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Home / Equine Research Bank / Front Vet Sci / Equine Asthma: Current Understanding and Future Directions.
Frontiers in veterinary science2020; 7; 450; doi: 10.3389/fvets.2020.00450

Equine Asthma: Current Understanding and Future Directions.

Abstract: The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the latest information on Equine Asthma and provide future research directions. Current clinical and molecular asthma phenotypes and endotypes in humans were discussed and compared to asthma phenotypes in horses. The role of infectious and non-infectious causes of equine asthma, genetic factors and proposed disease pathophysiology were reviewed. Diagnostic limitations were evident by the limited number of tests and biomarkers available to field practitioners. The participants emphasized the need for more accessible, standardized diagnostics that would help identify specific phenotypes and endotypes in order to create more targeted treatments or management strategies. One important outcome of the workshop was the creation of the Equine Asthma Group that will facilitate communication between veterinary practice and research communities through published and easily accessible guidelines and foster research collaboration.
Copyright © 2020 Couetil, Cardwell, Leguillette, Mazan, Richard, Bienzle, Bullone, Gerber, Ivester, Lavoie, Martin, Moran, Niedźwiedź, Pusterla and Swiderski.
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Publication Date: 2020-07-30 PubMed ID: 32903600PubMed Central: PMC7438831DOI: 10.3389/fvets.2020.00450Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research summary centres around a workshop held in 2019 where scientists and clinicians converged to discuss recent developments and future prospects in equine asthma research. The discussions covered the features of human and equine asthma, the causes, genetics, and disease pathologies, the existing diagnostic practices and their limitations, as well as the demand for more standardized and precise diagnosis.

Human and Equine Asthma

  • The workshop highlighted how understanding of human asthma can be used in the study of equine asthma. Experts discussed the clinical and molecular asthma phenotypes (observable physical or biochemical traits) and endotypes (specific molecular or pathophysiological mechanisms) in humans, comparing these with those in horses. The aim was to establish a common ground and draw parallels for future research.

Asthma Causes

  • The role of infectious and non-infectious triggers in equine asthma was deliberated. Infectious causes might include pathogens like viruses and bacteria, while non-infectious causes might encompass allergens like dust and mould. Understanding these causes is core to developing preventative measures and treatments.

Equine Asthma Genetics and Pathophysiology

  • Genetic factors that might influence susceptibility to or severity of asthma in horses were discussed. Investigations into the pathophysiology (disease processes) underlying equine asthma were also reviewed, aiding in the holistic understanding of the disorder.

Diagnostic Limitations and Future Directions

  • It was noted that field practitioners face significant restrictions due to the limited number of available tests and biomarkers for diagnosing equine asthma. Therefore, there was a call for more standardized and specific diagnostic tools which can help identify asthma phenotypes and endotypes. Having more accurate diagnoses would allow for more targeted and efficient treatment or management strategies.
  • The workshop proposed the need for development of accessible guidelines in equine asthma diagnosis and treatment, prompting the formation of the Equine Asthma Group. This group facilitates communication between veterinary practice and research communities, and will focus on fostering research collaboration to further the understanding and management of equine asthma.

Cite This Article

APA
Couetil L, Cardwell JM, Leguillette R, Mazan M, Richard E, Bienzle D, Bullone M, Gerber V, Ivester K, Lavoie JP, Martin J, Moran G, Niedźwiedź A, Pusterla N, Swiderski C. (2020). Equine Asthma: Current Understanding and Future Directions. Front Vet Sci, 7, 450. https://doi.org/10.3389/fvets.2020.00450

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 7
Pages: 450
PII: 450

Researcher Affiliations

Couetil, Laurent
  • College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.
Cardwell, Jacqueline M
  • Department of Pathobiology and Population Sciences, Royal Veterinary College, London, United Kingdom.
Leguillette, Renaud
  • College of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Mazan, Melissa
  • Cummings School of Veterinary Medicine, Tufts University, Grafton, MA, United States.
Richard, Eric
  • LABÉO (Frank Duncombe), Normandie Université, UniCaen, Caen, France.
Bienzle, Dorothee
  • Department of Pathobiology, University of Guelph, Guelph, ON, Canada.
Bullone, Michela
  • Department of Veterinary Sciences, University of Turin, Grugliasco, Italy.
Gerber, Vinzenz
  • Vetsuisse Faculty, Institut Suisse de Médecine Équine (ISME), University of Bern and Agroscope, Bern, Switzerland.
Ivester, Kathleen
  • College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.
Lavoie, Jean-Pierre
  • Faculty of Veterinary Medicine, University of Montreal, Montreal, QC, Canada.
Martin, James
  • Meakins Christie Laboratories, McGill University Health Center Research Institute, Montreal, QC, Canada.
Moran, Gabriel
  • Department of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Niedźwiedź, Artur
  • Department of Internal Diseases With Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wrocław, Poland.
Pusterla, Nicola
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Swiderski, Cyprianna
  • College of Veterinary Medicine, Mississippi State University, Starkville, MS, United States.

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