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Topic:Orthopedics

Orthopedics in horses involves the study and treatment of disorders affecting the musculoskeletal system, including bones, joints, ligaments, tendons, and muscles. This field addresses a range of conditions, from developmental disorders and degenerative diseases to traumatic injuries. Common orthopedic issues in horses include fractures, osteoarthritis, tendonitis, and ligament injuries. Diagnostic techniques such as radiography, ultrasonography, and MRI are employed to assess these conditions. Treatment options may include surgical intervention, physical therapy, and pharmacological management. This page compiles peer-reviewed research studies and scholarly articles that explore the diagnosis, treatment, and management of orthopedic conditions in equine patients.
Surgical versus conservative management of osteochondrosis.
Veterinary journal (London, England : 1997)    June 7, 2013   Volume 197, Issue 1 19-28 doi: 10.1016/j.tvjl.2013.03.037
McIlwraith CW.The paper reviews current knowledge on conservative versus surgical options for the treatment of osteochondrosis entities in the horse. Clinical and radiographic signs of each significant osteochondrosis entity in the horse are presented, followed by the value of conservative treatment versus arthroscopic surgery options as well as the results for each option with the various entities. The entities presented in detail include, osteochondritis dissecans (OCD) of the femoropatellar, tarsocrural, metacarpophalangeal and metatarsophalangeal, and glenohumural articulations. The various treatment op...
Bone mineral density (BMD) and computer tomographic measurements of the equine proximal phalanx in correlation with breaking strength.
Polish journal of veterinary sciences    May 23, 2013   Volume 16, Issue 1 3-8 doi: 10.2478/pjvs-2013-0001
Tóth P, Horváth C, Ferencz V, Tóth B, Váradi A, Szenci O, Bodó G.Despite the fact that bone mineral density (BMD) is an important fracture risk predictor in human medicine, studies in equine orthopedic research are still lacking. We hypothesized that BMD correlates with bone failure and fatigue fractures of this bone. Thus, the objectives of this study were to measure the structural and mechanical properties of the proximal phalanx with dual energy X-ray absorptiometry (DXA), to correlate the data obtained from DXA and computer tomography (CT) measurements to those obtained by loading pressure examination and to establish representative region of interest (...
Mesenchymal stem cell therapy in horses: useful beyond orthopedic injuries?
The veterinary quarterly    May 22, 2013   Volume 33, Issue 4 234-241 doi: 10.1080/01652176.2013.800250
De Schauwer C, Van de Walle GR, Van Soom A, Meyer E.In the past decade, mesenchymal stem cells (MSC) have received much attention in equine veterinary medicine. The first therapeutic use of equine MSC was reported in 2003. Since then, the clinical application of MSC has been exploding with thousands of horses now treated worldwide. At present, MSC are mainly used in veterinary medicine to treat musculoskeletal diseases based on their ability to differentiate into various tissues of mesodermal origin. This is in marked contrast to human medicine, where MSC therapies are primarily focused on immune-mediated, inflammatory, and ischemic diseases. I...
Study design for the investigation of likely aetiological factors of juvenile osteochondral conditions (JOCC) in foals and yearlings.
Veterinary journal (London, England : 1997)    April 30, 2013   Volume 197, Issue 1 36-43 doi: 10.1016/j.tvjl.2013.03.039
Robert C, Valette JP, Jacquet S, Lepeule J, Denoix JM.The possible aetiology of osteochondrosis and, to a lesser extent, other developmental orthopaedic diseases or juvenile osteochondral conditions (JOCC), has been intensively investigated. However, most studies have focused on single factors of this multi-factorial disorder, or have been conducted under experimental conditions. This paper aims to present and discuss the scientific background of the BOSAC (Breeding, Osteochondral Status and Athletic Career) research program, a multi-factorial investigation on JOCC risk factors in field conditions. The epidemiology of JOCC in horses born in Norma...
Prevalence of clinical findings at examinations of young Swedish warmblood riding horses.
