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Topic:Veterinary Research

Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Hypothermic storage of equine isolated hepatocytes.
Polish journal of veterinary sciences    March 29, 2007   Volume 10, Issue 1 11-18 
Bakała A, Karlik W, Wiechetek M.The aim of the study was to establish the optimal methods for hypothermic storage of equine isolated hepatocytes. Viability of equine isolated hepatocytes after hypothermic storage was dependent on the type of storage medium as well as on the cell density in the storage suspension and the preservation period. Hepatocytes stored at 4 degrees C in Hanks' Balanced Salt Solution (HBSS) and Williams' Medium E (WE) for 24 h showed very low viability, numerous cell membrane blebs, very low attachment rate (11.9 +/- 6.5% and 34.8 +/- 19.1%, respectively) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylte...
Molecular genetic analysis of the ATP2A2 gene as candidate for chronic pastern dermatitis in German draft horses.
The Journal of heredity    March 29, 2007   Volume 98, Issue 3 267-271 doi: 10.1093/jhered/esm004
Mömke S, Distl O.Chronic pastern dermatitis predominantly affects draft horses, and this condition is characterized by hyperkeratotic-hyperplastic dermal alterations. Chronic pastern dermatitis resembles the acral-hemorrhagic phenotype of Darier-White disease in humans. The ATP2A2 gene has been shown to be responsible for human Darier-White. Thus, we chose ATP2A2 on equine chromosome 8 (ECA8) as candidate for chronic pastern dermatitis in coldblood horses. A linkage analysis was performed in 10 paternal half-sib families consisting of 85 German coldblood horses using a microsatellite closely linked to ATP2A2, ...
Ultrasonographic anatomy of the temporomandibular joint in healthy pure-bred Spanish horses. Rodríguez MJ, Soler M, Latorre R, Gil F, Agut A.The objective was to describe the normal ultrasonographic appearance of the soft tissue and bony structures of the temporomandibular joint in Pure-Bred Spanish horses using frozen and plastinated sections performed as anatomical references. The temporomandibular joint of five healthy Pure-Bred Spanish horses and the head specimens from 12 Pure-Bred Spanish cadavers that were subjected to euthanasia for reasons other than temporomandibular joint problems were studied sonographically and anatomically. An 11 MHz linear-array transducer was used to obtain longitudinal ultrasonographic images of th...
Asymmetric signal intensity in normal collateral ligaments of the distal interphalangeal joint in horses with a low-field MRI system due to the magic angle effect. Spriet M, Mai W, McKnight A.Increased signal intensity in one of the collateral ligaments of the distal interphalangeal (DIP) joint of sound horses in images acquired using a low-field magnet with vertical orientation of the magnetic field was investigated as a possible manifestation of the magic angle effect. Three isolated equine digits were imaged using the following pulse sequences: (1) spin echo TI, (2) turbo spin echo proton density and T2, and (3) 3D gradient echo T1, in different positions by mildly changing the orientation of the long axis of the digit, in the dorsal plane, relative to the magnetic field. The si...
Caries in the infundibulum of the second upper premolar tooth in the horse.
Acta veterinaria Scandinavica    March 28, 2007   Volume 49, Issue 1 10 doi: 10.1186/1751-0147-49-10
Lundström TS, Dahlén GG, Wattle OS.Swedish equine dental practices have empirically found that the prevalence of infundibular caries as a primary disorder in the first permanent premolar teeth (P2) of the horse upper jaw has increased during the last 10 years. A previously unknown bacterial species, Streptococcus devriesei (CCUG 47155T), which is related to Streptococcus mutans, has recently been isolated from these carious lesions. To understand the aetiology of caries in horses, it is essential to elucidate the relationship between S. devriesei and P2 infundibular caries. Methods: The anterior infundibulum of maxillary P2, or...
Reported morbidities following 861 anaesthetics given at four equine hospitals.
The Veterinary record    March 27, 2007   Volume 160, Issue 12 407-408 doi: 10.1136/vr.160.12.407
Senior JM, Pinchbeck GL, Allister R, Dugdale AH, Clark L, Clutton RE, Coumbe K, Dyson S, Clegg PD.No abstract available
Classes and crossreactivity of proteinases in the excretory-secretory products of Caenorhabditis elegans.
Journal of helminthology    March 27, 2007   Volume 81, Issue 1 93-99 doi: 10.1017/S0022149X0724725X
Nic An Ultaigh S, Ryan MF.Proteinases released during the in vitro maintenance of asynchronous cultures of the free-living nematode Caenorhabditis elegans were characterized on the basis of subunit composition, fluorogenic substrate specificity, inhibitor sensitivity and pH optima. Cysteine proteinases are present in the excretory-secretory products (ESP) as indicated by the hydrolysis of cathepsin fluorogenic substrates and confirmed by immunoblotting. Serine proteinases were predominant as indicated by substrate gel analysis and inhibitor studies. The presence of metallo-proteinases was also indicated by inhibitor st...
