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Topic:Disease Management

Disease management in horses encompasses the strategies and practices employed to prevent, control, and treat diseases affecting equine populations. This field involves understanding the etiology, transmission, and clinical presentation of various equine diseases, as well as implementing biosecurity measures and therapeutic interventions. Common diseases in horses include equine influenza, strangles, and equine herpesvirus. Effective disease management relies on accurate diagnosis, vaccination protocols, and the use of antimicrobials and other treatments. This page compiles peer-reviewed research studies and scholarly articles that explore the methodologies, challenges, and advancements in managing diseases in equine health.
Equine Anthelmintic Resistance: Horse Owner and Yard Manager Perception of the Barriers Affecting Strategic Control Measures in England.
Veterinary sciences    October 11, 2022   Volume 9, Issue 10 doi: 10.3390/vetsci9100560
McTigue FE, Mansbridge SC, Pyatt AZ.Equine anthelmintic resistance poses a threat to the health and welfare of horses worldwide. With no new imminent anthelmintic classes, it is vital to decrease the resistance rate and preserve available classes. Traditional indiscriminate anthelmintic use is not synonymous with a strategic control ideology; however, many continue to implement outdated practices. In comparison to livestock farmers, there have been few social science studies examining horse owner behaviours. This study aimed to understand the perceived barriers faced by horse owners and yard managers to adopting a strategic appr...
Pituitary Pars Intermedia Dysfunction (PPID) in Horses.
Veterinary sciences    October 10, 2022   Volume 9, Issue 10 556 doi: 10.3390/vetsci9100556
Kirkwood NC, Hughes KJ, Stewart AJ.Substantial morbidity results from pituitary pars intermedia dysfunction (PPID) which is often underestimated by owners and veterinarians. Clinical signs, pathophysiology, diagnostic tests, and treatment protocols of this condition are reviewed. The importance of improved recognition of early clinical signs and diagnosis are highlighted, as initiation of treatment will result in improved quality of life. Future research should be targeted at improving the accuracy of the diagnosis of PPID, as basal adrenocorticotropic hormone (ACTH) concentration can lack sensitivity and thyrotropin releasing ...
Comparative Genome Analysis of All Nine African Horse Sickness Serotypes Isolated From Equine Fatalities in Kenya and South Africa.
Journal of equine veterinary science    October 9, 2022   Volume 119 104137 doi: 10.1016/j.jevs.2022.104137
Hoffmann B, Joseph S, Patteril NAG, Caveney MR, Elizabeth SK, Muhammed R, Wernery R, Wernery U.African horse sickness (AHS) is a viral disease of equids, caused by a virus of the genus Orbivirus, family Reoviridae. The African horse sickness virus (AHSV) genome is made up of ten double-stranded RNA (dsRNA) segments that together code for seven structural and four nonstructural proteins. AHS is endemic in sub-Saharan countries. The efficacy and safety of inactivated AHS vaccines containing all nine serotypes, produced at the Central Veterinary Research Laboratory (CVRL) in Dubai, United Arab Emirates have been proven in the past. All nine AHSV serotypes were isolated from 102 samples col...
Study design synopsis: Evidence syntheses-What are they and why do we need them?
Equine veterinary journal    October 6, 2022   Volume 54, Issue 6 1011-1012 doi: 10.1111/evj.13872
Freeman SL.No abstract available
Biomarkers of Kidney Disease in Horses: A Review of the Current Literature.
Animals : an open access journal from MDPI    October 5, 2022   Volume 12, Issue 19 2678 doi: 10.3390/ani12192678
Galen GV, Olsen E, Siwinska N.Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease. The objectives are to describe new equine kidney biomarkers. This systematic review assesses the available literature, including the validation process and reference values, following which the authors suggest recommendations for clinical use. SDMA may have some potential as equine kidney biomarker, but there is currently a lack of evidence that SDMA offers any advan...
Characterization of an outbreak of equine coronavirus infection in adult horses in Switzerland.
