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Home / Equine Research Bank / Stem Cell Rev Rep / Adipose-Derived Stromal/Stem Cells from Large Animal Models:...
Stem cell reviews and reports2020; 17(3); 719-738; doi: 10.1007/s12015-020-10049-y

Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science.

Abstract: Adipose-derived stem cells (ASCs) isolated from domestic animals fulfill the qualitative criteria of mesenchymal stem cells, including the capacity to differentiate along multiple lineage pathways and to self-renew, as well as immunomodulatory capacities. Recent findings on human diseases derived from studying large animal models, have provided evidence that administration of autologous or allogenic ASCs can improve the process of healing. In a narrow group of large animals used in bioresearch studies, pigs and horses have been shown to be the best suited models for study of the wound healing process, cardiovascular and musculoskeletal disorders. To this end, current literature demonstrates that ASC-based therapies bring considerable benefits to animal health in both spontaneously occurring and experimentally induced clinical cases. The purpose of this review is to provide an overview of the diversity, isolation, and characterization of ASCs from livestock. Particular attention has been paid to the functional characteristics of the cells that facilitate their therapeutic application in large animal models of human disease. In this regard, we describe outcomes of ASCs utilization in translational research with pig and horse models of disease. Furthermore, we evaluate the current status of ASC-based therapy in veterinary practice, particularly in the rapidly developing field of equine regenerative medicine. In conclusion, this review presents arguments that support the relevance of animal ASCs in the field of regenerative medicine and it provides insights into the future perspectives of ASC utilization in animal husbandry.
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Publication Date: 2020-10-06 PubMed ID: 33025392PubMed Central: PMC8166671DOI: 10.1007/s12015-020-10049-yGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the potential uses of adipose-derived stem cells (ASCs) from large animals, like pigs and horses, for improving healing processes. It evaluates the efficacy of these stem cells in treating human diseases and also discusses their application in veterinary medicine.

Stem Cells from Large Animal Models

The researchers studied the use of adipose-derived stem cells (ASCs) that are isolated from domestic animals such as pigs and horses. These cells are described as having:

  • The qualitative criteria of mesenchymal stem cells, which includes the ability to differentiate along multiple lineage pathways and to self-renew.
  • Immunomodulatory capacities, which means they can modulate or regulate the immune response.

Application of ASCs in Healing

The study reports that administration of these ASCs, from the same animal (autologous) or a different animal (allogenic), can improve the process of healing. The researchers focused on pigs and horses as they found them to be the best models for studying conditions such as wound healing process, cardiovascular, and musculoskeletal disorders.

Use of ASCs in Clinical Cases

The evidence indicates that ASC-based therapies are beneficial to animal health in both naturally occurring and experimentally induced clinical cases. The researchers explored the functional characteristics of ASCs that facilitate their therapeutic application in large animal models. They also covered the outcomes of ASC usage in translational research, where the findings in animal models are applied to human disease treatments.

ASC-based Therapy in Veterinary Practice

The research reveals the progress of ASC-based therapy in veterinary practice, especially in the rapidly developing field of equine regenerative medicine. It demonstrates how stem cells from large animals can be used in regenerative medicine. The researchers examined animal ASCs’ relevance in regenerative medicine and its potential future application in animal husbandry.

Conclusion

The study concludes by endorsing the importance of animal ASCs in regenerative medicine. It argues that these stem cells provide significant potential for use in disease treatment, not only improving healing in human diseases but also in veterinary medicine.

Cite This Article

APA
Bukowska J, Szóstek-Mioduchowska AZ, Kopcewicz M, Walendzik K, Machcińska S, Gawrońska-Kozak B. (2020). Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science. Stem Cell Rev Rep, 17(3), 719-738. https://doi.org/10.1007/s12015-020-10049-y

Publication

Stem cell reviews and reports
ISSN: 2629-3277
NlmUniqueID: 101752767
Country: United States
Language: English
Volume: 17
Issue: 3
Pages: 719-738

Researcher Affiliations

Bukowska, Joanna
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland. j.bukowska@pan.olsztyn.pl.
Szóstek-Mioduchowska, Anna Zuzanna
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland.
Kopcewicz, Marta
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland.
Walendzik, Katarzyna
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland.
Machcińska, Sylwia
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland.
Gawrońska-Kozak, Barbara
  • Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland.

MeSH Terms

  • Adipocytes
  • Adipose Tissue
  • Animals
  • Horses
  • Mesenchymal Stem Cells / metabolism
  • Stem Cells
  • Stromal Cells
  • Swine

Conflict of Interest Statement

The authors report no conflicts of interest.

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