Heart rate in horses is a physiological parameter that reflects the number of heartbeats per minute. It is an important indicator of cardiovascular function and can be influenced by factors such as exercise, stress, excitement, and health status. Monitoring heart rate provides valuable insights into the horse's physical condition and can aid in assessing fitness levels or detecting potential health issues. In equine practice, heart rate is often measured using stethoscopes, heart rate monitors, or electrocardiograms. This page compiles peer-reviewed research studies and scholarly articles that explore the determinants, measurement techniques, and implications of heart rate variations in equine health and performance.
De Mello Costa MF, Anderson GA, Davies HM, El-Hage CM, Slocombe RF.Investigate angiotensin converting enzyme (ACE) activity in equine plasma as a predictor of performance in endurance competitions and the effect of endurance exercise on ACE activity. Objective: Precompetition values of ACE activity in equine blood are correlated with performance results and with heart rates pre- and post competition used as indicators of fitness. Endurance exercise increases ACE activity. Methods: Nineteen horses participating in an 80 km endurance competition had venous blood samples collected before and after the ride. ACE activity and total protein were measured in the blo...
Munsters CC, Visser KE, van den Broek J, Sloet van Oldruitenborgh-Oosterbaan MM.A good horse-rider 'match' is important in the context of equine welfare. To quantify the influence of repetition and horse-rider matching on the stress of horses encountering challenging objects, 16 Warmblood horses were ridden in a test-setting on three occasions. On each occasion the horse was ridden by a different rider and was challenged by three objects (A-C). Heart rate (HR), heart rate variability (HRV) of horse and rider, and behaviour score (BS) of the horse were obtained for each object and as a total for each test. The horse-rider interaction was evaluated with each combination and...
Christensen JW, Zharkikh TL, Antoine A, Malmkvist J.During riding, horses are frequently exposed to pressure from the rider, e.g. through the bit and reins, but few studies have investigated at which point rein tension becomes uncomfortable for the horse. Objective: To investigate how much rein tension young inexperienced horses are willing to accept in order to obtain a food reward; whether the tension acceptance changes during 3 consecutive test days; and whether rein tension correlates with the expression of conflict behaviour and heart rate. Objective: Pressure-naïve horses will apply only little rein tension in the first voluntary trial, ...
König von Borstel U, Euent S, Graf P, König S, Gauly M.The aim of the present study was to compare horses' heart rate (HR), heart rate variability (RMSSD, pNN50) and behaviour in the same temperament test when being ridden, led, and released free. Behavioural measurements included scores and linear measurements for reactivity (R), activity (A), time to calm down (T) and emotionality (E), recorded during the approach (1) and/or during confrontation with the stimulus (2). Sixty-five horses were each confronted 3 times (1 ridden, 1 led, 1 free running in balanced order) with 3 novel and/or sudden stimuli. Mixed model analysis indicated that leading r...
Dziezyc J, Taylor L, Boggess MM, Scott HM.To determine the effect of ocular blinkers on driving horses' reactions to visual and audible stimuli. Methods: Balanced crossover trial with horses randomly assigned to either wear blinkers or not wear blinkers first or second, then subjected to repeated sequences of four distinct stimuli (chain rattle, cap gun, umbrella opening, and shaking of an aluminum can containing coins). Two weeks later, this process was repeated with the ordering of wearing blinkers reversed. Methods: Eight driving horses of various breeds. Methods: Responses were recorded quantitatively as inter-beat times (the time...
Bettschart-Wolfensberger R, Dicht S, Vullo C, Frotzler A, Kuemmerle JM, Ringer SK.To test if the addition of butorphanol by constant rate infusion (CRI) to medetomidine-isoflurane anaesthesia reduced isoflurane requirements, and influenced cardiopulmonary function and/or recovery characteristics. Methods: Prospective blinded randomised clinical trial. Methods: 61 horses undergoing elective surgery. Methods: Horses were sedated with intravenous (i.v.) medetomidine (7 μg kg(-1)); anaesthesia was induced with i.v. ketamine (2.2 mg kg(-1)) and diazepam (0.02 mg kg(-1)) and maintained with isoflurane and a CRI of medetomidine (3.5 μg kg(-1) hour(-1)). Group MB (n = 31) receive...
