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Topic:Equine Medicine
Equine Medicine encompasses the study and application of medical practices specifically related to the health and well-being of horses. This field involves the diagnosis, treatment, and prevention of diseases and disorders affecting equine species. It covers a wide range of topics, including internal medicine, surgery, reproduction, and pharmacology. Research in equine medicine often focuses on understanding the physiological and pathological processes unique to horses, as well as developing effective therapeutic interventions. This page aggregates peer-reviewed research studies and scholarly articles that explore various aspects of equine medicine, providing insights into the latest advancements and methodologies in the care and management of horse health.
A comparison of the efficacy of three commercial human embryo vitrification kits for cryopreservation of in vivo produced equine embryos. Different cryoprotectants can influence the ability of embryos to successfully survive vitrification and subsequent warming before transfer. Objective: To compare pregnancy rates for embryos ≤500 μm vitrified, without puncture or aspiration of the blastocoele cavity, with one of three commercial human embryo vitrification kits containing the same penetrating cryoprotectants (DMSO and EG) but varying in their non-penetrating cryoprotectants (NPCPAs; sucrose, trehalose, dextran serum supplement [DSS], and hydroxypropyl cellulose [HPC]). Methods: In vivo experiments. Methods: Embryos (n =â...
A comparison of a transdermal eutectic lidocaine/prilocaine cream and subcutaneous lidocaine injection prior to jugular vein catheterization in horses: a randomized crossover study. To compare horses' aversive behavioural responses to the application of 5% prilocaine/lidocaine eutectic mixture of local anaesthetics (EMLA) cream versus subcutaneous infiltration of 2% lidocaine, followed by jugular vein catheterization. Methods: Blinded, randomized study. Methods: A group of 26 university-owned research horses. Methods: Each horse received both treatments at opposite jugular sites with ≥ 12 hours between procedures. One randomly assigned jugular site received 1 g cm of 5% EMLA cream 60 minutes before catheterization, while the contralateral site received 1.5 mL of 2% lido...
Antimicrobial resistance in bacteria isolated from diseased horses in Poland, 2010-2022. The rise of antibiotic resistance is a global health crisis affecting human and veterinary medicine, highlighted within the One Health framework. Horses, classified as both meat and companion animals, play a crucial role in facilitating resistant bacteria spread to humans. Despite increased awareness and reduced antibiotic use in livestock, data on equine antibiotic use and resistance remain limited. This retrospective study examines antimicrobial resistance in 978 bacterial isolates from horses in Poland over 12 years (2010-2022), utilizing data from the Microbiological Diagnostic Laboratory ...
Haemoglobin concentration measurement agreement obtained from three different devices in anaesthetised horses. Accurate measurement of haemoglobin concentration is crucial for monitoring the oxygen-carrying capacity in anaesthetised horses. This prospective study aimed to determine the agreement in haemoglobin concentration in anaesthetised horses using the SpHb pulse co-oximeter, an Epoc® blood gas analyser, and values derived from packed cell volume (PCV), which served as the reference method in this study. The study included 34 horses undergoing elective surgeries. Blood samples were collected from each horse and divided for analysis using the microhaematocrit method to estimate haemoglobin concent...
Detection using chamber digital PCR with a DNA extraction-free method for gene-doping control. Gene doping, which entails the administration of transgenes, poses a serious threat to the integrity of equine sports and also raises both ethical and regulatory concerns. Current methods used for the detection of such doping often necessitate the extraction of DNA from plasma, which can be time-consuming and labour-intensive. To overcome this limitation, we developed a direct chamber digital PCR (cdPCR) method that enables transgene detection in equine plasma without the need for DNA purification. Using the equine erythropoietin (EPO) transgene as a model, we validated the assay by analysing ...
Donkey and Hybrid Anaesthetic Mortality in an Observational, Prospective, Multicentre Cohort Study. Equid anaesthetic mortality is of interest to practitioners. Data for donkey and hybrid mortality have not been specifically described. The main aim of this worldwide observational, prospective, multicentre cohort study was to report on mortality in the 7 days following a general anaesthetic or standing sedation in donkeys and hybrids. This study hypothesised that donkeys and hybrids would have higher mortalities compared to horses. Data were collected as part of the fourth Confidential Enquiry into Perioperative Equine Fatalities (CEPEF4). A total of 825 cases were included, with 757 donkeys ...
