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Topic:Veterinary Medicine

Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications.
Journal of the American Veterinary Medical Association    August 9, 2003   Volume 223, Issue 3 336-339 doi: 10.2460/javma.2003.223.336
Orsini JA, Haddock M, Stine L, Sullivan EK, Rabuffo TS, Smith G.To determine the odds of moderate or severe gastric ulceration in racehorses treated with various antiulcer medications. Methods: Unmatched case-control study. Methods: 798 horses in active race training (252 Thoroughbreds and 546 Standardbreds). Only horses that had been receiving a single antiulcer medication or no antiulcer medication for at least 2 weeks prior to examination were included. Methods: Gastroscopy was performed on each horse by a single individual who was not aware of the horses' antiulcer treatments, and severity of gastric ulceration was scored. Signalment and medication his...
Thyroid function in mature horses ingesting endophyte-infected fescue seed.
Journal of the American Veterinary Medical Association    August 9, 2003   Volume 223, Issue 3 340-345 doi: 10.2460/javma.2003.223.340
Breuhaus BA.To determine whether ingestion of fescue seed infected with the endophyte Neotyphodium coenophialum would alter thyroid function in adult horses. Methods: Original study. Methods: 4 adult mares that were not pregnant and 6 adult geldings. Methods: Thyrotropin releasing hormone stimulation tests were performed while horses received a standard diet and after infected seed (2.3 kg/d [5 lb/d]) had been fed for 1 and 2 months. Serum prolactin concentrations were measured to verify endophyte absorption. Results: Serum prolactin concentrations indicated that at least 8 of 10 horses absorbed the endop...
Architectural properties of distal forelimb muscles in horses, Equus caballus.
Journal of morphology    August 9, 2003   Volume 258, Issue 1 106-114 doi: 10.1002/jmor.10113
Brown NA, Kawcak CE, McIlwraith CW, Pandy MG.Articular injuries in athletic horses are associated with large forces from ground impact and from muscular contraction. To accurately and noninvasively predict muscle and joint contact forces, a detailed model of musculoskeletal geometry and muscle architecture is required. Moreover, muscle architectural data can increase our understanding of the relationship between muscle structure and function in the equine distal forelimb. Muscle architectural data were collected from seven limbs obtained from five thoroughbred and thoroughbred-cross horses. Muscle belly rest length, tendon rest length, m...
Pregnancy: a cloned horse born to its dam twin.
Nature    August 9, 2003   Volume 424, Issue 6949 635 doi: 10.1038/424635a
Galli C, Lagutina I, Crotti G, Colleoni S, Turini P, Ponderato N, Duchi R, Lazzari G.Several animal species, including sheep, mice, cattle, goats, rabbits, cats, pigs and, more recently, mules have been reproduced by somatic cell cloning, with the offspring being a genetic copy of the animal donor of the nuclear material used for transfer into an enucleated oocyte. Here we use this technology to clone an adult horse and show that it is possible to establish a viable, full-term pregnancy in which the surrogate mother is also the nuclear donor. The cloned offspring is therefore genetically identical to the mare who carried it, challenging the idea that maternal immunological rec...
Presentation and binding affinity of equine infectious anemia virus CTL envelope and matrix protein epitopes by an expressed equine classical MHC class I molecule.
Journal of immunology (Baltimore, Md. : 1950)    August 7, 2003   Volume 171, Issue 4 1984-1993 doi: 10.4049/jimmunol.171.4.1984
McGuire TC, Leib SR, Mealey RH, Fraser DG, Prieur DJ.Control of a naturally occurring lentivirus, equine infectious anemia virus (EIAV), occurs in most infected horses and involves MHC class I-restricted, virus-specific CTL. Two minimal 12-aa epitopes, Env-RW12 and Gag-GW12, were evaluated for presentation by target cells from horses with an equine lymphocyte Ag-A1 (ELA-A1) haplotype. Fifteen of 15 presented Env-RW12 to CTL, whereas 11 of 15 presented Gag-GW12. To determine whether these epitopes were presented by different molecules, MHC class I genes were identified in cDNA clones from Arabian horse A2152, which presented both epitopes. This h...
Effects of in vitro production on horse embryo morphology, cytoskeletal characteristics, and blastocyst capsule formation.
