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Topic:Human Health

The relationship between human health and horses encompasses various aspects of interaction, including therapeutic, occupational, and zoonotic elements. Equine-assisted therapy is utilized in some therapeutic settings to support mental and physical health in humans, leveraging the horse's role in facilitating emotional and physical rehabilitation. Occupational health considerations arise for individuals working with horses, addressing potential risks such as injuries and allergic reactions. Additionally, zoonotic diseases, which can be transmitted between horses and humans, are an area of concern for public health, necessitating research into prevention and control measures. This page compiles peer-reviewed research studies and scholarly articles that explore the multifaceted connections between human health and horses, focusing on therapeutic applications, occupational health, and zoonotic disease dynamics.
Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments.
Zoonoses and public health    March 25, 2018   Volume 65, Issue 5 519-527 doi: 10.1111/zph.12462
Adams RJ, Kim SS, Mollenkopf DF, Mathys DA, Schuenemann GM, Daniels JB, Wittum TE.Antimicrobial-resistant bacteria represent an important concern impacting both veterinary medicine and public health. The rising prevalence of extended-spectrum beta-lactamase (ESBL), AmpC beta-lactamase, carbapenemase (CRE) and fluoroquinolone-resistant Enterobacteriaceae continually decreases the efficiency of clinically important antibiotics. Moreover, the potential for zoonotic transmission of antibiotic-resistant enteric bacteria increases the risk to public health. Our objective was to estimate the prevalence of specific antibiotic-resistant bacteria on human contact surfaces in various ...
Alphaviruses: Serological Evidence of Human Infection in Paraguay (2012-2013).
Vector borne and zoonotic diseases (Larchmont, N.Y.)    March 13, 2018   Volume 18, Issue 5 266-272 doi: 10.1089/vbz.2017.2178
Alphaviruses can produce febrile illness and encephalitis in dead-end hosts such as horses and humans. Within this genus, the Venezuelan Equine Encephalitis virus (VEEV) complex includes pathogenic epizootic subtypes and enzootic subtypes that are not pathogenic in horses (except subtype IE, Mexican strains), although they can cause febrile symptoms in humans. The Rio Negro virus (RNV-VEEV subtype VI) circulates in Argentina, where it was associated with undifferentiated febrile illness. Mayaro (MAYV) and Una (UNAV) viruses belong to a different group, the Semliki Forest virus complex, with co...
Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer.
Allergy    February 27, 2018   Volume 73, Issue 7 1436-1446 doi: 10.1111/all.13417
Einhorn L, Hofstetter G, Brandt S, Hainisch EK, Fukuda I, Kusano K, Scheynius A, Mittermann I, Resch-Marat Y, Vrtala S, Valenta R, Marti E, Rhyner C....Companion animals are also affected by IgE-mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles. Methods: Custom-designed allergen microarray was produced on the basis of the ImmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity. The included horse patients were diagnosed for eczema due to insect bite hypersensitivity, chronic coughing, recurrent airway obstructio...
Targeting gait and life quality in persons with Parkinson’s disease: Potential benefits of Equine-Assisted Interventions.
Parkinsonism & related disorders    December 11, 2017   Volume 47 94-95 doi: 10.1016/j.parkreldis.2017.12.003
Peppe A, Costa A, Cerino S, Caltagirone C, Alleva E, Borgi M, Cirulli F.No abstract available
The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.
International journal of molecular sciences    December 5, 2017   Volume 18, Issue 12 2612 doi: 10.3390/ijms18122612
Bullone M, Lavoie JP.Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure an...
High Occurrence of Methicillin-Resistant Staphylococcus aureus in Horses at Slaughterhouses Compared with Those for Recreational Activities: A Professional and Food Safety Concern?
Foodborne pathogens and disease    October 25, 2017   Volume 14, Issue 12 735-741 doi: 10.1089/fpd.2017.2300
Parisi A, Caruso M, Normanno G, Latorre L, Miccolupo A, Fraccalvieri R, Intini F, Manginelli T, Santagada G.The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in horses and its zoonotic potential is poorly understood. The objective of this study is to provide data on the prevalence and genetic characteristics of MRSA isolated from horses on farms, at racecourses, and at slaughterhouses in Italy, using standard and molecular methods. In addition, we report the prevalence of MRSA in horse handlers. Among 388 horses tested by nasal swabs, 27 (7%) were positive for MRSA ST398 (t011, t899, t1255) and ST1 (t127). The prevalence of MRSA in horses tested at slaughterhouses was significan...