Acta veterinaria Scandinavica    April 18, 2013   Volume 55, Issue 1 34 doi: 10.1186/1751-0147-55-34
Jönsson L, Roepstorff L, Egenvall A, Näsholm A, Dalin G, Philipsson J.Soundness of an individual horse is important for animal welfare and owner economy. However, knowledge of health status in normal horse populations is limited due to lack of systematic health recordings. The aim of the investigation was to study the prevalence of veterinary clinical findings in 4-5-year-old Swedish warmblood riding horses, and their influence on overall health scores, where associations to future longevity has been indicated. Results: The prevalence of clinical findings in 8,281 horses examined during 1983-2005 was studied according to a standardised protocol and related to ov...
Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses.
American journal of veterinary research    March 28, 2013   Volume 74, Issue 4 550-556 doi: 10.2460/ajvr.74.4.550
Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR.To determine the pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Methods: 8 healthy horses. Methods: A single dose of zoledronic acid (0.057 mg/kg, IV) was administered during a 30-minute period. Venous blood was collected at several time points. Zoledronic acid concentration in plasma was measured by liquid chromatography-tandem mass spectrometry, and pertinent pharmacokinetic parameters were determined. Plasma was analyzed for total calcium, BUN, and creatinine concentrations and a marker for bone resorption (C-terminal telopeptides of type I collagen). Results: ...
[Orthopedics and head shaking at the Voorjaarsdagen].
Tijdschrift voor diergeneeskunde    March 22, 2013   Volume 138, Issue 3 152-153 
van Overbeeke J.No abstract available
Equine hoof slip distance during trot at training speed: comparison between kinematic and accelerometric measurement techniques.
Veterinary journal (London, England : 1997)    March 13, 2013   Volume 197, Issue 2 198-204 doi: 10.1016/j.tvjl.2013.02.004
Holden-Douilly L, Pourcelot P, Desquilbet L, Falala S, Crevier-Denoix N, Chateau H.Longitudinal sliding of horse's hooves at the beginning of stance can affect both performance and orthopaedic health. The objective of this study was to compare two measurement methods for quantifying hoof slip distances at training trot. The right front hoof of four French Trotters was equipped with an accelerometer (10 kHz) and kinematic markers. A firm wet sand track was equipped with a 50 m calibration corridor. A high-frequency camera (600 Hz) was mounted in a vehicle following each horse trotting at about 7 m/s. One of the horses was also trotted on raw dirt and harrowed dirt tracks. Lon...
Genetic analysis of clinical findings at health examinations of young Swedish warmblood riding horses.
Acta veterinaria Scandinavica    March 8, 2013   Volume 55, Issue 1 22 doi: 10.1186/1751-0147-55-22
Jönsson L, Näsholm A, Roepstorff L, Egenvall A, Dalin G, Philipsson J.Soundness is important for welfare and utility of the riding horse. Musculoskeletal disorders are the most common causes of interruption in training and of culling. Despite great importance, heritability of a majority of health traits in horses has previously not been estimated. The objective was to perform genetic analyses of medical and orthopaedic health traits in young riding horses, including estimates of heritability and genetic correlations between health traits, and to reveal possibilities for genetic evaluation of stallions for progeny health. Results: The heritability of health trait...
Do developmental orthopaedic disorders influence future jumping performances in Warmblood stallions?
Equine veterinary journal    January 24, 2013   Volume 45, Issue 5 578-581 doi: 10.1111/evj.12027
Verwilghen DR, Janssens S, Busoni V, Pille F, Johnston C, Serteyn D.Few reports are available on the relationship between developmental orthopaedic diseases (DOD) and future performances in Warmblood horses. Objective: To investigate the relationship between performance and the presence of DOD lesions. Methods: Records of Warmblood stallions for which radiographic and performance data were available were collected. Showjumping performances were expressed as scores derived from the final ranking of horses in each competition. These scores are available in an established performance database. The relationship between radiographic findings and both performance sc...
Equine cellular therapy–from stall to bench to bedside?
