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Topic:Veterinary Medicine

Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Liquid chromatography-tandem mass spectrometric method for determination of mosapride citrate in equine tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences    August 22, 2007   Volume 858, Issue 1-2 135-142 doi: 10.1016/j.jchromb.2007.08.017
Aoki Y, Hakamata H, Igarashi Y, Uchida K, Kobayashi H, Hirayama N, Kotani A, Kusu F.A simple method for determination of mosapride citrate and its metabolite, des-p-fluorobenzyl mosapride (M-1), in equine muscle, liver, kidney, adipose tissue and intestine by liquid chromatography-tandem mass spectrometry has been developed. (+/-)-4-Amino-5-chloro-2-ethoxy-N-[[4-(2-chlorobenzyl)morpholinyl]methyl]benzamide was used as an internal standard. The analytes and internal standard were spiked and extracted from tissues by acetonitrile. The chromatographic separation was performed on a reversed-phase TSK-GEL SUPER ODS column with a mobile phase of acetonitrile-0.05% (v/v) formic acid...
Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004).
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 812-819 doi: 10.1892/0891-6640(2007)21[812:capcvc]2.0.co;2
Levine JM, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND.Cervical vertebral compressive myelopathy (CVCM) is a common cause of myelopathy in horses aged 6 months to 4 years. Little information is available regarding the types of lesions, treatment, and outcomes in horses with CVCM that are > or =4 years old. Methods: Twenty-two affected horses (10 with a confirmed diagnosis of CVCM and 12 presumptive cases) and 210 contemporaneous control horses. Methods: Horses > or =4 years old that were diagnosed with CVCM between January 1992 and January 2004 were identified from medical records at Texas A&M University and the University of Florida. Data analyze...
Humoral immune responses in the horse after intrathecal challenge with ovalbumin.
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 806-811 doi: 10.1892/0891-6640(2007)21[806:hirith]2.0.co;2
Furr M.Diagnosis of neuro-inflammatory conditions in the horse can be challenging. Current methods include evaluation of cerebrospinal fluid (CSF) for inflammation and determination of specific antibody status. The antibody index (AI) and Goldman-Witmer coefficient (C-value) can be used to aid in the interpretation. Objective: The null hypothesis to be tested was that the Al and C-values do not change in horses with neuroinflammation. Methods: Twelve horses of various ages (3-17 years) and breeds (Thoroughbred, Thoroughbred cross, draft, and Arabian) were included in the study. Methods: The study was...
Diagnosis and treatment of a selective immunoglobulin M glomerulonephropathy in a quarter horse gelding.
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 874-877 doi: 10.1892/0891-6640(2007)21[874:datoas]2.0.co;2
Mcsloy A, Poulsen K, Fisher PJ, Armien A, Chilton JA, Peek S.No abstract available
Plasma adrenocorticotropin, cortisol, and adrenocorticotropin/cortisol ratios in septic and normal-term foals.
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 791-796 doi: 10.1892/0891-6640(2007)21[791:pacacr]2.0.co;2
Gold JR, Divers TJ, Barton MH, Lamb SV, Place NJ, Mohammed HO, Bain FT.Little information exists on the hypothalamic-pituitary-adrenal axis in septic foals. Objective: The plasma concentrations of adrenocorticotropin (ACTH) and cortisol are expected to be higher in septic foals as compared to normal foals. The concentrations of hormones in septic foals also are expected to differ further depending upon survival. Methods: Twenty-eight control foals and 46 septic foals 11 or a positive blood culture. The control foals were age matched to the septic foals in the study. ACTH and cortisol concentrations were measured by a chemiluminescent immunoassay system. Results: ...
Treatment with amiodarone of refractory ventricular tachycardia in a horse.
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 878-880 doi: 10.1892/0891-6640(2007)21[878:twaorv]2.0.co;2
De Clercq D, van Loon G, Baert K, De Backer P, Deprez P.No abstract available
Serum opsonization capacity, phagocytosis, and oxidative burst activity in neonatal foals in the intensive care unit.
Journal of veterinary internal medicine    August 22, 2007   Volume 21, Issue 4 797-805 doi: 10.1892/0891-6640(2007)21[797:socpao]2.0.co;2
Gardner RB, Nydam DV, Luna JA, Bicalho ML, Matychak MB, Flaminio MJ.Phagocytic activity of neonatal foals has been reported to be similar to that of adult horses, but serum opsonization capacity develops with age and may be further altered when opsonins are consumed during infection. Objective: Phagocytosis, oxidative burst activity, and serum opsonization capacity in neonatal foals admitted to an intensive care unit are reduced in comparison with control foals. Methods: Blood samples were collected from hospitalized neonatal foals and from control foals. Hospitalized foals were characterized as sick or septic on the basis of a sepsis score and received intrav...
