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Topic:Disease Management

Disease management in horses encompasses the strategies and practices employed to prevent, control, and treat diseases affecting equine populations. This field involves understanding the etiology, transmission, and clinical presentation of various equine diseases, as well as implementing biosecurity measures and therapeutic interventions. Common diseases in horses include equine influenza, strangles, and equine herpesvirus. Effective disease management relies on accurate diagnosis, vaccination protocols, and the use of antimicrobials and other treatments. This page compiles peer-reviewed research studies and scholarly articles that explore the methodologies, challenges, and advancements in managing diseases in equine health.
Anesthesia and analgesia for standing equine surgery.
The Veterinary clinics of North America. Equine practice    December 31, 2013   Volume 30, Issue 1 1-17 doi: 10.1016/j.cveq.2013.11.008
Vigani A, Garcia-Pereira FL.Morbidity and mortality rate in equine anesthesia is still unacceptably high. Thus it is critical contemplating whether the benefit of general anesthesia for a specific patient and procedure outweighs the risks. Sedative protocols that would allow performing diagnostic and surgical procedures with the patient remaining standing would therefore be ideal. Infusion of short-acting agents allows to rapidly achieve a titratable steady state of sedation. Supplementing sedatives and tranquilizers with systemic analgesic or regional anesthetic techniques (i.e. epidurals) facilitates standing surgical ...
The management of anthelmintic resistance in grazing ruminants in Australasia–strategies and experiences.
Veterinary parasitology    December 31, 2013   Volume 204, Issue 1-2 44-54 doi: 10.1016/j.vetpar.2013.12.022
Leathwick DM, Besier RB.In many countries the presence of anthelmintic resistance in nematodes of small ruminants, and in some cases also in those infecting cattle and horses, has become the status quo rather than the exception. It is clear that consideration of anthelmintic resistance, and its management, should be an integral component of anthelmintic use regardless of country or host species. Many years of research into understanding the development and management of anthelmintic resistance in nematodes of small ruminants has resulted in an array of strategies for minimising selection for resistance and for dealin...
Anthelmintic resistance in equine parasites–current evidence and knowledge gaps.
Veterinary parasitology    December 31, 2013   Volume 204, Issue 1-2 55-63 doi: 10.1016/j.vetpar.2013.11.030
Nielsen MK, Reinemeyer CR, Donecker JM, Leathwick DM, Marchiondo AA, Kaplan RM.Anthelmintic resistance is becoming increasingly prevalent among equine nematode parasites. The first reports documenting resistance were published in the 1960s, just a short time after introduction of the first modern anthelmintics phenothiazine and thiabendazole. Several factors are known to influence development of resistance, but evidence specific to equine parasites is limited. Most current knowledge and applications have been extrapolated from research with trichostrongylid parasites of sheep. The number of cyathostomin species co-infecting horses adds to the complexity of investigating ...
Comparing the genetic diversity of ORF30 of Australian isolates of 3 equid alphaherpesviruses.
Veterinary microbiology    December 25, 2013   Volume 169, Issue 1-2 50-57 doi: 10.1016/j.vetmic.2013.12.007
Cuxson JL, Hartley CA, Ficorilli NP, Symes SJ, Devlin JM, Gilkerson JR.A single nucleotide polymorphism (SNP) has been previously associated with EHV-1 neurological disease in several countries around the world. This disease is very uncommon in Australia and little information is available about the presence of this SNP in Australian EHV-1 isolates. The ORF30 sequence of 66 Australian EHV-1 isolates was determined and the genotype was compared to the disease manifestation of the case from which the virus was isolated. Of the 66 isolates, 61 were from cases of abortion and 5 were cases associated with equine herpesvirus myeloencephalopathy (EHM). There was no asso...
The future of helminth control in horses.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 10-11 doi: 10.1111/evj.12200
Matthews JB.No abstract available
Current status and future directions: equine pituitary pars intermedia dysfunction and equine metabolic syndrome.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 99-102 doi: 10.1111/evj.12194
Sojka-Kritchevsky JE, Johnson PJ.No abstract available
EVE and EVJ online collection of equine endocrinology: recent and future directions; a great start, but still a long way to go.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 97-98 doi: 10.1111/evj.12217
Marr CM, Mair TS.No abstract available
The dilemmas of medicine selection for equine veterinarians.
