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Topic:Aorta

The aorta is the main artery in horses, responsible for transporting oxygenated blood from the left ventricle of the heart to the rest of the body. It is a large, elastic blood vessel that withstands high pressure and plays a vital role in the circulatory system. The structure and function of the equine aorta can be affected by various conditions, including aneurysms, rupture, and degenerative changes, which may impact a horse's health and performance. This page compiles peer-reviewed research studies and scholarly articles that explore the anatomy, physiology, pathologies, and clinical implications of aortic health in horses.
Aortic-iliac thrombosis in horses.
Compendium (Yardley, PA)    May 1, 2011   Volume 33, Issue 5 E1-E3 
Swanson TD.No abstract available
[Acute coronary syndrome due to abnormal fibrous tissue growth after Aubert-Imai modification for transposition of the great arteries].
Kyobu geka. The Japanese journal of thoracic surgery    March 11, 2011   Volume 64, Issue 2 109-113 
Maekawa Y, Sakamoto T, Umezu K, Ohashi N, Harada Y, Yasukochi S, Takigiku K, Takei K, Nakano Y, Inoue N, Otagiri T, Hashida Y.We report a female infant with acute coronary syndrome after Aubert-Imai modification for transposition of the great arteries. Two months postoperatively, she visited the emergency room because of perspiration and tachypnea. She was diagnosed with acute coronary syndrome by blood chemistry examination. Cardiac catheterization revealed Aubert route stenosis, and emergency operation was performed. The lumen around the aortopulmonary window was almost totally occluded by fibrous tissue extending from the equine pericardial patch. This fibrous tissue was completely resected and the aortopulmonary ...
Vulnerability of an equine pericardial roll graft to Gram-positive cocci after graft replacement for a ruptured infected abdominal aorta.
Interactive cardiovascular and thoracic surgery    February 8, 2011   Volume 12, Issue 5 866-868 doi: 10.1510/icvts.2010.262667
Yamamoto H, Yamamoto F, Tanaka F, Nishikawa Y.We describe the influence of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia on histopathological alteration of a glutaraldehyde-fixed equine pericardial roll (EPR) graft in a 77-year-old male who underwent in-situ EPR replacement of a ruptured infected abdominal aorta with concomitant repair of the perforated duodenum. The patient died of circulatory failure after septic shock due to MRSA infection and gastrointestinal bleeding on postoperative day (POD) 23. The autopsy revealed no perforation of the EPR graft or anastomotic disruption between the native abdominal aorta and EPR ...
What is your diagnosis? Ruptured right aortic sinus (sinus of Valsalva) aneurysm, valvular endocarditis, and cardiac volume overload with early failure.
Journal of the American Veterinary Medical Association    December 16, 2010   Volume 237, Issue 12 1371-1372 doi: 10.2460/javma.237.12.1371
Norman TE, Achen SE, Coleman MC, Schroeder JD.No abstract available
Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17{beta}-estradiol.
Hypertension (Dallas, Tex. : 1979)    July 6, 2010   Volume 56, Issue 3 405-411 doi: 10.1161/HYPERTENSIONAHA.110.151969
Novensa L, Selent J, Pastor M, Sandberg K, Heras M, Dantas AP.Conjugated equine estrogen therapy is the most common hormone replacement strategy used to treat postmenopausal women. However, the ability of an individual conjugated equine estrogen to modulate NO production and, therefore, to induce cardiovascular protection is largely unknown. The effects of equine and naturally occurring estrogens on NO generation were evaluated in human aortic endothelial cells by measuring in vivo NO production, as well as NO synthase (eNOS) activity and expression. The transcriptional activity on the eNOS gene was determined by the ability of estrogen receptors (alpha ...
Percutaneous transcatheter closure of an aorto-cardiac fistula in a Thoroughbred stallion using an Amplatzer occluder device.
Journal of veterinary internal medicine    May 11, 2010   Volume 24, Issue 4 994-998 doi: 10.1111/j.1939-1676.2010.0523.x
Javsicas LH, Giguère S, Maisenbacher HW, Schmidt M, Frederick JD, Conway JA, Estrada AH.No abstract available
Surgical thrombectomy in horses with aortoiliac thrombosis: 17 cases.
