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Topic:Treatment

Treatments for horses encompasses a range of medical and therapeutic interventions aimed at maintaining or restoring equine health. This field involves the use of pharmaceuticals, surgical procedures, and alternative therapies to address various conditions affecting horses. Common treatments include the administration of anti-inflammatory drugs, antibiotics, and vaccines, as well as physical therapies and nutritional management. Research in this area focuses on evaluating the efficacy, safety, and outcomes of different treatment modalities. This page collects peer-reviewed research studies and scholarly articles that explore the methods, advancements, and clinical outcomes associated with equine treatment practices.
Advances in the treatment of diseased equine cheek teeth.
The Veterinary clinics of North America. Equine practice    June 12, 2013   Volume 29, Issue 2 441-vii doi: 10.1016/j.cveq.2013.04.013
Tremaine H.The last decade has seen a number of studies that have illuminated our knowledge of hypsodont dental disease and re-examined some of the traditionally performed practices. In addition there has been a major interest in routine preventative dentistry and non-traumatic treatments. These have highlighted some potential risks of the use of modern tools when applied to traditional techniques. This has also led to a reflective review of equine dentistry with the emphasis on attempting to preserve and salvage dental and periodontal tissues, with minimal trauma. In addition, precise imaging and instru...
Surgical versus conservative management of osteochondrosis.
Veterinary journal (London, England : 1997)    June 7, 2013   Volume 197, Issue 1 19-28 doi: 10.1016/j.tvjl.2013.03.037
McIlwraith CW.The paper reviews current knowledge on conservative versus surgical options for the treatment of osteochondrosis entities in the horse. Clinical and radiographic signs of each significant osteochondrosis entity in the horse are presented, followed by the value of conservative treatment versus arthroscopic surgery options as well as the results for each option with the various entities. The entities presented in detail include, osteochondritis dissecans (OCD) of the femoropatellar, tarsocrural, metacarpophalangeal and metatarsophalangeal, and glenohumural articulations. The various treatment op...
Accelerometric comparison of the locomotor pattern of horses sedated with xylazine hydrochloride, detomidine hydrochloride, or romifidine hydrochloride.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 828-834 doi: 10.2460/ajvr.74.6.828
López-Sanromán FJ, Holmbak-Petersen R, Varela M, del Alamo AM, Santiago I.To evaluate the duration of effects on movement patterns of horses after sedation with equipotent doses of xylazine hydrochloride, detomidine hydrochloride, or romifidine hydrochloride and determine whether accelerometry can be used to quantify differences among drug treatments. Methods: 6 healthy horses. Methods: Each horse was injected IV with saline (0.9% NaCl) solution (10 mL), xylazine diluted in saline solution (0.5 mg/kg), detomidine diluted in saline solution (0.01 mg/kg), or romifidine diluted in saline solution (0.04 mg/kg) in random order. A triaxial accelerometric device was used f...
Advanced imaging in equine dental disease.
The Veterinary clinics of North America. Equine practice    May 28, 2013   Volume 29, Issue 2 397-vi doi: 10.1016/j.cveq.2013.04.009
Selberg K, Easley JT.Dental and sinus disorders are relatively common and of major clinical importance in equine medicine. Advanced diagnostic imaging has become an integral part of equine veterinary medicine. Advanced imaging has progressed the understanding, diagnosis, and treatment of dental- and sinus-related diseases. As a clinician, it is important to realize the value of advanced diagnostic imaging. Although computed tomography and magnetic resonance imaging are both significantly more expensive compared with other diagnostic tools, the financial cost of inaccurate diagnosis and treatment can often result i...
Three cases of a presumptive atypical myopathy in New Zealand horses.
New Zealand veterinary journal    May 20, 2013   Volume 61, Issue 6 367-372 doi: 10.1080/00480169.2013.796436
McKenzie RK, Gibson IR, Ritmeester A.Three weanling Thoroughbred fillies were presented during autumn with depression, muscle rigidity and, in one case, colic symptoms and cardiovascular shock. Results: All fillies had abnormal physical examinations that included elevated heart rates and respiratory rates coupled with muscle rigidity through the back and rump. Biochemistry revealed markedly elevated creatinine kinase and aspartate aminotransferase which indicated a myopathy. Methods: All three horses were diagnosed with presumptive equine atypical myopathy. The horses received supportive therapy as per the literature available at...