Biology of reproduction    August 6, 2003   Volume 69, Issue 6 1895-1906 doi: 10.1095/biolreprod.103.018515
Tremoleda JL, Stout TA, Lagutina I, Lazzari G, Bevers MM, Colenbrander B, Galli C.Blastocyst formation rates during horse embryo in vitro production (IVP) are disappointing, and embryos that blastulate in culture fail to produce the characteristic and vital glycoprotein capsule. The aim of this study was to evaluate the impact of IVP on horse embryo development and capsule formation. IVP embryos were produced by intracytoplasmic sperm injection of in vitro matured oocytes and either culture in synthetic oviduct fluid (SOF) or temporary transfer to the oviduct of a ewe. Control embryos were flushed from the uterus of mares 6-9 days after ovulation. Embryo morphology was eval...
Evidence for a new field Culicoides vector of African horse sickness in South Africa.
Preventive veterinary medicine    August 6, 2003   Volume 60, Issue 3 243-253 doi: 10.1016/s0167-5877(02)00231-3
Meiswinkel R, Paweska JT.Between February and May 1998, approximately 100 horses died of African horse sickness (AHS) in the cooler, mountainous, central region of South Africa. On 14 affected farms, 156,875 Culicoides of 27 species were captured. C. imicola Kieffer, hitherto considered the only field vector for AHS virus (AHSV), constituted <1% of the total Culicoides captured, and was not found on 29% of the farms. In contrast, 65% of the Culicoides were C. bolitinos Meiswinkel, and was found on all farms. Five isolations of AHSV were made from C. bolitinos, and none from 18 other species of Culicoides (including C....
A case control study of factors and infections associated with clinically apparent respiratory disease in UK Thoroughbred racehorses.
Preventive veterinary medicine    August 6, 2003   Volume 60, Issue 1 107-132 doi: 10.1016/s0167-5877(03)00085-0
Newton JR, Wood JL, Chanter N.A matched case control study was used to determine infections and other factors associated with clinically apparent respiratory disease in young racehorses in training in the UK. A total of 170 cases, defined as horses with sudden onset coughing, nasal discharge or pyrexia, were identified and matched to 632 non-affected controls by trainer and time period. Factors examined included age, sex, time since entry into the training yard, time since last race and different infections including tracheal and nasopharyngeal (NP) bacteria and viruses. Multivariable conditional logistic regression (CLR) ...
Embryogenesis and the first-stage larva of Thelazia lacrymalis.
Journal of helminthology    August 5, 2003   Volume 77, Issue 3 227-233 doi: 10.1079/JOH2003167
Dongus H, Beelitz P, Schöl H.The female reproductive system of Thelazia lacrymalis (Nematoda: Thelaziidae) was investigated by light and scanning electron microscopy (SEM) with regard to the developmental stages and the stage deposited by the gravid nematode. Female T. lacrymalis have a didelphic and opisthodelphic type of reproductive system with paired ovaries, oviducts and uteri and a single vagina and vulva. Round and spindle-shaped primary oocytes are documented within the ovaries and oviducts, respectively. The distal part of each uterus provides a fertilization chamber filled with spermatozoa, followed by a sphinct...
[Gutteral pouch tympany in German warmblood foals: influence of sex, inbreeding and blood proportions of founding breeds as well as estimation of heritability].
Berliner und Munchener tierarztliche Wochenschrift    August 5, 2003   Volume 116, Issue 7-8 346-351 
Blazyczek I, Hamann H, Ohnesorge B, Deegen E, Distl O.The objective of the present study was to analyse the importance of the influences of sex, inbreeding coefficient, proportion of genes of the original breeds and the additive genetic contribution to the occurrence of guttural pouch tympany in foals belonging to German Warmblood breeds. Foals affected by guttural pouch tympany were ascertained in the Clinic of Horses, School of Veterinary Medicine Hannover. This data set comprised 22 German Warmblood foals with guttural pouch tympany, which were patients of the Clinic for Horses between 1994 and 2001. Information on the pedigrees and all availa...
Muscarinic receptor subtypes mediate vasorelaxation in isolated horse deep dorsal penile vein.