Cytometry. Part A : the journal of the International Society for Analytical Cytology    October 18, 2012   Volume 83, Issue 1 103-113 doi: 10.1002/cyto.a.22216
Burk J, Badylak SF, Kelly J, Brehm W.Pioneering clinical stem cell research is being performed in the horse, a recipient of cutting edge veterinary medicine as well as a unique animal model, paving the way for human medical applications. Although demonstrable progress has been made on the clinical front, in vitro characterization of equine stem cells is still in comparatively early stages. To translate the promising results of clinical stem cell therapy in the horse, advances must be made in the characterization of equine stem cells. Aiming to improve communication between veterinarians and other natural scientists, this review g...
Early experience with continuous positive airway pressure (CPAP) in 5 horses — a case series.
The Canadian veterinary journal = La revue veterinaire canadienne    October 2, 2012   Volume 53, Issue 4 426-429 
MacFarlane PD, Mosing M.This case series is the first report of the use of CPAP (continuous positive airway pressure) ventilation in adult horses. Two horses and 3 ponies anesthetized for orthopedic procedures in lateral recumbency received 10 cm H(2)O CPAP. During anesthesia, arterial oxygen partial pressure tended to increase and arterial carbon dioxide pressure tended to increase despite increased minute ventilation index. The measured cardiovascular parameters were within physiologic limits. Cette série de cas est le premier rapport sur l’utilisation de la ventilation spontanée en pression positive continue ...
Comparison of isolation and expansion techniques for equine osteogenic progenitor cells from periosteal tissue. McD○ LA.Stem cell therapy and cell-based therapies using other progenitor cells are becoming the treatment of choice for many equine orthopedic lesions. Important criteria for obtaining autogenous equine progenitor cells in vitro for use in clinical cell-based therapy include the ability to isolate and expand cells repeatedly to high numbers (millions) required for therapy, in a clinically relevant time frame. Cells must also maintain their ability to differentiate into the tissue type of choice. The objective of this study was to compare isolation and expansion techniques for preparation of periostea...
Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?
Sports medicine (Auckland, N.Z.)    September 12, 2012   Volume 42, Issue 10 871-890 doi: 10.1007/BF03262300
Spaas JH, Guest DJ, Van de Walle GR.Tendon injuries are one of the most common orthopaedic problems in both human and equine athletes. When a damaged tendon heals naturally, it loses a substantial part of the original strength and elasticity. Therefore, tendons recover structurally (reparation) but not functionally (regeneration) after conservative medical or surgical treatment. Since the structure and matrix composition of human and equine tendons share many similarities, the nature of tendon injuries are also strongly comparable in both species. Therefore, the evaluation of regenerative therapies in horses may have application...
A computer-assisted microscopic analysis of bone tissue developed inside a polyactive polymer implanted into an equine articular surface.
Histology and histopathology    July 19, 2012   Volume 27, Issue 9 1203-1209 doi: 10.14670/HH-27.1203
Albert R, Vásárhelyi G, Bodó G, Kenyeres A, Wolf E, Papp T, Terdik T, Módis L, Felszeghy S.One of the most promising applications for the restoration of small or moderately sized focal articular lesions is mosaicplasty (MP). Although recurrent hemarthrosis is a rare complication after MP, recently, various strategies have been designed to find an effective filling material to prevent postoperative bleeding from the donor site. The porous biodegradable polymer Polyactive (PA; a polyethylene glycol terephthalate - polybutylene terephthalate copolymer) represents a promising solution in this respect. A histological evaluation of the longterm PA-filled donor sites obtained from 10 exper...
Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles.
Osteoarthritis and cartilage    July 7, 2012   Volume 20, Issue 10 1147-1151 doi: 10.1016/j.joca.2012.06.005
Malda J, Benders KE, Klein TJ, de Grauw JC, Kik MJ, Hutmacher DW, Saris DB, van Weeren PR, Dhert WJ.Articular cartilage defects are common after joint injuries. When left untreated, the biomechanical protective function of cartilage is gradually lost, making the joint more susceptible to further damage, causing progressive loss of joint function and eventually osteoarthritis (OA). In the process of translating promising tissue-engineering cartilage repair approaches from bench to bedside, pre-clinical animal models including mice, rabbits, goats, and horses, are widely used. The equine species is becoming an increasingly popular model for the in vivo evaluation of regenerative orthopaedic ap...
