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Topic:Disease

The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).
Journal of proteomics    February 24, 2017   Volume 158 62-72 doi: 10.1016/j.jprot.2017.02.015
Segura Á, Herrera M, Reta Mares F, Jaime C, Sánchez A, Vargas M, Villalta M, Gómez A, Gutiérrez JM, León G.The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic properties. This venom is composed of 68% Zn2+-dependent metalloproteinases (SVMPs), 14% phospholipases A2 (PLA2s), 11% serine proteinases, 4% SVMPs-inhibitor tripeptides (SVMP-ITs), 2% bradykinin-potentiating peptides (BPPs), 0.6% cysteine-rich secretory proteins (CRISPs), and 0.2% l-amino acid oxidases (LAAOs). SVMPs present in the venom are responsible for azocasein hydrolysis and hemorrhagic activity, but their contribution to the lethal...
Volumetric capnography to diagnose venous air embolism in an anaesthetised horse.
Veterinary anaesthesia and analgesia    February 23, 2017   Volume 44, Issue 1 189-190 doi: 10.1111/vaa.12383
Sacks M, Mosing M.No abstract available
A case of airway obstruction caused by probable nasotracheal tube cuff herniation in a horse.
Veterinary anaesthesia and analgesia    February 23, 2017   Volume 44, Issue 1 191-192 doi: 10.1111/vaa.12401
Richardson E, McMillan M.No abstract available
Genomics and genetics: A daily double for the horse industry.
Equine veterinary journal    February 22, 2017   Volume 49, Issue 3 260-262 doi: 10.1111/evj.12668
Rothschild MF.No abstract available
Gingival Fibrosarcoma in a Horse.
Journal of veterinary dentistry    February 22, 2017   Volume 33, Issue 4 243-248 doi: 10.1177/0898756417690845
Horbal A, Dixon PM.A 4-year-old thoroughbred cross mare was referred to the University of Edinburgh Veterinary School Equine Hospital for treatment of a soft tissue tumor on the buccal gingival margin of the rostral right maxillary cheek teeth. The lesion was initially surgically excised and diagnosed as a fibrosarcoma via histopathology. Adjunctive treatment with intralesional cisplatin chemotherapy was begun. The tumor recurred and was repeatedly treated with intralesional cisplatin injections and additional surgical resection over the course of 14 weeks. Despite the initial poor response to treatment, no furt...
Encysted cyathostomin larvae in foals – progression of stages and the effect of seasonality.
Veterinary parasitology    February 20, 2017   Volume 236 108-112 doi: 10.1016/j.vetpar.2017.02.013
Nielsen MK, Lyons ET.Cyathostomins (small strongyles) are ubiquitous in grazing horses and are known pathogens as cause of larval cyathostominosis. As part of their life cycle, cyathostomin larvae invade the mucosal walls of the large intestines and undergo encystment. Newly ingested third stage larvae are known to undergo arrested development and this can lead to an accumulation of encysted burdens over the course of a grazing season. It is believed that the host immune system plays a significant role in triggering this arrestment. Little is known about the development and progression of larval stages in foals th...
Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.
Journal of veterinary internal medicine    February 16, 2017   Volume 31, Issue 2 582-592 doi: 10.1111/jvim.14670
Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S.Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objective: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. Methods: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. Methods: Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. ...
Multilocus sequence typing identifies an avian-like Chlamydia psittaci strain involved in equine placentitis and associated with subsequent human psittacosis.
Emerging microbes & infections    February 15, 2017   Volume 6, Issue 2 e7 doi: 10.1038/emi.2016.135
Jelocnik M, Branley J, Heller J, Raidal S, Alderson S, Galea F, Gabor M, Polkinghorne A.No abstract available
Use of Renal Replacement Therapy in a Neonatal Foal with Postresuscitation Acute Renal Failure.
