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Topic:Thoroughbreds

Thoroughbreds are a breed of horse known for their agility, speed, and spirit, often associated with horse racing and equestrian sports. Originating from crossbreeding native English mares with imported Arabian, Barb, and Turkoman stallions, Thoroughbreds have a well-documented pedigree that traces back to the late 17th and early 18th centuries. This breed is characterized by a refined head, deep chest, and long legs, contributing to their athletic capabilities. Thoroughbreds are primarily bred for their performance in racing but are also utilized in other equestrian disciplines. This page compiles peer-reviewed research studies and scholarly articles that explore the genetics, physiology, and performance characteristics of Thoroughbreds, as well as their management and welfare in various equine activities.
The relationship of air hygiene in stables to lower airway disease and pharyngeal lymphoid hyperplasia in two groups of Thoroughbred horses.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 524-530 doi: 10.1111/j.2042-3306.1987.tb02665.x
Clarke AF, Madelin TM, Allpress RG.The relationship between air hygiene within two types of identically managed horse housing and the incidence of covert respiratory disease (as revealed by endoscopic examination) of their inhabitants was assessed. The horses were all under the supervision of the same trainer. In one yard the design ensured the boxes were well ventilated in still air conditions. In the other yard the boxes were insulated and there was little provision for natural ventilation in still air conditions. There was heavy fungal and actinomycete contamination of wood shavings in the heavily insulated, poorly ventilate...
Oral administration of ascorbic acid to horses.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 520-523 doi: 10.1111/j.2042-3306.1987.tb02664.x
Snow DH, Gash SP, Cornelius J.The effects of oral administration of high doses of ascorbic acid on plasma concentrations were investigated in both experimental Thoroughbred horses and those within racing stables. A single oral dose (20 g) did not result in any increase in plasma concentrations. However, daily administration of either 4.5 g or 20 g doses resulted in significant increases in plasma concentrations. Monthly variations in plasma ascorbate concentrations were found in both supplemented (20 g daily) and unsupplemented stables. It is concluded that oral supplementation with ascorbic acid is a satisfactory route to...
Immunocytochemical localisation of carbonic anhydrase isozyme III in equine skeletal muscle.
Equine veterinary journal    November 1, 1987   Volume 19, Issue 6 509-513 doi: 10.1111/j.2042-3306.1987.tb02660.x
Nishita T, Matsushita H, Kai M.The location of carbonic anhydrase III (CA-III) in frozen sections of biopsies of Thoroughbred horse skeletal muscle was studied. Fibre types were determined by ATP-ase and succinate dehydrogenase staining. CA-III isozyme was detected using a peroxidase conjugated anti-CA-III antibody. CA-III was found to be localised in slow twitch oxidative fibres (ST), but was also present in fast twitch oxidative (FTH) fibres in small amounts. Fast twitch glycolytic (FT) fibres were stained lightly compared with control sections. The concentrations of CA-III in muscle and liver were 70 micrograms/mg protei...
Studies of the pathogenesis of Rhodococcus equi infection in foals.
Australian veterinary journal    November 1, 1987   Volume 64, Issue 11 332-339 doi: 10.1111/j.1751-0813.1987.tb06061.x
Barton MD, Embury DH.Pyogranulomatous pneumonia was induced in Thoroughbred foals by intranasal challenge with freeze-dried cultures of Rhodococcus equi (previously Corynebacterium equi). The incubation period was about 18 days and clinical signs were not seen for a further week. There were marked seasonal and individual foal differences in responses to infection. Elevations in serum caeruloplasmin oxidase activity and copper concentrations appeared to be sensitive indicators of infection. Serum zinc concentrations and serum alpha-mannosidase and alkaline phosphatase activities fell in the more severely infected f...
Auscultatory and phonocardiographic studies on the cardiovascular system of the newborn thoroughbred foal.
The Japanese journal of veterinary research    October 1, 1987   Volume 35, Issue 4 235-250 
Machida N, Yasuda J, Too K.No abstract available
Leptospirosis in horses in Ontario.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire    October 1, 1987   Volume 51, Issue 4 448-451 
Kitson-Piggot AW, Prescott JF.Sera from Thoroughbred and Standardbred horses in southwest Ontario were tested for antibody to seven Leptospira interrogans serovars (autumnalis, bratislava, canicola, grippotyphosa, hardjo, icterohaemorrhagiae, pomona), using the microscopic agglutination test. There was significantly higher seroprevalence of bratislava than of other serovars, in which prevalence was low. Seroprevalence of bratislava increased significantly with age; only 5% of two to three year old horses had titers greater than or equal to 1:80 compared to 52% of horses older than seven years. Eight of 16 foals from two fa...
