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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Equine rhinosporidiosis: an exotic disease in the UK.
The Veterinary record    April 24, 2007   Volume 160, Issue 16 552-554 doi: 10.1136/vr.160.16.552
Leeming G, Hetzel U, Campbell T, Kipar A.No abstract available
Efficacy of 2,6-dichlorophenol lure to control Dermacentor nitens.
Veterinary parasitology    April 24, 2007   Volume 147, Issue 1-2 155-160 doi: 10.1016/j.vetpar.2007.02.037
Borges LM, Ferreira LA, da Silva LS, de Oliveira RA, Mussi SV, Faria KA, Melo LS, Abud LJ, Costa GL, Soares SF.This study was carried out with the objective of evaluating the efficacy of a 2,6-dichlorophenol (2,6-DCP) lure to control Dermacentor nitens (Acari: Ixodidae). Slow-release formulations of the pheromone formulated with and without cypermethrin were prepared. Olfactometer bioassays were used to define the best dose of the pheromone and to evaluate the effect of cypermethrin with 2,6-DCP attractiveness. Sexually active males were released 15 cm from 2 cmx1 cm pieces of polypropylene treated with different odors: 2,6-DCP in a liposphere system (1.5, 30 and 300 microg--without cypermethrin and 30...
Plasma colloid osmotic pressure and total protein trends in horses during anesthesia.
Veterinary anaesthesia and analgesia    April 23, 2007   Volume 34, Issue 4 275-283 doi: 10.1111/j.1467-2995.2006.00326.x
Boscan P, Watson Z, Steffey EP.To investigate the changes in colloid osmotic pressure (COP) and total protein concentrations during routine general anesthesia in horses. Methods: Prospective, clinical study. Methods: Twelve adult healthy horses aged 9.1 +/- 4.7 years and weighing 474 +/- 79 kg presented for elective surgery and 14 adult horses aged 8.7 +/- 7.3 years and weighing 510 +/- 85 kg. Methods: All horses were premedicated with xylazine and anesthesia induced with ketamine, diazepam and guaifenesin, and maintained with isoflurane for 2.5 hours. Lactate Ringer's solution was administered at 11 mL kg(-1) hour(-1). Osm...
Grid keratotomy as a treatment for superficial nonhealing corneal ulcers in 10 horses.
Veterinary ophthalmology    April 21, 2007   Volume 10, Issue 3 162-167 doi: 10.1111/j.1463-5224.2007.00526.x
Brünott A, Boevé MH, Velden MA.To describe the clinical symptoms of 10 cases of superficial nonhealing corneal ulcers in horses and to evaluate the results of grid keratotomy in these patients. Methods: Retrospective study. Methods: Ten horses with superficial nonhealing corneal ulceration in one eye. Methods: The signalment, history and clinical symptoms are reported of 10 patients with superficial nonhealing corneal ulcers during the period from August 2003 to February 2005. Grid keratotomy was performed in all cases. In addition, the surgical procedure of grid keratotomy and response to therapy are described. Results: Ho...
Safety of elevated dosages of a 0.24% diflubenzuron pellet administered orally to horses.
Veterinary therapeutics : research in applied veterinary medicine    April 21, 2007   Volume 8, Issue 1 61-76 
Ross DH, Heird C, Byrd JW, Beauchemin V, Kiess W.The safety of a feed-thru pellet formulation containing the insect growth regulator diflubenzuron (0.24%) for control of manure-breeding flies (Musca domestica L. and Stomoxys calcitrans L.) in horses was evaluated. Pellets were administered orally at 0, 1, 3, and 5 times the clinical dosage (0.12 to 0.20 mg/kg) on a daily basis for 31 consecutive days. Variables examined included daily clinical observations, hematology, coagulation, serum chemistry, acetylcholinesterase inhibition, body weights, and physical examinations. Horses remained healthy throughout the study, and no adverse reactions ...
Pharmacokinetics and in vitro effects of tegaserod, a serotonin 5-hydroxytryptamine 4 (5-HT4) receptor agonist with prokinetic activity in horses.
