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Topic:Disease Management

Disease management in horses encompasses the strategies and practices employed to prevent, control, and treat diseases affecting equine populations. This field involves understanding the etiology, transmission, and clinical presentation of various equine diseases, as well as implementing biosecurity measures and therapeutic interventions. Common diseases in horses include equine influenza, strangles, and equine herpesvirus. Effective disease management relies on accurate diagnosis, vaccination protocols, and the use of antimicrobials and other treatments. This page compiles peer-reviewed research studies and scholarly articles that explore the methodologies, challenges, and advancements in managing diseases in equine health.
Prevalence and molecular epidemiology of equine piroplasmosis in China: a neglected tick-borne disease.
Science China. Life sciences    December 16, 2021   Volume 65, Issue 2 445-447 doi: 10.1007/s11427-021-2021-3
Chen K, Hu Z, Li J, Wang J, Liu D, Qi T, Guo W, Du C, Wang X.No abstract available
Association of Equine Herpesvirus 5 with Mild Respiratory Disease in a Survey of EHV1, -2, -4 and -5 in 407 Australian Horses.
Animals : an open access journal from MDPI    November 30, 2021   Volume 11, Issue 12 doi: 10.3390/ani11123418
El-Hage C, Mekuria Z, Dynon K, Hartley C, McBride K, Gilkerson J.Equine herpesviruses (EHVs) are common respiratory pathogens in horses; whilst the alphaherpesviruses are better understood, the clinical importance of the gammaherpesviruses remains undetermined. This study aimed to determine the prevalence of, and any association between, equine respiratory herpesviruses EHV1, -2, -4 and -5 infection in horses with and without clinical signs of respiratory disease. Nasal swabs were collected from 407 horses in Victoria and included clinically normal horses that had been screened for regulatory purposes. Samples were collected from horses during Australia's e...
Retrospective Analysis of Cause-of-Death at an Equine Retirement Center in the Netherlands Over an Eight-Year Period.
Journal of equine veterinary science    November 27, 2021   Volume 110 103824 doi: 10.1016/j.jevs.2021.103824
van Proosdij R, Frietman S.Geriatric horses (>15 years) represent a substantial proportion of the equine population. The objective of this study was to (1) report on the cause of death in geriatric horses on a single retirement centre, (2) to evaluate the relationship between PPID status, and mortality rate. Data of 194 horses was collected over an eight-year period. This providing data for 80 geriatric cases of mortality. The average age of horses that died was 26.2 years (±4.8 years). The majority (95%) of mortalities were euthanised, most frequently due to colic (20%), old age (19%), and lameness (15%). Overall m...
Development and Use of an Enzyme-Linked Immunosorbent Assay to Determine Temporal Exposure Patterns to Putative Agents of Nocardioform Placentitis.
Journal of equine veterinary science    November 26, 2021   Volume 109 103826 doi: 10.1016/j.jevs.2021.103826
Page AE, Partridge E, Erol E, Scoggin KE, Fedorka CE, Ruby RE, Ball BA, Horohov DW, Adam E.Cases of nocardioform placentitis are characterized by focal, mucoid placentitis resulting in late-term abortion, premature birth, or small, full-term foals, occur sporadically, and are most commonly associated with Crossiella equi and Amycolatopsis spp. infection. The goal of this project was to develop an enzyme-linked immunosorbent assay (ELISA) for quantifying antibodies against Crossiella equi and Amycolatopsis spp. and utilize the ELISA to determine when exposure occurs. Serum samples collected during the 2020 foaling season from Crossiella equi (n = 8) and Amycolatopsis spp. (n = 32...
Investigation of Cerebellar Abiotrophy (CA), Lavender Foal Syndrome (LFS), and Severe Combined Immunodeficiency (SCID) Variants in a Cohort of Three MENA Region Horse Breeds.
Genes    November 26, 2021   Volume 12, Issue 12 doi: 10.3390/genes12121893
Ayad A, Almarzook S, Besseboua O, Aissanou S, Piórkowska K, Musiał AD, Stefaniuk-Szmukier M, Ropka-Molik K.Genetic disorders in horses are mostly fatal or usually cause significant economic losses for breeders and owners. Here we studied a total of 177 Arabian, Barb and Arab-Barb horses from the Middle East and North Africa (MENA) using Sanger Sequencing and PCR-ACRS (polymerase chain reaction-artificially created restriction site) approaches to examine the genetic disorders in the studied horse breeds. We identified the genetic variations related to Cerebellar Abiotrophy (CA), Severe Combined Immunodeficiency (SCID) occurrence, and the studied population was free of the mutant allele determined La...