Equine veterinary journal    December 18, 2013   Volume 46, Issue 1 15-16 doi: 10.1111/evj.12195
Chandler KJ, Sutton DG.No abstract available
Response to Stancampiano et al. (2013), Letter to the Editor.
Veterinary parasitology    December 14, 2013   Volume 200, Issue 1-2 229-230 doi: 10.1016/j.vetpar.2013.12.006
Lichtenfels JR, Kharchenko VA.No abstract available
Applying Bayesian network modelling to understand the links between on-farm biosecurity practice during the 2007 equine influenza outbreak and horse managers’ perceptions of a subsequent outbreak.
Preventive veterinary medicine    December 14, 2013   Volume 116, Issue 3 243-251 doi: 10.1016/j.prevetmed.2013.11.015
Firestone SM, Lewis FI, Schemann K, Ward MP, Toribio JA, Taylor MR, Dhand NK.Australia experienced its first ever outbreak of equine influenza in August 2007. Horses on 9359 premises were infected over a period of 5 months before the disease was successfully eradicated through the combination of horse movement controls, on-farm biosecurity and vaccination. In a previous premises-level case-control study of the 2007 equine influenza outbreak in Australia, the protective effect of several variables representing on-farm biosecurity practices were identified. Separately, factors associated with horse managers' perceptions of the effectiveness of biosecurity measures have b...
In vitro reproduction of the life cycle of Pythium insidiosum from kunkers’ equine and their role in the epidemiology of pythiosis.
Mycopathologia    December 11, 2013   Volume 177, Issue 1-2 123-127 doi: 10.1007/s11046-013-9720-6
Fonseca AO, Botton Sde A, Nogueira CE, Corrêa BF, Silveira Jde S, de Azevedo MI, Maroneze BP, Santurio JM, Pereira DI.Pythium insidiosum is an important pathogen of mammals' species, including humans. Equine is the main species affected by this oomycete. P. insidiosum requires an aquatic environment to develop its life cycle, and the susceptible hosts are contaminated when they contact the microorganism in swampy areas. The equine pythiosis is characterized by the formation of irregular masses within the cutaneous lesions, called kunkers, which easily detach from the lesion. From these structures, it is possible to isolate P. insidiosum in pure cultures. The present study aimed to reproduce in vitro the life ...
Faecal worm egg count analysis for targeting anthelmintic treatment in horses: points to consider.
Equine veterinary journal    December 10, 2013   Volume 46, Issue 2 139-145 doi: 10.1111/evj.12199
Lester HE, Matthews JB.Equine gastrointestinal nematodes are ubiquitous; in horses that graze contaminated pasture and that are not treated appropriately, large numbers of worms can accumulate, which can lead to serious clinical disease. Nematode control has traditionally followed interval treatment regimens, which involve regular anthelmintic administration to all horses based on the strongyle egg reappearance periods of each drug, usually defined around the time of licensing. Interval treatment programmes have resulted in substantial reductions in large strongyle disease, but have made major contributions to the d...
Three-dimensional anatomy of equine incisors: tooth length, enamel cover and age related changes.
BMC veterinary research    December 9, 2013   Volume 9 249 doi: 10.1186/1746-6148-9-249
Schrock P, Lüpke M, Seifert H, Staszyk C.Equine incisors are subjected to continuous occlusal wear causing multiple, age related changes of the extragingival crown. It is assumed that the occlusal wear is compensated by continued tooth elongation at the apical ends of the teeth. In this study, μCT-datasets offered the opportunity to analyze the three-dimensional appearance of the extra- and intraalveolar parts of the enamel containing dental crown as well as of the enamel-free dental root. Multiple morphometric measurements elucidated age related, morphological changes within the intraalveolar part of the incisors. Results: Equine i...
Comparison of two sampling and culture systems for detection of Salmonella enterica in the environment of a large animal hospital.