Urinary bladder rupture in a two-year-old horse: sequel to a surgically repaired neonatal injury.
Journal of the American Veterinary Medical Association    September 1, 1987   Volume 191, Issue 5 560-562 
Pankowski RL, Fubini SL.After routine cryptorchid castration, a 2-year-old Thoroughbred colt was admitted 72 hours later because of depression, abdominal distention, and pollakiuria, with production of small quantities of urine. A diagnosis of a ruptured bladder was made on the basis of a large volume of abdominal fluid and a disparity between the urea nitrogen and creatinine concentrations in the serum (70 mg/dl and 8.4 mg/dl, respectively) and in the abdominal fluid (154 mg/dl and 43 mg/dl, respectively). The colt had undergone surgical correction of a ruptured urinary bladder at 4 days of age, and a 5-cm tear thro...
Exercise-induced pulmonary haemorrhage in the horses: results of a detailed clinical, post mortem and imaging study. VII. Ventilation/perfusion scintigraphy in horses with EIPH.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 423-427 doi: 10.1111/j.2042-3306.1987.tb02635.x
O'Callaghan MW, Hornof WJ, Fisher PE, Pascoe JR.Detailed post mortem examination of the lungs of horses with exercise-induced pulmonary haemorrhage (EIPH) has demonstrated significant small airway disease and intense bronchial arterial proliferation in the dorsocaudal lungfields. The purpose of this study was to investigate ventilation and perfusion distribution in the lungs of a similar group of horses to compare changes in the live animal with the previously reported post mortem findings. Thoracic radiography and ventilation/perfusion (V/Q) scintigraphy were performed on five racing Thoroughbreds with recent histories of EIPH. Parametric ...
Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. V. Microscopic observations.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 411-418 doi: 10.1111/j.2042-3306.1987.tb02632.x
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.Lungs from 19 Thoroughbred racehorses with a history of exercise-induced pulmonary haemorrhage (EIPH) were studied using several forms of microscopy. Light microscopy of paraffin sections revealed three lesions in the caudodorsal region of the lungs from each horse. These correspond with the location of blue to brown stains seen at necropsy. These lesions include sequelae of bronchiolitis, hemosiderophages and increased connective tissue. Much of each of the lungs appeared normal, especially the more cranial or ventral portions. Foci of eosinophil infiltration were found in seven of the 19 lun...
Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. VIII. Conclusions and implications.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 428-434 doi: 10.1111/j.2042-3306.1987.tb02636.x
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.This paper reviews a series of clinical, post mortem and imaging studies on exercise-induced pulmonary haemorrhage (EIPH) performed on 26 Thoroughbred racehorses. Post mortem techniques included routine gross, subgross and histological examination; coloured latex perfusions of pulmonary and bronchial circulations; and microradiography and computerised tomography scans of lungs with contrast injected vasculature. The major lesions were multiple, separate and coalescing foci of moderately proliferative small airway disease accompanied by intense neovascularisation of the bronchial circulation. A...
Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. III. Subgross findings in lungs subjected to latex perfusions of the bronchial and pulmonary arteries.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 394-404 doi: 10.1111/j.2042-3306.1987.tb02629.x
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.Latex was injected under pressure into bronchial and pulmonary arteries of the inflated lungs of Thoroughbreds and transverse sections taken to calculate the area of lesions resulting from exercise-induced pulmonary haemorrhage. Extensive areas of dense brown haemosiderin varying from 0 to 45 per cent of total lung volume were identified, predominantly in the dorsocaudal lungfields. Bronchial arterial proliferation appeared to have replaced the pulmonary supply in affected areas of the lung. Closely associated with the staining and bronchial arterialisation, there was widespread small airway d...
Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. I. Clinical profile of horses.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 384-388 doi: 10.1111/j.2042-3306.1987.tb02626.x
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.Detailed physical and clinical examinations were performed on 26 Thoroughbred racehorses which were used subsequently in a series of studies to investigate the contribution of the pulmonary and bronchial arterial circulations to the pathophysiology of exercise-induced pulmonary haemorrhage (EIPH). Twenty-five of the horses had been retired from race training in Hong Kong during the 1984-85 season, all but four raced that season; one horse had been retired the previous season. The average number of races for the group that season was 4.1 +/- 2 with an average distance of 1502 +/- 216 metres, me...
Serum ferritin, serum iron, and erythrocyte values in foals.
American journal of veterinary research    September 1, 1987   Volume 48, Issue 9 1348-1352 
Harvey JW, Asquith RL, Sussman WA, Kivipelto J.Twenty-one healthy Thoroughbred and Quarter Horse foals were studied from birth until 1 year of age. Foals had access to an iron-supplemented creep feed before weaning and were fed an iron-supplemented concentrate as part of their diet after weaning at 4 months of age. Initial blood samples were taken before foals were allowed to nurse. Serum iron concentration, total iron-binding capacity, and PCV decreased during the foal's first 24 hours of life. Serum iron concentration decreased rapidly from 446 +/- 16 micrograms/dl (mean +/- SE) at birth to 105 +/- 11 micrograms/dl at 3 days of age. Seru...
Effects of a specific thromboxane synthetase inhibitor in equine endotoxaemia.
Research in veterinary science    September 1, 1987   Volume 43, Issue 2 137-142 
Semrad SD, Moore JN.Thromboxane A2 may play a major role in circulatory shock. In some species, thromboxane synthetase inhibitors have a beneficial effect on shock induced by endotoxin, trauma, sepsis and administration of arachidonate. In some shock models, however, results with thromboxane synthetase inhibitors have been conflicting. The effect of UK-38,485, a selective thromboxane inhibitor, was evaluated in ponies injected with endotoxin intraperitoneally. Four groups of ponies were used to compare the effects of endotoxin alone, UK-38,485 alone, treatment with UK-38,485 before endotoxin challenge and treatme...
Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. II. Gross lung pathology.
Equine veterinary journal    September 1, 1987   Volume 19, Issue 5 389-393 doi: 10.1111/j.2042-3306.1987.tb02628.x
O'Callaghan MW, Pascoe JR, Tyler WS, Mason DK.Gross post mortem examinations were performed on the lungs of 26 Thoroughbred horses of known exercise-induced pulmonary haemorrhage (EIPH) status. The most consistent finding was a variable degree of bilaterally symmetrical, dark discolouration of the dorsocaudal regions of the caudal lung lobes. In more severely affected lungs, the stained areas extended cranially along the dorsal surfaces of the lungs, and in some cases affected approximately one third of the lung surface. Discoloured areas of lung were denser than normal, collapsed less readily, often contained trapped air and were slow to...
Arthroscopic surgery for the treatment of osteochondral chip fractures in the equine carpus.
Journal of the American Veterinary Medical Association    September 1, 1987   Volume 191, Issue 5 531-540 
McIlwraith CW, Yovich JV, Martin GS.The technique and results of arthroscopic surgery for the removal of osteochondral fragments from 1,000 carpal joints in 591 horses are reported. Of the 591 horses, 580 were racehorses (including 349 Quarter Horses and 220 Thoroughbreds). The distal aspect of the radial carpal bone was the most commonly affected site, followed by the proximal aspect of the intermediate carpal bone and distolateral aspect of the radius. More than one carpal joint was simultaneously operated on in 58.9% of the Quarter Horses and in 37.4% of the Thoroughbreds. Marked differences in the amount of damage were noted...
Species differences in the changes in heart rate and T-wave amplitude after autonomic blockade in Thoroughbred horses, ponies, cows, pigs, goats and chickens.
Nihon juigaku zasshi. The Japanese journal of veterinary science    August 1, 1987   Volume 49, Issue 4 637-644 doi: 10.1292/jvms1939.49.637
Matsui K, Sugano S.No abstract available
Surgical repair of a supraglenoid tubercle fracture in a horse.
Journal of the American Veterinary Medical Association    August 1, 1987   Volume 191, Issue 3 332-334 
Adams SB.A fractured right supraglenoid tubercle in a 15-month-old Thoroughbred gelding was repaired by partial biceps brachii tenotomy, interfragmentary compression, and tension band wiring. The horse is currently being ridden daily and has remained sound for 4 years.
Omental fibrosarcoma in a horse.