Veterinary therapeutics : research in applied veterinary medicine    April 21, 2007   Volume 8, Issue 1 77-87 
Delco ML, Nieto JE, Craigmill AL, Stanley SD, Snyder JR.Tegaserod, a serotonin agonist, has been shown to have prokinetic effects in horses, but pharmacokinetic information is not currently available. The pharmacokinetics and in vitro effects of tegaserod were evaluated. Tegaserod increased the contractile activity of smooth muscle preparations of the equine pelvic flexure. Pertinent pharmacokinetic parameters for a single IV and oral dose were determined. Therapeutic plasma concentrations of tegaserod were achieved by a single oral dose at 0.27 mg/kg. These findings indicate that further clinical studies are warranted to investigate potential bene...
Suspected air embolism associated with post-anesthetic pulmonary edema and neurologic sequelae in a horse.
Veterinary anaesthesia and analgesia    April 21, 2007   Volume 34, Issue 3 217-222 doi: 10.1111/j.1467-2995.2006.00317.x
Holbrook TC, Dechant JE, Crowson CL.A 523 kg Quarter Horse was anesthetized for unilateral eye enucleation. The anesthetic period was unremarkable. During anesthetic recovery the cap on the jugular venous catheter became dislodged. Clinical signs of pulmonary edema associated with moderate arterial hypoxemia subsequently developed. Although pulmonary edema resolved with medical therapy, the day following anesthetic recovery, clinical signs of vestibular disease and blindness developed. Treatment included nasal oxygen insufflation, flunixin meglumine, furosemide, dexamethasone, thiamine, dimethylsulfoxide, antimicrobials, and phe...
Horseback riding as therapy for children with cerebral palsy: is there evidence of its effectiveness?
Physical & occupational therapy in pediatrics    April 20, 2007   Volume 27, Issue 2 5-23 
Snider L, Korner-Bitensky N, Kammann C, Warner S, Saleh M.A systematic review of the literature on horseback riding therapy as an intervention for children with cerebral palsy (CP) was carried out. The terms horse, riding, hippotherapy, horseback riding therapy, equine movement therapy, and cerebral palsy were searched in electronic databases and hand searched. Retrieved articles were rated for methodological quality using PEDro scoring to assess the internal validity of randomized trials and the Newcastle Ottawa Quality Assessment Scale to assess cohort studies. PICO questioning (Population, Intervention, Comparison, and Outcomes) was used to identi...
Potential involvement of EGF-like growth factors and phosphodiesterases in initiation of equine oocyte maturation.
Animal reproduction science    April 20, 2007   Volume 103, Issue 1-2 187-192 doi: 10.1016/j.anireprosci.2007.04.006
Lindbloom SM, Farmerie TA, Clay CM, Seidel GE, Carnevale EM.Human chorionic gonadotropin (hCG) was administered to mares in estrus with large, dominant ovarian follicles to initiate follicular and oocyte maturation. Follicular contents were collected at 0, 2, 4 and 6 h after hCG. Epiregulin, amphiregulin and phosphodiesterase (PDE) mRNA contents of granulosa cells (PDE 4D) were determined by reverse transcription and real-time PCR; PDE 3A mRNA content of single oocytes was determined similarly. Copy numbers of mRNA did not increase for PDE 3A or 4D over the time interval studied. Amounts of epiregulin and amphiregulin mRNA were correlated (r=0.98) when...
Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
Journal of proteome research    April 20, 2007   Volume 6, Issue 6 2121-2131 doi: 10.1021/pr060668y
Hauck SM, Schoeffmann S, Amann B, Stangassinger M, Gerhards H, Ueffing M, Deeg CA.Spontaneous equine recurrent uveitis (ERU) is an incurable autoimmune disease affecting the eye. Although retinal-autoantigen specific T-helper 1 cells have been demonstrated to trigger disease progression and relapses, the molecular processes leading to retinal degeneration and consequent blindness remain unknown. To elucidate such processes, we studied changes in the total retinal proteome of ERU-diseased horses compared to healthy controls. Severe changes in the retinal proteome were found for several markers for blood-retinal barrier breakdown and whose emergence depended upon disease seve...
Storage of equine red blood cells as a concentrate.
Veterinary journal (London, England : 1997)    April 20, 2007   Volume 176, Issue 2 227-231 doi: 10.1016/j.tvjl.2007.02.015
Niinistö K, Raekallio M, Sankari S.The study was undertaken to determine how equine red blood cells (RBCs) survive in storage bags designed for use with human RBCs. Separated RBCs were stored in a routine manner for 35 days and examined every 7 days for storage lesions. Measured parameters included haematology, haemolysis, pH, potassium, lactate, adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (2,3-DPG). All tests were performed in vitro. Haematology did not change significantly. Haemolysis increased during storage but did not exceed human limits. pH and 2,3-DPG decreased, while lactate, potassium and ATP increased. RBC...