Purification of equine IgG using membrane based enhanced hybrid bioseparation technique: a potential method for manufacturing hyperimmune antibody.
Biotechnology and bioengineering    August 21, 2007   Volume 99, Issue 3 625-633 doi: 10.1002/bit.21614
Wang L, Sun X, Ghosh R.Hyperimmune equine IgG is widely used as antivenom and anti-rabies agents. This article discusses a membrane based enhanced hybrid bioseparation technique for efficient and scalable purification of equine immunoglobulin G (IgG) from horse serum. This technique is an improved version of a standard hybrid bioseparation technique developed within our group earlier for fractionation of human plasma proteins (Ghosh. 2004. J Membr Sci 237: 109-117). In the presence of a high antichaotropic salt concentration, equine IgG is selectively and reversibly captured within a stirred cell membrane module fro...
Prevalence of equine herpesvirus-1 infection among Thoroughbreds residing on a farm on which the virus was endemic.
Journal of the American Veterinary Medical Association    August 19, 2007   Volume 231, Issue 4 577-580 doi: 10.2460/javma.231.4.577
Brown JA, Mapes S, Ball BA, Hodder AD, Liu IK, Pusterla N.To determine the incidence of equine herpesvirus-1 (EHV-1) infection among Thoroughbreds residing on a farm on which the virus was known to be endemic. Methods: Prospective cohort study. Methods: 10 nonpregnant mares, 8 stallions, 16 weanlings, 11 racehorses, and 30 pregnant mares and their foals born during the 2006 foaling season. Methods: Blood and nasopharygeal swab samples were collected every 3 to 5 weeks for 9 months, and placenta and colostrum samples were collected at foaling. All samples were submitted for testing for EHV-1 DNA with a PCR assay. A type-specific EHV-1 ELISA was used t...
Comments on AVMA support of companion animal and equine research institute.
Journal of the American Veterinary Medical Association    August 19, 2007   Volume 231, Issue 3 374-375 
Olson PN.No abstract available
A comparison of intradermal testing and detection of allergen-specific immunoglobulin E in serum by enzyme-linked immunosorbent assay in horses affected with skin hypersensitivity.
Veterinary immunology and immunopathology    August 19, 2007   Volume 120, Issue 3-4 160-167 doi: 10.1016/j.vetimm.2007.08.007
Morgan EE, Miller WH, Wagner B.Skin hypersensitivities (allergies) in horses are often diagnosed using clinical signs only. Intradermal testing or serological assays are diagnostic options to confirm the allergic nature of the disease and to identify the allergen(s). Our objective was to develop an allergen-specific enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody specific for horse IgE and to examine its potential for allergen detection in serum in comparison to intradermal testing. Intradermal testing with 61 allergen extracts was performed on 10 horses affected with skin hypersensitivity. Their sera ...
Magnetic resonance imaging features of oblique and straight distal sesamoidean desmitis in 27 horses. Sampson SN, Schneider RK, Tucker RL, Gavin PR, Zubrod CJ, Ho CP.Injury to the oblique and straight distal sesamoidean ligaments is becoming recognized as a more common cause of lameness in horses than was previously thought. The purpose of this study was to review the magnetic resonance (MR) imaging findings of 27 horses affected with desmitis of the oblique and/or straight distal sesamoidean ligament and determine long-term prognosis for horses with this diagnosis. Imaging was performed with horses in right lateral recumbency in a high-field 1 T magnet. All horses had lameness localized to the digit or metacarpophalangeal/metatarsophalangeal joint region ...
Equine disease surveillance, January to March 2007.
The Veterinary record    August 19, 2007   Volume 161, Issue 3 79-82 doi: 10.1136/vr.161.3.79
No abstract available
Non-specific haemolytic alloantibody causing equine neonatal isoerythrolysis.
The Veterinary record    August 19, 2007   Volume 161, Issue 6 202-204 doi: 10.1136/vr.161.6.202
de Graaf-Roelfsema E, van der Kolk JH, Boerma S, van Haeringen H.No abstract available
Treatment in the field of 27 horses with epiglottic entrapment.
The Veterinary record    August 19, 2007   Volume 161, Issue 6 187-189 doi: 10.1136/vr.161.6.187
Russell T, Wainscott M.Twenty-seven horses were treated for epiglottic entrapment by using an oral, hand-assisted bistoury knife technique, under general anaesthesia; 26 of them returned successfully to racing, but one developed a permanently displaced soft palate. After the surgery 13 of the horses had an increased handicap rating and 13 had a decreased rating.
Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire    August 19, 2007   Volume 71, Issue 3 213-217 
Pearson W, Omar S, Clarke AF.The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, and 5 received molasses only. On day 14, each horse was vaccinated against EHV-1. The time course of the antibody response to vaccination was significantly altered in the horses receiving ginseng, a clinically relevant increase in antibody titer being observed by postvaccination day 2 compared with day 6 i...