Equine veterinary journal    December 5, 2013   Volume 46, Issue 4 499-502 doi: 10.1111/evj.12193
Ruple-Czerniak A, Bolte DS, Burgess BA, Morley PS.Nosocomial salmonellosis is an important problem in veterinary hospitals that treat horses and other large animals. Detection and mitigation of outbreaks and prevention of healthcare-associated infections often require detection of Salmonella enterica in the hospital environment. Objective: To compare 2 previously published methods for detecting environmental contamination with S. enterica in a large animal veterinary teaching hospital. Methods: Hospital-based comparison of environmental sampling techniques. Methods: A total of 100 pairs of environmental samples were collected from stalls us...
Factors associated with survival in 148 recumbent horses.
Equine veterinary journal    December 5, 2013   Volume 46, Issue 5 575-578 doi: 10.1111/evj.12147
Winfield LS, Kass PH, Magdesian KG, Madigan JE, Aleman M, Pusterla N.There are currently few data available on the prognosis and outcome of recumbent horses. Objective: To investigate the outcome of hospitalised horses that had been recumbent in the field or hospital and factors affecting their survival within the first 3 days of hospitalisation and survival after 3 days to hospital discharge. Methods: Retrospective analysis of clinical records. Methods: Records of 148 horses admitted to the William R. Pritchard Veterinary Medical Teaching Hospital, University of California Davis from January 1995 to December 2010 with a history of recumbency or horses that bec...
Diagnoses, clinical pathology findings, and treatment outcome of geriatric horses: 345 cases (2006-2010).
Journal of the American Veterinary Medical Association    December 5, 2013   Volume 243, Issue 12 1762-1768 doi: 10.2460/javma.243.12.1762
Silva AG, Furr MO.To compare clinical, clinical pathology, and outcome variables between geriatric and nongeriatric horses. Methods: Retrospective case-control study. Methods: 690 horses (345 horses ≥ 20 years old and 345 horses > 1 and 1 and < 20 years old. Results: Mean ± SD age was 23.9 ± 4.6 years for cases and 9.2 ± 3.6 years for controls. Arabian and pony breeds were significantly overrepresented in the geriatric group, compared with the control group. Diagnoses related to the digestive system, musculoskeletal system, and respiratory system were most common in this hospital population overall ...
Epidemiological investigation of equine piroplasmosis in China by enzyme-linked immunosorbent assays.
The Journal of veterinary medical science    November 29, 2013   Volume 76, Issue 4 549-552 doi: 10.1292/jvms.13-0477
Wang M, Guo W, Igarashi I, Xuan X, Wang X, Xiang W, Jia H.The objective of this study is to investigate the seroprevalence of equine piroplasmosis in China. A total of 1990 sera were collected from clinically healthy horses in various districts located in ten different provinces of China and examined by using indirect enzyme-linked immunosorbent assays (ELISAs) with recombinant Theileria equi (T. equi) merozoite antigen 2 (rEMA-2) and Babesia caballi (B. caballi) 48-kDa rhoptry protein (rBc48), respectively. The results showed that 1,018 (51.16%) and 229 (11.51%) samples were positive for B. caballi and T. equi infection, respectively. The number of ...
Syndromic surveillance for evaluating the occurrence of healthcare-associated infections in equine hospitals.
Equine veterinary journal    November 29, 2013   Volume 46, Issue 4 435-440 doi: 10.1111/evj.12190
Ruple-Czerniak AA, Aceto HW, Bender JB, Paradis MR, Shaw SP, Van Metre DC, Weese JS, Wilson DA, Wilson J, Morley PS.Methods that can be used to estimate rates of healthcare-associated infections and other nosocomial events have not been well established for use in equine hospitals. Traditional laboratory-based surveillance is expensive and cannot be applied in all of these settings. Objective: To evaluate the use of a syndromic surveillance system for estimating rates of occurrence of healthcare-associated infections among hospitalised equine cases. Methods: Multicentre, prospective longitudinal study. Methods: This study included weaned equids (n = 297) that were admitted for gastrointestinal disorders at ...
Recrudescent infection supports Hendra virus persistence in Australian flying-fox populations.