Evaluation of lung maturity by amniotic fluid analysis in equine neonate.
Theriogenology    April 19, 2007   Volume 67, Issue 9 1455-1462 doi: 10.1016/j.theriogenology.2007.02.013
Castagnetti C, Mariella J, Serrazanetti GP, Grandis A, Merlo B, Fabbri M, Mari G.The aim of this study was to gather useful new data for evaluation of lung maturity in the neonatal foal. Because equine neonatal intensive therapy is very expensive, a precocious diagnosis could help to express a prognosis and to offer a respiratory support early after birth, increasing the survival rate and reducing complications. Amniotic fluid was collected at parturition on n=18 mares. Lamellar bodies were isolated in the amniotic fluid and measured with transmission electron microscopy (TEM). Furthermore two tests on amniotic fluid that are commonly used in humane medicine were utilized:...
[Veterinary drugs in horses. The law and its meaning of the positive list].
Tijdschrift voor diergeneeskunde    April 18, 2007   Volume 132, Issue 6 216-220 
van Herten J, Kamphuis T.No abstract available
Modification of host erythrocyte membranes by trypsin and chymotrypsin treatments and effects on the in vitro growth of bovine and equine Babesia parasites.
The Journal of parasitology    April 18, 2007   Volume 93, Issue 1 208-211 doi: 10.1645/GE-914R.1
Okamura M, Yokoyama N, Takabatake N, Okubo K, Ikehara Y, Igarashi I.In the present study, we investigated the effects of protease pretreatments of host erythrocytes (RBC) on the in vitro growth of bovine Babesia parasites (Babesia bovis and B. bigemina) and equine Babesia parasites (B. equi and B. caballi). The selected proteases, trypsin and chymotrypsin, clearly modified several membrane proteins of both bovine and equine RBC, as demonstrated by SDS-PAGE analysis; however, the protease treatments also modified the sialic acid content exclusively in bovine RBC, as demonstrated by lectin blot analysis. An in vitro growth assay using the protease-treated RBC sh...
Identification of normal parameters for ultrasonographic examination of the equine large colon and cecum.
The Canadian veterinary journal = La revue veterinaire canadienne    April 18, 2007   Volume 48, Issue 3 289-291 
Hendrickson EH, Malone ED, Sage AM.Six healthy horses were examined by using transabdominal ultrasonography, as described (1-3), to evaluate activity and size of the large colon and cecum at various locations. Using size and number of sacculations, activity patterns and contractile frequency; significant differences that would allow ultrasonographic identification of dorsal versus ventral colons, if they were displaced, were not found. The cecum had significantly greater activity than the colon, and a trend was seen towards smaller sacculations in the cecum than in the large colon. Six chevaux en santé ont été examinés par...
Expression and nephron segment-specific distribution of major renal aquaporins (AQP1-4) in Equus caballus, the domestic horse.
American journal of physiology. Regulatory, integrative and comparative physiology    April 18, 2007   Volume 293, Issue 1 R492-R503 doi: 10.1152/ajpregu.00689.2005
Floyd RV, Mason SL, Proudman CJ, German AJ, Marples D, Mobasheri A.Aquaporins (AQPs) play fundamental roles in water and osmolyte homeostasis by facilitating water and small solute movement across plasma membranes of epithelial, endothelial, and other tissues. AQP proteins are abundantly expressed in the mammalian kidney, where they have been shown to play essential roles in fluid balance and urine concentration. Thus far, the majority of studies on renal AQPs have been carried out in laboratory rodents and sheep; no data have been published on the expression of AQPs in kidneys of equines or other large mammals. The aim of this comparative study was to determ...
Masticatory motor patterns in ungulates: a quantitative assessment of jaw-muscle coordination in goats, alpacas and horses.
Journal of experimental zoology. Part A, Ecological genetics and physiology    April 17, 2007   Volume 307, Issue 4 226-240 doi: 10.1002/jez.362
Williams SH, Vinyard CJ, Wall CE, Hylander WL.We investigated patterns of jaw-muscle coordination during rhythmic mastication in three species of ungulates displaying the marked transverse jaw movements typical of many large mammalian herbivores. In order to quantify consistent motor patterns during chewing, electromyograms were recorded from the superficial masseter, deep masseter, posterior temporalis and medial pterygoid muscles of goats, alpacas and horses. Timing differences between muscle pairs were evaluated in the context of an evolutionary model of jaw-muscle function. In this model, the closing and food reduction phases of masti...