Cruz FS, Carregaro AB, Machado M, Antonow RR.This study investigated the sedative, cardiopulmonary, and gastrointestinal effects produced by buprenorphine and xylazine given in combination to horses. Six healthy adult horses underwent 4 randomized treatments, with an interval of 1 wk between treatments. A control group was given a saline solution intravenously (IV) and the experimental groups received buprenorphine [10 μg/kg bodyweight (BW)] in combination with 1 of 3 different doses of xylazine: 0.25 mg/kg BW (BX25), 0.50 mg/kg BW (BX50), or 0.75 mg/kg BW (BX75), all of them by IV. Cardiopulmonary parameters were evaluated for 120 min ...
Wagner AE, Mama KR, Steffey EP, Ferreira TH, Rezende ML.To compare cardiovascular effects of sevoflurane alone and sevoflurane plus an IV infusion of lidocaine in horses. Animals-8 adult horses. Methods: Each horse was anesthetized twice via IV administration of xylazine, diazepam, and ketamine. During 1 anesthetic episode, anesthesia was maintained by administration of sevoflurane in oxygen at 1.0 and 1.5 times the minimum alveolar concentration (MAC). During the other episode, anesthesia was maintained at the same MAC multiples via a reduced concentration of sevoflurane plus an IV infusion of lidocaine. Heart rate, arterial blood pressures, blood...
Pollard RE, Puchalski SM.The purpose of this report was to evaluate the frequency and type of reactions to intraarterial iodinated contrast medium injection in horses. Ninety-seven received an intraarterial injection of ionic, iodinated contrast medium for computed tomographic assessment of the distal limb. Nine (9.0%) horses developed a reaction attributable to the contrast medium administration. Of those, 4/97 (4.0%) developed a skin response (three with urticaria, one with facial edema) within 20 min. Five (5.0%) developed elevation of heart rate and/or blood pressure immediately upon administration of the contrast...
Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G.The quantification of equine left ventricular (LV) function is generally limited to short-axis M-mode measurements. However, LV deformation is 3-dimensional (3D) and consists of longitudinal shortening, circumferential shortening, and radial thickening. In human medicine, longitudinal motion is the best marker of subtle myocardial dysfunction. Objective: To evaluate the feasibility and reliability of 2-dimensional speckle tracking (2DST) for quantifying equine LV longitudinal function. Methods: Ten healthy untrained trotter horses; 9.6 ± 4.4 years; 509 ± 58 kg. Methods: Prospective study. Re...
Nagel C, Aurich J, Aurich C.Abortion and preterm birth of foals are major reasons for reproductive losses in the horse. Risk pregnancies require close supervision so that adequate treatment can be initiated in time. The aim of this study was to determine normal values in heart rate (HR) and heart rate variability (HRV) of the pregnant mare compared to her foetus and to detect physiological changes during ongoing gestation. In mares, the RR interval decreased from 1480±29 ms on day 270 of pregnancy to 1190±58 ms on day 330 of pregnancy (p<0.05). In contrast, foetal RR interval increased during the same time period from ...
Hartmann E, Christensen JW, Keeling LJ.The intensity with which a horse responds to separation from its group and subsequently to being alone is relevant for both horse and handler safety. Identification of training methods that may reduce responses to separation would be useful in practice. Objective: To investigate whether the initial presence of a familiar companion horse modifies responses to separation from the group, lowers stress levels (as measured by heart rate) and increases training efficiency. Objective: Habituation to separation proceeds more quickly if the horse is first trained with a companion, and heart rate is low...