Equine chlamydiosis-An emerging infectious disease requiring a one health surveillance approach.
Zoonoses and public health    October 5, 2017   Volume 65, Issue 1 218-221 doi: 10.1111/zph.12391
Taylor KA, Durrheim D, Heller J, O'Rourke B, Hope K, Merritt T, Freeman P, Chicken C, Carrick J, Branley J, Massey P.Psittacosis is a rare but potentially fatal zoonosis caused by Chlamydia psittaci, an organism that is typically associated with bird contact. However C. psittaci is capable of infecting other non-avian hosts, such as horses, sheep, cattle and goats. Stud staff and veterinarians have significant exposure to parturient animals and reproductive materials in their routine work. To investigate the zoonotic potential associated with the emergence of C. psittaci as an abortifacient agent in horses, we established a programme of joint human and animal surveillance in a sentinel horse-breeding regio...
Emerging arboviruses in Quebec, Canada: assessing public health risk by serology in humans, horses and pet dogs.
Epidemiology and infection    September 28, 2017   Volume 145, Issue 14 2940-2948 doi: 10.1017/S0950268817002205
Rocheleau JP, Michel P, Lindsay LR, Drebot M, Dibernardo A, Ogden NH, Fortin A, Arsenault J.Periodic outbreaks of West Nile virus (WNV), Eastern equine encephalitis virus (EEEV) and to a lesser extent, California serogroup viruses (CSGV), have been reported in parts of Canada in the last decade. This study was designed to provide a broad assessment of arboviral activity in Quebec, Canada, by conducting serological surveys for these arboviruses in 196 horses, 1442 dogs and 485 humans. Sera were screened by a competitive enzyme linked immunosorbent assay and positive samples confirmed by plaque reduction neutralisation tests. The percentage of seropositive samples was 83·7%, 16·5%, 7...
Australian horse owners and their biosecurity practices in the context of Hendra virus.
Preventive veterinary medicine    September 28, 2017   Volume 148 28-36 doi: 10.1016/j.prevetmed.2017.09.013
Wiethoelter AK, Schembri N, Dhand NK, Sawford K, Taylor MR, Moloney B, Wright T, Kung N, Field HE, Toribio JLML.In recent years, outbreaks of exotic as well as newly emerging infectious diseases have highlighted the importance of biosecurity for the Australian horse industry. As the first potentially fatal zoonosis transmissible from horses to humans in Australia, Hendra virus has emphasised the need to incorporate sound hygiene and general biosecurity practices into day-to-day horse management. Recommended measures are widely publicised, but implementation is at the discretion of the individual owner. This cross-sectional study aimed to determine current levels of biosecurity of horse owners and to ide...
A Brief Account of the Discovery of the Fetal/Placental Unit for Estrogen Production in Equine and Human Pregnancies: Relation to Human Medicine.
The Yale journal of biology and medicine    September 25, 2017   Volume 90, Issue 3 449-461 
Raeside JI.The role of steroids in human medicine is well recognized, but the major contributions made by the large domestic animals as a source of material in the discovery, isolation, and determination of the structure of the steroid hormones is less well appreciated. After a brief reminder of the early efforts to obtain a reliable source of steroids for clinical use, the narrative here is to outline one example where success was ultimately achieved for estrogen replacement therapy. Whereas knowledge of the high concentrations of estrogens in urine of pregnant women and mares dates from the late 1920s,...
Ultrasensitive and rapid immuno-detection of human IgE anti-therapeutic horse sera using an electrochemical immunosensor.
Analytical biochemistry    September 14, 2017   Volume 538 13-19 doi: 10.1016/j.ab.2017.09.008
Prado IC, Souza ALA, Provance DW, Cassella RJ, De-Simone SG.Antivenom allergy disease mediated by patient IgE is an important public health care concern. To improve detection of hypersensitive individuals prior to passive antibody therapy, an amperometric immunosensor was developed to detect reactive human IgE. Whole horse IgG3 (hoIgG3) was immobilized onto the surface of carbon or gold screen-printed electrodes through a cross-linking solution of glutaraldehyde on a chitosan film. Sera from persons with a known allergic response to hoIgG3 or non-allergic individuals was applied to the sensor. Bound human IgE (humIgE) was detected by an anti-humIgE ant...