Reviving a tradition: The Development of Strongylus vulgaris in larval culture.
Veterinary parasitology    November 26, 2021   Volume 300 109619 doi: 10.1016/j.vetpar.2021.109619
Scare Kenealy JA, Steuer AE.All horses are susceptible to the equine gastrointestinal parasite, Strongylus vulgaris, which is known to cause significant disease and death. The parasite undergoes development from the egg through the first (L1), second (L2) and third (L3) larval stages outside the horse. The L3 is the infective stage. The universally available technique for detection of S. vulgaris larvae is the larval culture method. This requires a 10-14 day culture period to induce development from egg to L3, followed by Baermannization and identification of the L3s to genus and/or species. It is unknown if the culture ...
Evaluation of risk factors affecting strongylid egg shedding on Hungarian horse farms.
Veterinary parasitology, regional studies and reports    November 23, 2021   Volume 27 100663 doi: 10.1016/j.vprsr.2021.100663
Joó K, Trúzsi RL, Kálmán CZ, Ács V, Jakab S, Bába A, Nielsen MK.In Hungary, equine parasite control is mostly based on traditional approaches involving rotational anthelmintic treatment at regular intervals. Almost no farms utilize fecal egg counts (FECs) on a regular basis to guide deworming treatments. This approach is certainly not sustainable and is the major factor responsible for the current high levels of anthelmintic resistance. The aims of this study were to statistically analyze risk factors associated with strongylid egg count magnitude and prevalence. Fecal samples and horse data (age, pasture history, stocking density, anthelmintic history) we...
Effects of sample homogenizing on the performance of an automated strongylid egg counting system.
Veterinary parasitology    November 22, 2021   Volume 300 109623 doi: 10.1016/j.vetpar.2021.109623
Nielsen MK, Doran D, Slusarewicz P.Fecal egg counts are essential monitoring tools in veterinary parasite control. In recent years, several groups have developed automated egg counting systems based on image analysis and deep learning algorithms. Work in our laboratory demonstrated that an automated system performed with significantly better precision than traditional egg counting techniques. However, while the counting process is no longer operator dependent, the pre-analytical homogenization steps still are. This study aimed at evaluating the influence of sample homogenization on diagnostic performance on an automated equine ...
Remembering our fallen horses.
The Veterinary record    November 20, 2021   Volume 189, Issue 10 410 doi: 10.1002/vetr.1206
Taylor N.No abstract available
Other Clinical Problems of the Equine Foot.
The Veterinary clinics of North America. Equine practice    November 17, 2021   Volume 37, Issue 3 695-721 doi: 10.1016/j.cveq.2021.08.005
Fürst AE, Lischer CJ.Many disorders affect the equine foot, and many hoof problems have multiple predisposing causes. Surgery may be necessary after conservative management has failed. Diseases of the hoof capsule may seem simple, but their effect on performance can be long-lasting and healing is often prolonged. Diagnosis of problems within the hoof capsule is enhanced with the use of computed tomography and MRI. The prognosis of fractures has improved with strategic placement of lag screws across fracture planes using aiming devices and advanced intraoperative imaging techniques. Collaboration between the clinic...
The effects of bit chewing on borborygmi, duodenal motility, and gastrointestinal transit time in clinically normal horses.
Veterinary surgery : VS    November 14, 2021   Volume 51, Issue 1 88-96 doi: 10.1111/vsu.13745
Patton ME, Leise BS, Baker RE, Andrews FM.To determine the influence of bit chewing on gastrointestinal transit in clinically normal horses. Methods: Prospective crossover designed study. Methods: Six healthy adult horses. Methods: Horses were assigned randomly to treatment (apple flavored bit) and control (no-bit) groups and studied for 2 × 1-week trial periods with a 2-week washout period between trials. Horses were fasted for 24 h and slowly refed over 3 days. The bit was placed for 20 min every 6 h. Duodenal contractions and borborygmi auscultations were evaluated every 12 h, approximately 5 min following bit placemen...
First Report of Trypanosoma theileri in Equine Host and Tabanus sp. in Malaysia.