Equine veterinary journal    January 26, 2010   Volume 41, Issue 8 754-758 doi: 10.2746/042516409x422939
Rijkenhuizen AB, Sinclair D, Jahn W.Aortoiliac thrombosis (AIT) is a progressive vascular disease characterised by an exercise-induced hindlimb lameness. After developing a surgical technique, a follow-up study was required. Objective: To assess the surgical results of a surgical thrombectomy in horses with AIT, a chronic arterial occlusive disease of the aorta and its caudal arteries. Methods: Seventeen cases showed the typical signs of AIT and diagnosis was confirmed by Doppler-ultrasonography. Average age of the horses was 12 years. Seven stallions, 6 mares and 4 geldings were included. Results: The thrombus was located in th...
Two-dimensional- and M-mode echocardiographic measurements and indices of cardiac function in Spanish colts and fillies of different age.
The Journal of veterinary medical science    August 5, 2009   Volume 71, Issue 7 957-964 doi: 10.1292/jvms.71.957
Rovira S, Muñoz A.Echocardiographic values need to be established for each age and breed to be applied to equine medicine. The present research aims to describe echocardiographic measurements in Spanish fillies and colts of different age, to compare these values with those previously described for other equine breeds and to determine whether there is an influence of gender on echocardiographic measurements. Seventy unsedated and healthy Spanish foals of both sexes (39 females and 31 males) were divided into five age groups: A (22-60 days; n=15), B (61-90 days; n=13), C (91-180 days; n=18), D (181-270 days; n=12...
Double-outlet right ventricle in a 10-month-old Friesian filly.
Australian veterinary journal    April 23, 2009   Volume 87, Issue 5 204-209 doi: 10.1111/j.1751-0813.2009.00424.x
Fennell L, Church S, Tyrell D, Forbes G, Charles J, McCowan C, Savage C.A 10-month-old Friesian filly had a presentation that was consistent with chronic left- and right-sided congestive heart failure. Clinical pathology findings included abnormal haematological and biochemical variables, abnormal blood gas values and increased serum concentration of cardiac troponin I. Echocardiography revealed cardiac chamber dilation and dextropositioning of the aorta. Radiography revealed a generally enlarged heart and pulmonary interstitial infiltration. These findings were supported at necropsy and the diagnosis of double-outlet right ventricle was confirmed. The pathologica...
[Aorto-iliac thrombosis in a gelding: treatment with the anticoagulant Phenprocoumon (Marcoumar)].
Schweizer Archiv fur Tierheilkunde    November 27, 2008   Volume 150, Issue 12 613-618 doi: 10.1024/0036-7281.150.12.613
Trachsel D, Cohausz O, Scharf G, Wehrli Eser M.A 14-year old Swiss warmblood gelding was presented to the equine hospital of the University of Zurich because of therapy-resistant fever. An intermittent lameness suggested the presence of an intravascular aorto-iliac thrombus which was confirmed sonographically. Subsequently, treatment was initiated with Heparin s.c. and continued for 7 months with Phenprocoumon (Marcoumar). The dosage was monitored and adjusted according to the prothrombin time, which was initially measured every week, and later maximally biweekly. The lameness improved and the regression of the thrombus could be followed s...
Idiopathic arterial medial calcification of the thoracic arteries in an adult horse. Fales-Williams A, Sponseller B, Flaherty H.A 6-year-old, gelded, Paint horse displayed clinical signs of muscle wasting and limb stiffness for a 6-month period. The horse's clinical signs abated with corticosteroid therapy, but returned upon cessation of treatment. Upon necropsy, severe lesions of aortic thickening and aortic valve rigidity were observed. Histologically, the tunica media of the aorta, coronary arteries, and pulmonary arteries were expanded by foci of elastin fiber calcification and extracellular matrix with lacunae formation. The vascular lesions are comparative to what has been described as medial arterial calcificati...
Effects of sedation with acepromazine on echocardiographic measurements in eight healthy thoroughbred horses.
The Veterinary record    July 8, 2008   Volume 163, Issue 1 21-25 doi: 10.1136/vr.163.1.21
Menzies-Gow NJ.Eight normal thoroughbred horses were examined by echocardiography before and 10 minutes after they had been sedated by the intravenous administration of 0.03 mg/kg acepromazine. There were significant (P<0.025) increases in the diameters of the pulmonary artery and the aorta, measured at end-systole, and in the thickness of the interventricular septum, measured at end-systole and end-diastole. In addition, there was a significant (P<0.001) decrease in the diameter of the left atrium measured at end-diastole. The remaining cardiac dimensions, all the indices of cardiac function, and the ...