Journal of veterinary internal medicine    February 12, 2017   Volume 31, Issue 2 593-597 doi: 10.1111/jvim.14665
Wong DM, Ruby RE, Eatroff A, Yaeger MJ.A newborn foal was presented because it was unresponsive and in cardiopulmonary arrest. Aggressive cardiopulmonary cerebral resuscitation was administered to the foal, which revived the foal; however, acute renal failure developed. Fluid retention and azotemia occurred although the foal was alert and able to suckle. A 6-hour renal replacement therapy session using hemodiafiltration and a continuous renal replacement therapy machine was administered to the foal at 3 days of age which lowered the foal's azotemia and facilitated removal of some of the excess body fluid. Despite therapy, the foal ...
Corrigendum: Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation.
Frontiers in veterinary science    February 10, 2017   Volume 4 10 doi: 10.3389/fvets.2017.00010
Stokol T, Serpa PB, Zahid MN, Brooks MB.[This corrects the article on p. 99 in vol. 3, PMID: 27909693.].
Science-in-brief: Streptococcus zooepidemicus: a versatile opportunistic pathogen that hedges its bets in horses.
Equine veterinary journal    February 9, 2017   Volume 49, Issue 2 146-148 doi: 10.1111/evj.12658
Waller AS.No abstract available
Strangles: A modern clinical view from the 17th century.
Equine veterinary journal    February 9, 2017   Volume 49, Issue 2 141-145 doi: 10.1111/evj.12659
Paillot R, Lopez-Alvarez MR, Newton JR, Waller AS.No abstract available
Genetic parameters of insect bite hypersensitivity in the Old Grey Kladruber horse.
Journal of animal science    February 9, 2017   Volume 95, Issue 1 53-58 doi: 10.2527/jas.2016.0745
Citek J, Vostry L, Vostra-Vydrova H, Brzakova M, Prantlova V.The objective of this study was to assess the genetic parameters of insect bite hypersensitivity (IBH) in the Old Grey Kladruber horse, an original Czech warmblood horse breed. Insect bite hypersensitivity is a recurrent allergic skin disease affecting horses worldwide. Its etiology is multifactorial. The defect is genetically controlled, and the starting impulse is a bite by midges of the spp. and less frequently spp. Knowledge about the associated genes is limited. Horses were kept by the National Stud in Kladruby (1,146 measurements) and by 10 private breeders (63 measurements). The horses ...
Cleaning with a wet sterile gauze significantly reduces contamination of sutures, instruments, and surgical gloves in an ex-vivo pelvic flexure enterotomy model in horses. Giusto G, Tramuta C, Caramello V, Comino F, Nebbia P, Robino P, Singer E, Grego E, Gandini M.The objective of this study was to investigate whether cleaning surgical materials used to close pelvic flexure enterotomies with a wet sterile gauze will reduce contamination and whether the use of a full thickness appositional suture pattern (F) or a partial thickness inverting (or Cushing) suture pattern (C) would make a difference in the level of contamination. Large colon specimens were assigned to group F or C and divided into subgroups N and G. In group G, a wet sterile gauze was passed over the suture material, another over the instruments, and another over the gloves. In group N, no t...
Preliminary study of ectoparasites of horses in the western highlands of Cameroon.
Veterinary medicine and science    February 2, 2017   Volume 3, Issue 2 63-70 doi: 10.1002/vms3.56
Payne VK, Mbafor FL, Wabo Pone J, Tchoumboué J.To evaluate the prevalence of infestation of ectoparasites of horses, a total of 894 horses (367 males and 527 females), aged 1-7 years old were examined. Horses were groomed for collection of ectoparasites. Out of the horses examined, 164 came from Fundong, 80 from Acha, 30 from Fongo-Tongo, 30 from Fokoue and 17 from Dschang, all of which were infested with ectoparasites. Five hundred and seventy-three (573) horses came from Banso and 99.48% were infested by ectoparasites. From the results obtained, three species of hard ticks ( and ) and one species of biting lice () were identified. (66%...
Efficacy of two extra-label anthelmintic formulations against equine strongyles in Cuba.