Journal of equine veterinary science    November 13, 2021   Volume 108 103807 doi: 10.1016/j.jevs.2021.103807
Tan LP, Mohd Rajdi NZI, Mohamad MA, Mohamed M, Hamdan RH, Goriman Khan MAK, Ahmad Syazwan S, Seng Hua L.Trypanosoma (Megatrypanum) theileri is a non-pathogenic or weakly pathogenic parasite of domestic cattle that is cyclically transmitted by blood-sucking insects, mainly tabanid flies. It has been reported in several countries like Brazil, Venezuela, Japan, Taiwan, Thailand, Vietnam, and the Philippines. Although the ruminant industry is actively expanded in Malaysia, T. theileri and T. theileri-like trypanosomes have never been reported from Malaysia. The low pathogenicity of this species might be the main reason for overlooking T. theileri in this country. This paper describes an unforeseen f...
Use of Antimicrobials in a French Veterinary Teaching Hospital: A Retrospective Study.
Antibiotics (Basel, Switzerland)    November 9, 2021   Volume 10, Issue 11 1369 doi: 10.3390/antibiotics10111369
Prouillac C.Antibiotic resistance has become a major concern for not only human health, but also for animal health. To preserve the efficacy of antibiotics, it has become essential to establish measures to regulate the prescription of antibiotics to ensure their prudent use. In France, these measures have been translated into regulations for animal health since 2015, with the publication of three important regulatory texts. The results obtained on a national scale in terms of reducing the use of antibiotics have been satisfactory. The aim of our study was to evaluate the differences related to the prescri...
Development of a real-time PCR assay to detect the single nucleotide polymorphism causing Warmblood Fragile Foal Syndrome.
PloS one    November 8, 2021   Volume 16, Issue 11 e0259316 doi: 10.1371/journal.pone.0259316
Flanagan S, Rowe Á, Duggan V, Markle E, O'Brien M, Barry G.Warmblood Fragile Foal syndrome (WFFS) is an autosomal recessive condition that affects the maturation of collagen in affected foals. Foals affected with the disease typically die or are euthanised shortly after birth. WFFS is caused by a single nucleotide change at position 2032 of the equine PLOD1 gene, causing an impairment of the wild-type enzyme. A commercial test for the causative genetic mutation is currently available from companies operating under licence from Cornell University but it has limitations. This test requires amplification of a region of the PLOD1 gene encompassing the sit...
Rapid Detection of Equine Piroplasms Using Multiplex PCR and First Genetic Characterization of Theileria haneyi in Egypt.
Pathogens (Basel, Switzerland)    October 31, 2021   Volume 10, Issue 11 1414 doi: 10.3390/pathogens10111414
Elsawy BSM, Nassar AM, Alzan HF, Bhoora RV, Ozubek S, Mahmoud MS, Kandil OM, Mahdy OA.Equine Piroplasmosis (EP) is an infectious disease caused by the hemoprotozoan parasites , , and the recently identified species . Hereby, we used a multiplex PCR (mPCR) targeting the 18S rRNA gene of and for the simultaneous detection of EP in Egyptian equids and examined the presence of infections in Egypt. Blood samples from 155 equids (79 horses and 76 donkeys) collected from different governorates of Egypt were examined by mPCR and PCR targeting . The mPCR method revealed a prevalence of of 20.3% in horses and of 13.1% in donkeys and a prevalence of . of 1.2% in horses. . was not de...
Lateral alveolar ridge augmentation using an equine-derived collagen-containing bone block: A prospective case series.
Clinical oral implants research    October 30, 2021   Volume 33, Issue 2 142-149 doi: 10.1111/clr.13873
Parvini P, Mihatovic I, Sahin D, Becker J, Schwarz F.To assess the clinical performance of an equine-derived collagen-containing bone block (CXBB) for lateral alveolar ridge augmentation and staged implant placement. Methods: A total of n = 16 patients (16 implants) had received a modified surgical protocol for lateral ridge augmentation using a size-adapted rigidly fixed CXBB and contour augmentation. After 26 weeks of submerged healing, the primary endpoint was defined as the final ridge width (RW26) sufficient to place an adequately dimensioned titanium implant at the respective sites. Secondary outcomes included the gain in ridge width (R...
Prevalence of the E321G MYH1 variant in Brazilian Quarter Horses.