Occurrence of roundworm (Parascaris equorum) in horses from small farms based on necropsy.
Wiadomosci parazytologiczne    April 17, 2007   Volume 52, Issue 4 323-326 
Kornaś S, Skalska M, Nowosad B.The objective of this study was to evaluate the level of roundworm infection in working horses slaughtered for meat. In these horses anthelmintics had not been used. Methods: Roundworms were collected post-mortem from small intestines of 83 horses. Results: The mean prevalence of roundworm infection was 12% and intensity--46.7 specimens per horse. Infection was found only in foals; 10 animals were infected (45.4%) among the 22 examined. Due to common occurrence of roundworms (Parascaris equorum) in foals this nematode control should focus particularly on regular anthelmintic treatment of young...
Louping ill in horses.
The Veterinary record    April 17, 2007   Volume 160, Issue 15 532 doi: 10.1136/vr.160.15.532
Hyde J, Nettleton P, Marriott L, Willoughby K.No abstract available
Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems.
Research in veterinary science    April 16, 2007   Volume 84, Issue 1 1-6 doi: 10.1016/j.rvsc.2007.02.008
Frontoso R, De Carlo E, Pasolini MP, van der Meulen K, Pagnini U, Iovane G, De Martino L.Bacterial pathogens are a potential cause when a mare fails to conceive to a fertile stallion on a well-managed breeding farm on one or more cycles in the same season. Furthermore, emerging bacterial resistance to commonly used (topical) antibiotics has been demonstrated. In this study, a total of 586 uterine swabs from mares with fertility problems were evaluated and the bacterial isolates were identified and measured for resistance to 10 antibiotics most commonly used during bacterial equine infection. Forty-nine percent of the examined mares were positive at bacteriological investigations. ...
Molecular characterization of the equine ATP2A2 gene.
Cytogenetic and genome research    April 14, 2007   Volume 116, Issue 4 256-262 doi: 10.1159/000100409
Mömke S, Distl O.The mammalian ATP2A2 gene encodes a P-type cation pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. We isolated one bacterial artificial chromosome (BAC) clone containing the equine ATP2A2 gene and determined the complete coding sequence of this gene. Cloning and characterization of the equine ATP2A2 gene revealed that the equine ATP2A2 gene consists of 20 exons. In total, 32 horses out of 16 breeds were analyzed for single nucleotide polymorphisms (SNPs). A mutation scan for SNPs included ten exons and their flanking introns. We detected in total 17 SNPs, 14 of which w...
Synthetic adrenocorticotropic hormone stimulation tests in healthy neonatal foals.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 314-321 doi: 10.1892/0891-6640(2007)21[314:sahsti]2.0.co;2
Hart KA, Ferguson DC, Heusner GL, Barton MH.Cosyntropin (adrenocorticotropic hormone [ACTH]) stimulation tests are used to evaluate adrenal function. Low-dose ACTH stimulation tests are the most accurate method for diagnosing relative adrenal insufficiency in critically ill humans but have not been evaluated in foals. Objective: Peak serum cortisol concentrations in healthy foals will not be significantly different after intravenous administration of 1, 10, 100, and 250 microg of cosyntropin. Methods: 14 healthy neonatal foals, 3-4 days of age. Methods: A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 micr...
Detection of fibrin deposits in tissues from horses with severe gastrointestinal disorders.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 308-313 doi: 10.1892/0891-6640(2007)21[308:dofdit]2.0.co;2
Cotovio M, Monreal L, Navarro M, Segura D, Prada J, Alves A.In humans and experimental animals, disseminated intravascular coagulation (DIC) causes fibrin deposition in several organs, which eventually leads to ischemia and multiorgan failure. Objective: Horses who died or were euthanized for severe gastrointestinal disorders could have fibrin deposits in different tissues. Methods: Tissue-organ samples collected during postmortem examinations on 66 colic horses with poor prognoses (eg, severe intestinal ischemia, enteritis, peritonitis), from 11 colic horses with good prognoses (eg, large-colon obstruction or displacement), and from 16 slaughter horse...