Anaphylaxis to horses and epinephrine use: Increasing awareness among pediatric patients and families.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology    August 7, 2017   Volume 28, Issue 6 608-610 doi: 10.1111/pai.12753
Cosme-Blanco W, López-Medina E, Morales-Bronner S, Blouin W, Hernandez-Trujillo V.No abstract available
Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO).
Multiple sclerosis (Houndmills, Basingstoke, England)    August 3, 2017   Volume 24, Issue 10 1375-1382 doi: 10.1177/1352458517721354
Vermöhlen V, Schiller P, Schickendantz S, Drache M, Hussack S, Gerber-Grote A, Pöhlau D.Evidence-based complementary treatment options for multiple sclerosis (MS) are limited. To investigate the effect of hippotherapy plus standard care versus standard care alone in MS patients. A total of 70 adults with MS were recruited in five German centers and randomly allocated to the intervention group (12 weeks of hippotherapy) or the control group. Primary outcome was the change in the Berg Balance Scale (BBS) after 12 weeks, and further outcome measures included fatigue, pain, quality of life, and spasticity. Covariance analysis of the primary endpoint resulted in a mean difference ...
Special issue on racehorse pathology: In the service of equine and human welfare. Uzal FA, Kennedy LA, Maxie G.No abstract available
Nematode Species Identification-Current Status, Challenges and Future Perspectives for Cyathostomins.
Frontiers in cellular and infection microbiology    June 28, 2017   Volume 7 283 doi: 10.3389/fcimb.2017.00283
Bredtmann CM, Krücken J, Murugaiyan J, Kuzmina T, von Samson-Himmelstjerna G.Human and animal health is globally affected by a variety of parasitic helminths. The impact of co-infections and development of anthelmintic resistance requires improved diagnostic tools, especially for parasitic nematodes e.g., to identify resistant species or attribute pathological effects to individual species or particular species combinations. In horses, co-infection with cyathostomins is rather a rule than an exception with typically 5 to 15 species (out of more than 40 described) per individual host. In cyathostomins, reliable morphological species differentiation is currently limited ...
Comprehensive qualification and quantification of triacylglycerols with specific fatty acid chain composition in horse adipose tissue, human plasma and liver tissue.
Talanta    May 19, 2017   Volume 172 206-214 doi: 10.1016/j.talanta.2017.05.042
Guan M, Dai D, Li L, Wei J, Yang H, Li S, Zhang Y, Lin Y, Xiong S, Zhao Z.High levels of triacylglycerols (TGs) have been linked to cardiovascular disease and liver diseases. Comprehensively analyzing TGs is helpful to understand the TGs functions in these diseases. However, due to the existence of a large number of isomers TGs and the lack of commercial standards, precise analysis of individual triacylglycerol (TG) with specific fatty acid chain composition is full of challenge. In this work, ultra-performance liquid chromatography (UPLC) coupled with electrospray ionization (ESI) mass spectrometry (MS) were employed for comprehensive qualification and quantificati...
‘It just opens up their world’: autism, empathy, and the therapeutic effects of equine interactions.
Anthropology & medicine    May 17, 2017   Volume 25, Issue 2 220-234 doi: 10.1080/13648470.2017.1291115
Malcolm R, Ecks S, Pickersgill M.Experiences of autism-spectrum disorder are now increasingly studied by social scientists. Human-animal relations have also become a major focus of social inquiry in recent years. Examining horse-assisted therapy for autistic spectrum disorders, this is the first paper that brings these fields together. Drawing on participant observation and interviews at a UK horse therapy Centre, this article examines how staff and the parents of riders account for the successes and limitations of equine therapy. To the respondents, horses 'open up' autistic children and make possible interactions that seeme...
Difficulties experienced by veterinarians when communicating about emerging zoonotic risks with animal owners: the case of Hendra virus.