Journal of the American Veterinary Medical Association    August 1, 1987   Volume 191, Issue 3 335-336 
Harvey KA, Morris DD, Saik JE, Donawick WJ.A 13-year-old Thoroughbred mare had a 2-week history of weight loss and intermittent fever. Examination of abdominal and pleural fluid revealed peritonitis and pleuritis. Ultrasonography of the ventral abdominal midline revealed an intra-abdominal mass. Exploratory celiotomy was performed, but the mass was not surgically excisable. The mare was euthanatized and necropsied. Histologically, the mass was determined to be a fibrosarcoma of omental origin.
Jejunocolic anastomosis for the surgical management of recurrent cecal impaction in a horse.
Veterinary surgery : VS    July 1, 1987   Volume 16, Issue 4 265-268 doi: 10.1111/j.1532-950x.1987.tb00950.x
Ross MW, Orsini JA, Ehnen SJ.A 5-year-old Thoroughbred gelding with recurrent cecal impaction refractory to medical management was treated with a side-to-side jejunocolic anastomosis. Cecal impaction did not recur after surgery. The horse gained weight and performed successfully for 14 months, but experienced three episodes of mild abdominal pain between 14 and 20 months after surgery. Mild cecal gas distention and firm ingesta in the colon were detected on rectal examination. The horse's feces remained soft after surgery, except during the colic episodes when dry, firm feces were passed.
Some metabolic and hormonal changes associated with general anaesthesia and surgery in the horse.
Equine veterinary journal    July 1, 1987   Volume 19, Issue 4 288-294 doi: 10.1111/j.2042-3306.1987.tb01413.x
Robertson SA.Three different anaesthetic techniques were studied in normal, healthy Thoroughbred or Thoroughbred type horses. These were (a) acepromazine, thiopentone and suxamethonium; (b) acepromazine, glyceryl guaiacolate and a 'half-dose' of thiopentone; and (c) xylazine and ketamine. Anaesthesia was maintained with halothane vaporized in oxygen and nitrous oxide. All horses underwent either laryngeal or body surface surgery. Heart rate, packed cell volume, blood glucose and lactate, plasma non-esterified fatty acids, insulin and cortisol were measured before, during and after surgery. The greatest met...
Botulism as a sequel to open castration in a horse.
Journal of the American Veterinary Medical Association    July 1, 1987   Volume 191, Issue 1 73-74 
Bernard W, Divers TJ, Whitlock RH, Messick J, Tulleners E.Clostridium botulinum and type-B C botulinum toxin were isolated from a necrotic wound that developed subsequent to castration in a 2-year-old Thoroughbred gelding. The horse had clinical signs of botulism and was successfully treated with wound debridement, C botulinum type-B antitoxin, potassium penicillin, and supportive care.
Metabolic response to maximal exercise of 800 and 2,000 m in the thoroughbred horse.
Journal of applied physiology (Bethesda, Md. : 1985)    July 1, 1987   Volume 63, Issue 1 12-19 doi: 10.1152/jappl.1987.63.1.12
Harris RC, Marlin DJ, Snow DH.To define the metabolic response to maximal exercise in the thoroughbred horse under field conditions, muscle biopsies and venous blood samples were taken from five horses after a single 800-m gallop and from four horses after a single 2,000-m gallop. Muscle and blood samples were also collected during 60 min of recovery. After exercise muscle ATP contents were decreased by 30 +/- 7 (SD) and 47 +/- 3% after the 800- and 2,000-m gallops, respectively. As indicators of purine catabolism, ammonia and uric acid increased in plasma, the accumulation being greater after the 2,000-m gallop. Blood amm...
Clinical, clinicopathologic, and epidemiologic features of anhidrosis in central Florida Thoroughbred horses.
Journal of veterinary internal medicine    July 1, 1987   Volume 1, Issue 3 136-141 doi: 10.1111/j.1939-1676.1987.tb02001.x
Mayhew IG, Ferguson HO.A group of 834 Thoroughbred horses was surveyed on four central Florida farms for clinical and epidemiologic features of anhidrosis. In addition, comparative analysis was made of serum thyroxine, serum electrolytes, and fractional urinary electrolyte excretion ratios. An overall disease prevalence of 6.12% was observed. Training horses and nonpregnant broodmares had a predilection for the disease. Adolescent horses were infrequently affected. There was no correlation with sex or color. Comparative clinical signs, related to thermoregulatory compromise, included tachypnea and hyperthermia. Long...
