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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Minimal redistribution of pulmonary blood flow with exercise in racehorses. We determined the spatial distribution of pulmonary blood flow at rest and during increasing levels of exercise (34, 59, and 90% of maximal oxygen consumption) in Thoroughbred racehorses (n = 4) using 15-microns fluorescent microspheres. After the horses were killed, the lungs were flushed free of blood, removed, air-dried at total lung capacity, and sliced into isogravitational planes, which were sampled in a systematic fashion for three-dimensional reconstruction. The fluorescence was measured for quantification of blood flow. Mean pulmonary blood flow heterogeneity (expressed as a coefficie...
Recombinant baculovirus-synthesized African horsesickness virus (AHSV) outer-capsid protein VP2 provides protection against virulent AHSV challenge. African horsesickness virus serotype 4 (AHSV-4) outer-capsid proteins VP2 or VP2 and VP5, prepared from single or dual recombinant baculovirus expression vectors grown in Sf9 insect cells, were administered in different amounts to horses and the neutralizing antibody responses were measured. Control and vaccinated horses were challenged with virulent AHSV-4 6 months later and monitored post challenge. The results indicated that two inoculations of extracts containing VP2 and VP5, or VP2 alone, in doses of 5 micrograms VP2 or more per horse, were sufficient to elicit protection against African ...
Dopaminergic regulation of gonadotrophin secretion in seasonally anoestrous mares. We have previously demonstrated that daily administration of the dopamine D2 antagonist, sulpiride, during seasonal anoestrus, effectively advances the mean time of onset of the breeding season in mares. The purpose of this study was to examine the effect of sulpiride administration on pulsatile FSH and LH secretion in seasonally anoestrous mares, follicular development, time of first ovulation and the fertility at the first ovulation. Fourteen anoestrous mares were selected based on progesterone concentrations < 1 ng ml-1 for 3 weeks and largest follicle diameter < 20 mm. Starting 30 Ja...
Tumour suppressor gene p53 in the horse: identification, cloning, sequencing and a possible role in the pathogenesis of equine sarcoid. The tumour suppressor protein p53 enhances the genetic stability of the cell and plays a critical role in tumour suppression. Equine p53 was analysed by sequencing exons 5 to 9, a region which includes most known mutations and all the mutational hotspots in the species that have been investigated. The fragment was amplified, cloned and sequenced from genomic and complementary DNA. A comparison of the predicted amino acid sequences between the horse and other species resulted in identities between 66 per cent with the clawed frog and 92 per cent with the cat. Using the single strand conformatio...
Pharmacokinetics of ketoprofen in the donkey (Equus asinus). The pharmacokinetic parameters of ketoprofen were determined in four donkeys after a single intravenous injection of a dose of 2.2 mg/kg body weight. The total body clearance (ClB) was 414.0 +/- 98.70 ml/h/kg (mean +/- SD), the volume of distribution at steady state (Vss) 263.10 +/- 55.43 ml/kg and the elimination half-life 1.30 +/- 0.75 h. These values were compared to those obtained in horses.
A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis. To evaluate various biochemical tests as indicators of subclinical liver disease in horses exposed to pyrrolizidine alkaloid toxicosis. Methods: A clinical pathology field study. Methods: Twenty-two clinically normal horses from four properties in the Kimberley region of Western Australia. Methods: Serum samples from each horse were assayed for gamma glutamyltransferase, alkaline phosphatase and aspartate aminotransferase activities, and for serum bile acid concentration, albumin and total protein. Serum protein electrophoresis was performed and their amino acid profiles determined. Bromosulph...
Preventing equestrian injuries. Locking the stable door. The medical and sports literature databases were searched for equestrian sports-related injury published in English since 1980, together with conference abstracts and discussions with equestrian sporting bodies. This literature was critically reviewed, with emphasis on measures to prevent or control injury i.e. countermeasures. While there is considerable literature available on the epidemiology of injury incurred in most equestrian sports, there is little on the prevention of these injuries. Case-control or other studies evaluating the effectiveness of the countermeasures suggested by authors...
Echinococcus granulosus in Spain: strain differentiation by SDS-PAGE of somatic and excretory/secretory proteins. A comparison was made, by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), of excretory/secretory (ES)-crude and immunopurified (with the corresponding anti-host serum) hydatid fluids-and somatic (S)-protoscoleces-proteins, from several ovine, equine, swine, bovine and human Echinococcus granulosus Spanish isolates. Likewise, the host influence on parasitic ES protein expression was studied, comparing purified hydatid fluids from ovine and equine cysts obtained from natural hosts and in RNMI mice. Purified hydatid fluids patterns, under reducing conditions, yielded the mos...