Urology    August 2, 2003   Volume 62, Issue 2 357-361 doi: 10.1016/s0090-4295(03)00253-x
Martínez AC, Hernández M, Rivera L, Recio P, García-Sacristán A, Benedito S.To investigate the effect of acetylcholine (ACh) on horse deep dorsal penile vein and to characterize the muscarinic receptor subtypes involved in this response. Methods: Vein rings were mounted in an organ bath chamber, and the isometric tension was recorded. Results: In phenylephrine-contracted veins, ACh (1 nM to 1 microM) induced endothelium-dependent relaxation. The muscarinic receptor antagonist, atropine, produced parallel rightward shifts of the ACh response curves (pA2 = 10.04; pK(B) = 9.98). Carbachol (10 nM to 100 microM) also evoked relaxation in the vein segments, but showed a low...
Parachute left atrioventricular valve causing stenosis and regurgitation in a Thoroughbred foal.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 579-582 doi: 10.1111/j.1939-1676.2003.tb02482.x
McGurrin MK, Physick-Sheard PW, Southorn E.No abstract available
Suppurative cholangiohepatitis and enteritis in adult horses.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 583-587 
Davis JL, Jones SL.No abstract available
Trace element, toxin and drug elimination in hair with particular reference to the horse.
Research in veterinary science    August 2, 2003   Volume 75, Issue 2 89-101 doi: 10.1016/s0034-5288(03)00074-2
Dunnett M, Lees P.No abstract available
Cardiac troponin I in pastured and race-training Thoroughbred horses.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 597-599 doi: 10.1111/j.1939-1676.2003.tb02486.x
Phillips W, Giguère S, Franklin RP, Hernandez J, Adin D, Peloso JG.Cardiac troponin I (cTnI), a myocardial polypeptide, is a highly sensitive and specific biomarker of myocardial injury in people and dogs. The structure of cTnI is highly conserved across species, and equine myocardium has high reactivity with human immunoassays. The purpose of this study was to describe cTnI concentrations in normal pastured and race-training Thoroughbred horses. Ten horses on pasture and 10 horses in race training were studied. Horses were considered normal on the basis of physical examination, training performance, electrocardiography (ECG), and echocardiography. Serum cTnI...
Accuracy of pulse oximetry and capnography in healthy and compromised horses during spontaneous and controlled ventilation. Koenig J, McDonell W, Valverde A.The objective of this prospective clinical study was to evaluate the accuracy of pulse oximetry and capnography in healthy and compromised horses during general anesthesia with spontaneous and controlled ventilation. Horses anesthetized in a dorsal recumbency position for arthroscopy (n = 20) or colic surgery (n = 16) were instrumented with an earlobe probe from the pulse oximeter positioned on the tip of the tongue and a sample line inserted at the Y-piece for capnography. The horses were allowed to breathe spontaneously (SV) for the first 20 min after induction, and thereafter ventilation wa...
Biochemical characterisation of navicular hyaline cartilage, navicular fibrocartilage and the deep digital flexor tendon in horses with navicular disease.
Research in veterinary science    August 2, 2003   Volume 75, Issue 2 113-120 doi: 10.1016/s0034-5288(03)00072-9
Viitanen M, Bird J, Smith R, Tulamo RM, May SA.The study hypothesis was that navicular disease is a process analogous to degenerative joint disease, which leads to changes in navicular fibrocartilage and in deep digital flexor tendon (DDFT) matrix composition and that the process extends to the adjacent distal interphalangeal joint. The objectives were to compare the biochemical composition of the navicular articular and palmar cartilages from 18 horses with navicular disease with 49 horses with no history of front limb lameness, and to compare navicular fibrocartilage with medial meniscus of the stifle and collateral cartilage of the hoof...
Serologic evidence of West Nile virus infection in horses, Yucatan State, Mexico.
Emerging infectious diseases    August 2, 2003   Volume 9, Issue 7 857-859 doi: 10.3201/eid0907.030167
Loroño-Pino MA, Blitvich BJ, Farfán-Ale JA, Puerto FI, Blanco JM, Marlenee NL, Rosado-Paredes EP, García-Rejón JE, Gubler DJ, Calisher CH....Serum samples were obtained from 252 horses in the State of Yucatan, Mexico, from July to October 2002. Antibodies to West Nile virus were detected by epitope-blocking enzyme-linked immunosorbent assays in three (1.2%) horses and confirmed by plaque reduction neutralization test. We report the first West Nile virus activity in the State of Yucatan.
Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada.
