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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Maximum permissible load weight of a Taishuh pony at a trot.
Journal of animal science    June 4, 2013   Volume 91, Issue 8 3989-3996 doi: 10.2527/jas.2012-5540
Matsuura A, Sakuma S, Irimajiri M, Hodate K.The aim of this study was to determine the loading capacity of a trotting Taishuh pony by gait analysis using a motion analysis system. Seven Taishuh Ponies (5 mares and 2 geldings) and their rider were fitted with a marker (70 mm in diameter placed on their chest) and recorded by 2 high-resolution digital DVD cameras (at a sampling frequency of 60 Hz) as they were trotting along a straight course. Each horse performed 7 tests: 1 test with a loaded weight of 70 kg, 5 tests with random loaded weights between 80 kg and 120 kg, and a final test with a loaded weight of 70 kg again. Three-dimension...
Deep digital flexor tendon injury within the hoof capsule; does lesion type or location predict prognosis?
The Veterinary record    June 4, 2013   Volume 173, Issue 3 70 doi: 10.1136/vr.101512
Cillán-García E, Milner PI, Talbot A, Tucker R, Hendey F, Boswell J, Reardon RJ, Taylor SE.The type and location of deep digital flexor tendon (DDFT) lesions may be important in predicting outcome. The objectives of this study were to determine the frequency of different types of DDFT lesions within the hoof capsule and to determine whether lesion type predicts return to athletic activity. Lesions of the DDFT were divided into: core lesions, dorsal border lesions and parasagittal splits. Lesion location was documented, and follow-up information was obtained by telephone survey at least 18 months after diagnosis. Of 168 horses with primary DDFT injury, 54 horses had dorsal border les...
Detection of myo-inositol tris pyrophosphate (ITPP) in equine following an administration of ITPP.
Drug testing and analysis    June 4, 2013   Volume 6, Issue 3 268-276 doi: 10.1002/dta.1473
Lam G, Zhao S, Sandhu J, Yi R, Loganathan D, Morrissey B.Myo-Inositol tris pyrophosphate (ITPP) is a powerful allosteric modulator of haemoglobin that increases oxygen-releasing capacity of red blood cells. It is capable of crossing the red blood cell membrane unlike its open polyphosphate analog myo-inositol hexakisphosphate (IHP). Systemic administration of ITPP enhanced the exercise capacity in mice. There have been rumours of its abuse in the horse racing industry to enhance the performance of racing horses. In this paper, the detection of ITPP in equine plasma and urine after an administration of ITPP is reported. A Standardbred mare was admini...
Can Theileria equi be eliminated from carrier horses?
Veterinary journal (London, England : 1997)    June 2, 2013   Volume 196, Issue 3 279 doi: 10.1016/j.tvjl.2013.03.016
Butler C.No abstract available
Demographics and management practices of horses and ponies in Great Britain: a cross-sectional study.
Research in veterinary science    June 2, 2013   Volume 95, Issue 2 410-417 doi: 10.1016/j.rvsc.2013.05.004
Wylie CE, Ireland JL, Collins SN, Verheyen KL, Newton JR.The objectives of this study were to describe the demographic characteristics and management practices undertaken by owners of horses/ponies within GB and assess seasonal and geographical variations in management practices. A cross-sectional study was conducted, surveying a random sample of veterinary-registered owners in GB, using a self-administered postal questionnaire. A total of 797 useable responses were received. Only 4.0% of animals were stabled 24h/day, this proportion being greater in winter compared to other seasons (p<0.001). Shavings (45.7%) and straw (35.3%) were the most freq...
A new genomic tool, ultra-frequently cleaving TaqII/sinefungin endonuclease with a combined 2.9-bp recognition site, applied to the construction of horse DNA libraries.
BMC genomics    June 1, 2013   Volume 14 370 doi: 10.1186/1471-2164-14-370
Zylicz-Stachula A, Zolnierkiewicz O, Jasiecki J, Skowron PM.Genomics and metagenomics are currently leading research areas, with DNA sequences accumulating at an exponential rate. Although enormous advances in DNA sequencing technologies are taking place, progress is frequently limited by factors such as genomic contig assembly and generation of representative libraries. A number of DNA fragmentation methods, such as hydrodynamic sharing, sonication or DNase I fragmentation, have various drawbacks, including DNA damage, poor fragmentation control, irreproducibility and non-overlapping DNA segment representation. Improvements in these limited DNA scissi...
Y-chromosome analysis in Retuertas horses.