A report of left dorsal displacement of the large colon in a tropical horse.
Asian Pacific journal of tropical biomedicine    April 27, 2013   Volume 3, Issue 4 325-329 doi: 10.1016/S2221-1691(13)60072-6
Sasani F, Javanbakht J, Ghamsari M, Hassan MA.We report one such case which was diagnosed intraoperatively as left dorsal colon volvulus due to multiple mesenteric abnormalities. A 17-year-old castrated male horse was taken to the Tehran University Veterinary Hospital for treatment of metacarpal wound accompanied by severe abdominal distension and acute colic. The treatment and measurement were taken for a month, and the prepared biopsy indicated that the healing trend was obvious. Unfortunately, prior to discharge, the clinical colic manifestations emerged and the animal suddenly died. Dilated large intestine was palpated per rectum and ...
Relationships between intrauterine infusion of N-acetylcysteine, equine endometrial pathology, neutrophil function, post-breeding therapy, and reproductive performance.
Theriogenology    April 25, 2013   Volume 80, Issue 3 218-227 doi: 10.1016/j.theriogenology.2013.03.026
Gores-Lindholm AR, LeBlanc MM, Causey R, Hitchborn A, Fayrer-Hosken RA, Kruger M, Vandenplas ML, Flores P, Ahlschwede S.Persistent endometritis in the mare is associated with hypersecretion of mucus by endometrial epithelium and migration of neutrophils into the uterine lumen. This study examines the relationships between N-acetylcysteine (NAC), a mucolytic agent with anti-inflammatory properties, and endometrial architecture, serum neutrophil function, post-breeding therapy, and reproductive performance of NAC-treated mares in a clinical setting. In study 1, endometrial biopsies from mares receiving intrauterine saline (fertile-control, n = 6) or 3.3% NAC (fertile-treatment, n = 6; barren-treatment, n = 10) we...
Effects of metformin hydrochloride on blood glucose and insulin responses to oral dextrose in horses.
Equine veterinary journal    April 22, 2013   Volume 45, Issue 6 751-754 doi: 10.1111/evj.12068
Rendle DI, Rutledge F, Hughes KJ, Heller J, Durham AE.Metformin is a potential therapeutic agent for the treatment of insulin resistance (IR). In laboratory animals, orally administered metformin reduces intestinal glucose absorption and may therefore affect insulinaemic responses to oral carbohydrate ingestion. Objective: To determine whether pretreatment with metformin reduces plasma glucose concentration and insulin responses following consumption of dextrose in horses. Methods: Therapeutic cross-over study. Methods: Seven healthy Standardbred and Thoroughbred geldings were subjected to an oral dextrose challenge test on 4 occasions: with and ...
Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses.
American journal of veterinary research    March 28, 2013   Volume 74, Issue 4 550-556 doi: 10.2460/ajvr.74.4.550
Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR.To determine the pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Methods: 8 healthy horses. Methods: A single dose of zoledronic acid (0.057 mg/kg, IV) was administered during a 30-minute period. Venous blood was collected at several time points. Zoledronic acid concentration in plasma was measured by liquid chromatography-tandem mass spectrometry, and pertinent pharmacokinetic parameters were determined. Plasma was analyzed for total calcium, BUN, and creatinine concentrations and a marker for bone resorption (C-terminal telopeptides of type I collagen). Results: ...
Renal replacement therapy in healthy adult horses.
Journal of veterinary internal medicine    March 4, 2013   Volume 27, Issue 2 308-316 doi: 10.1111/jvim.12049
Wong DM, Witty D, Alcott CJ, Sponseller BA, Wang C, Hepworth K.Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF. Objective: To investigate efficacy and safety of RRT in horses. Methods: Five healthy adult horses. Methods: A prospective study was performed on horses restrained in stocks and intravenously connected to a commercial RRT machine to allow continuous venovenous hemodiafiltration to be performed for 6 hours. The RRT machine was set at the following flow rates: blood ...