Schweizer Archiv fur Tierheilkunde    October 5, 2022   Volume 164, Issue 10 733-739 doi: 10.17236/sat00372
Fouché N, Remy-Wohlfender F, Blau D, Franzen J, Gurtner C, Seuberlich T, Unger L, Gerber V.Outbreaks of equine coronavirus (ECoV) infections have been described in different parts of the world including Europe. The aim of this report was to describe clinical signs, diagnostic work-up and outcome of the first documented outbreak of ECoV in Switzerland in order to raise the awareness for the disease and its various clinical presentations. The outbreak occurred on a farm with 26 horses. Of these, seven horses developed clinical disease ranging from mild signs such as fever and anorexia to severe signs of acute colitis. One horse died due to severe endotoxemia and circulatory shock seco...
Epidemiological investigation of equine hindlimb ataxia with Setaria digitata in South Korea.
Journal of veterinary science    September 30, 2022   Volume 23, Issue 5 e75 doi: 10.4142/jvs.22045
Hwang H, Ro Y, Lee H, Kim J, Lee K, Choi EJ, Bae YC, So B, Kwon D, Kim H, Lee I.Since 2013, the number of requests for diagnosis for horses based on neurological symptoms has increased rapidly in South Korea. The affected horses have commonly exhibited symptoms of acute seasonal hindlimb ataxia. A previous study from 2015-2016 identified as the causative agent. Objective: This study is an epidemiological investigation to find out risk factors related to the rapid increase in hindlimb ataxia of horses due to aberrant parasites in South Korea. Methods: An epidemiological investigation was conducted on 155 cohabiting horses in 41 horse ranches where the disease occurred. Th...
Molecular detection and therapeutic study of Trypanosoma brucei evansi from naturally infected horses in Punjab, Pakistan.
Polish journal of veterinary sciences    September 27, 2022   Volume 25, Issue 3 429-435 doi: 10.24425/pjvs.2022.142027
Zahoor J, Kashif M, Nasir A, Bakhsh M, Qamar MF, Sikandar A, Rehman A.Trypanosomiasis is one of the severe pathogenic infections, caused by several Trypanosoma species, affecting both animals and humans, causing substantial economic losses and severe illness. The objective of this study was to determine the molecular diagnosis and the risk factors associated with trypanosomiasis in District Jhang, Punjab, Pakistan. For this purpose, blood samples were randomly collected from 200 horses. A predesigned questionnaire was used to collect data on risk factors before the sample collection. The microscopy examination through Giemsa staining, formol gel test and PCR tec...
High-throughput sequencing technologies in the detection of livestock pathogens, diagnosis, and zoonotic surveillance.
Computational and structural biotechnology journal    September 26, 2022   Volume 20 5378-5392 doi: 10.1016/j.csbj.2022.09.028
Suminda GGD, Bhandari S, Won Y, Goutam U, Kanth Pulicherla K, Son YO, Ghosh M.Increasing globalization, agricultural intensification, urbanization, and climatic changes have resulted in a significant recent increase in emerging infectious zoonotic diseases. Zoonotic diseases are becoming more common, so innovative, effective, and integrative research is required to better understand their transmission, ecological implications, and dynamics at wildlife-human interfaces. High-throughput sequencing (HTS) methodologies have enormous potential for unraveling these contingencies and improving our understanding, but they are only now beginning to be realized in livestock resea...
Management of pituitary pars intermedia dysfunction in practice: A clinical audit.
Veterinary journal (London, England : 1997)    September 24, 2022   Volume 289 105899 doi: 10.1016/j.tvjl.2022.105899
Steel NL, Ireland JL, McGowan CM.In horses/ponies with pituitary pars intermedia dysfunction (PPID), pergolide mesylate treatment, with monitoring of therapeutic response, is recommended by contemporaneous literature and equine endocrinologists. However, it is unknown whether these recommendations are adhered to in private practice. This clinical audit aimed to compare treatment and monitoring of PPID cases in veterinary practice against available recommendations. Case data and basal plasma adrenocorticotropic hormone (ACTH) concentrations from all equids tested for PPID between 2012 and 2016 from a single veterinary practice...
Correction to: Potent Neutralizing Activity of Polyclonal Equine Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern.
The Journal of infectious diseases    September 22, 2022   Volume 227, Issue 7 926 doi: 10.1093/infdis/jiac374
No abstract available
Antimicrobial resistance among Streptococcus equi subspecies zooepidemicus and Rhodococcus equi isolated from equine specimens submitted to a diagnostic laboratory in Kentucky, USA.