Larval viability and serological response in horses with long-term Trichinella spiralis infection.
Veterinary parasitology    March 26, 2007   Volume 146, Issue 1-2 107-116 doi: 10.1016/j.vetpar.2007.02.011
Hill DE, Forbes L, Kramer M, Gajadhar A, Gamble HR.The horse is considered an aberrant host for the nematode parasite Trichinella spiralis, and many aspects of the biology and epidemiology of Trichinella infection in the horse are poorly understood. It has been reported that experimentally-infected horses produce a transient serological response to infection and that muscle larvae are cleared more rapidly than in parasite-adapted hosts such as the pig and humans. However, limited numbers of animals have been studied, and both the longevity of larvae in horse musculature and the immune response to Trichinella larvae remain unclear. In this stud...
Descriptive analysis of retirement of Thoroughbred racehorses due to tendon injuries at the Hong Kong Jockey Club (1992-2004).
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 143-148 doi: 10.2746/042516407x159132
Lam KH, Parkin TD, Riggs CM, Morgan KL.This study was part of a programme to optimise the longevity and maximise the health and welfare of the Thoroughbred racehorses in Hong Kong. Injuries to the superficial digital flexor (SDF) tendon are the most common veterinary reason for premature retirement in this population. Objective: To describe the frequency and pattern of retirements associated with SDF tendon injuries in Thoroughbred racehorses and to compare the characteristics of these horses with those that retired for other reasons. Methods: A retrospective analysis of retirement records documented in the Hong Kong Jockey Club cl...
Fire and smoke inhalation injury in horses.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 19-30 doi: 10.1016/j.cveq.2006.11.005
Marsh PS.Although not common in horses, fire and smoke inhalation trauma may require veterinary assistance at several levels. Most commonly, the equine clinician is called on to provide care of potentially complex and emotionally charged cases. Thermal injury, along with smoke inhalation, can cause local and diffuse lesions. Massive tissue edema may occur, which can be a challenge to manage as well as creating organ dysfunction at distant sites. Further complications of severely affected patients are varied and include life-threatening sepsis. This article reviews some of the important features of this...
Management of equine poisoning and envenomation.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 31-47 doi: 10.1016/j.cveq.2006.11.007
Landolt GA.Acute poisoning and envenomation often represent a diagnostic and therapeutic challenge. Although identification ultimately may benefit the affected animal, treatment frequently must commence before an etiologic diagnosis is established. Therefore, the goals for the management of acutely intoxicated horses must be focused on emergency intervention and stabilization of the patient, prevention of further exposure, and aggressive decontamination. This article reviews the treatment steps that should be considered during the management of horses experiencing poisoning or envenomation.
Injury to synovial structures.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 103-116 doi: 10.1016/j.cveq.2006.12.001
Joyce J.Injuries to synovial structures are common in horses and may be life threatening or career ending if severe. Early recognition and initiation of aggressive treatment in the form of appropriate systemic and local antimicrobial therapy and surgical treatment improve the likelihood of a good outcome. Chronic injuries and delayed treatment may result in progression of infection into tendons, bone, and other structures, thus complicating treatment and resulting in a poorer prognosis for return to function.
Neonatal foal resuscitation.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 159-182 doi: 10.1016/j.cveq.2006.11.001
Palmer JE.Cardiac arrest in foals is generally secondary to other serious systemic diseases. Although it can often be anticipated, a clear plan is vital to success. Establishing cardiac output through chest compressions is the most important first step. This step should be followed by ventilation, drug therapy, identifying the nonperfusing cardiac rhythm, and following a preplanned treatment algorithm. Birth resuscitation requires special treatment considerations. The clinician should be prepared to perform resuscitation any time a birth is attended.
Ophthalmic emergencies in horses.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 49-65 doi: 10.1016/j.cveq.2006.11.009
Schaer BD.The emergency clinician is frequently in the position of receiving, evaluating, and initiating treatment on horses with ophthalmic emergencies or orbital trauma. In the best of circumstances, an ophthalmologist is available to guide initial therapy and ultimately assume responsibility for the management of the patient during the remainder of its hospitalization, but this is not always the case. The information presented here is meant to provide the emergency clinician with basic guidelines for the initial assessment and management of horses sustaining ocular injuries or presented with an ophth...
Thoracic trauma in horses.