PloS one    November 28, 2013   Volume 8, Issue 11 e80430 doi: 10.1371/journal.pone.0080430
Wang HH, Kung NY, Grant WE, Scanlan JC, Field HE.Zoonoses from wildlife threaten global public health. Hendra virus is one of several zoonotic viral diseases that have recently emerged from Pteropus species fruit-bats (flying-foxes). Most hypotheses regarding persistence of Hendra virus within flying-fox populations emphasize horizontal transmission within local populations (colonies) via urine and other secretions, and transmission among colonies via migration. As an alternative hypothesis, we explore the role of recrudescence in persistence of Hendra virus in flying-fox populations via computer simulation using a model that integrates publ...
Epidemiological and virological investigations of equine influenza outbreaks in Ireland (2010-2012).
Influenza and other respiratory viruses    November 28, 2013   Volume 7 Suppl 4, Issue Suppl 4 61-72 doi: 10.1111/irv.12192
Gildea S, Fitzpatrick DA, Cullinane A.Outbreaks of equine influenza (EI) in endemic populations cause disruption and economic loss. Objective: To identify (i) factors involved in the spread of EI (ii) virus strains responsible for outbreaks (iii) single radial haemolysis (SRH) antibody levels correlating with protection against current virus strains (iv) evidence of vaccination breakdown. Methods: RT-PCR, virus isolation and SRH were carried out on nasopharyngeal swabs and blood samples collected from horses, ponies and donkeys on affected premises. Data relating to 629 samples from 135 equidae were analysed. Conclusions: Outbreak...
Equine Pastern Dermatitis.
The Veterinary clinics of North America. Equine practice    November 26, 2013   Volume 29, Issue 3 577-588 doi: 10.1016/j.cveq.2013.09.003
Yu AA.Equine Pastern Dermatitis (EPD) is not a single disease, but a cutaneous reaction pattern of the horse. EPD should be considered a syndrome, rather than a diagnosis. Uncovering the underlying etiology prior to treatment is key to minimizing treatment failures and frustration. To achieve a positive therapeutic outcome, treating the predisposing and perpetuating factors is just as important as addressing the primary cause of EPD. This article reviews clinical signs, differential diagnoses, diagnosis, and treatment of EPD.
Colic in equine neonates: 137 cases (2000-2010).
Journal of the American Veterinary Medical Association    November 23, 2013   Volume 243, Issue 11 1586-1595 doi: 10.2460/javma.243.11.1586
Mackinnon MC, Southwood LL, Burke MJ, Palmer JE.To document causes of colic in equine neonates, evaluate clinical features of neonates managed medically versus surgically, determine short- and long-term survival rates for neonates with specific medical and surgical lesions, and assess ability of patients to achieve intended use. Methods: Retrospective case series. Methods: 137 client-owned equine neonates (< 30 days old) with a history of colic or signs of colic within 1 hour after hospital admission examined between 2000 and 2010. Methods: Signalment, history, results of physical examination, laboratory data, ancillary diagnostic tests, de...
Allele frequency of hereditary equine regional dermal asthenia in American Quarter horses in Brazil determined by quantitative real-time PCR with high resolution melting analysis.
Veterinary journal (London, England : 1997)    November 19, 2013   Volume 199, Issue 2 306-307 doi: 10.1016/j.tvjl.2013.11.008
Badial PR, Oliveira-Filho JP, Winand NJ, Borges AS.Hereditary equine regional dermal asthenia (HERDA) is a genetic disorder that occurs in the American Quarter horse (AQH) and is caused by a c.115G>A missense mutation in the peptidylprolyl isomerase B (PPIB) gene. Using a quantitative real-time PCR high resolution melting analysis genotyping assay for the PPIB mutation, the estimated HERDA allele and carrier frequencies in a sample of Brazilian AQHs were 2.9% and 5.8%, respectively.
Horse-, rider-, venue- and environment-related risk factors for elimination from Fédération Equestre Internationale endurance rides due to lameness and metabolic reasons.