PeerJ    September 21, 2022   Volume 10 e13682 doi: 10.7717/peerj.13682
Lord J, Carter C, Smith J, Locke S, Phillips E, Odoi A.Surveillance of antimicrobial resistance (AMR) among veterinary pathogens is necessary to identify clinically relevant patterns of AMR and to inform antimicrobial use practices. Streptococcus equi subsp. zooepidemicus and Rhodococcus equi are bacterial pathogens of major clinical importance in horses and are frequently implicated in respiratory tract infections. The objectives of this study were to describe antimicrobial resistance patterns and identify predictors of AMR and multidrug resistance (MDR) (resistance to three or more antimicrobial classes) among equine S. zooepidemicus and R. equi...
Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update.
Animals : an open access journal from MDPI    September 20, 2022   Volume 12, Issue 19 doi: 10.3390/ani12192486
Pacchiarotti G, Nardini R, Scicluna MT.Viral hepatitis has recently assumed relevance for equine veterinary medicine since a variety of new viruses have been discovered. Equine Hepacivirus (EqHV) is an RNA virus belonging to the Flaviviridae family that can cause subclinical hepatitis in horses, occasionally evolving into a chronic disease. EqHV, to date, is considered the closest known relative of human HCV. EqHV has been reported worldwide therefore assessing its features is relevant, considering both the wide use of blood products and transfusions in veterinary therapies and its similitude to HCV. The present review resumes the ...
Epidemiological and Genomic Characterisation of Middelburg and Sindbis Alphaviruses Identified in Horses with Febrile and Neurological Infections, South Africa (2014-2018).
Viruses    September 11, 2022   Volume 14, Issue 9 2013 doi: 10.3390/v14092013
Fourie I, Snyman J, Williams J, Ismail A, Jansen van Vuren P, Venter M.Although Old World alphaviruses, Middelburg- (MIDV) and Sindbis virus (SINV), have previously been detected in horses and wildlife with neurologic disease in South Africa, the pathogenesis and clinical presentation of MIDV and SINV infections in animals are not well documented. Clinical samples from horses across South Africa with acute or fatal neurologic and febrile infections submitted between 2014-2018 were investigated. In total, 69/1084 (6.36%) and 11/1084 (1.01%) horses tested positive for MIDV and SINV, respectively, by real-time reverse transcription (RT) PCR. Main signs/outcomes for ...
Equine disease surveillance: quarterly update.
The Veterinary record    September 10, 2022   Volume 191, Issue 5 e2207 doi: 10.1002/vetr.2207
No abstract available
Reflecting on the 11th International Equine Infectious Diseases Conference.
The Veterinary record    September 10, 2022   Volume 191, Issue 5 e2208 doi: 10.1002/vetr.2208
Kydd J, Nielsen M, Waller A.Julia Kydd, Martin Nielsen and Andrew Waller highlight some of the key presentations given at last year's 11th International Equine Infectious Diseases Conference, which was held virtually.
Criteria for Progressive Pulmonary Fibrosis: Getting the Horse Ready for the Cart.
American journal of respiratory and critical care medicine    September 7, 2022   Volume 207, Issue 1 11-13 doi: 10.1164/rccm.202208-1639ED
Cottin V.No abstract available
Rapid risk assessment tool (RRAT) to prioritize emerging and re-emerging livestock diseases for risk management.
Frontiers in veterinary science    September 7, 2022   Volume 9 963758 doi: 10.3389/fvets.2022.963758
de Vos CJ, Petie R, van Klink EGM, Swanenburg M.Increasing globalization and international trade contribute to rapid expansion of animal and human diseases. Hence, preparedness is warranted to prevent outbreaks of emerging and re-emerging diseases or detect outbreaks in an early stage. We developed a rapid risk assessment tool (RRAT) to inform risk managers on the incursion risk of multiple livestock diseases, about the main sources for incursion and the change of risk over time. RRAT was built as a relational database to link data on disease outbreaks worldwide, on introduction routes and on disease-specific parameters. The tool was parame...
Epidemiology of equine influenza in the Maghreb area.