Effects of repeated intra-articular administration of amikacin on serum amyloid A, total protein and nucleated cell count in synovial fluid from healthy horses.
Equine veterinary journal. Supplement    March 2, 2013   Issue 43 12-16 doi: 10.1111/j.2042-3306.2012.00637.x
Sanchez Teran AF, Rubio-Martinez LM, Villarino NF, Sanz MG.Serum amyloid A (SAA) in synovial fluid has recently been used as a marker for septic arthritis in horses but the effects of repeated intra-articular (IA) administration of amikacin on synovial SAA concentrations are unknown. Objective: To report the effect of repeated IA administration of amikacin on SAA, total protein (TP), nucleated cell count (NCC) and differential NCC in synovial fluid of healthy equine joints. Methods: A controlled, 2 period crossover study was performed on 5 clinically healthy horses. Each intercarpal joint received one of 2 treatments every 48 h for 5 consecutive times...
Large segmental mandibulectomy for treatment of an undifferentiated sarcoma in a horse.
Veterinary surgery : VS    February 21, 2013   Volume 42, Issue 4 433-439 doi: 10.1111/j.1532-950X.2013.01086.x
Carmalt JL, Linn KA.To describe a large segmental (sub-total) mandibulectomy for removal of an undifferentiated sarcoma in a horse. Methods: Clinical report. Methods: A 10-year-old mare. Methods: A combination of methods including computed tomography (CT) were used to diagnose a large undifferentiated sarcoma of the right mandible. A large segmental mandibulectomy extending from 3 cm below the right temporomandibular joint to immediately caudal to tooth 407 was used to perform an en-bloc resection of the mass under general anesthesia. Results: Surgery time was 11 hours and 35 minutes and total anesthesia time, 12...
Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin.
Research in veterinary science    February 15, 2013   Volume 95, Issue 1 212-218 doi: 10.1016/j.rvsc.2013.01.019
Olsén L, Bremer H, Olofsson K, Bröjer J, Bondesson U, Bergh A, Nostell K, Broström H, Bengtsson B, Ingvast-Larsson C.The aim was to supply information about the possibility of replacing the procaine salt with the sodium salt for benzylpenicillin IM treatment in horse in order to diminish the risk for procaine adverse effects. In a crossover study eight horses were given 15 mg/kg sodium benzylpenicillin (Na-pc) twice daily or procaine benzylpenicillin (control) once daily IM for four days. The half-life of Na-pc was 1.9h, peak concentration was 14,600 ng/mL reached after about 23 min. Trough plasma concentration was 281 ng/mL and protein binding 62.8%. The fT>MIC for Staphylococcus aureus was 63% and 100% for...
Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses.
American journal of veterinary research    February 1, 2013   Volume 74, Issue 2 324-332 doi: 10.2460/ajvr.74.2.324
Link KA, Koenig JB, Silveira A, Plattner BL, Lillie BN.To compare the effect of extracorporeal shock wave therapy (ESWT) on expression of fibroblast growth factor-7 (FGF-7), transforming growth factor-β1 (TGF-β1), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor-A (PDGF), and vascular endothelial growth factor-A (VEGF) in skin with surgically created skin wounds and intact skin in horses. Methods: 14 healthy horses. Methods: 8 horses were treated with ESWT at 6 locations along the neck at 36, 24, 12, 6, 2, or 1 hour prior to collection of full-thickness biopsy specimens from each location; a control specimen was collected fro...
Muscle and tendon heating rates with therapeutic ultrasound in horses.
Veterinary surgery : VS    February 1, 2013   Volume 42, Issue 3 243-249 doi: 10.1111/j.1532-950X.2013.01099.x
Montgomery L, Elliott SB, Adair HS.To (1) determine the temperature change in equine tendon and muscle during therapeutic ultrasound and (2) develop guidelines for treating horses for muscular or tendinous injury using therapeutic ultrasound. Methods: Experimental, in vivo study. Methods: Adult horses (n = 10). Methods: Thermistors were inserted in the superficial and deep digital flexor tendons (SDFT and DDFT) of the thoracic limbs of 10 adult horses. On the left, 3.3 MHz therapeutic continuous ultrasound was done for 10 minutes at an intensity of 1.0 W/cm(2) and for the right thoracic limb at 1.5 W/cm(2). Thermistors were pla...