Zeitler-Feicht MH, Streit S, Dempfle L.Comparison with regard to animal welfare of different automatic feeding systems for hay and concentrate in group housing systems for horses using parameters of ethology and physiology. Methods: Parameters of research comprised: duration of stay, frequency of visit, threatening behaviour with and without risk of injury, and avoiding behaviour as well as heart rate and injuries of the integument. 452 horses were observed at the feeding area of 32 run-out-sheds. Every group of horses was continuously observed following the pie chart system for 24 hours. Results: The "walk-through" station signifi...
Bringewatt T, Hopster K, Kästner SB, Rohn K, Ohnesorge B.The influence of a modified open lung concept (mOLC) on pulmonary and cardiovascular function during total intravenous anaesthesia (TIVA) in horses was evaluated. Forty-two warmblood horses (American Society of Anesthesiologists class 1 to 2), scheduled for elective surgery (mean [sd] weight 526 [65] kg, age 6.4 [5.4] years) were randomly divided into three groups: ventilation with mOLC, intermittent positive-pressure ventilation (IPPV), and spontaneous breathing. Premedication (0.8 mg/kg xylazine), induction (2.2 mg/kg ketamine and 0.05 mg/kg diazepam) and maintenance of anaesthesia with TIVA...
Dickey EJ, McKenzie H, Johnson A, Furr MO.Arginine vasopressin (AVP) is used in human medicine in the management of vasodilatory shock and cardiac arrest, but it is not widely used in equine neonatal intensive care because of concerns about potential side effects and suboptimal efficacy. This retrospective study reports the clinical use of AVP and norepinephrine (NE) in foals with refractory hypotension. Objective: To report the cardiovascular responses and fluid balance in critically ill, hypotensive foals receiving either NE or AVP. Methods: The medical records of neonatal foals (<7 days of age) from 2000 to 2007 admitted to the ...
Collins NM, Palmer L, Marr CM.The aim of this study was to establish reference values for a series of conventional two-dimensional (2-D) and M-mode echocardiographic variables in Thoroughbred foals at increasing age intervals. Methods: Nineteen healthy Thoroughbred foals (11 males, 8 females) were examined at 1, 2, 4, 8, 12 and 16 weeks of life. Auscultatory findings were recorded and echocardiographic examinations (2-D and M-mode) were performed. Descriptive statistical analyses, including mean, standard deviation and 95% confidence interval for the means, were used to summarise the data. The relationships between selecte...
Matsuura A, Tanaka M, Irimajiri M, Yamazaki A, Nakanowatari T, Hodate K.Horse trekking (HT) is having a stroll on a horse along a walking trail in a forest, field, and/or sandy beach. Generally in HT, horses exercise in tandem line outside the riding facilities. Because the leading horse will be confronted with stressors in the forefront, we hypothesized that the leading horse shows higher stress responses than the following one. In order to verify the hypothesis, we compared short-term stress responses between each position in six horses. Exercise consisted of 15 min of ground riding and 45 min of HT with walking and trotting. Heart rate variability was analyzed ...
Lindner A, López RA, Durante E, Hernandez H, Botta V, Sadaba S, Boffi FM.This study examined the effect of exercising horses five times per fortnight with two bouts of 5 min duration at their v(10) with 2 days between consecutive exercise sessions. Five Anglo-Arabian horses were treadmill-conditioned for 6 weeks. A standardized exercise test (SET) was performed at the beginning of the conditioning period (CP) to determine the blood lactate-running speed (BLRS) and the heart rate-running speed (HRRS) relationship and the SET was repeated every 2 weeks. After each SET, the BLRS relation was used to calculate the horse's speed (v = velocity), which produced a blood la...
Pimenta EL, Teixeira Neto FJ, Sá PA, Pignaton W, Garofalo NA.Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia. Objective: Hyoscine would induce positive chronotropism of shorter duration than atropine, without adversely impairing intestinal motility in detomidine sedated horses. Methods: Ten minutes after detomidine (0.02 mg/kg bwt, i.v.), physiological saline (control), atropine (0.02 mg/kg bwt) or hyoscine (0.2 mg/kg bwt) were randomly administered i.v. to 6 horses, allowing one week intervals between treatments. Investigators blinded to the treatments monitored cardiopulmonary data and intestinal auscultation ...