Comparative immunology, microbiology and infectious diseases    September 6, 2022   Volume 89 101868 doi: 10.1016/j.cimid.2022.101868
Kareche H, Daly JM, Laabassi F.Equine influenza (EI) is one of the most contagious respiratory infections in horses, donkeys and mules, caused by equine influenza A virus (EIV). It remains a disease with a strong economic stake for the equine industry. This review focuses on the epidemiological situation of EIV in the Maghreb area, which includes Algeria, Morocco and Tunisia. There is serological evidence for extensive circulation of EIV in the Maghreb area since the early 1970s, but reports of detailed investigation of outbreaks are scarce with no documented isolation or molecular characterization of EIV from Tunisia. Isol...
Batting below Average: Failure to Manage Fatal Zoonotic Diseases.
Journal of law and medicine    September 4, 2022   Volume 29, Issue 3 700-706 
O'Connor M.Zoonotic diseases are those which originate in animals but are transmitted to humans often through an intermediate host such as a wild animal. In Australia Hendra virus (HeV) is a disease of horses with occasional human fatalities and which is spread by the fruit bat. This article explores the lessons learnt from managing the Queensland outbreak of HeV in 1994. The legal framework for the notification and management of prohibited matter including zoonotic diseases in Queensland and New South Wales has been strengthened by provisions in the Biosecurity Act 2015 (NSW) which create strong penalti...
Participatory appraisal for healthcare and welfare management strategies of donkeys (Equus ascinus) in Balochistan, Pakistan.
Frontiers in veterinary science    September 2, 2022   Volume 9 1005079 doi: 10.3389/fvets.2022.1005079
Kamran K, Akbar A, Naseem M, Samad A, Samiullah , Achakzai JK, Rehman ZU, Sohail Sajid M, Ali A.In spite of the significant importance of the donkeys () as draft animal in resource-poor countries like Pakistan, they are equines not receiving the appropriate care. They face challenges including injuries, diseases, lack of basic environment and mismanagement by their owners. The present study aims to provide a brief update on the current status of management of healthcare and the welfare of domestic donkeys using participatory epidemiological tools. These tools can help to provide better strategies for improving their productivity and inclusion in human society. This study was mainly focus...
Co-Occurrence of Hypoglycin A and Hypoglycin B in Sycamore and Box Elder Maple Proved by LC-MS/MS and LC-HR-MS.
Toxins    September 1, 2022   Volume 14, Issue 9 doi: 10.3390/toxins14090608
El-Khatib AH, Engel AM, Weigel S.Hypoglycin A (HGA) and methylenecyclpropylglycine (MCPrG) are formed by some maple trees (Acer species) and have been associated with incidences of atypical myopathy among horses in pastures. In this work, a simple and sensitive ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method without derivatization was developed for the quantification of HGA and MCPrG in maple samples and validated according to EU guidelines. The LOQ presented here for HGA (16.4 µg/kg) is considerably lower than the lowest published LOQ (500 µg/kg). This method confirms that sycamore and ...
Clinical insights: Clinicopathological parameters for diagnosing and predicting outcome of horses with colic.
Equine veterinary journal    August 31, 2022   Volume 54, Issue 6 1005-1010 doi: 10.1111/evj.13871
Long A.No abstract available
An epidemiological overview of the equine influenza epidemic in Great Britain during 2019.
Equine veterinary journal    August 31, 2022   Volume 55, Issue 1 153-164 doi: 10.1111/evj.13874
Whitlock F, Grewar J, Newton R.During 2019, an epidemic of equine influenza (EI) occurred in Europe. Objective: To describe the epidemiology of the 2019 EI epidemic within Great Britain (GB). Methods: Retrospective descriptive study of laboratory confirmed EI cases. Methods: Epidemiological data were obtained from veterinary surgeons referring samples for EI virus testing. Where available, data on confirmed cases and their wider resident population on EI-infected premises were collated and described. On a national level, spatial and temporal representations, consisting of choropleth maps and epidemic curves, described the s...