The Canadian veterinary journal = La revue veterinaire canadienne    August 2, 2003   Volume 44, Issue 7 581-585 
Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G.The efficacy of a paste formulation of the H+, K+, -ATPase inhibitor omeprazole was evaluated in standardbred racehorses for the treatment and prevention of gastric ulcers. Twenty standardbred racehorses in training, aged 2 to 9 years, were enrolled from 2 training centres in this field trial. Endoscopic examinations confirmed the presence of gastric ulcers in all horses, prior to allocation and treatment and on day 0. Lesions were scored on a scale of 0 to 3 (intact epithelium to extensive ulceration). Replicates were formed, based on training level and location. Within replicates, 1 horse wa...
Cardiac amyloidosis in a horse.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 588-592 
Nout YS, Hinchcliff KW, Bonagura JD, Meurs KM, Papenfuss TL.No abstract available
Effects of topical perineural capsaicin in a reversible model of equine foot lameness.
Journal of veterinary internal medicine    August 2, 2003   Volume 17, Issue 4 563-566 doi: 10.1111/j.1939-1676.2003.tb02479.x
Seino KK, Foreman JH, Greene SA, Goetz TE, Benson GJ.Capsaicin is a local substance P depleter with dramatic analgesic effects. We tested the hypothesis that the topical application of capsaicin ointment over the palmar digital nerves would attenuate the clinical effects of a reversible model of equine foot lameness. Seven healthy adult horses shod unilaterally with adjustable heart bar shoes were studied in a crossover design for 2 weeks. Grade 5.0/5.0 lameness (nonweight bearing) was induced by tightening the adjustable heart bar shoe. One hour later, capsaicin ointment was applied over the medial and lateral palmar digital nerves 3 cm proxima...
Serologic evidence of West Nile virus infection in horses, Coahuila State, Mexico.
Emerging infectious diseases    August 2, 2003   Volume 9, Issue 7 853-856 doi: 10.3201/eid0907.030166
Blitvich BJ, Fernandez-Salas I, Contreras-Cordero JF, Marlenee NL, Gonzalez-Rojas JI, Komar N, Gubler DJ, Calisher CH, Beaty BJ.Serum samples were obtained from 24 horses in the State of Coahuila, Mexico, in December 2002. Antibodies to West Nile virus were detected by epitope-blocking enzyme-linked immunosorbent assay and confirmed by plaque reduction neutralization test in 15 (62.5%) horses. We report the first West Nile virus activity in northern Mexico.
Ovarian hematoma in an 11-year-old Thoroughbred-Hanovarian mare.
The Canadian veterinary journal = La revue veterinaire canadienne    August 2, 2003   Volume 44, Issue 7 589-591 
Curtin DJ.An aggressive mare, presented for prebreeding examination, was found to have a significantly enlarged ovary (soccer ball size). A granulosa thecal cell tumor was initially suspected. Following laboratory and repeated clinical examination, the mare was diagnosed with an ovarian hematoma, which regressed with treatment.
Clinical efficacy of trimethoprim/sulfadiazine and procaine penicillin G in a Streptococcus equi subsp. zooepidemicus infection model in ponies.
Journal of veterinary pharmacology and therapeutics    July 31, 2003   Volume 26, Issue 4 247-252 doi: 10.1046/j.1365-2885.2003.00483.x
Ensink JM, Smit JA, van Duijkeren E.Tissue chambers, implanted subcutaneously on both sides of the neck in eight ponies, were inoculated with Streptococcus equi subsp. zooepidemicus in order to compare the clinical efficacy of trimethoprim/sulfadiazine (TMP/SDZ) and penicillin G treatment in a purulent infection. The TMP/SDZ treatment consisted of one intravenous (i.v.) injection of 5 mg/kg TMP and 25 mg/kg SDZ and the same dose of TMP/SDZ per os (p.o.), both given 20 h after inoculation. The oral dose was then repeated every 12 h for 21 days. The penicillin treatment consisted of one i.v. injection of 20 000 IU/kg sodium penici...
Effect of alkalinization on the local analgesic efficacy of ketamine in the abaxial sesamoid nerve block in horses.
Journal of veterinary pharmacology and therapeutics    July 31, 2003   Volume 26, Issue 4 265-269 doi: 10.1046/j.1365-2885.2003.00489.x
López-Sanromán J, Cruz J, Santos M, Mazzini R, Tabanera A, Tendillo FJ.The objective of this study was to determine the effects of the alkalinization on the local analgesic efficacy of 1% ketamine in the abaxial sesamoid nerve block in horses. Thirty-six mature healthy horses were randomly assigned to four groups for the following treatments; an abaxial sesamoid block with 5 mL of saline solution (control saline); an abaxial sesamoid block with 5 mL of a solution containing 1% ketamine (KETs 1%); an abaxial sesamoid block with 5 mL of a solution containing saline solution and 0.5 mEq of sodium bicarbonate (control bicarbonate); and an abaxial sesamoid block with ...