Cardiovascular effects of acute pulmonary obstruction in horses with recurrent airway obstruction.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 302-307 doi: 10.1892/0891-6640(2007)21[302:ceoapo]2.0.co;2
Johansson AM, Gardner SY, Atkins CE, LaFevers DH, Breuhaus BA.Recurrent airway obstruction (RAO) is common in horses. Although pulmonary artery (PA) pressure increases during RAO, cardiac function in horses with RAO has received limited attention. Objective: The purpose of this study was to noninvasively determine the cardiovascular effects of acute pulmonary obstruction (APO) in horses with RAO and their reversibility. Methods: Five geldings with RAO, inducible by exposure to moldy hay, were studied. Methods: Pulmonary mechanics, echocardiography, serum troponin I concentrations, arterial blood gases, and hematocrit were obtained before and after 7 days...
Determination of lactate concentrations in blood plasma and peritoneal fluid in horses with colic by an Accusport analyzer.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 293-301 doi: 10.1892/0891-6640(2007)21[293:dolcib]2.0.co;2
Delesalle C, Dewulf J, Lefebvre RA, Schuurkes JA, Proot J, Lefere L, Deprez P.Intestinal hypoperfusion can lead to increased lactate concentrations in plasma and peritoneal fluid of horses with colic. Objective: The purposes of this study were to (1) evaluate the reliability of the Accusport analyzer to assess peritoneal fluid lactate (PFL) concentrations in healthy horses and those with colic, (2) identify clinical features associated with abnormal blood plasma lactate (BPL) and PFL concentrations, and (3) evaluate the prognostic value of BPL and PFL. Methods: BPL and PFL were determined in 20 healthy horses and in 106 horses with colic. Results: The Accusport was reli...
Inflammatory airway disease of horses.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 356-361 doi: 10.1892/0891-6640(2007)21[356:iadoh]2.0.co;2
Couëtil LL, Hoffman AM, Hodgson J, Buechner-Maxwell V, Viel L, Wood JL, Lavoie JP.The purpose of this consensus statement is to provide a review of current knowledge and opinions concerning inflammatory airway disease (IAD) and to help practitioners differentiate IAD from heaves (or recurrent airway obstruction; RAO) and other inflammatory respiratory diseases of horses.
Multicentric mastocytoma in a horse.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 340-343 doi: 10.1892/0891-6640(2007)21[340:mmiah]2.0.co;2
Tan RH, Crisman MV, Clark SP, Gagea M, Zimmerman K.No abstract available
Presumptive fluphenazine-induced hepatitis and urticaria in a horse.
Journal of veterinary internal medicine    April 13, 2007   Volume 21, Issue 2 336-339 doi: 10.1892/0891-6640(2007)21[336:pfhaui]2.0.co;2
Rodriguez-Palacios A, Quesada R, Baird J, Stalker M, McGurrin K.No abstract available
A polymorphism within the equine CRISP3 gene is associated with stallion fertility in Hanoverian warmblood horses.
Animal genetics    April 13, 2007   Volume 38, Issue 3 259-264 doi: 10.1111/j.1365-2052.2007.01594.x
Hamann H, Jude R, Sieme H, Mertens U, Töpfer-Petersen E, Distl O, Leeb T.Fertility of stallions is of high economic importance, especially for large breeding organisations and studs. Breeding schemes with respect to fertility traits and selection of stallions at an early stage may be improved by including molecular genetic markers associated with traits. The genes coding for equine cysteine-rich secretory proteins (CRISPs) are promising candidate genes because previous studies have shown that CRISPs play a role in the fertilising ability of male animals. We have previously characterised the three equine CRISP genes and identified a non-synonymous polymorphism in th...
Restricted and selective tropism of a Venezuelan equine encephalitis virus-derived replicon vector for human dendritic cells.
Viral immunology    April 12, 2007   Volume 20, Issue 1 88-104 doi: 10.1089/vim.2006.0090
Nishimoto KP, Laust AK, Wang K, Kamrud KI, Hubby B, Smith JF, Nelson EL.Dendritic cells (DCs) consist of heterogeneous phenotypic populations and have diverse immunostimulatory functions dependent on both lineage and functional phenotype, but as exceptionally potent antigen-presenting cells, they are targets for generating effective antigen-specific immune responses. A promising replicon particle vector derived from Venezuelan equine encephalitis virus (VEE) has been reported to transduce murine footpad DCs. However, the receptive DC subset, the degree of restriction for this tropism, and the extent of conservation between rodents and humans have not been well cha...