Scintigraphic evaluation of the stifle in normal horses and horses with forelimb lameness. Dyson S, McNie K, Weekes J, Murray R.We tested the hypotheses that mature horses without lameness have a repeatable radiopharmaceutical uptake pattern in the stifle, which is bilaterally symmetric; immature horses have a different radiopharmaceutical uptake pattern; and forelimb lameness alters the radiopharmaceutical uptake pattern in the stifle. The objectives of the study were to describe the normal radiopharmaceutical uptake patterns using region of interest (ROI) analysis; to compare uptake patterns between left and right stifles of the same horse and between mature and immature horses; to compare radiopharmaceutical uptake ...
Serosurvey of West Nile virus in equids and bovids in Spain.
The Veterinary record    August 19, 2007   Volume 161, Issue 6 212 doi: 10.1136/vr.161.6.212
Jiménez-Clavero MA, Tejedor CG, Rojo G, Soriguer R, Figuerola J.No abstract available
Theriogenology question of the month. Bilateral testicular neoplasia.
Journal of the American Veterinary Medical Association    August 19, 2007   Volume 231, Issue 4 531-534 doi: 10.2460/javma.231.4.531
No abstract available
Three-dimensional ultrasonographic in vitro imaging of lesions of the meniscus and femoral trochlea in the equine stifle. Koneberg DG, Edinger J.The purpose of this in vitro study was to evaluate the value of three-dimensional (3D) ultrasonography for the diagnosis of equine meniscal and trochlear ridge lesions under in vitro conditions. Lesions were created in the isolated meniscus and femoral trochlea of 25 cadaver stifle joints. Cylindric, conic, and cuboid lesions were created on the trochlear ridge. Five different meniscal tear configurations were created. A total of 107 lesions of the trochlear ridge and 103 lesions of the meniscus were created. 3D ultrasonography was performed in a waterbath, using a 7.5 MHz 3D scanner. Trochlea...
Evaluation of periodontal changes following intra-alveolar prosthesis for maxillary cheek tooth extraction in ponies.
Journal of veterinary dentistry    August 19, 2007   Volume 24, Issue 2 77-84 doi: 10.1177/089875640702400202
Vlaminck LE, Steenhault M, Maes D, Huys L, Gasthuys F.This study investigated the placement of an intra-alveolar prosthesis of bone substitute on gingival/periodontal health in 5 ponies following repulsion of cheek teeth 108 and 208. In each pony, one randomly chosen alveolus was allowed to heal by second intention while the other was filled with a non-resorbable, biocompatible bone substitute. At 6, 12 and 24-months after surgery, both maxillary arches were evaluated for wear abnormalities and for gingival health using a periodontal scoring system. Recorded changes included development of overgrowths on mandibular cheek teeth, widening of maxill...
Cell phenotypic variation in normal and damaged tendons.
International journal of experimental pathology    August 19, 2007   Volume 88, Issue 4 227-235 doi: 10.1111/j.1365-2613.2007.00549.x
Clegg PD, Strassburg S, Smith RK.Injuries to tendons are common in both human athletes as well as in animals, such as the horse, which are used for competitive purposes. Furthermore, such injuries are also increasing in prevalence in the ageing, sedentary population. Tendon diseases often respond poorly to treatment and require lengthy periods of rehabilitation. The tendon has a unique extracellular matrix, which has developed to withstand the mechanical demands of such tensile-load bearing structures. Following injury, any repair process is inadequate and results in tissue that is distinct from original tendon tissue. There ...
Pro-inflammatory and antiviral cytokine expression in vaccinated and unvaccinated horses exposed to equine influenza virus.
Vaccine    August 17, 2007   Volume 25, Issue 41 7056-7064 doi: 10.1016/j.vaccine.2007.07.059
Quinlivan M, Nelly M, Prendergast M, Breathnach C, Horohov D, Arkins S, Chiang YW, Chu HJ, Ng T, Cullinane A.Most studies of the cytokine response to influenza virus infection have been carried out in human, porcine and murine models, however the data available on equine cytokines is limited. An experimental challenge study was undertaken in unvaccinated naïve horses and horses vaccinated with a commercial inactivated influenza vaccine. The humoral antibody response to vaccination and virus challenge was measured by single radial haemolysis (SRH) assay and clinical signs of influenza and viral shedding were monitored post-challenge. Levels of three equine pro-inflammatory cytokines interleukin (IL)-...
The diversity of coliphages and coliforms in horse feces reveals a complex pattern of ecological interactions.