The Veterinary clinics of North America. Equine practice    March 24, 2007   Volume 23, Issue 1 67-80 doi: 10.1016/j.cveq.2006.11.006
Hassel DM.Thoracic trauma represents an important cause of morbidity in mortality after injury in human beings and animals. After any form of suspected chest wall trauma, initial emergency management should include assurance of a patent airway and adequate ventilation, along with treatment for shock if present. As with any open wound, tetanus prophylaxis should be instituted. Types of trauma to the thoracic region of the horse include pectoral and axillary lacerations, penetrating chest wounds, flail chest, fractures of the ribs, blunt thoracic trauma, and several potential sequelae that include pneumot...
Oral and intravenous administration of nimesulide in the horse: rational dosage regimen from pharmacokinetic and pharmacodynamic data.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 136-142 doi: 10.2746/042516407x159123
Villa R, Cagnardi P, Belloli C, Zonca A, Zizzadoro C, Ferro E, Carli S.The selective COX-2-inhibitor nimesulide is used extra-label in equine veterinary practice as an anti-inflammatory agent. However, there are no data on which to base the rational use of the drug in this species. Objective: To determine the effective COX selectivity of nimesulide in the horse, and suggest a suitable dosing schedule. Methods: The pharmacokinetics of nimesulide in the horse after oral administration (1 mg/kg bwt), and oral and i.v. administration (1.5 mg/kg bwt) were investigated, effects of feeding status on bioavailability determined, and plasma protein binding of the drug and ...
Defocused CO2 laser on equine skin: a histological examination.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 114-119 doi: 10.2746/042516407x164019
Bergh A, Ridderstråle Y, Ekman S.No studies have been published on effects of treatment with a defocused beam carbon dioxide (CO2) laser on equine skin histology. A better understanding of this will help to define how lasers should be used, in order to reduce potential side effects. Objective: To describe the acute effects of different doses of defocused CO2 laser, ranging from therapeutic to surgical levels, on equine skin. Methods: Defocused CO2 laser was administered to the skin in the hamstrings (91 J/cm2), fetlock (137 J/cm2) and loin (450 J/cm2) areas of 13 Standardbred horses. The acute effects on skin histology were e...
Detection of nandrolone administration to the entire male horse by a provisional concentration threshold for urinary oestranediol determined by gas chromatography-mass spectrometry.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 186-188 doi: 10.2746/042516407x170418
Dehennin L, Bonnaire Y, Plou P.No abstract available
Equine sarcoids are not induced by an infectious cell line.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 189-191 doi: 10.2746/042516407x179879
Gobeil P, Gault EA, Campo MS, Gow J, Morgan IM, Nasir L.No abstract available
Detection of rib trauma in newborn foals in an equine critical care unit: a comparison of ultrasonography, radiography and physical examination.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 158-163 doi: 10.2746/042516407x166657
Jean D, Picandet V, Macieira S, Beauregard G, D'Anjou MA, Beauchamp G.Previous studies have shown that in man ultrasonography is more accurate than radiography for detecting rib fractures. Objective: To describe clinical, radiographic and ultrasonographic findings related with rib fractures in newborn foals in an equine critical care unit; and to compare diagnostic accuracy of ultrasonography to radiography. Methods: A prospective ultrasonographic study was performed on 29 foals presented to the emergency unit. This study was performed at the Centre Hospitalier Universitaire Vétérinaire (CHUV), University of Montreal. Physical examination as well as radiograph...
Comparison of prednisolone and dexamethasone effects in the presence of environmental control in heaves-affected horses.
Veterinary journal (London, England : 1997)    March 23, 2007   Volume 175, Issue 2 227-233 doi: 10.1016/j.tvjl.2006.12.006
Couroucé-Malblanc A, Fortier G, Pronost S, Siliart B, Brachet G.This study was designed to compare the efficacy of oral prednisolone and intramuscular (IM) dexamethasone in heaves-affected horses with environmental control. A total of 16 horses, aged 8-20years, with heaves were included in the study. Complete examinations were performed on Day 0 (before treatment), Day 13 (after treatment) and Day 30. Clinical variables, arterial blood gases, mucus scoring and carina evaluation (during endoscopy), and bronchoalveolar lavage (BAL) cytological analysis were all assessed. The horses were randomly assigned to receive either oral prednisolone (1mg/kg) or IM dex...
The distribution of ganglion cells in the equine retina and its relationship to skull morphology.
Anatomia, histologia, embryologia    March 21, 2007   Volume 36, Issue 2 151-156 doi: 10.1111/j.1439-0264.2006.00749.x
Evans KE, McGreevy PD.It has recently been reported that a strong correlation exists between the distribution of retinal ganglion cells and nose length in the domestic dog. To determine if this phenomenon occurs in another domestic species with diverse skull morphology, the current study examined the distribution of retinal ganglion cells in 30 horses from a variety of breeds. There was a significant variation in the density of ganglion cells found across the retinae. Breed was a significant predictor for ganglion cell density within the visual streak. A strong positive correlation exists between the density of gan...
