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The Veterinary clinics of North America. Equine practice2014; 30(3); 579-589; doi: 10.1016/j.cveq.2014.08.004

Hendra virus.

Abstract: Hendra virus infection of horses occurred sporadically between 1994 and 2010 as a result of spill-over from the viral reservoir in Australian mainland flying-foxes, and occasional onward transmission to people also followed from exposure to affected horses. An unprecedented number of outbreaks were recorded in 2011 leading to heightened community concern. Release of an inactivated subunit vaccine for horses against Hendra virus represents the first commercially available product that is focused on mitigating the impact of a Biosafety Level 4 pathogen. Through preventing the development of acute Hendra virus disease in horses, vaccine use is also expected to reduce the risk of transmission of infection to people.
Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.
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Publication Date: 2014-09-30 PubMed ID: 25281398PubMed Central: PMC4252762DOI: 10.1016/j.cveq.2014.08.004Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the development and impact of a vaccine to control the spread of Hendra virus from horses to humans. Originated from flying-foxes in Australia, Hendra virus posed a significant risk, leading to an increased number of outbreaks in 2011. However, a recently commercially available vaccine for horses against the virus is not only minimizing its impact but also cutting down human infection risk.

Overview of Hendra Virus and its Impact

  • The Hendra virus was notably affecting horses who picked up the infection from Australian flying-foxes, the virus’s reservoir.
  • These infected horses then occasionally transmitted the virus to people, leading to the occasional outbreaks of the disease in humans during the period from 1994 to 2010.
  • This situation drastically changed in 2011 when an unprecedented number of outbreaks occurred, leading to heightened concerns in the affected communities.

Development and Implementation of the Vaccine

  • In response to growing concerns, an inactivated subunit vaccine for horses against Hendra virus was commercially produced and released.
  • This vaccine claims the landmark of being the first commercial product that aims to mitigate the impact of a Biosafety Level 4 pathogen, the category which includes some of the most dangerous pathogens for humans.

Impact of the Vaccine on Controlling the Spread of Hendra Virus

  • The proactive vaccination of horses is not only intended to prevent the development of acute Hendra virus disease in these animals, but also significantly reduces the risk of transmitting the infection to humans.
  • Theoretically, as more horses get vaccinated, fewer horses would get infected and, thus, the chances of the virus crossing over to humans would decrease.

Cite This Article

APA
Middleton D. (2014). Hendra virus. Vet Clin North Am Equine Pract, 30(3), 579-589. https://doi.org/10.1016/j.cveq.2014.08.004

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 30
Issue: 3
Pages: 579-589

Researcher Affiliations

Middleton, Deborah
  • Australian Animal Health Laboratory, CSIRO, PB 24, Geelong, Victoria 3220, Australia. Electronic address: Deborah.middleton@csiro.au.

MeSH Terms

  • Animals
  • Australia / epidemiology
  • Chiroptera / virology
  • Hendra Virus / isolation & purification
  • Henipavirus Infections / epidemiology
  • Henipavirus Infections / veterinary
  • Henipavirus Infections / virology
  • Horse Diseases / epidemiology
  • Horse Diseases / virology
  • Horses
  • Humans
  • Zoonoses / epidemiology
  • Zoonoses / virology

Grant Funding

  • U01 AI077995 / NIAID NIH HHS
  • U01-A107795 / PHS HHS

Conflict of Interest Statement

Conflict of interest: Dr Middleton: Nil

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