Applied and environmental microbiology    August 17, 2007   Volume 73, Issue 19 5975-5981 doi: 10.1128/AEM.01145-07
Golomidova A, Kulikov E, Isaeva A, Manykin A, Letarov A.The diversity of coliphages and indigenous coliform strains (ICSs) simultaneously present in horse feces was investigated by culture-based and molecular methods. The richness of coliforms (as estimated by the Chao1 method) is about 1,000 individual ICSs distinguishable by genomic fingerprinting present in a single sample of feces. This unexpectedly high value indicates that some factor limits the competition of coliform bacteria in the horse gut microbial system. In contrast, the diversity of phages active against any selected ICS is generally limited to one to three viral genotypes present in...
Boosting in equine influenza vaccination schedules: timing and time for a re-evaluation of requirements of national and international authorities.
Veterinary journal (London, England : 1997)    August 16, 2007   Volume 174, Issue 3 449-450 doi: 10.1016/j.tvjl.2007.06.012
Wood JL, Mumford JA, Mair TS, Slater J.No abstract available
Comparison of ticarcillin and piperacillin in Kenney’s semen extender.
Theriogenology    August 15, 2007   Volume 68, Issue 6 848-852 doi: 10.1016/j.theriogenology.2007.03.031
Dietz JP, Sertich PL, Boston RC, Benson CE.Ticarcillin and piperacillin were compared to determine their effect on sperm motility and bacterial growth of equine semen samples diluted in Kenney's glucose skim milk semen extender. Each ejaculate (n=11) was divided into three portions and glucose skim milk semen extender solution was added. The control semen extender solution contained extended semen and no antibiotic, whereas ticarcillin and piperacillin solutions contained extended semen plus 1.0mg/mL of ticarcillin or piperacillin, respectively. An aliquot was removed (1h after collection) to evaluate sperm motility and microbial conce...
Experimental Rhodococcus equi and equine infectious anemia virus DNA vaccination in adult and neonatal horses: effect of IL-12, dose, and route.
Vaccine    August 15, 2007   Volume 25, Issue 43 7582-7597 doi: 10.1016/j.vaccine.2007.07.055
Mealey RH, Stone DM, Hines MT, Alperin DC, Littke MH, Leib SR, Leach SE, Hines SA.Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine pathogens that also serve as important large animal models of neonatal immunity and lentiviral immune control. Neonates present a unique challenge for immunization due to their diminished immunologic capabilities and apparent Th2 bias. In an effort to augment R. equi- and EIAV-specific Th1 responses induced by DNA vaccination, we hypothesized that a du...
Transport of equine ovaries for assisted reproduction.
Animal reproduction science    August 15, 2007   Volume 108, Issue 1-2 171-179 doi: 10.1016/j.anireprosci.2007.08.001
Ribeiro BI, Love LB, Choi YH, Hinrichs K.Use of assisted reproduction to obtain foals from valuable mares post-mortem typically necessitates holding of ovaries during shipment to a laboratory. The present study evaluated whether holding ovaries briefly at a warm ( approximately 30 degrees C) temperature improves meiotic and developmental competence of oocytes, as determined after maturation in vitro and intracytoplasmic sperm injection. Ovaries were packaged in pairs in insulated containers, and held either at 24 or 25-35 degrees C for 4h, followed by cooling. Ovaries in both treatments were held for either a short (mean, 7-7.4h) or ...
Multilineage differentiation potential of equine blood-derived fibroblast-like cells.
Differentiation; research in biological diversity    August 14, 2007   Volume 76, Issue 2 118-129 doi: 10.1111/j.1432-0436.2007.00207.x
Giovannini S, Brehm W, Mainil-Varlet P, Nesic D.Tissue engineering (TE) has emerged as a promising new therapy for the treatment of damaged tissues and organs. Adult stem cells are considered as an attractive candidate cell type for cell-based TE. Mesenchymal stem cells (MSC) have been isolated from a variety of tissues and tested for differentiation into different cell lineages. While clinical trials still await the use of human MSC, horse tendon injuries are already being treated with autologous bone marrow-derived MSC. Given that the bone marrow is not an optimal source for MSC due to the painful and risk-containing sampling procedure, i...
Detection and semi-quantification of Strongylus vulgaris DNA in equine faeces by real-time quantitative PCR.
International journal for parasitology    August 14, 2007   Volume 38, Issue 3-4 443-453 doi: 10.1016/j.ijpara.2007.07.014
Nielsen MK, Peterson DS, Monrad J, Thamsborg SM, Olsen SN, Kaplan RM.Strongylus vulgaris is an important strongyle nematode with high pathogenic potential infecting horses world-wide. Several decades of intensive anthelmintic use has virtually eliminated clinical disease caused by S. vulgaris, but has also caused high levels of anthelmintic resistance in equine small strongyle (cyathostomin) nematodes. Recommendations aimed at limiting the development of anthelmintic resistance by reducing treatment intensity raises a simultaneous demand for reliable and accurate diagnostic tools for detecting important parasitic pathogens. Presently, the only means available t...