Development of a real-time RT-PCR assay for improved detection of Borna disease virus.
Journal of virological methods    March 21, 2007   Volume 143, Issue 1 1-10 doi: 10.1016/j.jviromet.2007.01.034
Wensman JJ, Thorén P, Hakhverdyan M, Belák S, Berg M.Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species. BDV is the causative agent of the neurological disorders in horses and sheep termed classical Borna disease (BD), as well as staggering disease in cats. At present, the diagnosis staggering disease or feline BD is made by histopathology or immunohistochemistry of the CNS. In order to obtain a better clinical diagnostic tool, a duplex real-time RT-PCR assay (rRT-PCR) was developed. TaqMan probes and primers specific for the BDV P and BDV L...
[Equine herpesvirus 2: A study on the relation between viral excretion and respiratory disease in thoroughbred horses].
Revista Argentina de microbiologia    March 21, 2007   Volume 38, Issue 4 216-218 
Craig MI, Barrandeguy ME, Fernández FM.Equine herpesvirus 2 (EHV-2) was isolated from healthy animals; therefore, the association between EHV-2 infection and respiratory disease raises the question of the role of this agent in this pathology. To date, there are no reports that relate viral excretion to health, this study then analysed 153 nasal swabs from horses in different age groups (older and younger than 1 year old) and state of health (clinically healthy and with respiratory symptoms). Results showed that the percentage of horses with viral excretion was higher within the clinically healthy group, being significative (p < 0.0...
Composition, physiochemical properties, nitrogen fraction distribution, and amino acid profile of donkey milk.
Journal of dairy science    March 21, 2007   Volume 90, Issue 4 1635-1643 doi: 10.3168/jds.2006-600
Guo HY, Pang K, Zhang XY, Zhao L, Chen SW, Dong ML, Ren FZ.This study investigated the changes in chemical composition, nitrogen fraction distribution, and AA profile of milk samples obtained during lactation from the Jiangyue breed of donkey in Northwest China. Results showed that donkey milk contained 9.53% total solids, 1.57% protein, 1.16% fat, 6.33% lactose, and 0.4% ash on average, which is more similar to mare and human milk than to the milk of other mammals. Throughout the lactation investigated, pH and density were constant, protein and ash content showed an apparent negative trend (an increase in lactose content during 120 d postpartum, foll...
Investigation and management of an outbreak of abortion related to equine herpesvirus type 1 in unvaccinated ponies.
The Veterinary record    March 21, 2007   Volume 160, Issue 11 378-380 doi: 10.1136/vr.160.11.378
Irwin VL, Traub-Dargatz JL, Newton JR, Scase TJ, Davis-Poynter NJ, Nugent J, Creis L, Leaman TR, Smith KC.No abstract available
Equinology.
Archives of dermatology    March 21, 2007   Volume 143, Issue 3 438 doi: 10.1001/archderm.143.3.438
Peterson JD, Wirges ML.No abstract available
Chromosomal assignment of the two candidate genes (EGFR, CLCA1) for equine recurrent airway obstruction (RAO) by FISH and RH mapping.
Hereditas    March 17, 2007   Volume 143, Issue 2006 138-141 doi: 10.1111/j.2006.0018-0661.01947.x
Klukowska-Rötzler J, Bugno M, Sander P, Slota E, Dolf G, Chowdhary BP, Leeb T, Gerber V.No abstract available
3D kinematics of the interphalangeal joints in the forelimb of walking and trotting horses.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    March 17, 2007   Volume 20, Issue 1 1-7 
Clayton HM, Sha DH, Stick JA, Robinson P.The objective was to measure 3D rotations of the distal (DIP) and proximal (PIP) interphalangeal joints at walk and trot. 3D trajectories of markers fixed to the proximal phalanx, middle phalanx and the hoof wall of the right forelimb of four sound horses were recorded at 120 Hz. Joint kinematics were calculated in terms of anatomically-based joint coordinate systems between the bone segments. Ranges of motion were similar at walk and trot. Values for the DIP joint were: flexion/extension: 46 +/- 3 degrees at walk, 47 +/- 4 degrees at trot; internal/external rotation: 5 +/- 1 degrees at walk, ...
A case of multiple epitrichial sweat gland ductal carcinomas in a horse.
Veterinary dermatology    March 16, 2007   Volume 18, Issue 2 134-137 doi: 10.1111/j.1365-3164.2007.00574.x
Cihocki LM, Divers TJ, Johnson AL, Warren AL, Schramme M, Rassnick KM, Scott DW.This case report describes a rare epitrichial sweat gland ductal carcinoma in a 14-year-old horse and is the first report of multiple carcinomas of this type in horses. Although several tumours developed, mostly on the distal extremities, over a 2-year period, the horse remained otherwise healthy. Topical treatment with imiquimod was successful for many of them.