Mycotic aneurysm in the aortic arch of a horse associated with invasive aspergillosis.
The Veterinary record    February 27, 2007   Volume 160, Issue 8 268-270 doi: 10.1136/vr.160.8.268
Okamoto M, Kamitani M, Tunoda N, Tagami M, Nagamine N, Kawata K, Itoh H, Kawasako K, Komine M, Akihara Y, Shimoyama Y, Miyasho T, Hirayama K....No abstract available
Percutaneous aortic valve implantation retrograde from the femoral artery.
Circulation    February 6, 2006   Volume 113, Issue 6 842-850 doi: 10.1161/CIRCULATIONAHA.105.582882
Webb JG, Chandavimol M, Thompson CR, Ricci DR, Carere RG, Munt BI, Buller CE, Pasupati S, Lichtenstein S.Percutaneous aortic valve implantation by an antegrade transvenous approach has been described but is problematic. Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported. Results: The valve prosthesis is constructed from a stainless steel stent with an attached trileaflet equine pericardial valve and a fabric cuff. After routine aortic balloon valvuloplasty, a 22F or 24F sheath is advanced from the femoral artery to the a...
Echocardiographic evidence of an aortico-pulmonary septal defect in a 4-day-old thoroughbred foal. Valdes-Martinez A, Eades SC, Strickland KN, Roberts ED.We describe the echocardiographic findings in a 4-day-old thoroughbred foal with an aortico-pulmonary septal defect. The foal had labored breathing, cyanotic mucous membranes and a continuous grade 5/6 heart murmur with point of maximal intensity over the base of the heart on the right side. Echocardiographically, there was a large communication between the aorta and the pulmonary artery just dorsal to the base of the heart. The cardiac anomaly seen during the echocardiographic exam was confirmed at necropsy where a large communication between the two great vessels was observed. These findings...
An unlucky horseshoe: blunt aortic rupture after horse kick.
The Journal of trauma    December 20, 2005   Volume 59, Issue 3 616-618 
Sarin EL, Moore JB, Moore EE, Sheppard FR.The majority of blunt aortic injuries (BAIs) are related to "rapid deceleration"mechanisms with motor vehicle crashes (MVCs) and falls accounting for the majority of these injuries. However, in recent years improved understanding of the mechanisms behind blunt aortic injury has led to an expansion of the "usual suspects" when evaluating blunt thoracic injury. Compression of the thoracic cage has proven to have a significant potential for blunt aortic injury, even in instances without "high-speed" mechanisms commonly sought when explaining the history for BAI risk factors. In this we report, ...
Early clinical experience with a new tubular equine pericardial stentless aortic valve.
The heart surgery forum    April 1, 2005   Volume 7, Issue 5 E498-E502 doi: 10.1532/HSF98.20041087
Eckstein FS, Tevaearai H, Keller D, Schmidli J, Immer FF, Seiler C, Saner H, Carrel TP.This study details a single-center experience with the 3F Therapeutics stentless aortic bioprosthesis(investigational device) and is part of a prospective,nonrandomized worldwide multicenter study. We assessed the implantation procedure and the valve's efficacy in terms of early mortality and morbidity and early echocardiographic valve performance. Methods: Between June 2001 and March 2004, 24 patients (14 men/10 women) underwent aortic valve replacement(AVR) with a 3F valve. Mean age was 72 +/- 13 years(range, 31-88 years). Combined revascularization was performed in 12 patients; 1 patient re...
Unusual vascular ring anomaly in a foal.
The Canadian veterinary journal = La revue veterinaire canadienne    January 14, 2005   Volume 45, Issue 12 1016-1018 
Smith TR.A 2.5-month-old filly was presented with signs of esophageal obstruction. The filly was euthanized and postmortem examination revealed a vascular ring anomaly. The vascular ring anomaly was not caused by a persistent right aortic arch, which is the only vascular ring anomaly reported to occur in horses. Une pouliche de 2 1/2 mois a été présentée avec des signes d’obstruction œsophagienne. Après euthanasie, l’examen a révélé une malformation vasculaire annulaire. L’anomalie vasculaire annulaire n’était pas due à la persistance de l’arc aortique droit, seule malformation va...