Use of ultrasound-guided autologous bone marrow transfer for treatment of suspensory ligament desmitis in 30 race horses (2003-2010).
Australian veterinary journal    January 29, 2013   Volume 91, Issue 3 102-107 doi: 10.1111/avj.12015
Hall MS, Vasey JR, Russell JW, Russell T.To evaluate the racing performance of horses that underwent ultrasound-guided intralesional injection of autologous bone marrow aspirate for treatment of selected forelimb suspensory ligament (body or branch) core lesions. Methods: Retrospective cohort study of 13 Standardbred and 17 Thoroughbred race horses. Methods: Autologous bone marrow aspirated from the sternebrae was injected, under ultrasound guidance, into suspensory ligament core lesions (body or branch). Racing records were reviewed for a comparison of performance before and after surgery. Results: Of the 13 Standardbreds, 9 (69%) h...
Equine sarcoidosis: clinical signs, diagnosis, treatment and outcome of 22 cases.
Veterinary dermatology    January 22, 2013   Volume 24, Issue 1 218-24.e48 doi: 10.1111/j.1365-3164.2012.01108.x
Sloet van Oldruitenborgh-Oosterbaan MM, Grinwis GC.Equine sarcoidosis may present as a generalized or localized exfoliative dermatitis and/or as a granulomatous inflammation of multiple organs. Objective: To report the clinical signs, diagnosis, treatment and outcome for 22 horses with histologically confirmed sarcoidosis. Methods: Twenty-two horses of different breeds, between 3 and 17 years of age. Methods: Diagnosis was based on clinical signs and histopathological findings. Results: The following three forms of equine sarcoidosis were identified: generalized (13.6%), partially generalized (18.2%) and localized (68.2%). High-dose systemic c...
Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses.
Veterinary dermatology    January 22, 2013   Volume 24, Issue 1 212-7.e7.0E47 doi: 10.1111/j.1365-3164.2012.01080.x
Innerå M, Petersen AD, Desjardins DR, Steficek BA, Rosser EJ, Schott HC.Pituitary pars intermedia dysfunction (PPID) in older equids is commonly recognized by a long hair coat that fails to shed. Objective: The aim of this study was to compare hair follicle stages in PPID-affected horses with excessively long hair coats with the stages of normal aged horses (controls) and to compare hair follicle stages in PPID-affected horses after 6 months of treatment with pergolide mesylate with those of control horses. Methods: Eight PPID-affected horses and four normal, age-matched, control horses. Methods: Skin biopsies were collected from the neck and rump of PPID-affected...
Anesthesia for ophthalmic procedures in the standing horse.
The Veterinary clinics of North America. Equine practice    January 18, 2013   Volume 29, Issue 1 179-191 doi: 10.1016/j.cveq.2012.12.001
Labelle AL, Clark-Price SC.Effective delivery of local anesthesia is essential for successful standing surgical procedures in the horse. Local anesthesia can be used to facilitate examination of the eye, diagnostic procedures, therapeutic techniques, and surgical procedures. Understanding the relevant clinical anatomy and techniques for performing local anesthesia is critical to delivering successful local and regional anesthesia and analgesia.
Complications associated with cheek tooth extraction in the horse.
Journal of veterinary dentistry    January 1, 2013   Volume 30, Issue 4 220-235 doi: 10.1177/089875641303000404
Earley ET, Rawlinson JE, Baratt RM.Common indications for cheek tooth extraction in the horse include dental fracture, periodontal disease, severe decay/ caries, mandibular fracture with alveolar/tooth involvement, and periapical abscess. Complications secondary to extraction of cheek teeth are prevalent. Typical complications may include retained root tip(s), collateral damage of neighboring teeth and alveolar bone, mandibular fracture non-union or delayed union, cemental ankylosis, dilacerated root(s), oroantral/oronasal fistula, palatal deviation of cheek teeth, bone sequestration, sinus involvement, alveolar plug failure, a...