BMC veterinary research    February 18, 2017   Volume 13, Issue 1 56 doi: 10.1186/s12917-017-0970-2
Mendez DH, Büttner P, Kelly J, Nowak M, Speare Posthumously R.Communication skills are essential for veterinarians who need to discuss animal health related matters with their clients. When dealing with an emerging zoonosis, such as Hendra virus (HeV), veterinarians also have a legal responsibility to inform their clients about the associated risks to human health. Here we report on part of a mixed methods study that examined the preparedness of, and difficulties experienced by, veterinarians communicating about HeV-related risks with their clients. Methods: Phase 1 was an exploratory, qualitative study that consisted of a series of face-to-face, semi-st...
Multilocus sequence typing identifies an avian-like Chlamydia psittaci strain involved in equine placentitis and associated with subsequent human psittacosis.
Emerging microbes & infections    February 15, 2017   Volume 6, Issue 2 e7 doi: 10.1038/emi.2016.135
Jelocnik M, Branley J, Heller J, Raidal S, Alderson S, Galea F, Gabor M, Polkinghorne A.No abstract available
Allergenicity of milk of different animal species in relation to human milk.
Postepy higieny i medycyny doswiadczalnej (Online)    December 31, 2016   Volume 70 1451-1459 doi: 10.5604/17322693.1227842
Pastuszka R, Barłowska J, Litwińczuk Z.Protein content in cow milk (with over 20 proteins, and peptides may also occur as a result of enzymatic hydrolysis) ranges from 2.5% to 4.2% and is about 1.5-2 times higher than in human milk. Its most important allergens are considered to be β-lactoglobulin (absent in human milk) and αs1-casein. The most similar in composition to human milk is horse and donkey milk. It contains considerably more whey proteins (35-50%) than cow milk (about 20%), and the concentration of the most allergenic casein fraction αs1 is 1.5-2.5 g/l. In comparison, the content of αs1-casein in cow milk is about 10...
Characterizing areas of potential human exposure to eastern equine encephalitis virus using serological and clinical data from horses.
Epidemiology and infection    December 1, 2016   Volume 145, Issue 4 667-677 doi: 10.1017/S0950268816002661
Rocheleau JP, Arsenault J, Ogden NH, Lindsay LR, Drebot M, Michel P.Eastern equine encephalitis (EEE) is a rare but severe emerging vector-borne disease affecting human and animal populations in the northeastern United States where it is endemic. Key knowledge gaps remain about the epidemiology of EEE virus (EEEV) in areas where its emergence has more recently been reported. In Eastern Canada, viral activity has been recorded in mosquitoes and horses throughout the 2000s but cases of EEEV in humans have not been reported so far. This study was designed to provide an assessment of possible EEEV human exposure by modelling environmental risk factors for EEEV in ...
Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.
Journal of virology    November 14, 2016   Volume 90, Issue 23 10670-10681 doi: 10.1128/JVI.01634-16
Anggakusuma , Brown RJP, Banda DH, Todt D, Vieyres G, Steinmann E, Pietschmann T.Multiple novel members of the genus Hepacivirus have recently been discovered in diverse mammalian species. However, to date, their replication mechanisms and zoonotic potential have not been explored in detail. The NS3/4A serine protease of hepatitis C virus (HCV) is critical for cleavage of the viral polyprotein. It also cleaves the cellular innate immune adaptor MAVS, thus decreasing interferon (IFN) production and contributing to HCV persistence in the human host. To investigate the conservation of fundamental aspects of the hepaciviral life cycle, we explored if MAVS cleavage and suppress...
West Nile virus ‘circulation’ in Vojvodina, Serbia: Mosquito, bird, horse and human surveillance.
Molecular and cellular probes    October 21, 2016   Volume 31 28-36 doi: 10.1016/j.mcp.2016.10.011
Efforts to detect West Nile virus (WNV) in the Vojvodina province, northern Serbia, commenced with human and mosquito surveillance in 2005, followed by horse (2009) and wild bird (2012) surveillance. The knowledge obtained regarding WNV circulation, combined with the need for timely detection of virus activity and risk assessment resulted in the implementation of a national surveillance programme integrating mosquito, horse and bird surveillance in 2014. From 2013, the system showed highly satisfactory results in terms of area specificity (the capacity to indicate the spatial distribution of t...
Neutral solute transport across osteochondral interface: A finite element approach.