Equine veterinary journal    October 28, 2021   Volume 54, Issue 5 952-957 doi: 10.1111/evj.13521
de Albuquerque AL, Zanzarini Delfiol DJ, Andrade DGA, Albertino LG, Sonne L, Borges AS, Valberg SJ, Finno CJ, Oliveira-Filho JP.In the Quarter Horse (QH), myosin heavy chain myopathy (MYHM), which is characterised by nonexertional rhabdomyolysis or immune-mediated myositis (IMM) with acute muscle atrophy, is strongly associated with the missense E321G MYH1 mutation. Objective: To document the existence of MYHM in the Brazilian QH population, this study includes a case report of two related QH foals with the E321G MYH1 mutation that had clinical signs of MYHM, with histological confirmation of IMM in one of the foals. This prompted an investigation the aim of which was to determine the allele frequency of the E321G MYH1...
Antimicrobial Resistance in Equine Reproduction.
Animals : an open access journal from MDPI    October 22, 2021   Volume 11, Issue 11 doi: 10.3390/ani11113035
Malaluang P, Wilén E, Lindahl J, Hansson I, Morrell JM.Bacteria develop resistance to antibiotics following low-level "background" exposure to antimicrobial agents as well as from exposure at therapeutic levels during treatment for bacterial infections. In this review, we look specifically at antimicrobial resistance (AMR) in the equine reproductive tract and its possible origin, focusing particularly on antibiotics in semen extenders used in preparing semen doses for artificial insemination. Our review of the literature indicated that AMR in the equine uterus and vagina were reported worldwide in the last 20 years, in locations as diverse as Euro...
Warmblood fragile foal syndrome causative single nucleotide polymorphism frequency in horses in Ireland.
Irish veterinary journal    October 18, 2021   Volume 74, Issue 1 27 doi: 10.1186/s13620-021-00206-1
Rowe Á, Flanagan S, Barry G, Katz LM, Lane EA, Duggan V.Warmblood Fragile Foal Syndrome (WFFS) is an autosomal recessive disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) gene. Homozygosity for the mutation results in defective collagen synthesis which clinically manifests as the birth of non viable or still born foals with abnormally fragile skin. While the mutation has been identified in non Warmblood breeds including the Thoroughbred, to date all homozygous clinically affected cases reported in the scientific literature are Warmblood foals. The objective of this study was to investigate the carrier f...
Fluid therapy in horses: how much is too much?
The Veterinary record    October 16, 2021   Volume 188, Issue 3 103-105 doi: 10.1002/vetr.164
Freeman DE.No abstract available
Risk and protective factors of Leishmaniasis in the rural area of the western border region of Rio Grande do Sul, Brazil.
BMC veterinary research    October 14, 2021   Volume 17, Issue 1 330 doi: 10.1186/s12917-021-03021-6
Pradella GD, Duarte CA, Escobar TA, Zuravski L, Góss GC, Skupien JA, Lübeck I.The Leishmaniases are on the top of the global list of tropical neglected diseases. The number of infected dogs in South America is estimated in millions and correlated to disease cases in humans, especially in Brazil. Equines may get infected too and can play a role in the epidemiological chain. Thus, the aim of the present study was to evaluate risk and protective factors of leishmaniasis in rural areas of the western border region of Rio Grande do Sul state, Brazil by Leishmania spp. protozoa molecular detection and serological evaluation (ELISA) in equine and canine blood samples. This wor...
Nasal high flow oxygen therapy in hospitalised neonatal foals.
Equine veterinary journal    October 13, 2021   Volume 54, Issue 5 946-951 doi: 10.1111/evj.13515
Floyd E, Danks S, Comyn I, Mackenzie C, Marr CM.Respiratory disease is common in critically ill neonatal foals. Traditional oxygen therapy (TOT) with nasal insufflation of oxygen is often used to provide first-line respiratory support. Mechanical ventilation is used in foals which require a greater level of support but requires specialist expertise and can be associated with significant complications. Non-invasive ventilation (NIV) enables a greater level of respiratory support without the need for intubation. High flow oxygen therapy (HFOT) is a mode of NIV commonly used in human intensive care. Objective: To describe the use of HFOT in ho...
Duplication of blaCTX-M-1 and a class 1 integron on the chromosome enhances antimicrobial resistance in Escherichia coli isolated from racehorses in Japan.