Effect of Centrifugation of Stallion Semen Through a Low Density Colloid Prior to Freezing on Sperm Cryosurvival. Sperm quality is adversely affected by cryopreservation due to the increased production of reactive oxygen species, which affects the integrity of sperm membranes, motility, and DNA fragmentation. Three methods for removing seminal plasma, washing (centrifuging extended semen at 800× for 10 min) and Single Layer Centrifugation with high or low density Equicoll, were used to prepare 29 ejaculates from ten stallions for freezing. Sperm quality parameters (kinematics, plasma membrane integrity, superoxide and hydrogen peroxide production, mitochondrial membrane potential, and DNA fragmentation)...
Comparison of early and late time-controlled adaptive ventilation on pulmonary gas exchange in anesthetized horses. To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. Methods: A crossover, nonrandomized, experimental study. Methods: Six healthy adult horses. Methods: Each horse underwent two anesthetics: 1) volume-controlled ventilation (VCV) began for 30 minutes before switching to APRV using the TCAV method (late TCAV, TCAV); and 2) ventilation began immediately with TCAV (early TCAV, TCAV). The study lasted 180 minutes, with arterial blood gases and respiratory m...
Efficacy of needle and endoscopic lavage on the recuperation of microspheres from the adult equine metacarpo-/metatarsophalangeal joint and digital flexor tendon sheath. To measure microsphere recovery following needle-through-and-through lavage (NTAT) of the metacarpo-/metatarsophalangeal joint (fetlock) and digital flexor tendon sheath (DFTS) compared to endoscopic lavage (EL). Methods: Ex vivo experimental study. Methods: Adult equine cadavers immediately following euthanasia (n = 10). Methods: Colored 15 μm microspheres (2 million) were injected into fetlock joints and DFTS. Synovial structures were assigned to NTAT or EL groups. Each lavage was performed using 5 L of 0.9% NaCl, sequentially collecting egress fluid for microsphere quantification. Re...
Pantoea agglomerans in Equine Ulcerative Keratitis: Prevalence and Comparative Efficacy of Four Topical Antiseptics. To determine the minimal bactericidal concentration (MBC) and effective contact time of four topical antiseptics-polyhexanide, povidone-iodine (PVP-I), hypochlorous acid (HOCl), and N-acetylcysteine (NAC)-against Pantoea agglomerans, a pathogen frequently isolated in equine ulcerative keratitis. Methods: Over a 17-month sampling period, clinical isolates were collected from horses with ulcerative keratitis. The most frequently isolated strain (Pantoea agglomerans, n = 14) was selected for in vitro analysis. Methods: All isolates were used to determine the MBCs of the four antiseptics. Eac...
Equine Bone Imaging, Part 1: Establishing an Equine Nuclear Medicine Facility. While the establishment and operation of an equine nuclear medicine department share several principles with those of human nuclear medicine departments, they require an additional skill set to ensure safe and effective operation. This article explores the practical aspects of equine nuclear medicine facility location and design and details important considerations for safe and practical operation. Key considerations associated with the differences in physical and radiation safety and imaging approaches are explored. Specific adaptations of γ-camera gantries to allow either planar imaging or ...
Is Rifampin (Rifampicin) Essential for the Treatment of Rhodococcus equi Infections in Foals? A Critical Review of the Role of Rifampin. Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a "moving target" along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years. The necessity of rifampin concomitant therapies is based on beliefs that both antimicrobials (e.g., rifampin plus macrolide) penetrate into pulmonary abscesses and intracellular compartments above R. equi minimum inhibitory concentrations (MICs), as well as better ef...
Stress responses of horses transported long-distance by road to and from a jumping competition in a tropical climate. Long-distance road transport is known to be stressful for horses, with most research conducted in temperate climates. This study investigated horses' stress responses during long-distance transport before and after a jumping competition in a tropical environment. Ten healthy horses (aged 7.9 ± 1.9 years) were studied. Blood cortisol concentrations, haematology, and heart rate variability (HRV) were monitored during outbound (OTJ) and inbound journeys (INJ). Cortisol concentrations increased five minutes after unloading and remained elevated for up to 180 minutes in the OTJ (P < 0.05-0.001)...
Equine Bone Imaging, Part 2: Role of Nuclear Medicine in Racehorses. The horse racing industry, like any sport, must contend with the effects of injuries on an athlete's performance and longevity. Catastrophic fractures linked to preexisting bone fatigue can be prevented with the use of imaging technology, such as the nuclear medicine bone scan. The accessibility and affordability of imaging for racehorses remain obstacles. The conventional role of bone scintigraphy has evolved with the advent of advanced techniques, including MRI, CT, and PET. Concurrently, SPECT has expanded the role of scintigraphy in the racehorse. This article explores the conventional and...