Diagnosis of aorto-iliac thrombosis in a quarter horse foal using Doppler ultrasound and nuclear scintigraphy.
Journal of veterinary internal medicine    November 2, 2004   Volume 18, Issue 5 753-756 doi: 10.1892/0891-6640(2004)18<753:doatia>2.0.co;2
Duggan VE, Holbrook TC, Dechant JE, Blaik MA, Ritchey JW.No abstract available
[Case report: aortic valve endocarditis in a horse].
DTW. Deutsche tierarztliche Wochenschrift    October 27, 2004   Volume 111, Issue 9 370-373 
Fröhlich W, Wlaschitz S, Riedelberger K, Reifinger M.A case of endocarditis of the aortic valve in a 11 year old thoroughbred is presented. Diagnostic approach, the value of echocardiography, and the various symptoms, complications and prognosis are discussed. The horse with ruptured aortic valves due to endocarditis with severe aortic and mitral regurgitation causing congestive heart failure, was euthanised due to bad prognosis.
In-vitro contraction of the equine aortic valve.
The Journal of heart valve disease    August 18, 2004   Volume 13, Issue 4 593-599 
Bowen IM, Marr CM, Chester AH, Wheeler-Jones CP, Elliott J.The equine aortic valve is subject to non-inflammatory degenerative changes, associated with aortic valvular regurgitation (AR). This disease shares pathological and epidemiological features with AR in humans, and may serve as a useful model to study in-vitro functional responses associated with aging and disease. The study aim was to determine the contractile properties of the normal equine aortic valve. Methods: The contractile responses of equine aortic valves to angiotensin II, the thromboxane-mimetic U44069, endothelin-1, 5-hydroxytryptamine and the alpha-adrenoceptor agonists medetomidin...
M-mode echocardiographic ratio indices in normal dogs, cats, and horses: a novel quantitative method.
Journal of veterinary internal medicine    October 8, 2003   Volume 17, Issue 5 653-662 doi: 10.1111/j.1939-1676.2003.tb02496.x
Brown DJ, Rush JE, MacGregor J, Ross JN, Brewer B, Rand WM.A novel method for quantitative echocardiographic interpretations is introduced based on the calculation of ratio indices in which each raw M-mode measurement is divided by the aortic root dimension (Ao). "Aorta-based" indices were calculated with the animal's measured aortic root dimension (Ao(m)) as the length standard. Conversely, "weight-based" indices employed an idealized estimate of aortic dimension (Ao(w)) with a weighted least squares linear regression against the cube root of body weight (Ao(w) = kW(1/3)). Use of these indices circumvented undesirable statistical characteristics inhe...
An assessment of the terminology used by diplomates and students to describe the character of equine mitral and aortic valve regurgitant murmurs: correlations with the physical properties of the sounds.
Journal of veterinary internal medicine    May 31, 2003   Volume 17, Issue 3 332-336 doi: 10.1111/j.1939-1676.2003.tb02457.x
Naylor JM, Wolker RE, Pharr JW.Twenty students and 16 diplomates listened to 7 recordings made from 7 horses with either aortic (n = 3) or mitral valve (n = 4) regurgitant murmurs. A total of 30 different terms were used to describe the character of these murmurs. However, only 4 terms were used in a repeatable and consistent manner. Most people described the character of a given mitral or aortic valve murmur with 1 or 2 terms. Diplomates drew from a pool of terms that was about half the size of that used by students--8.1 +/- 2.0 terms for diplomats (mean +/- 1 SD) versus 13.1 +/- 1.8 terms for students (P > .001). Only blo...
Cardiac disease in the geriatric horse.
The Veterinary clinics of North America. Equine practice    January 9, 2003   Volume 18, Issue 3 575-viii doi: 10.1016/s0749-0739(02)00023-8
Sage AM.Almost all equine cardiac diseases may affect the geriatric horse. This article focuses on those cardiac diseases that are most common in the older horse, including degenerative valve disease, aortocardiac fistula, and congestive heart failure. Other cardiac diseases, such as bacterial endocarditis, pericarditis, and arrhythmias, are seen in all age groups of horses and are beyond the scope of this article.