Anesthesia for dystocia and anesthesia of the equine neonate.
The Veterinary clinics of North America. Equine practice    December 23, 2012   Volume 29, Issue 1 215-222 doi: 10.1016/j.cveq.2012.11.003
Bidwell LA.Equine anesthesia is complicated regardless of the procedure being performed. Anesthesia for the mare experiencing dystocia is complicated by the size of the fetus, positioning of the mare for the procedure, and concern over drug effect on the fetus through the neonatal period. Anesthesia of the neonate is complicated by multiple factors, specifically, sensitivity to the drugs administered. Ventilatory support, minimizing drugs administered, and minimizing anesthesia time are essential for a positive outcome.
Ovarian response to porcine FSH in association with ablation-induced or spontaneous follicular wave development during the estrous cycle in crossbred and Brazilian Warmblood mares.
Animal reproduction science    December 20, 2012   Volume 137, Issue 1-2 82-87 doi: 10.1016/j.anireprosci.2012.12.003
Ignácio FS, Bergfelt DR, Mendes D, Orlandi C, Araújo GH, Oliveira JV, Montechiesi DF, Carvalho LR, Meira C.The primary objective of this study was to examine the follicular and ovulatory responses following treatment with pFSH in association with ablation-induced or spontaneous follicular wave emergence or follicle deviation during diestrus in crossbred (Mangalarga×Arabian) and Brazilian Warmblood mares with a propensity for spontaneous multiple ovulations; secondary considerations were given to the collection of embryos. In Experiment 1, crossbred mares were administered (im) saline (control, n=7) or pFSH (25mg) when the largest follicle of the ablation-induced follicular wave reached ≥13mm (n=...
Use of continuous positive airway pressure (CPAP) to optimise oxygenation in anaesthetised horses–a clinical study.
Equine veterinary journal    December 19, 2012   Volume 45, Issue 4 414-418 doi: 10.1111/evj.12011
Mosing M, Rysnik M, Bardell D, Cripps PJ, MacFarlane P.Hypoxaemia is a common problem during equine anaesthesia. Continuous positive airway pressure (CPAP) is a ventilation mode routinely employed in man to overcome hypoxaemia but has not been objectively assessed in horses. Objective: To test the effects of CPAP on oxygenation and its indices in anaesthetised horses in a clinical setting. Methods: Twenty-four healthy horses requiring anaesthesia in dorsal recumbency were anaesthetised using a standard protocol. Following orotracheal intubation and connection to an anaesthetic machine capable of applying CPAP, horses were randomly allocated to ven...
Comparison of the use of scapular ultrasonography, physical examination, and measurement of serum biomarkers of bone turnover versus scintigraphy for detection of bone fragility syndrome in horses.
Journal of the American Veterinary Medical Association    December 14, 2012   Volume 242, Issue 1 76-85 doi: 10.2460/javma.242.1.76
Arens AM, Puchalski SM, Whitcomb MB, Bell R, Gardner IA, Stover SM.To define scintigraphic, physical examination, and scapular ultrasonographic findings consistent with bone fragility syndrome (BFS) in horses; develop indices of BFS severity; and assess accuracy of physical examination, scapular ultrasonography, and serum biomarkers for BFS diagnosis. Methods: Prospective case-control study. Methods: 48 horses (20 horses with BFS and 28 control horses). Methods: Horses underwent forelimb scintigraphic evaluation, physical examination, scapular ultrasonography, and serum collection. Scintigraphy was used as a reference standard to which physical examination, s...
Risk factors associated with cast complications in horses: 398 cases (1997-2006).