Plasma profiles of ivermectin in horses following oral or intramuscular administration.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    July 31, 2003   Volume 50, Issue 6 297-302 doi: 10.1046/j.1439-0442.2003.00531.x
Pérez R, Godoy C, Palma C, Cabezas I, Muñoz L, Rubilar L, Arboix M, Alvinerie M.A study was undertaken in order to evaluate and compare ivermectin's (IVM) plasma disposition kinetic parameters after oral or intramuscular (IM) administration in horses. Ten clinically healthy adult horses, weighing 380-496 kg body weight (BW), were allocated to two experimental groups of five horses. Group I, was treated with an oral paste formulation of IVM at the manufacturer's recommended dose of 0.2 mg/kg BW. Group II, was treated IM with an injectable 1% formulation of IVM at a dose of 0.2 mg/kg BW. Blood samples were collected by jugular puncture at different times between 0.5 h and 7...
Expression and binding activity of luteinizing hormone/chorionic gonadotropin receptors in the primary corpus luteum during early pregnancy in the mare.
Biology of reproduction    July 30, 2003   Volume 69, Issue 5 1743-1749 doi: 10.1095/biolreprod.103.018812
Saint-Dizier M, Chopineau M, Dupont J, Daels PF, Combarnous Y.Luteal steroids are necessary to maintain the first 70-90 days of pregnancy in the mare. At 35 days postovulation, the resurgence of the primary corpus luteum (CL) coincides with the secretion of the fetal hormone eCG. In order to study the responsiveness of the primary CL to eCG, we have examined levels of luteal equine LH/CG receptors (eLH/CG-R) mRNAs by Northern blot analysis and measured concentrations of eLH/CG binding sites on luteal membranes using 125I-eLH saturation binding assays at three stages of gestation: before the onset of eCG secretion (Days 14-31), from onset to maximum eCG s...
Analysis of the beta-tubulin codon 200 genotype distribution in a benzimidazole-susceptible and -resistant cyathostome population.
Parasitology    July 30, 2003   Volume 127, Issue Pt 1 53-59 doi: 10.1017/s0031182003003317
Pape M, Posedi J, Failing K, Schnieder T, von Samson-Himmelstjerna G.To study the prevalence of the polymorphism in position 200 of the beta-tubulin gene in the mechanism of benzimidazole (BZ) resistance in cyathostomes of horses, an allele-specific PCR was used to detect the genotype of individuals of BZ-susceptible and BZ-resistant populations. The molecular analysis of 100 adults recovered from an anthelmintic-naïve horse revealed 80% homozygous TTC/TTC individuals, 17% heterozygous TTC/TAC and 3% homozygous TAC/TAC. A naturally infected horse was treated with increasing fenbendazole (FBZ) dosages to select a BZ-resistant population of cyathostomes. The PCR...
The John Hickman Memorial Lecture: colic by numbers.
Equine veterinary journal    July 26, 2003   Volume 35, Issue 4 343-349 doi: 10.2746/042516403776014244
Cohen ND.No abstract available
Long-term survey of laryngoplasty and ventriculocordectomy in an older, mixed-breed population of 200 horses. Part 1: Maintenance of surgical arytenoid abduction and complications of surgery.
Equine veterinary journal    July 26, 2003   Volume 35, Issue 4 389-396 doi: 10.2746/042516403776014172
Dixon RM, McGorum BC, Railton DI, Hawe C, Tremaine WH, Dacre K, McCann J.Laryngoplasty (LP) is currently the most common surgical treatment for equine laryngeal paralysis, however, there have been no reports quantifying the degree of retention of arytenoid abduction following LP. Additionally, the complications of LP have been poorly documented. Objective: To record the degree of arytenoid abduction retention following LP and to accurately document all complications of surgery. Methods: A study (1986-1998) of 200 horses of mixed breed and workload, median age 6 years (prospective 136 cases and retrospective 64 cases) undergoing LP (using 2 stainless steel wires) an...