Chronic clenbuterol administration negatively alters cardiac function.
Medicine and science in sports and exercise    April 5, 2002   Volume 34, Issue 4 643-650 doi: 10.1097/00005768-200204000-00013
Sleeper MM, Kearns CF, McKeever KH.Chronic administration of pharmacological levels of beta2-agonists have been shown to have toxic effects on the heart; however, no data exist on cardiac function after chronic clenbuterol administration. The purpose of this study was to examine the effect of therapeutic levels of clenbuterol on cardiac performance. Methods: Twenty unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 microg.kg(-1) twice daily 5 d.wk(-1)) plus exercise (20 min at 50% .VO(2max)) (CLENEX; N = 6), clenbuterol (CLEN; N = 6), exercise (EX; N = 4), and control (CON; N = 4). M-mode and ...
Aortic root disease in four horses.
Journal of the American Veterinary Medical Association    August 24, 2001   Volume 219, Issue 4 491-459 doi: 10.2460/javma.2001.219.491
Sleeper MM, Durando MM, Miller M, Habecker PL, Reef VB.Clinical findings in 4 horses with aortic root disease are described. Three of the horses had aneurysms of the right aortic sinus, and in 2 of the 3, the aneurysm ruptured, creating a fistula between the aorta and right ventricle. One of these horses had had a murmur since birth, and the aortic sinus aneurysm may have been a congenital anomaly. In a second horse, the aneurysm may have been an acquired condition that developed secondary to chronic aortic regurgitation. Another horse had a large subendocardial hematoma associated with dissection of blood from the aorta to the interventricular se...
Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses.
American journal of veterinary research    October 20, 2000   Volume 61, Issue 10 1282-1288 doi: 10.2460/ajvr.2000.61.1282
Raisis AL, Young LE, Blissitt KJ, Walsh K, Meire HB, Taylor PM, Lekeux P.To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. Methods: 6 adult Thoroughbred horses. Methods: Anesthesia was induced by use of romifidine (100 microg/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO), velocity time integral, maximal aortic blood flow velocity and acceleration, and left ventricular preejection peri...
Aortitis in a Paint gelding.
Equine veterinary journal    August 22, 2000   Volume 32, Issue 4 354-357 doi: 10.2746/042516400777032255
Diaz OS, Sleeper MM, Reef VB, Acland HM.No abstract available
A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses.
Equine veterinary journal    August 22, 2000   Volume 32, Issue 4 318-326 doi: 10.2746/042516400777032282
Raisis AL, Young LE, Blissitt KJ, Brearley JC, Meire HB, Taylor PM, Lekeux P.The purpose of this study was to compare the haemodynamic effects of equipotent isoflurane and halothane anaesthesia. Six adult horses were investigated on two separate occasions at least 4 weeks apart. On both occasions anaesthesia was induced by ketamine 2.2 mg/kg bwt given 5 min after i.v. administration 100 microg/kg bwt romifidine. Anaesthesia was maintained either by halothane or isoflurane (end-tidal concentrations 0.9-1.0% and 1.3-1.4%, respectively). Horses were ventilated by intermittent positive pressure to maintain PaCO2 between 40-50 mmHg. Haemodynamic variables were measured usin...
Concentration of cardiac troponin I in a horse with a ruptured aortic regurgitation jet lesion and ventricular tachycardia.
Journal of the American Veterinary Medical Association    July 26, 2000   Volume 217, Issue 2 231-235 doi: 10.2460/javma.2000.217.231
Cornelisse CJ, Schott HC, Olivier NB, Mullaney TP, Koller A, Wilson DV, Derksen FJ.An 18-year-old Thoroughbred gelding was evaluated because of sudden onset of ventricular tachycardia and signs of colic. Three years earlier, a diastolic decrescendo murmur, consistent with aortic regurgitation, had been detected, but the horse continued to perform well and compete successfully. Cardiac ultrasonographic examination revealed a defect in the interventricular septum below the aortic root, and serum concentrations of cardiac troponin I (cTnI) were higher than those measured in clinically normal horses. Repeated development of tachyarrhythmia during hospitalization prompted a decis...