Development of a diagnostic DNA probe to detect Setaria digitata: the causative parasite of cerebrospinal nematodiasis in goats, sheep and horses. Two repetitive sequences (IpSdM and IpSdS) have been cloned and sequenced from the genome of Setaria digitata. When IpSdM (214 bp) and IpSdS (201 bp) were aligned, a high degree of homology (85%) was observed, indicating that they belong to the same family of repeats. IpSdM represents a complete repeating element while IpSdS consists of two partial repeating elements arranged in tandem. The elements are present in about 10 000 copies comprising 2.8% of the S. digitata genome. As a diagnostic probe IpSdM detects as little as 100 pg DNA of both S. digitata and S. labiato-papillosa. It can also d...
Suppression of testicular function using two dose rates of a reversible water soluble gonadotrophin releasing hormone (GnRH) vaccine in colts. To investigate the effect of two dose rates (200 and 400 ng) of a gonadotrophin releasing hormone (GnRH) vaccine on testicular function. Methods: A vaccination dose rate experiment. Methods: Two injections were administered 4 weeks apart to six colts in each treatment group. To maintain immunosuppression until the end of the breeding season, a third injection was given if antibody titres fell below 1000. Results: Effective antibody titres were present for 12 to 27 weeks. Testosterone concentrations decreased from 2.22 to 0.31 nmol/L 6 weeks after primary vaccination. Androstenedione concentrat...
Assessment of autonomic nervous function by power spectral analysis of heart rate variability in the horse. We studied power spectral analysis of heart rate (HR) variability in the horse, with the hypothesis that the quantitative information provided by the spectral analysis of HR variability reflects the interaction between sympathetic and parasympathetic regulatory activities. For this purpose, electrocardiogram, blood pressure (BP) and respiratory (Resp) waveform were simultaneously recorded from Thoroughbred horses (3-5 years old) and analyzed by power spectrum. There were two major spectral components at low-frequency (LF) and high-frequency (HF) bands for HR variability. The peak of Resp varia...
Cardiopulmonary effects of desflurane in ponies, after induction of anaesthesia with xylazine and ketamine. Cardiopulmonary parameters were measured in 12 ponies (small horses) before anaesthesia and, following induction with xylazine and ketamine, during maintenance of anaesthesia with desflurane. In six of the ponies (group A) anaesthesia was maintained for three hours with desflurane at an end-tidal concentration of 7.4 per cent. In the other six ponies (group B), anaesthesia was maintained in the same way for one hour and then the effects of end-tidal desflurane concentrations of 7.4 per cent and 9.6 per cent with and without artificial ventilation were investigated. In group A ponies the arteri...
Risk factors associated with development of diarrhea in horses after celiotomy for colic: 190 cases (1990-1994). To determine the incidence of the risk factors for developing diarrhea in horses after celiotomy for colic. Methods: Retrospective cohort study. Methods: 357 adult horses that had celiotomy for colic at the teaching hospital between Jan 1, 1990 and Sep 1, 1994. Methods: Medical records of horses that had celiotomy for colic were reviewed to abstract information regarding development of diarrhea, signalment, history, and treatment. Results: In horses that had celiotomy for colic, the incidence of diarrhea was 53.2% (190/357). Using multiple logistic regression, horses with a disorder of the lar...
Corynebacterium pseudotuberculosis infection in horses: 538 cases (1982-1993). To describe clinical manifestations of Corynebacterium pseudotuberculosis infection in horses and to evaluate diagnostic methods for identification of this disease. Methods: Retrospective case series. Methods: 538 horses with a diagnosis of C pseudotuberculosis infection. Results: Median age of horses with external abscesses was similar to that in horses with internal abscesses. Breed and sex did not appear to be associated with infection. Cases were detected during all 12 months; however, the disease was most common in the fall and early winter, with the highest incidence in September, Octobe...
Laryngeal and pharyngeal dysfunction in horses homozygous for hyperkalemic periodic paralysis. Evaluate histories, clinical signs, and laboratory data of 69 horses homozygous by DNA testing for hyperkalemic periodic paralysis (HPP). Methods: Cohort study. Methods: 69 of 189 horses testing homozygous for HPP between October 1992 and November 1994. Methods: Questionnaires addressing signalment, training regimes, medical history, and current status of affected horses were sent to owners, trainers, or attending veterinarians. Data from completed questionnaires were tabulated and evaluated, using descriptive statistics. Results: Sixty-nine (37%) of 189 questionnaires were completed and retur...
Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia. Six Welsh gelding ponies (weight 246 +/- 6 kg) were premedicated with 0.03 mg/kg of acepromazine intravenously (i.v.) followed by 0.02 mg/kg of detomidine i.v. Anaesthesia was induced with 2 mg/kg of ketamine i.v. Ponies were intubated and lay in left lateral recumbency. On one occasion anaesthesia was maintained for 2 h using 1.2% halothane in oxygen. The same group of ponies were anaesthetized 1 month later using the same induction regime and anaesthesia was maintained with a combination of detomidine, ketamine and guaiphenesin, while the ponies breathed oxygen-enriched air. Electrocardiogra...
Instrumentation and techniques in equine gastrointestinal surgery. Recent advances in abdominal surgical techniques in the horse have resulted in improved survival rates and reduced postoperative morbidity. The development of abdominal surgical procedures in horses has paralleled the development of safe anesthetic protocols and innovative technological advancements in humans. Irrespective of the species, the application of sound surgical principles is still the foundation of surgical intervention. This article describes recent advances in equine gastrointestinal surgical techniques. The availability and application of innovative intestinal surgical devices an...
Instrumentation and techniques in equine fracture fixation. In recent years fracture fixation in the horse has changed significantly. New devices, mainly adapted from the human field, have been successfully introduced into large animal surgery. Examples of such implants include the DCS/DHS implant system, the self-tapping screw, the cannulated screw, and the pinless external fixator. However, new devices have also been developed exclusively for equine fracture management, including the interlocking intramedullary nail and the external skeletal fixation device. With these devices the surgeon has more options for repairing fractures in horses. Neverthele...
Should a doctor prescribe hormone replacement therapy which has been manufactured from mare’s urine? Many clinicians are experiencing consumer resistance to the prescription of equine HRT (that is hormone replacement therapy which has been manufactured from mare's urine). In this paper I consider the ethical implications of prescribing these preparations. I decide that patients should have a right to refuse such treatment but also ask whether a prescribing doctor should choose one preparation over another on moral grounds. I determine that there is prima facie evidence to suggest that mares may suffer and that prescription of equine HRT (instead of synthetic oestrogen-oestriol) would therefor...
Instrumentation and techniques in transendoscopic upper respiratory tract laser surgery. Transendoscopic laser surgery provides equine surgeons with a safe, reliable, and minimally invasive method of performing many surgical procedures in the upper respiratory tract. Although the Nd:YAG laser has proven efficacy, other newer lasers such as the diode and holmium: YAG lasers may prove to be useful tools for equine upper respiratory tract surgery. Long grasping forceps and a high quality fiberoptic or video endoscope are critical components necessary for performing transendoscopic laser surgery. For many of the most common upper respiratory tract abnormalities, a laryngotomy can be e...
Instrument sterilization, skin preparation, and wound management. Recent advances in instrument sterilization include the introduction of gas plasma sterilization and the increased use of glutaraldehyde. Gas plasma sterilization has the advantages of no toxic residue effects, reduced turnover time, and applicability for sterilization of heat- and moisture-sensitive instruments. Chlorhexidine gluconate (4%) appears to be a superior preoperative surgical scrub for both the surgeon and the patient because of its increased antimicrobial efficacy, residual activity, and minimal tissue reactions. There are many new wound dressings and topical medications for treat...
Control of an outbreak of salmonellosis caused by drug-resistant Salmonella anatum in horses at a veterinary hospital and measures to prevent future infections. Salmonella anatum was isolated from horses treated at a private veterinary clinic or at a university veterinary medical teaching hospital. All isolates were resistant to most commonly used antibiotics. Because of the severity of disease resulting from outbreaks of infections with drug-resistant strains of S anatum, an epidemiologic investigation was conducted. Enteric bacteria, including S anatum, that were resistant to most antibiotics were isolated from the private veterinary clinic environment. Salmonella anatum was not isolated from the university teaching hospital environment. To prevent ...
Effects of altered FIO2 on maximum VO2 in the horse. Although the horse is considered an elite athlete with a specific VO2max some 2-4 times higher than man, maximal O2 transport is compromised both by moderately severe arterial desaturation and by failure to extract all O2 from blood perfusing exercising muscle. This prompted the present study to ascertain whether correction of arterial desaturation would proportionally augment VO2max and, if so, would O2 extraction behave in a manner predicted by diffusional transport limitation. Six two year old thoroughbreds were exercised to VO2max on a treadmill each on three separate occasions breathing g...