Veterinary parasitology, regional studies and reports    February 1, 2017   Volume 8 39-42 doi: 10.1016/j.vprsr.2017.01.010
Salas-Romero J, Gomez-Cabrera K, Molento MB, Lyons ET, Delgado A, González L, Arenal A, Nielsen MK.Equine cyathostomin parasites are ubiquitous in grazing horses and have been shown to cause severe inflammatory disease in the large intestine of horses. Decades of intensive anthelmintic therapy have led to widespread anthelmintic resistance in cyathostomins across the world. In Cuba, no anthelmintic products are formulated and sold for equine usage and little is known about anthelmintic efficacy of ruminant and swine formulations used. A strongyle fecal egg count reduction test was used to assess the efficacy of a liquid formulation of ivermectin labelled for use in swine, ruminants and carn...
A brief and critical review on hydrofluorosis in diverse species of domestic animals in India.
Environmental geochemistry and health    January 31, 2017   Volume 40, Issue 1 99-114 doi: 10.1007/s10653-017-9913-x
Choubisa SL.India is one of the fluoride-endemic countries where the maximum numbers of ground or drinking water sources are naturally fluoridated. In India, a total of 23, out of 36 states and union territories have drinking water contaminated with fluoride in varying concentration. In the present scenario, especially in rural India, besides the surface waters (perennial ponds, dams, rivers, etc.), bore wells and hand pumps are the principal drinking water sources for domestic animals such as cattle (Bos taurus), water buffaloes (Bubalus bubalis), sheep (Ovis aries), goats (Capra hircus), horses (Equus c...
Structural Protein VP2 of African Horse Sickness Virus Is Not Essential for Virus Replication In Vitro.
Journal of virology    January 31, 2017   Volume 91, Issue 4 doi: 10.1128/JVI.01328-16
van Gennip RGP, van de Water SGP, Potgieter CA, van Rijn PA.The Reoviridae family consists of nonenveloped multilayered viruses with a double-stranded RNA genome consisting of 9 to 12 genome segments. The Orbivirus genus of the Reoviridae family contains African horse sickness virus (AHSV), bluetongue virus, and epizootic hemorrhagic disease virus, which cause notifiable diseases and are spread by biting Culicoides species. Here, we used reverse genetics for AHSV to study the role of outer capsid protein VP2, encoded by genome segment 2 (Seg-2). Expansion of a previously found deletion in Seg-2 indicates that structural protein VP2 of AHSV is not essen...
Isolation of equine herpesvirus 3 (EHV-3) from equine coital exanthema of two stallions and sero-epidemiology of EHV-3 infection in Japan.
The Journal of veterinary medical science    January 27, 2017   Volume 79, Issue 3 636-643 doi: 10.1292/jvms.16-0518
Kirisawa R, Toishi Y, Akamatsu A, Soejima K, Miyashita T, Tsunoda N.In the spring of 2015, two stallions reared in Farms A and B in Hokkaido in Japan showed symptoms of equine coital exanthema. Equine herpesvirus 3 (EHV-3) was isolated from penis swab samples of both stallions, and the isolates from each stallion in Farms A and B were designated as SS-1 and YS-1 strains, respectively. BamHI restriction profiles of SS-1 and Japanese reference strain Iwate-1 were indistinguishable, but the BamHI-A fragment of YS-1 was larger than those of SS-1 and Iwate-1 by 1.9 kbp because of the lack of two BamHI sites. Nucleotide sequence analyses of glycoprotein G (gG), gB, ...
Osteochondroma on the cranial aspect of the distal radial metaphysis causing tenosynovitis of the extensor carpi radialis tendon sheath in a horse.
Australian veterinary journal    January 27, 2017   Volume 95, Issue 1-2 46-48 doi: 10.1111/avj.12543
Russell JW, Hall MS, Kelly GM.A 3-year-old Thoroughbred gelding was presented with a grade 3/5 lameness of the right forelimb and effusion of the extensor carpi radialis tendon sheath (ECRTS). Radiographic and ultrasonographic examinations revealed an osteochondroma on the cranial aspect of the distal radius projecting into the fibrous lining of the ECRTS. An open surgical approach was used to remove the osteochondroma and some of the proliferative synovial tissue. Conclusions: Six months after surgery the clinical signs had resolved and the horse raced successfully.
Molecular characterization of Rhodococcus equi isolates from horses in Poland: pVapA characteristics and plasmid new variant, 85-kb type V.