Current status of glanders in Brazil: recent advances and challenges.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]    August 31, 2022   Volume 53, Issue 4 2273-2285 doi: 10.1007/s42770-022-00814-1
Mota RA, Junior JWP.Glanders is an infectious disease that causes serious damage to the equine production chain in countries where it occurs endemically and poses a risk to public health. This study aimed to conduct an integrative review of the advances in the knowledge of glanders in Brazil over the last three decades since its re-emergence. Documentary research was conducted for the period between the years 2000 and 2022. SCOPUS and PUBMED databases were used to search for scientific articles, dissertations, and thesis, in addition to the Brazilian Digital Library of Thesis and Dissertations (BDTD). A total of ...
Equine genital leptospirosis: Evidence of an important silent chronic reproductive syndrome.
Theriogenology    August 28, 2022   Volume 192 81-88 doi: 10.1016/j.theriogenology.2022.08.029
Di Azevedo MIN, Lilenbaum W.Leptospirosis may be associated with important syndromes in equines, including reproductive ones. Recently, our group demonstrated a reproductive syndrome of leptospirosis in ruminants (Bovine Genital Leptospirosis - BGL), that presents its own agent, particular diagnostic methods, and specific treatment and prevention, requiring special attention. We realized that the genital syndrome of leptospirosis may not be exclusive to ruminants and may also affect horses. The aim of the present study is to gather the available data on leptospirosis in equine reproduction and propose a new genital lepto...
Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response.
Pathogens (Basel, Switzerland)    August 27, 2022   Volume 11, Issue 9 979 doi: 10.3390/pathogens11090979
Abo-Aziza FAM, Hendawy SHM, Abdullah HHAM, El Namaky A, Laidoudi Y, Mediannikov O.Equine filariosis (EF) is a neglected vector-borne disease caused by nematode species belonging to the Onchocercidae and Setariidae families. Aside from their zoonotic potential, some species are responsible for serious health problems in equids worldwide, leading to significant economic difficulties. Here, we molecularly investigated equine blood samples (320 horses and 109 donkeys from Egypt) and four adult worms isolated from the peritoneal cavity of 5 out of the 94 slaughtered donkeys. In addition, quantitative enzyme-linked immunoassays (ELISAs) targeting circulating cytokines were used t...
The equine ascarids: resuscitating historic model organisms for modern purposes.
Parasitology research    August 20, 2022   Volume 121, Issue 10 2775-2791 doi: 10.1007/s00436-022-07627-z
Cain JL, Nielsen MK.The equine ascarids, Parascaris spp., are important nematode parasites of juvenile horses and were historically model organisms in the field of cell biology, leading to many important discoveries, and are used for the study of chromatin diminution. In veterinary parasitology, Parascaris spp. are important not only because they can cause clinical disease in young horses but also because they are the only ascarid parasites to have developed widespread anthelmintic resistance. Despite this, much of the general biology and mechanisms of anthelmintic resistance are poorly understood. This review co...
Getah Virus (Alphavirus): An Emerging, Spreading Zoonotic Virus.
Pathogens (Basel, Switzerland)    August 20, 2022   Volume 11, Issue 8 945 doi: 10.3390/pathogens11080945
Li B, Wang H, Liang G.Getah virus (GETV) is a zoonotic virus transmitted by mosquitoes, belonging to the family, genus. It was first isolated from mosquitoes in Malaysia in 1955, being widespread in island countries in the South Pacific region. Since the beginning of the 21st century, GETV expanded its range and geographical distribution from low-latitude tropical regions to 60° north latitude, being isolated from 17 different species of mosquitoes belonging to five genera of Culicidae (, , , and ), as well as from midges in Eurasia. Molecular genetic evolution analysis revealed large molecular differences betw...
Investigation of Strongyle Prevalence and Associated Risk Factors in Horses in and around Alage District, Ethiopia.
Journal of parasitology research    August 12, 2022   Volume 2022 3935008 doi: 10.1155/2022/3935008
Alemayehu MT, Abebe BK, Haile SM.Horses are used for a variety of purposes in Ethiopia. However, their service is hampered by a variety of health issues. Strongylosis is a parasitic infestation of the gastrointestinal tract that has a significant impact on the working ability, reproductive performance, well-being, and welfare of horses. The existence of Strongylosis in the study area is reported from clinical cases; however, its prevalence has not been well studied. Unassigned: The current study was carried out from January 2019 to July 2019, to determine the prevalence and associated risk factors of Strongyle in horses in an...
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