HPLC determination and pharmacokinetics of thiabendazole and its major metabolite 5-OH thiabendazole in equine plasma.
Research in veterinary science    July 1, 1987   Volume 43, Issue 1 13-17 
Hardee GE, Tshabalala MA, Moore JN, Gokhales RD.Separate high performance liquid chromatographic methods were developed for thiabendazole (TBZ) and 5-hydroxy thiabendazole (5-OH-TBZ) determination in horse plasma using 1-methyl-2-phenyl benzimidazole (MPBZ) as an internal standard. In both methods TBZ and 5-OH-TBZ were extracted from plasma using organic solvents, injected on to a C-18 column, and eluents monitored by a fluorescence detector. However, mobile phase composition, extraction solvent as well as detector wavelength differed in the two methods. The linear range for TBZ was 0.02 to 0.77 microgram ml-1 while that for 5-OH-TBZ was 0....
Thoroughbred blood serum inorganic phosphate concentrations in relation to feeding regime and racing performance.
Journal of the South African Veterinary Association    June 1, 1987   Volume 58, Issue 2 85-87 
Denny JE.Horses receiving a pelleted or cubed dietary supplementation with roughage, have serum inorganic phosphate (SIP) concentrations consistently below an accepted mean of 1,032 mmol l-1 or 3, 1 mg dl-1. Further, it has been reported that the best eight, two-year-old Irish Thoroughbred track performers of 51 horses tested over a 10 month period, had significantly lower SIP concentrations than the worst eight track performers. In an endeavour to assess any nutritive effect on SIP concentrations and also to assess any effect of SIP concentrations on track performance, metabolic blood profiles from 30...
Echographic diagnosis of twin pregnancy in thoroughbreds.
The Veterinary record    May 9, 1987   Volume 120, Issue 19 466 doi: 10.1136/vr.120.19.466-c
Rossdale PD, D'Eath FM.No abstract available
Plasma antithrombin-III values in healthy horses: effect of sex and/or breed.
American journal of veterinary research    May 1, 1987   Volume 48, Issue 5 866-868 
Bernard W, Morris DD, Divers TJ, Ramberg C.Plasma antithrombin-III (AT-III) values were determined in 74 healthy horses by an automated spectrophotometric assay. The mean plasma AT-III value was 218% +/- 18% of normal human plasma. Plasma AT-III values did not differ significantly (P less than 0.05) among Thoroughbred, Standardbred, Quarter Horse, and other breeds or among mares, geldings, or stallions.
Multivariate statistical analysis of stride-timing measurements of nonfatigued racing Thoroughbreds.
American journal of veterinary research    May 1, 1987   Volume 48, Issue 5 880-888 
Leach DH, Sprigings EJ, Laverty WH.Standard univariate and bivariate statistical methods and two multivariate methods, stepwise regression and factor analyses, were used to analyze 17 stride-timing measurements of 22 racing Thoroughbreds filmed at the beginning of races. All horses were in a right-lead transverse gallop. Data were extracted from frame-by-frame analysis of 16-mm film taken with a high-speed camera. The mean stride duration was 0.405 s and the mean stride frequency was 2.47 strides/s. Stride duration had a higher correlation to the suspension-phase duration (r = 0.864) than to stride-stance-phase duration (r = 0....
Running and shipping elevate plasma levels of beta-endorphin-like substance (B-END-LI) in thoroughbred horses.
Life sciences    April 6, 1987   Volume 40, Issue 14 1411-1421 doi: 10.1016/0024-3205(87)90332-8
Li WI, Chen CL.A specific RIA for beta-endorphin (B-END) was developed to measure horse plasma levels of B-END-like material (B-END-LI) during exercises and shipping. Three exercise speeds and durations were: trot at 260-300 m/min for 10 min; slow gallop at 390-420 m/min for 5 min and fast gallop at 700-800 m/min for 2 min. Blood samples were taken from 4 horses before, immediately after, 30 and 60 min after exercise. Trotting increased plasma B-END-LI from a basal level of 109 +/- 7 pg/ml to 172 +/- 22 at the end of exercise and returned to 127 +/- 17 and 107 +/- 10 pg/ml at 30 and 60 min after exercise. Si...