Journal of global antimicrobial resistance    October 13, 2021   Volume 27 225-227 doi: 10.1016/j.jgar.2021.10.004
Tamamura-Andoh Y, Niwa H, Kinoshita Y, Uchida-Fujii E, Arai N, Watanabe-Yanai A, Iwata T, Akiba M, Kusumoto M.Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have become a cause for great concern. Although some studies have reported the prevalence of ESBL-producing bacteria and ESBL-encoding genes in horses worldwide, the genetic structure surrounding the ESBL gene has not been analysed in detail. In the present study, we isolated two ESBL-producing Escherichia coli strains from diseased racehorses in Japan and demonstrated the mechanisms underlying the acquisition of their antimicrobial resistance (AMR) genes. Two ESBL-producing E. coli strains (E148 and E189) were isolated from th...
Clinical insights: Equine herpesvirus myeloencephalopathy: The conundrum of vaccination in performance and leisure horses.
Equine veterinary journal    October 7, 2021   Volume 53, Issue 6 1088-1090 doi: 10.1111/evj.13509
Kydd JH.No abstract available
Clinical insights: Assisted reproductive techniques: More than a solution to subfertility?
Equine veterinary journal    October 7, 2021   Volume 53, Issue 6 1084-1087 doi: 10.1111/evj.13510
Stout TAE, Griffiths H.No abstract available
Anthelmintic resistance: is a solution possible?
Experimental parasitology    October 7, 2021   Volume 230 108169 doi: 10.1016/j.exppara.2021.108169
Ahuir-Baraja AE, Cibot F, Llobat L, Garijo MM.More than 50 years after anthelmintic resistance was first identified, its prevalence and impact on the animal production industry continues to increase across the world. The term "anthelmintic resistance" (AR) can be briefly defined as the reduction in efficacy of a certain dose of anthelmintic drugs (AH) in eliminating the presence of a parasite population that was previously susceptible. The main aim of this study is to examine anthelmintic resistance in domestic herbivores. There are numerous factors playing a role in the development of AR, but the most important is livestock management. T...
First outbreak of glanders in Nepal and possible implications for the animal sector.
Transboundary and emerging diseases    October 6, 2021   Volume 68, Issue 6 3015-3017 doi: 10.1111/tbed.14338
Acharya KP, Marahatta S, Wilson RT.No abstract available
A retrospective study of twin pregnancy management in mares.
Theriogenology    October 1, 2021   Volume 176 183-187 doi: 10.1016/j.theriogenology.2021.09.018
Raś A, Raś-Noryńska M.The aim of the study was to compare three methods of reducing twin pregnancy in mares to maintain a single pregnancy. As multiple pregnancies in mare are always undesirable, early ultrasound diagnosis makes possible management of twin pregnancies and extra embryo removal. In years 2010-2018, 16494 mares were sonographically tested for early pregnancy, finding 868 cases of twins (471 bilateral and 397 unilateral). 260 mares with a confirmed bilateral tween pregnancy were subjected to manual crushing of one embryo and administration of flunixin at a dose of 1.1 mg/kg BW. 186 mares were subjecte...
A Survey of Control Strategies for Equine Small Strongyles in Lithuania.
Helminthologia    September 30, 2021   Volume 58, Issue 3 225-232 doi: 10.2478/helm-2021-0031
Dauparaitė E, Kupčinskas T, Hoglund J, Petkevičius S.Anthelmintic resistance (AR) in equine cyathostomins is being reported all over the world. In Lithuania, however, the last study on this subject was published more than fifteen years ago, thus little is known about the current situation. The aim of this study was to determine the factors that may associated with the development of AR on equine studs in Lithuania. A questionnaire containing seven open-ended and nine closed multiple-choice questions about worm control strategies, use of anthelmintic substances and stable management practices was posted to 71 randomly selected horse establishment...
Surveillance of strangles in UK horses between 2015 and 2019 based on laboratory detection of Streptococcus equi.
The Veterinary record    September 27, 2021   Volume 189, Issue 12 e948 doi: 10.1002/vetr.948
McGlennon A, Waller A, Verheyen K, Slater J, Grewar J, Aanensen D, Newton R.Previously national surveillance data for monitoring strangles (Streptococcus equi infection) in UK horses was limited. Improved awareness and knowledge of positive diagnoses would permit the optimisation of biosecurity protocols, decreasing the prevalence of strangles. Methods: Seven UK laboratories reported positive strangles diagnoses between 1 January 2015 and 31 December 2019 based on identifying Streptococcus equi via agent detection assays from field-based practitioner-submitted samples. Associated clinical history and animal signalment were collected where provided, and descriptive ana...
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