Journal of the American Veterinary Medical Association    December 14, 2012   Volume 242, Issue 1 93-98 doi: 10.2460/javma.242.1.93
Janicek JC, McClure SR, Lescun TB, Witte S, Schultz L, Whittal CR, Whitfield-Cargile C.To determine the frequency of and risk factors for complications associated with casts in horses. Methods: Multicenter retrospective case series. Methods: 398 horses with a half-limb or full-limb cast treated at 1 of 4 hospitals. Methods: Data collected from medical records included age, breed, sex, injury, limb affected, time from injury to hospital admission, surgical procedure performed, type of cast (bandage cast [BC; fiberglass tape applied over a bandage] or traditional cast [TC; fiberglass tape applied over polyurethane resin-impregnated foam]), limb position in cast (flexed, neutral, o...
Abdominal abscesses in adult horses: 61 cases (1993-2008).
Journal of the American Veterinary Medical Association    December 12, 2012   Volume 241, Issue 12 1659-1665 doi: 10.2460/javma.241.12.1659
Arnold CE, Chaffin MK.To determine clinical signs, diagnostic methods, treatment, and outcome for a series of adult horses with abdominal abscesses. Methods: Retrospective case series. Methods: 61 adult horses. Methods: Medical records of adult horses with abdominal abscesses treated at Texas A&M Veterinary Medical Teaching Hospital (1993 to 2008) were reviewed. Information was recorded regarding signalment, history, clinical signs, diagnosis, treatment, and short- and long-term outcomes. Risk factors for survival were determined. Results: 61 horses met the criteria for inclusion. Clinical signs included colic ...
Corneal stromal abscessation in two horses treated with intracorneal and subconjunctival injection of 1% voriconazole solution.
Veterinary ophthalmology    December 10, 2012   Volume 16, Issue 6 451-458 doi: 10.1111/vop.12014
Tsujita H, Plummer CE.To describe and evaluate intrastromal and subconjunctival injection of voriconazole for the therapy of deep corneal stromal abscess (DSA) in horses. Methods: A retrospective clinical study describing the indications for intrastromal and subconjunctival voriconazole injection and the outcomes of this procedure in two eyes of two horses. Methods: The two horses in this study failed to respond to medical therapy. Treatment with intracorneal and subconjunctival administration of 1% voriconazole was performed in this study. Results: Treatment with intracorneal and subconjunctival administration of ...
The effect of short- and long-term treatment with manuka honey on second intention healing of contaminated and noncontaminated wounds on the distal aspect of the forelimbs in horses.
Veterinary surgery : VS    December 5, 2012   Volume 42, Issue 2 154-160 doi: 10.1111/j.1532-950X.2012.01083.x
Bischofberger AS, Dart CM, Perkins NR, Kelly A, Jeffcott L, Dart AJ.To compare the effects of manuka honey and manuka honey gel on second intention healing of noncontaminated distal limb wounds and those contaminated with feces. Methods: Experimental study. Methods: Standardbred horses (n = 10). Methods: Five full-thickness wounds (2 × 2 cm) were created on both metacarpi. Wounds on 1 forelimb were covered with horse feces for 24 hours. Wounds on the contralateral limb were left uncontaminated. Wounds were assigned to the following 5 different treatments: manuka honey, manuka honey gel or gel applied for 12 days, manuka honey gel applied throughout healing an...
Advances in equine computed tomography and use of contrast media.
The Veterinary clinics of North America. Equine practice    November 28, 2012   Volume 28, Issue 3 563-581 doi: 10.1016/j.cveq.2012.08.002
Puchalski SM.Advances in equine computed tomography have been made as a result of improvements in software and hardware and an increasing body of knowledge. Contrast media can be administered intravascularly or intrathecally. Contrast media is useful to differentiate between tissues of similar density. Equine computed tomography can be used for many different clinical conditions, including lameness diagnosis, fracture identification and characterization, preoperative planning, and characterization of skull diseases.
The role of MRI in selected equine case management.
The Veterinary clinics of North America. Equine practice    November 28, 2012   Volume 28, Issue 3 647-658 doi: 10.1016/j.cveq.2012.08.006
Barrett MF, Frisbie DD.Magnetic resonance imaging (MRI) allows for excellent evaluation of many types of soft tissue and osseous lesions. Using MRI as a diagnostic modality can help in developing an individualized treatment protocol. Case management can include both surgical and medical intervention. Various MRI findings and associated treatment protocols are described.
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