A Pilot Study on Blood Concentration of β-Amyloid (40 and 42) and Phospho-Tau 181 in Horses. In humans, aging is often accompanied by cognitive decline, as seen in Alzheimer's disease. In contrast, the aging process in horses remains poorly characterized. This study aims to explore the presence of blood-based biomarkers associated with cognitive degeneration in this species. Twenty-three Arabian horses were enrolled, and 5 mL of blood was collected from each to measure serum levels of β-amyloid peptides (Aβ40 and Aβ42) and phosphorylated tau protein (pTau181), both considered reliable indicators of cognitive impairment in other species. Aβ42 was undetectable in all samples, while ...
Ultrasonographic diagnosis of caudoproximal humeral stress fracture in thoroughbred racehorses. Humeral stress fractures in racehorses can progress to catastrophic fracture if unrecognised. Scintigraphy is the gold standard diagnostic technique but is limited by accessibility and cost. It was hypothesised that ultrasonography could be used to visualise caudoproximal humeral stress fractures. Objective: To determine the utility of ultrasonography to identify caudoproximal humeral stress fractures in racehorses. Methods: Clinical case series. Methods: Seven racehorses that had a clinical history consistent with the presence of a humeral stress fracture were examined using humeral ultrasono...
Effectiveness of steam cleaning technology on reducing the occurrence of ESKAPE organisms and Escherichia coli in the stables of an equine referral hospital. The "ESKAPE" bacteria include a group of organisms known for their multidrug resistance and potential association with nosocomial infections in human and veterinary hospitals. Objective: This study aimed to evaluate the effectiveness of steam cleaning in reducing the number of ESKAPE organisms on environmental surfaces from the stables of an equine veterinary referral hospital. Methods: Environmental sampling was performed at two timepoints (pre- and post-steam cleaning) on smooth metallic doors and rough rubber stable walls. Microbiological culture targeted ESKAPE organisms and Escherichia co...
Methodology of easy-to-use horizontally centrifuged platelet-rich fibrin as a topical treatment for equine ulcerative keratitis in 5 horses. To describe the most efficient topical horizontally centrifuged platelet-rich fibrin (H-PRF) treatment protocol for equine ulcerative keratitis (EUK) that is easy to use, and to report the preliminary concentration of growth factors and cytokines in equine H-PRF. Unassigned: 5 client-owned horses diagnosed with EUK were enrolled over an 11-month period. Unassigned: 3 horses were geldings, and 2 were mares. The mean (± SD) age was 5.95 ± 5.01 years. The owners' main goal was to avoid surgery for EUK. Unassigned: H-PRF was used in 3 different protocols: solid H-PRF, sutured to the EUK area (n ...
Follicular fluid secretome enhances the meiotic competence of in vitro matured equine oocytes, but not the developmental competence of zygotes after intracytoplasmic sperm injection (ICSI). In vitro embryo production is widely used in equine clinical reproduction; however, its efficiency remains suboptimal due to the undermined developmental competence of in vitro-matured oocytes. In this work, we evaluated the effect of mare preovulatory follicular fluid (PFF) secretome supplementation during in vitro maturation (IVM) of equine oocytes recovered post-mortem. Secretome was isolated from PFF and was added to the IVM medium at concentrations of 20 µg/ml (S20) or 40 µg/ml (S40). The percentage of mature oocytes, as well as embryo cleavage, blastocyst development, and gene expr...
Effects of Induced Endotoxaemia on Global Cardiovascular, Oxygenation and Haematologic Variables and the Integrity of the Endothelial Glycocalyx in the Horse. Endotoxaemia is a significant cause of morbidity and mortality in equids due to perfusion impairment and possible destruction of the glycocalyx. To evaluate our hypothesis that endotoxaemia induces changes in global cardiovascular and haematologic parameters and compromises glycocalyx integrity, evidenced by an early rise in plasma shedding products. In vivo experiments METHODS: In a prospective, randomised, controlled experimental trial, endotoxaemia was induced with E. coli B55:O5 LPS 30Â ng kg over 30 min IV in six healthy adult horses ventilated with oxygen supplemented with isoflurane. St...
Objective Evaluation of Gait Asymmetries in Traditional Racehorses During Pre-Race Inspection: Application of a Markerless AI System in Straight-Line and Lungeing Conditions. Subtle locomotor asymmetries are common in horses and may go unnoticed during routine pre-race clinical inspections, particularly when based solely on subjective evaluation. This study aimed to describe vertical head and pelvic movement asymmetries in racehorses that passed official pre-race inspections at a traditional racing event. Twenty-four horses were analysed using a markerless AI-based gait analysis system while trotting in-hand and during lungeing in both directions. Asymmetry parameters (HDmin, HDmax, PDmin, and PDmax) were extracted from video recordings, with values ≥0.5 consider...