Effect of sequential removal of parts of the second metacarpal bone on the biomechanical stability of the equine carpus.
Veterinary surgery : VS    June 25, 2012   Volume 41, Issue 7 862-868 doi: 10.1111/j.1532-950X.2012.01011.x
Seabaugh KA, Hubert JD, Kawcak CE, McGilvray KC, Santoni BG, Rao S, Baxter GM.To quantify changes in biomechanical stability and stiffness within the equine carpus after removal of 50%, 80%, and 100% of the second metacarpal bone (MC2). Methods: In vitro biomechanical study. Methods: Cadaveric equine forelimbs (n = 16) were evaluated. Intact constructs were loaded in axial compression from 0 to 5000 N and compression + torsion (5000 N ± 20°) for 5 cycles. This was repeated after removal of 50%, 80%, and 100% of MC2. The primary biomechanical outcome variables were the compressive stiffness and compressive + torsional stiffness of the carpus. Relative kinematic motion ...
In vitro biomechanical evaluation and comparison of a new prototype locking plate and a limited-contact self compression plate for equine fracture repair.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    June 13, 2012   Volume 25, Issue 4 273-280 doi: 10.3415/VCOT-11-01-0011
Quinteros DD, García-López JM, Abuja GA, Tarkanian M, Maranda LS, Bubeck K, Kowaleski MP.To determine if the mechanical properties (strength and stiffness) of a new prototype 4.5 mm broad locking plate (NP-LP) are comparable with those of a traditional 4.5 mm broad limited-contact self compression plate (LC-SCP), and to compare the bending and torsional properties of the NP-LP and LC-SCP when used in osteotomized equine third metacarpal bones (MC3). Methods: The plates alone were tested in four-point bending single cycle to failure. The MC3-plate constructs were created with mid-diaphyseal osteotomies with a 1 cm gap. Constructs were tested in four-point bending single cycle to fa...
Evaluation of regional limb perfusion with amikacin using the saphenous, cephalic, and palmar digital veins in standing horses.
Journal of veterinary pharmacology and therapeutics    May 18, 2012   Volume 36, Issue 3 236-240 doi: 10.1111/j.1365-2885.2012.01414.x
Kelmer G, Bell GC, Martin-Jimenez T, Saxton AM, Catasus C, Elliot SB, Meibohm B.Previous studies have shown that regional limb perfusion (RLP) using the palmar digital (PD) vein delivers therapeutic concentration of amikacin to the distal limb. Our hypothesis was that using the cephalic and saphenous veins for RLP will enable delivery of therapeutic concentrations of amikacin to the distal limb. Nineteen healthy horses participated in the study. The cephalic, saphenous, or PD vein was used to perfuse the limb with amikacin. Two grams of amikacin was used for RLP using the saphenous and the cephalic veins, and one gram was used in the PD vein. Synovial samples were collect...
Musculoskeletal disease and injury, now and in the future. Part 2: Tendon and ligament injuries.
Equine veterinary journal    April 11, 2012   Volume 44, Issue 3 371-375 doi: 10.1111/j.2042-3306.2012.00563.x
Clegg PD.Tendon and ligament injuries continue to be one of the most frequent causes of orthopaedic injury and early retirement in the Thoroughbred racehorse. In the UK, the Horserace Betting Levy Board has invested considerable research funding in the last decade in order to investigate aspects of tendon epidemiology, biology and therapy, in order to decrease both the welfare and economic consequence of such injuries. This review summarises key aspects of this research effort and identifies specific research directions for the future.
Innovative approach to investigating the microstructure of calcified tissues using specular reflectance Fourier transform-infrared microspectroscopy and discriminant analysis.