BMC veterinary research    January 26, 2017   Volume 13, Issue 1 35 doi: 10.1186/s12917-017-0954-2
Witkowski L, Rzewuska M, Takai S, Chrobak-Chmiel D, Kizerwetter-Świda M, Feret M, Gawryś M, Witkowski M, Kita J.Rhodococcus equi is one of the most significant bacterial pathogens affecting foals up to 6 months of age worldwide. Rhodococcosis is present in Poland however information about molecular characterization of R. equi isolates is scarce. This study describes molecular characterization of Rhodococcus equi infection on 13 horse breeding farms in Poland between 2001 and 2012. Samples were collected by tracheobronchial aspiration from pneumonic foals or during necropsy. The R. equi isolates were genotyped by plasmid profiling and pulsed-field gel electrophoresis. Results: Totally, 58 R. equi isolat...
Diagnosis of resistance alleles in codon 167 of the beta-tubulin (Cya-tbb-1) gene from third-stage larvae of horse cyathostomins.
Research in veterinary science    January 25, 2017   Volume 115 92-95 doi: 10.1016/j.rvsc.2017.01.019
Ishii JB, Arenal A, Felix A, Yoshitani U, Beech R, Molento MB.Anthelmintic resistance is a serious problem for the control of equine gastrointestinal nematodes. In the present survey, 173 third stage larvae of cyathostomins were investigated from three different locations for the presence of the resistant genotype at codon 167 of the beta-tubulin gene, as this is the most prevalent mutation. The larvae from the state of Parana (n=67), Sao Paulo (n=54) and Santa Catarina (n=52), showed 61.2; 31.5 and 38.5% of the heterozygous resistant genotype - TTC/TAC, respectively. An unpublished mutation at codon 172 that results in a serine (S) to threonine (T) subs...
What Is Your Diagnosis?
Journal of the American Veterinary Medical Association    January 25, 2017   Volume 250, Issue 3 275-277 doi: 10.2460/javma.250.3.275
Trolinger-Meadows KD, Gaschen LE, Riggs LM.No abstract available
Echocardiographic Assessment of Left Ventricular Function in Healthy Horses and in Horses with Heart Disease Using Pulsed-Wave Tissue Doppler Imaging.
Journal of veterinary internal medicine    January 21, 2017   Volume 31, Issue 2 556-567 doi: 10.1111/jvim.14641
Koenig TR, Mitchell KJ, Schwarzwald CC.Assessment of left ventricular (LV) function by tissue Doppler imaging (TDI) is not well established in horses with heart disease. Objective: To describe the use of pulsed-wave (PW) TDI for the assessment of LV function, establish reference intervals, investigate effects of mitral regurgitation (MR), aortic regurgitation (AR), and primary myocardial disease (MD), and provide proof of concept for the use of PW TDI in Warmblood horses with heart disease. Methods: Thirty healthy horses, 38 horses with MR, 25 with AR, 8 with MD. Methods: Echocardiograms were retrospectively analyzed. Reference int...
Influence of 2nd-degree AV blocks, ECG recording length, and recording time on heart rate variability analyses in horses.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology    January 20, 2017   Volume 19, Issue 2 160-174 doi: 10.1016/j.jvc.2016.10.006
Eggensperger BH, Schwarzwald CC.To assess the influence of 2nd-degree AV blocks (AVB) on RR interval-based heart rate variability (HRV) variables; to investigate the effect of using PP interval time series and of artifact filtering on HRV analyses; to investigate the influence of electrocardiogram (ECG) recording length and time of recording; and to calculate day-to-day variability and reference intervals of HRV variables. Methods: Thirty healthy adult horses. Methods: RR and PP interval time series were extracted from 10-h Holter ECGs and an automated filter was applied to the RR time series (RR). Time-domain HRV variables...
Identification of Arcanobacterium hippocoleae by MALDI-TOF MS analysis and by various genotypical properties.