An ex vivo comparison of jejunal transection angles and the effect on lumen diameter following end-to-end jejunojejunal anastomoses. To evaluate three different jejunal transection angles for end-to-end jejunojejunostomies, comparing construction time, lumen size, and suture number. Methods: Ex vivo cadaver study. Methods: Eight euthanized horses each had three mid-jejunal specimens harvested. Methods: Jejunal segments were assigned to one of three groups (A30, A45, and A60) and transected at 30, 45, or 60°, respectively. Following transection, a standardized handsewn single-layer interrupted modified Lembert anastomosis was performed, and construction time and number of sutures placed were recorded. Anastomotic index (AI)...
Equine MicroRNAs: Performance, Reproduction, and Disease. MicroRNAs (miRNAs) are molecules that regulate gene expression by targeting the 3' untranslated region (UTR) of mRNAs. They are essential in numerous biological processes like growth, metabolism, and muscle development. miRNA research has become crucial in livestock breeding, offering solutions for improving animal health and productivity. This review focuses on miRNAs' roles in equine performance, reproduction, and disease, highlighting key findings and future applications in these areas. It discusses the use of circulating miRNAs (ci-miRNA) as biomarkers for athletic performance, particularl...
Exposure of horses to biotoxins, phytoestrogens, and pesticides from different feed materials and supplementary feeds. The occurrence of biotoxins and chemical residues in marketed horse feeds has direct influences on horse health but has not been studied yet. Objective: The study investigated the exposure and health implications of contaminants in various horse feedstuffs available on the European market. Methods: A total of 108 feed samples representing diverse product categories such as hay, processed roughage products, grains, and various supplementary feeds were collected from different European countries and analyzed for contaminants, including mycotoxins, phytoestrogens, pesticides, and veterinary drug ...
Group housing increases alertness and social interaction compared to traditional single stabling in two-year-old sport horse stallions during pretraining. Horses in training are often stabled individually, but this is increasingly questioned. We have investigated the effects of different stabling systems in Warmblood stallions during a 12-week pretraining programme. Stallions were 24 months old and housed either in a group stable (Group 24, n = 9) or in individual boxes (Box 24, n = 10), or they were 30 months of age and housed in individual boxes (Box 30, n = 10). Cortisol, heart rate, heart rate variability (HRV), body development, injuries and selected behaviour patterns were analysed (1) at transfer from pasture to stable and (2) the...
Equine botulism. Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on clinical experience and presenting signs. Delay in case identification and treatment results in rapid deterioration of the patient. Treatment of recumbent equine botulism cases presents challenges due to patient size and requires intensive nursing care. This...
Suspensory Ligament Injuries: Diagnosis and Treatment. The location of a suspensory ligament (SL) injury heavily influences the clinical presentation, prognosis, and treatment options. Diagnostic imaging is necessary to provide an accurate diagnosis and is critical to ensure the institution of the most appropriate treatment. The hindlimb proximal SL in particular can be challenging to diagnosis, carries a guarded prognosis, and typically requires aggressive treatment to achieve soundness.
Adjunct Therapies for Tendon/Ligament Healing: Therapeutic Laser and Extracorporeal Shockwave Therapy. High-power laser therapy and extracorporeal shock wave therapy (ESWT) can be safely used to treat tendon and ligament injuries in horses, and the potential beneficial effects have been described. The power of low level lasers is not sufficient for treatment of tendon and ligament injuries in horses. ESWT is used more often to treat tendon and ligament injuries than it is for any other type of condition in horses, but there is limited supporting scientific evidence. Further research should focus on establishing dosage and treatment protocols for both laser therapy and ESWT in horses with clinic...
Current and Emerging Biologic Therapies for Equine Tendon and Ligament Injuries. This review explores the use of biologics in the treatment of tendon and ligament injuries in horses, focusing on current and emerging therapies aimed at enhancing tissue repair and regeneration. It discusses the role of scaffold-based therapies, growth factors, blood-derived and tissue-derived biologics, and gene therapy as biologic regenerative therapies for improving healing outcomes. The review evaluates the mechanisms, efficacy, and challenges of biologics in clinical applications, highlighting recent advances and clinical studies. It provides an overview of current trends and future dire...
Techniques for Equine Tendon Tenorrhaphy. Equine tendon lacerations are not uncommon secondary to traumatic wounds and degloving lacerations. These wounds are often contaminated and, therefore, basic principles of wound assessment and management are critical to identify the extent of an injury. Ancillary tools to aid physical examination include radiography, ultrasonography, and synoviocentesis (eg, if involving a joint and/or tendon sheath). Prolonged convalescence period, continued external coaptation, and controlled exercise are mainstays of treatment following tenorrhaphy. A poor prognosis for return to full athletic function is e...