Dimaio Knych HK, Steffey EP, Stanley SD.Yohimbine is an alpha 2 adrenergic receptor antagonist, which has been shown to counteract the CNS depressant effects of alpha 2 receptor agonists in a number of species. Recently, our laboratory identified yohimbine in the absence of detectable concentrations of an alpha 2 agonist in a regulatory sample collected from a horse racing in California. This coupled with anecdotal reports of CNS stimulation and documented reports of cardiovascular changes when administered in conjunction with an agonist led us to investigate the pharmacokinetics and pharmacodynamics of yohimbine when administered a...
Muñoz A, Riber C, Trigo P, Castejón F.Arginine vasopressin (AVP) is released in response to depletion of the effective circulating blood volume. Endurance horses might develop exhaustion because loss of water and electrolytes in sweat with hypovolaemia and electrolytes abnormalities. Therefore, AVP should act in the control of volemia in these animals. This research evaluates the differences in AVP, hydration, electrolyte status and serum muscle enzymes in successful endurance horses in comparison with those eliminated from the competition because of exhaustion. Eighteen endurance horses, divided into two groups, successful (n = 1...
Southwood LL, Gassert T, Lindborg S.It is the impression of some surgeons that geriatric horses have a lower survival rate compared to mature nongeriatric horses following colic surgery. One possible reason for this is that geriatric horses may be more critically ill at admission and have more severe disease than mature nongeriatric horses. Objective: To compare admission historical, physical examination and laboratory data for geriatric and mature nongeriatric horses referred for signs of colic. Methods: Medical records of horses admitted with a presenting complaint of colic between 2000 and 2006 were reviewed. Geriatric horses...
Rezende ML, Boscan P, Stanley SD, Mama KR, Steffey EP.To characterize cardiovascular, respiratory and biochemical effects and recovery behavior associated with a 3-hour continuous infusion of a micellar microemulsion propofol formulation in horses. Methods: Prospective experimental trial. Methods: Six healthy adult horses, 9 +/- 2 years old and weighing 557 +/- 14 kg. Methods: All horses received xylazine (1 mg kg(-1), IV) 5 minutes prior to anesthetic induction. Each horse was anesthetized on two occasions with a 5% micellar microemulsion propofol formulation (2 mg kg(-1), IV); first as a single bolus (phase I) and then as a 3-hour continuous in...
Muñoz A, Riber C, Trigo P, Castejón FM, Lucas RG, Palacio J.This study investigated the effect of hypertonic dehydration on exercise in horses. Valencian draft horses (n=43) with hypertonic dehydration following water and food deprivation and competing in pulling events (COM), were compared to euhydrated horses (n=11) during a pulling exercise test (PET). Both groups were divided into bodyweight (BW) categories A (≤350 kg), B (351-450 kg), and C (≥451 kg), and pulled 2, 2.25, and 2.5 times BW, respectively. Exercise duration (ED) was 1.3±0.8 min. Heart rate, respiratory rate, rectal temperature and blood samples were taken at rest, after exercise,...
Marcilla MG, Schauvliege S, Duchateau L, Gasthuys F.To evaluate the cardiopulmonary effects of two different constant rate infusions (CRI) of dexmedetomidine (1 and 1.75 microg kg(-1 )hour(-1)) in experimental ponies. Methods: Six healthy ponies (mean 306 +/- SD 71 kg, 7.0 +/- 1.6 years). Methods: Prospective, randomized, experimental study. Methods: After premedication with intravenous (IV) dexmedetomidine (3.5 microg kg(-1)), anaesthesia was induced (T0) with ketamine (2.2 mg kg(-1) IV) and midazolam (0.06 mg kg(-1) IV) and maintained with isoflurane (Fe'ISO 1.50%) in 55% oxygen for 150 minutes. Normocapnia was maintained using artificial ven...