Research in veterinary science    January 17, 2017   Volume 115 10-12 doi: 10.1016/j.rvsc.2017.01.006
Wickhorst JP, Sammra O, Hassan AA, Alssashen M, Lämmler C, Prenger-Berninghoff E, Erhard M, Metzner M, Paschertz K, Timke M, Abdulmawjood A.In the present study an Arcanobacterium hippocoleae strain isolated from a uterus swab of an apparently healthy mare could be identified by phenotypic properties, by MALDI-TOF MS analysis and genotypically by investigating the molecular targets 16S rDNA, 16S-23S rDNA intergenic spacer region and the genes encoding the β subunit of bacterial RNA polymerase (rpoB), elongation factor tu (tuf) and glyceraldehyde 3-phosphate dehydrogenase (gap). The presented data are one of the few reports about the species A. hippocoleae and might help to elucidate the role this species plays in infections of ho...
Association analysis of KIT, MITF, and PAX3 variants with white markings in Spanish horses.
Animal genetics    January 13, 2017   Volume 48, Issue 3 349-352 doi: 10.1111/age.12528
Negro S, Imsland F, Valera M, Molina A, Solé M, Andersson L.Several variants in the KIT, PAX3 and MITF genes have previously been associated with white markings in horses. In this study, we examined eight variants of these genes in 70 Menorca Purebred horses (PRMe, only black solid-coloured horses) and 70 Spanish Purebred horses (PRE, different coat colour patterns) that were scored for the extent of white markings. A maximum-likelihood chi-square test, logistic regression model and ridge regression analyses showed that a missense mutation (p.Arg682His) in KIT was associated with white facial markings (P < 0.05) and with total white markings (P &...
A Serologic and Polymerase Chain Reaction Survey of Equine Herpesvirus in Burchell’s Zebras (Equus quagga), Hartmann’s Mountain Zebras (Equus zebra hartmannae), and Thomson’s Gazelles (Eudorcas thomsonii) in a Mixed Species Savannah Exhibit.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians    January 13, 2017   Volume 47, Issue 4 1013-1018 doi: 10.1638/2013-0297.1
Lopez KM, Fleming GJ, Mylniczenko ND.Reports of equine herpesvirus (EHV) 1 and EHV-9 causing clinical disease in a wide range of species have been well documented in the literature. It is thought that zebras are the natural hosts of EHV-9 both in the wild and in captive collections. Concerns about potential interspecies transmission of EHV-1 and EHV-9 in a mixed species savannah exhibit prompted serologic and polymerase chain reaction surveys. Eighteen Burchell's zebras ( Equus quagga ), 11 Hartmann's mountain zebras ( Equus zebra hartmannae), and 14 Thomson's gazelles ( Eudorcas thomsonii ) cohabitating the same exhibit were exa...
Expression of Toll-like receptors 2, 4 and 6 in equine endometrial epithelial cells: A comparative in situ and in vitro study.
Research in veterinary science    January 12, 2017   Volume 112 34-41 doi: 10.1016/j.rvsc.2017.01.004
Schöniger S, Böttcher D, Theuß T, Schoon HA.Endometrial epithelial cells form a luminal barrier and are exposed to pathogens and non-infectious antigens. Toll-like receptors (TLRs) mediate pathogen defenses and tissue homeostasis, but are also involved in the pathogenesis of inflammatory and fibrosing alterations. Endometrial diseases are important causes of subfertility in mares. The pathogenesis of some types of persistent inflammation and periglandular fibrosis (endometrosis) is unknown. The aim of this study was to compare by in situ and in vitro immunohistochemistry the expression of TLRs 2, 4 and 6 in equine endometrial epithelial...
Detection of Strongylus vulgaris in equine faecal samples by real-time PCR and larval culture – method comparison and occurrence assessment.
BMC veterinary research    January 11, 2017   Volume 13, Issue 1 19 doi: 10.1186/s12917-016-0918-y
Kaspar A, Pfister K, Nielsen MK, Silaghi C, Fink H, Scheuerle MC.Strongylus vulgaris has become a rare parasite in Germany during the past 50 years due to the practice of frequent prophylactic anthelmintic therapy. To date, the emerging development of resistance in Cyathostominae and Parascaris spp. to numerous equine anthelmintics has changed deworming management and the frequency of anthelmintic usage. In this regard, reliable detection of parasitic infections, especially of the highly pathogenic S. vulgaris is essential. In the current study, two diagnostic methods for the detection of infections with S. vulgaris were compared and information on the occ...
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