimming.
Equine veterinary journal    January 20, 2005   Volume 36, Issue 8 778-782 doi: 10.2746/0425164044847993
van Heel MC, Barneveld A, van Weeren PR, Back W.Studies on hoof balance have, so far, only assessed the effects of strong and relatively unrealistic interventions due to technical limitations of measuring equipment. For the assessment of more subtle interventions, other techniques are necessary. Objective: To test a sensitive pressure measurement system during locomotion and to set a standard for further studies by using the system to evaluate the effects of trimming. Methods: Eighteen horses were measured before and after trimming with an interval of 4 weeks. Trimming was standardised to a straight hoof-pastern axis. The horses trotted ove...
Ultrastructural immunolocalisation of bone sialoprotein in the osteocartilagenous interface of the equine third carpal bone.
Equine veterinary journal    January 18, 2005   Volume 37, Issue 1 26-30 doi: 10.2746/0425164054406937
Ekman S, Skiöldebrand E, Heinegård D, Hultenby K.One of the most common causes of lameness in racehorses is osteoarthritis (OA). Pathogenesis is not clear and pathological processes of the different joint tissues interact in often progressive events. The interface between cartilage and newly synthesised bone has been shown to be particularly enriched in bone sialoprotein (BSP), a cell-binding matrix protein. Objective: To establish whether changes in the concentration of BSP may serve as a marker for early biochemical changes of the subchondral bone. Methods: Articular cartilage, cartilage/bone interface and subchondral bone of the proximal ...
Enhanced concentration of COMP (cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society    December 21, 2004   Volume 23, Issue 1 156-163 doi: 10.1016/j.orthres.2004.05.013
Skiöldebrand E, Heinegård D, Eloranta ML, Nilsson G, Dudhia J, Sandgren B, Ekman S.The aim of the present study was to correlate the levels of COMP and aggrecan as indicators of tissue damage, in synovial fluid (sf) from carpal joints of acutely lame racehorses, with macroscopical lesions of articular cartilage (OA), osteochondral fractures and ligament tears found at arthroscopy. Sixty-three lame horses [49 Standardbred trotters (STB) and 14 Thoroughbreds (TB)] in conventional training and racing that underwent arthroscopy of their middle carpal or radiocarpal joints were included in the study. Intact as well as fragmented COMP and aggrecan released into the synovial fluid ...
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