Analytical chemistry    March 21, 2012   Volume 84, Issue 7 3369-3375 doi: 10.1021/ac300123r
Nicholson CL, Firth EC, Waterland MR, Jones G, Ganesh S, Stewart RB.Although bone fracture has become a serious global health issue, current clinical assessments of fracture risk based on bone mineral density are unable to accurately predict whether an individual is likely to suffer a fracture. There is increasing recognition that the chemical structure and composition, or microstructure, of mineralized tissues has an important role to play in determining the fracture resistance of bone. The objective of this preliminary study was to evaluate the use of specular reflectance Fourier transform infrared (SR FT-IR) microspectroscopy in conjunction with discriminan...
Effects of a novel hydrogel on equine bone healing: a pilot study.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    February 27, 2012   Volume 25, Issue 3 184-191 doi: 10.3415/VCOT-11-01-0006
Cohen JM, Southwood LL, Engiles J, Leitch M, Nunamaker DM.To examine the efficacy and biocompatibility of a thiolated gelatin-thiolated carboxymethyl hyaluronan (CMHA-SGX) sponge as an osteoconductive device in an equine second and fourth metacarpal bone defect model. Methods: Seven millimetre segmental ostectomies were created bilaterally in the second and fourth metacarpal bones of four horses. The left and right metacarpal defects were randomly assigned to (1) be filled with a CMHA-SGX sponge (treated) or (2) were left unfilled (control). The duration of the study was nine weeks. Bone healing was evaluated using serial radiology, as well as histol...
Gambling on putative biomarkers of osteoarthritis and osteochondrosis by equine synovial fluid proteomics.
Journal of proteomics    February 15, 2012   Volume 75, Issue 14 4478-4493 doi: 10.1016/j.jprot.2012.02.008
Chiaradia E, Pepe M, Tartaglia M, Scoppetta F, D'Ambrosio C, Renzone G, Avellini L, Moriconi F, Gaiti A, Bertuglia A, Beccati F, Scaloni A.Osteoarthritis (OA) and osteochondrosis (OC) are two of the main challenges in orthopedics, whose definitive diagnosis is usually based on radiographic/arthroscopic evidences. Their early diagnosis should allow preventive or timely therapeutic actions, which are generally precluded from the poor relationships occurring between symptomatologic and radiographic evidences. These limitations should be overcome by improving the knowledge on articular tissue metabolism and on molecular factors regulating its normal homeostasis, also identifying novel OA and OC biomarkers suitable for their earlier d...
Conservative management of a transverse fracture of the distal phalanx in a Quarter Horse.
Journal of the American Veterinary Medical Association    December 17, 2011   Volume 240, Issue 1 82-86 doi: 10.2460/javma.240.1.82
Sherlock CE, Eggleston RB, Howerth EW.A 7-year-old Quarter Horse gelding was evaluated because of sudden onset of severe left forelimb lameness of 4 days' duration. Results: Clinical evaluation and diagnostic perineural analgesia localized the lameness to the distal portion of the left forelimb. Radiography revealed a transverse fracture of the distal phalanx of the left forelimb. Results: The horse was treated conservatively with stall rest and stabilization of the hoof with fiberglass cast material and an elevated heel support. These treatments improved the lameness considerably. Over the following 4 months, the horse was exerci...
Incidence of support limb laminitis in horses treated with half limb, full limb or transfixation pin casts: a retrospective study of 113 horses (2000-2009).
Equine veterinary journal. Supplement    December 7, 2011   Issue 40 7-11 doi: 10.1111/j.2042-3306.2011.00491.x
Virgin JE, Goodrich LR, Baxter GM, Rao S.To determine the incidence of support limb laminitis among horses treated with half limb, full limb or transfixation pin casts and determine potential risk factors. Methods: Medical records of 113 horses treated with half limb, full limb or transfixation pin casts at an equine referral hospital from 2000 to 2009 were reviewed. Associations between potential risk factors and development of support limb laminitis were evaluated by bivariable and multivariable logistic regression analyses. Results: Of the 113 horses that received casts, 14 (12%) developed confirmed support limb laminitis. The bod...
Effect of sequential hole enlargement on cortical bone temperature during drilling of 6.2-mm-diameter transcortical holes in the third metacarpal bones of horse cadavers.