Schmidt A, Hödl S, Möstl E, Aurich J, Müller J, Aurich C.Domestic animals are often repeatedly exposed to the same anthropogenic stressors. Based on cortisol secretion and heart rate, it has been demonstrated that transport is stressful for horses, but so far, changes in this stress response with repeated road transport have not been reported. We determined salivary cortisol concentrations, fecal cortisol metabolites, cardiac beat-to-beat (RR) interval, and heart rate variability (HRV) in transport-naive horses (N = 8) transported 4 times over a standardized course of 200 km. Immunoreactive salivary cortisol concentrations always increased in respon...
Physick-Sheard PW, McGurrin MK.A lack of information on normal heart rhythm at maximal effort hampers investigation of poor performance and sudden death in Standardbred racing. Objective: To characterize rhythm variations during scheduled racing in clinically normal Standardbred horses. Methods: Two hundred and eighty-eight Standardbred horses competing in 40 scheduled races at a Southern Ontario racetrack. Methods: Observational study, convenience sampling: Heart rhythm was monitored by ECG from harnessing to postrace recovery and assessed visually and by examining heart rate intervals. Rhythm variations were used as respo...
Schmidt A, Aurich J, Möstl E, Müller J, Aurich C.Based on cortisol release, a variety of situations to which domestic horses are exposed have been classified as stressors but studies on the stress during equestrian training are limited. In the present study, Warmblood stallions (n=9) and mares (n=7) were followed through a 9 respective 12-week initial training program in order to determine potentially stressful training steps. Salivary cortisol concentrations, beat-to-beat (RR) interval and heart rate variability (HRV) were determined. The HRV variables standard deviation of the RR interval (SDRR), RMSSD (root mean square of successive RR di...
Dmitrović P, Vanaga J, Dupont J, Franck T, Gougnard A, Detilleux J, Kovalcuka L, Salciccia A, Serteyn D, Sandersen C.Controversy continues to surround the use of opioids in equine anaesthesia, with variable effects reported. This blinded clinical study aimed to investigate the influence of a low-dose fentanyl continuous rate infusion (CRI) on isoflurane requirements, parasympathetic tone activity (PTA), and anaesthetic parameters in horses during general anaesthesia. All of the twenty-two horses included in the research underwent a standard anaesthetic protocol. Eleven horses in the fentanyl group (Group F) received a loading dose of fentanyl at 6 µg/kg, followed by a CRI of 0.1 µg/kg/min during anaesthesi...
Nagel C, Trenk L, Wulf M, Ille N, Aurich J, Aurich C.In mares, foaling is associated with changes in hematology, plasma electrolytes, blood pressure and heart rate and it has been hypothesized that these are induced by oxytocin. To test this hypothesis, mares (n = 8-14/group) were treated with oxytocin (OT; 20 I.U.) or saline (CON) at 1 h (test A) and 12 h after foaling (test B) and during first postpartum diestrus (test C). Heart rate, heart rate variability (HRV), atrioventricular blocks, salivary cortisol concentration, blood pressure, plasma electrolytes and blood count were determined. Heart rate decreased from test A to C (P < 0.001)...
L'Ami JJ, Vermunt LE, van Loon JP, Sloet van Oldruitenborgh-Oosterbaan MM.A single dose of 40 μg/kg bodyweight (BW) of oromucosal detomidine gel was administered sublingually to 10 healthy Dutch Warmblood mares aged 7 ± 4 years (mean ± SD) and BW 580 ± 69 kg. Blood and urine samples were collected before and for 8 days following administration and evaluated qualitatively in an FEI Reference Laboratory and quantitatively in a research laboratory. Clinical effects were evaluated at baseline and for 24 h after administration. Sedation was determined using head height and scores of reaction to auditory and mixed auditory/sensory stimuli. Mechanical nociceptive thres...