Journal of biomechanics    October 19, 2016   Volume 49, Issue 16 3833-3839 doi: 10.1016/j.jbiomech.2016.10.015
Arbabi V, Pouran B, Weinans H, Zadpoor AA.Investigation of the solute transfer across articular cartilage and subchondral bone plate could nurture the understanding of the mechanisms of osteoarthritis (OA) progression. In the current study, we approached the transport of neutral solutes in human (slight OA) and equine (healthy) samples using both computed tomography and biphasic-solute finite element modeling. We developed a multi-zone biphasic-solute finite element model (FEM) accounting for the inhomogeneity of articular cartilage (superficial, middle and deep zones) and subchondral bone plate. Fitting the FEM model to the concentra...
Intensity modulated radiation therapy for women with gynecologic cancers: this horse is also already out of the barn.
Gynecologic oncology    September 22, 2016   Volume 143, Issue 1 1-2 doi: 10.1016/j.ygyno.2016.09.007
Kamrava M.No abstract available
Occupational allergy to horse allergens: More than exposure to horses!
International journal of occupational medicine and environmental health    August 16, 2016   Volume 29, Issue 5 721-723 doi: 10.13075/ijomeh.1896.00770
No abstract available
[Dangerous animals].
Duodecim; laaketieteellinen aikakauskirja    August 16, 2016   Volume 132, Issue 13-14 1247-1251 
Koljonen V, Söderlund T, Mäkisalo H, Gissler M.Contacts between humans and animals inevitably involve encounters possibly resulting in the human being injured. During the period of 2000 to 2014 almost 90 people died in this kind of conflict in Finland. Of these deaths, one third were associated with horses. In addition, over the same period 85 people died in traffic accidents in which an animal was hit by a car. Accidents requiring hospitalization occurred for approx. 8 000 people.
Estimating the economic impact of a possible equine and human epidemic of West Nile virus infection in Belgium.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin    August 16, 2016   Volume 21, Issue 31 doi: 10.2807/1560-7917.ES.2016.21.31.30309
Humblet MF, Vandeputte S, Fecher-Bourgeois F, Léonard P, Gosset C, Balenghien T, Durand B, Saegerman C.This study aimed at estimating, in a prospective scenario, the potential economic impact of a possible epidemic of WNV infection in Belgium, based on 2012 values for the equine and human health sectors, in order to increase preparedness and help decision-makers. Modelling of risk areas, based on the habitat suitable for Culex pipiens, the main vector of the virus, allowed us to determine equine and human populations at risk. Characteristics of the different clinical forms of the disease based on past epidemics in Europe allowed morbidity among horses and humans to be estimated. The main costs ...
Amiata Donkey Milk Chain: Animal Health Evaluation and Milk Quality.
Italian journal of food safety    August 3, 2016   Volume 5, Issue 3 5951 doi: 10.4081/ijfs.2016.5951
Ragona G, Corrias F, Benedetti M, Paladini M, Salari F, Altomonte L, Martini M.This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological examination; cervical swabs for the detection of bacteria causing reproductive disorders; and blood samples for serological diagnosis of main zoonotic (Brucella spp., Leptospira spp.) and donkey abortion agents (Brucella spp., Leptospira spp., Salmonella abortus equi, Equine viral arterithis virus, Equine herpesvirus type 1). In addition, indiv...
Assessment of regeneration in meniscal lesions by use of mesenchymal stem cells derived from equine bone marrow and adipose tissue.
American journal of veterinary research    June 28, 2016   Volume 77, Issue 7 779-788 doi: 10.2460/ajvr.77.7.779
González-Fernández ML, Pérez-Castrillo S, Sánchez-Lázaro JA, Prieto-Fernández JG, López-González ME, Lobato-Pérez S, Colaço BJ, Olivera ER....OBJECTIVE To assess the ability to regenerate an equine meniscus by use of a collagen repair patch (scaffold) seeded with mesenchymal stem cells (MSCs) derived from bone marrow (BM) or adipose tissue (AT). SAMPLE 6 female Hispano-Breton horses between 4 and 7 years of age; MSCs from BM and AT were obtained for the in vitro experiment, and the horses were subsequently used for the in vivo experiment. PROCEDURES Similarities and differences between MSCs derived from BM or AT were investigated in vitro by use of cell culture. In vivo assessment involved use of a meniscus defect and implantation o...
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