American journal of veterinary research    December 1, 2011   Volume 72, Issue 12 1687-1694 doi: 10.2460/ajvr.72.12.1687
Lescun TB, Frank EA, Zacharias JR, Daggy JK, Moore GE.To compare the bone temperature and final hole dimensions associated with sequential overdrilling (SO) and single 6.2-mm drill bit (S6.2DB) methods used to create transcortical holes in the third metacarpal bones (MCIIIs) of horse cadavers. Methods: 60 MCIIIs from 30 horse cadavers. Methods: In phase 1, hole diameter, tap insertion torque, peak bone temperature, and postdrilling bit temperature for 6.2-mm-diameter holes drilled in the lateral or medial cortical region of 12 MCIIIs via each of three 2-bit SO methods with a single pilot hole (diameter, 3.2, 4.5, or 5.5 mm) and the S6.2DB method ...
Variation in equine management factors between riding schools with high vs. low insurance claims for orthopaedic injury: a field study.
Veterinary journal (London, England : 1997)    November 30, 2011   Volume 193, Issue 1 109-113 doi: 10.1016/j.tvjl.2011.11.003
Lönnell C, Roepstorff L, Egenvall A.Lameness is the most commonly diagnosed condition in equine veterinary practice. To examine whether variations in management and husbandry strategies in riding schools could influence wastage due to orthopaedic injury schools with high (HUIO) or low (LUIO) insurance claims for orthopaedic injuries (as an indirect measure of wastage) were compared epidemiologically using an extensive questionnaire and field study visits. Schools differed in management strategies and these influence injury rate and longevity. For horses in the LUIO schools a significantly longer time period had elapsed since acq...
A genome-wide association study of osteochondritis dissecans in the Thoroughbred.
Mammalian genome : official journal of the International Mammalian Genome Society    November 4, 2011   Volume 23, Issue 3-4 294-303 doi: 10.1007/s00335-011-9363-1
Corbin LJ, Blott SC, Swinburne JE, Sibbons C, Fox-Clipsham LY, Helwegen M, Parkin TD, Newton JR, Bramlage LR, McIlwraith CW, Bishop SC, Woolliams JA....Osteochondrosis is a developmental orthopaedic disease that occurs in horses, other livestock species, companion animal species, and humans. The principal aim of this study was to identify quantitative trait loci (QTL) associated with osteochondritis dissecans (OCD) in the Thoroughbred using a genome-wide association study. A secondary objective was to test the effect of previously identified QTL in the current population. Over 300 horses, classified as cases or controls according to clinical findings, were genotyped for the Illumina Equine SNP50 BeadChip. An animal model was first implemented...
Processing of equine bone marrow using the automated MarrowXpress System: RBC depletion, volume reduction, and mononuclear cell recovery.
Veterinary clinical pathology    November 3, 2011   Volume 40, Issue 4 444-449 doi: 10.1111/j.1939-165X.2011.00368.x
Owens SD, Burges J, Johns JL, Carrade DD, Galuppo LD, Librach F, Borjesson DL.The therapeutic use of bone marrow-derived mononuclear cells (MNCs) and mesenchymal stem cells for the treatment of soft tissue and orthopedic injuries in equine patients is expanding. After collection, bone marrow must be reduced in volume and depleted of RBCs for immediate therapeutic use or to prepare cells for culture or cryopreservation and storage. The MarrowXpress (MXP) System is an automated, closed, sterile system designed to process human bone marrow samples. Objective: The purpose of this study was to evaluate the capacity of the MXP System to process equine bone marrow to reduce vo...
Differentiation of ataxic and orthopedic gait abnormalities in the horse.
The Veterinary clinics of North America. Equine practice    October 21, 2011   Volume 27, Issue 3 411-416 doi: 10.1016/j.cveq.2011.08.007
Licka TF.The differentiation of ataxia and orthopedic disease can be facilitated by the use of several additional tests, not commonly part of either neurologic or orthopedic examination protocols. However, a full neurologic and orthopedic examination and suitable diagnostic imaging will of course also be necessary in such cases. The common association of orthopedic and neurologic disease makes it even more necessary to correctly attribute movement or posture abnormalities to potentially treatable structures.
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