Lindner A, López RA, Durante E, Hernandez H, Botta V, Sadaba S, Boffi FM.This study examined the effect of exercising horses five times per fortnight with two bouts of 5 min duration at their v(10) with 2 days between consecutive exercise sessions. Five Anglo-Arabian horses were treadmill-conditioned for 6 weeks. A standardized exercise test (SET) was performed at the beginning of the conditioning period (CP) to determine the blood lactate-running speed (BLRS) and the heart rate-running speed (HRRS) relationship and the SET was repeated every 2 weeks. After each SET, the BLRS relation was used to calculate the horse's speed (v = velocity), which produced a blood la...
Hörnicke H, von Engelhardt W, Ehrlein HJ.Carotid loops were prepared in 3 horses several months prior to the experiments. Systemic blood pressure was recorded at rest and during exercise by insertion of a plastic cannula into the carotid artery. The pressure transducer was fixed at the neck of the animal. The blood pressure signal was transmitted by telemetry. When the horses were standing under the rider, the following results were obtained: heart rate 38 +/- 5 beats-min-1, systolic pressure 115 +/- 15, disstolic pressure 83 +/- 10, mean pressure 97 +/- 12, and pulse pressure 32 +/- 9 mm Hg. During steady gallop at a mean speed of 5...
Lemasson A, Remeuf K, Trabalon M, Cuir F, Hausberger M.We investigated the possibility that stallion whinnies, known to encode caller size, also encoded information about caller arousal and fertility, and the reactions of mares in relation to type of voice. Voice acoustic features are correlated with arousal and reproduction success, the lower-pitched the stallion's voice, the slower his heart beat and the higher his fertility. Females from three study groups preferred playbacks of low-pitched voices. Hence, females are attracted by frequencies encoding for large male size, calmness and high fertility. More work is needed to explore the relative i...
Leblanc PH, Eberhart SW.This study was designed to determine whether the epidural administration of an alpha2 agonist, xylazine, would produce measurable changes in arterial blood pressure, electrocardiographic (ECG) activity and arterial blood gas values in horses. Six horses were given each of four treatments: epidural xylazine, intravenous xylazine, epidural lidocaine and epidural saline. A carotid artery catheter was used to measure arterial blood pressure and to collect samples for blood gas analysis before treatment and at intervals post treatment. Heart rate, arterial pressures, ECG activity and respiratory ra...
Bisgard GE, Orr JA, Will JA.Hemodynamic measurements were made in 6 ponies at low altitude (Madison, WI, altitude, 250 m) and after 1, 2, 4, and 6 weeks at high altitude (Climax, CO, altitude, 3,400 m). The salient findings were that ponies maintain an increased heart rate and cardiac output and develop significant pulmonary hypertension at high altitude. The average control resting mean pulmonary artery pressure (BPpul) was 25.1 mm of Hg at 250 m; this value increased to 56.3 mm of Hg after 6 weeks at 3,400 m. An additional finding was that the pulmonary vascular response to acute hypoxia seemed to increase with time at...
Hamlin MJ, Shearman JP, Hopkins WG.Various changes in physiological parameters are associated with overtraining, which can be a serious problem for human and equine athletes. A 34 week longitudinal study was conducted to investigate the effects of an acute training overload on physiological parameters in 10 Standardbred racehorses. After 24 weeks of training, horses received 8 weeks of increased workload, followed by 2 weeks recovery. Horses performed a 2400 m time trial and a progressive submaximal exercise test on alternate weeks. By the end of the heavy training period, the average time for the final 1200 m of the time trial...
Skarda RT, Muir WW, Milne DW, Gabel AA.Five healthy, mature, previously trained Standardbred horses were given no exercise (left in a stall) for 4 months, then jogged (slow exercise) for 3 weeks, and placed in a 6-week training period. Cardiac variables were measured at the beginning of training and after 14, 20, 35, and 42 days of training before and at 10, 15, 20, 25, and 30 minutes after a 1.8-km (in 3:12 +/- 2 seconds) standard, submaximal exercise test on a deep 0.53-km track. There was no significant change during the 6-week conditioning period in the following variables at rest or at any of the times observed during recovery...