Equine veterinary journal    November 18, 2013   Volume 46, Issue 3 294-299 doi: 10.1111/evj.12170
Nagy A, Murray JK, Dyson SJ.There is limited information on risk factors for elimination from endurance rides. Objective: To assess risk factors for elimination for lameness and metabolic reasons from Fédération Equestre Internationale (FEI) endurance rides of 80-160 km distance. Methods: Unmatched case-control. Methods: Venue-, horse- and rider-related data were collected from the FEI website. Data on weather conditions and terrain were collected at the venue. Univariable and multivariable logistic regression analyses were used to assess risk factors for elimination for lameness and metabolic reasons, respectively. Re...
Understanding virus-host dynamics following EIAV infection in SCID horses.
Journal of theoretical biology    November 16, 2013   Volume 343 1-8 doi: 10.1016/j.jtbi.2013.11.003
Ciupe SM, Schwartz EJ.We develop a mathematical model for the interaction between two competing equine infectious anemia virus strains and neutralizing antibodies. We predict that elimination of one or both virus strains depends on the initial antibody levels, the strength of antibody mediated neutralization, and the persistence of antibody over time. We further show that the ability of a subdominant, neutralization resistant virus to dominate the infection transiently or permanently is dependent on the antibody-mediated neutralization effect. Finally, we determine conditions for persistence of both virus strains. ...
Hendra virus and horse owners–risk perception and management.
PloS one    November 15, 2013   Volume 8, Issue 11 e80897 doi: 10.1371/journal.pone.0080897
Kung N, McLaughlin A, Taylor M, Moloney B, Wright T, Field H.Hendra virus is a highly pathogenic novel paramyxovirus causing sporadic fatal infection in horses and humans in Australia. Species of fruit-bats (genus Pteropus), commonly known as flying-foxes, are the natural host of the virus. We undertook a survey of horse owners in the states of Queensland and New South Wales, Australia to assess the level of adoption of recommended risk management strategies and to identify impediments to adoption. Survey questionnaires were completed by 1431 respondents from the target states, and from a spectrum of industry sectors. Hendra virus knowledge varied with ...
Management of animal botulism outbreaks: from clinical suspicion to practical countermeasures to prevent or minimize outbreaks.
Biosecurity and bioterrorism : biodefense strategy, practice, and science    November 6, 2013   Volume 11 Suppl 1 S191-S199 doi: 10.1089/bsp.2012.0089
Anniballi F, Fiore A, Löfström C, Skarin H, Auricchio B, Woudstra C, Bano L, Segerman B, Koene M, Båverud V, Hansen T, Fach P, Tevell Aberg A....Botulism is a severe neuroparalytic disease that affects humans, all warm-blooded animals, and some fishes. The disease is caused by exposure to toxins produced by Clostridium botulinum and other botulinum toxin-producing clostridia. Botulism in animals represents a severe environmental and economic concern because of its high mortality rate. Moreover, meat or other products from affected animals entering the food chain may result in a public health problem. To this end, early diagnosis is crucial to define and apply appropriate veterinary public health measures. Clinical diagnosis is based on...
Distribution and predictive factors of seizure types in 104 cases.
Equine veterinary journal    October 30, 2013   Volume 46, Issue 4 441-445 doi: 10.1111/evj.12149
Lacombe VA, Mayes M, Mosseri S, Reed SM, Ou TH.Although many studies have been performed to classify seizures by type in man and small animals, a similar study in horses is lacking. Objective: The aims of this study were as follows: 1) to characterise the distribution of seizure types in 104 horses presented for seizure disorders to a referral veterinary hospital; and 2) to characterise the various types of seizures by identifying associated clinical factors. Methods: Retrospective analysis of clinical records. Methods: Seizures were classified based on seizure type, according to the most recent accepted definitions in both human and small...
Diagnostic ophthalmology.
The Canadian veterinary journal = La revue veterinaire canadienne    October 25, 2013   Volume 54, Issue 5 514-515 
Sandmeyer LS, Bauer BS, Grahn BH.No abstract available
An ethicist’s commentary on horse with possible equine herpes virus.
The Canadian veterinary journal = La revue veterinaire canadienne    October 25, 2013   Volume 54, Issue 10 922 
Rollin BE.No abstract available
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