Nilsfors L, Kvart C, Kallings P, Carlsten J, Bondesson U.Cardiorespiratory and sedative effects of a combination of acepromazine, xylazine and methadone were studied in the horse. Acepromazine and xylazine produced cardiovascular effects whereas methadone mainly affected respiratory rate. Decreases in heart rate, arterial blood pressure and respiratory rate were seen. Sedation was superior to that of acepromazine, xylazine or a combination of these. No serious side effects were seen.
Perkins JD, Bowen IM, Else RW, Marr CM, Mayhew IG.The parasympathetic terminal cardiac ganglia were examined in three normal horses and in five horses with grass sickness. Histopathological changes, consistent with those observed in other ganglia of horses with grass sickness, were identified in the terminal cardiac ganglia of the affected horses. A functional analysis of cardiac autonomic control by time domain analysis (TDA) of heart rate variability was applied to eight horses with grass sickness, and double-paired to 16 normal horses on the basis of their age, sex and breed, and the time of day at which the electrocardiographs were obtain...
Foreman JH, Ruemmler R.There are no peer reviewed, blinded controlled studies regarding the skeletal analgesic efficacy of intramuscularly administered meperidine in horses. Objective: Using an adjustable heart bar shoe model of equine foot pain, the objective of this study was to test the hypothesis that meperidine (pethidine) administered intramuscularly would prove more efficacious in alleviating lameness than a saline placebo. Methods: Crossover pharmacodynamic experiment. Methods: Eight healthy adult Thoroughbred horses randomly underwent weekly i.m. treatments 1 h after lameness induction: saline placebo (1â...
Knych HK, Corado CR, McKemie DS, Steffey EP.Both the potential analgesic effect and the conflicting reports describing tramadol disposition in the horse warrant further study of the pharmacokinetics of tramadol in this species. Objective: To describe the pharmacokinetics of tramadol and its metabolites, O-desmethyltramadol and N-desmethyltramadol, following i.v. administration of 3 doses to the horse. Methods: Nine adult horses received a single i.v. dose of 0.5, 1.5 and 3 mg/kg bwt tramadol. Blood samples were collected prior to and at various times up to 72 h post administration. Plasma samples were analysed using liquid chromatograph...
Durando MM, Slack J, Reef VB, Birks EK.There is interest in using pharmacological stress testing (PST) as a substitute for exercise stress testing (EST) to evaluate cardiac function in horses. Objective: To compare the effect of PST and EST on right ventricular pressure dynamics and stress echocardiography. Methods: Five horses completed a PST and EST in a randomised crossover design. High fidelity pressure transducers were placed in the right ventricle. Continuous pressure signals were digitally collected and stored, and dP/dtmax, dP/dtmin and tau calculated from these measurements. ECGs were recorded continuously for 20 h. Echoca...
Manohar M, Goetz TE, Humphrey S, Depuy T.It has been suggested that pulmonary injury and inflammation-induced histamine release from airway mast cells may contribute to exercise-induced arterial hypoxemia (EIAH). Because stress failure of pulmonary capillaries and EIAH are routinely observed in exercising horses, we examined whether preexercise administration of an H1-receptor antagonist may mitigate EIAH. Two sets of experiments, placebo (saline) and antihistaminic (tripelennamine HCl at 1.10 mg/kg iv, 15 min preexercise) studies, were carried out on seven healthy, exercise-trained Thoroughbred horses in random order 7 days apart. A...
Frank N, Buchanan BR, Elliott SB.To determine the effects of long-term oral levothyroxine sodium (L-T(4)) administration on serum thyroid hormone concentrations, thyroid gland function, clinicopathologic variables, and echocardiographic examination measurements in adult euthyroid horses. Methods: 6 healthy adult mares. Methods: Horses received L-T(4) (48 mg/d) orally for 48 weeks. Every 4 weeks, physical examinations were performed; blood samples were collected for CBC, plasma biochemical analyses, and assessments of serum total triiodothyronine (tT(3)) and thyroxine (tT(4)) concentrations. Plasma creatine kinase MB activity ...
Huang YH, Lyle JV, Ab Razak AS, Nandi M, Marr CM, Huang CL, Aston PJ, Jeevaratnam K.Atrial fibrillation (AF) is a common cardiac arrhythmia in both human and equine populations. It is associated with adverse outcomes in humans and decreased athletic performance in both populations. Paroxysmal atrial fibrillation (PAF) presents with intermittent, self-terminating AF episodes, and is difficult to diagnose once sinus rhythm resumes. Unassigned: We aimed to detect PAF subjects from normal sinus rhythm equine electrocardiograms (ECGs) using the Symmetric Projection Attractor Reconstruction (SPAR) method to encapsulate the waveform morphology and variability as the basis of a machi...
Winchell WW, Hardy J, Levine DM, Parker TS, Gordon BR, Saal SD.To evaluate the effect of a phospholipid emulsion (PLE) on the initial response of horses to administration of endotoxin. Methods: 12 healthy adult horses. Methods: Horses were assigned to 2 treatment groups (6 horses/group). The control group was administered 1 L of saline (0.9% NaCl) solution, and the treated group was administered PLE (200 mg/kg, IV); treatments were administered during a period of 120 minutes. An infusion of endotoxin was initiated in both groups starting 1 hour after initiation of the saline or PLE solutions. Physical examination and hemodynamic variables were recorded, a...
Jones JH, Cox KS, Takahashi T, Hiraga A, Yarbrough TB, Pascoe JR.We determined whether the caudodorsal region of the intrapleural space in exercising horses experiences larger pressure fluctuations than other regions and whether systematic phase-shifting of peak intrapleural pressures along the length of the thorax suggests the existence of locomotor-induced intrapleural pressure waves. We utilised percutaneous introducers and solid-state pressure-tip transducers implanted along the dorsal aspect of the thorax, mid-thorax or oesophagus to measure regional intrapleural pressures while 3 horses galloped on a flat treadmill at 13-14 m/s, then recorded pressure...
Caivano D, Corda A, Rishniw M, Giorgi ME, Parpaglia MLP, Conti MB, Porciello F, Birettoni F.Equine cardiovascular structures and function are routinely assessed by transthoracic echocardiography. Recently, investigators have described the echocardiographic visualization of equine pulmonary vein ostia. In companion animals, the right pulmonary vein (RPV) to right pulmonary artery (RPA) ratio has been used as an index to estimate the severity of cardiac diseases resulting in left ventricular volume overload. We sought to assess the feasibility of measuring RPV and RPA dimensions, and sought to provide various previously examined RPV and RPA variables in clinically healthy horses that c...
Nyman G, Grubb TL, Heinonen E, Frendin J, Edner A, Malavasi LM, Frostell C, Högman M.The study aimed to investigate the effect of varying pulse lengths of inhaled nitric oxide (iNO), and 2.5 hours of continuous pulse-delivered iNO on pulmonary gas exchange in anaesthetized horses. Methods: Experimental study. Methods: Six Standardbred horses. Methods: Horses received acepromazine, detomidine, guaifenesin, thiopentone and isoflurane in oxygen, were positioned in dorsal recumbency and were breathing spontaneously. iNO was on average pulsed during the first 20, 30, 43 or 73% of the inspiration in 15 minute steps. The pulse length that corresponded to the highest (peak) partial pr...
Baska-Vincze B, Baska F, Szenci O.Monitoring fetal heart rate (FHR) and fetal heart rate variability (FHRV) helps to understand and evaluate normal and pathological conditions in the foal. The aim of this study was to establish normal heart rate reference values for the ongoing equine pregnancy and to perform a heart rate variability (HRV) time-domain analysis in Lipizzaner mares. Seventeen middle- and late-term (days 121-333) pregnant Lipizzaner mares were examined using fetomaternal electrocardiography (ECG). The mean FHR (P = 0.004) and the standard deviation of FHR (P = 0.012) significantly decreased during the pregnancy. ...