PloS one    May 31, 2013   Volume 8, Issue 5 e64985 doi: 10.1371/journal.pone.0064985
Brandariz-Fontes C, Leonard JA, Vega-Pla JL, Backström N, Lindgren G, Lippold S, Rico C.Several studies based on a variety of genetic markers have attempted to establish the origins of horse domestication. Thus far a discrepancy between the results of mitochondrial DNA analysis, which show high levels of diversity, and results from the Y-chromosome, with almost no genetic variability, has been identified. Most previous work on the horse Y-chromosome has focused on widespread, popular breeds or local Asian breeds. It is possible that these breeds represent a reduced set of the genetic variation present in the species. Additional genetic variation may be present in local breeds and...
Accelerometric comparison of the locomotor pattern of horses sedated with xylazine hydrochloride, detomidine hydrochloride, or romifidine hydrochloride.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 828-834 doi: 10.2460/ajvr.74.6.828
López-Sanromán FJ, Holmbak-Petersen R, Varela M, del Alamo AM, Santiago I.To evaluate the duration of effects on movement patterns of horses after sedation with equipotent doses of xylazine hydrochloride, detomidine hydrochloride, or romifidine hydrochloride and determine whether accelerometry can be used to quantify differences among drug treatments. Methods: 6 healthy horses. Methods: Each horse was injected IV with saline (0.9% NaCl) solution (10 mL), xylazine diluted in saline solution (0.5 mg/kg), detomidine diluted in saline solution (0.01 mg/kg), or romifidine diluted in saline solution (0.04 mg/kg) in random order. A triaxial accelerometric device was used f...
Effect of gluteus medius muscle sample collection depth on postprandial mammalian target of rapamycin signaling in mature Thoroughbred mares.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 910-917 doi: 10.2460/ajvr.74.6.910
Wagner AL, Urschel KL, Lefta M, Esser KA.To determine the effect of biopsy collection depth on the postprandial activation of mammalian target of rapamycin (mTOR) signaling factors, particularly protein kinase B, ribosomal protein S6 kinase, ribosomal protein S6, and eukaryotic initiation factor 4E binding protein 1 in middle-aged horses. Methods: 6 healthy Thoroughbred mares (mean ± SD age, 13.4 ± 3.4 years). Methods: Horses were fed a high-protein feed at 3 g/kg. Sixty minutes after horses were fed, the percutaneous needle biopsy technique was used to collect biopsy specimens from the gluteus medius muscle at 6, 8, and 10 cm belo...
Clinical snapshot: depression and hemorrhagic diarrhea in a thoroughbred colt.
Compendium (Yardley, PA)    May 31, 2013   Volume 34, Issue 6 E4 
Close K.No abstract available
Performance of a gravitational marrow separator, multidirectional bone marrow aspiration needle, and repeated bone marrow collections on the production of concentrated bone marrow and separation of mesenchymal stem cells in horses.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 854-863 doi: 10.2460/ajvr.74.6.854
Ishihara A, Helbig HJ, Sanchez-Hodge RB, Wellman ML, Landrigan MD, Bertone AL.Objective-To determine the efficiency of a novel point-of-care gravitational marrow separator and bone marrow aspiration needle for concentrated bone marrow production and bone marrow-derived mesenchymal stem cell (MSC) separation and assess the effect of repeated bone marrow collections in horses. Animals-8 healthy adult horses. Procedures-Bone marrow aspiration was performed twice (1 month apart) from sternebral bodies with a standard or prototype multidirectional needle. Concentrated bone marrow was obtained by gravitational marrow separation and evaluated for WBC and platelet counts, autom...
Telemetric analysis of breathing pattern variability in recurrent airway obstruction (heaves)-affected horses.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 925-933 doi: 10.2460/ajvr.74.6.925
Behan AL, Hauptman JG, Robinson NE.To use noninvasive respiratory inductance plethysmography (RIP) to investigate differences in breathing patterns between horses with and without recurrent airway obstruction (RAO) during the onset of airway obstruction induced through confinement to stables. Methods: 12 horses with no history or clinical signs of respiratory disease (control horses) and 7 RAO-affected horses. Methods: The study involved 2 phases. In phase 1, the optimal position of RIP bands for recording pulmonary function was investigated in 12 control horses. In phase 2, 7 RAO-affected and 7 control horses were confined to ...
Evaluation of osteochondral sample collection guided by computed tomography and magnetic resonance imaging for early detection of osteoarthritis in centrodistal joints of young Icelandic horses.
American journal of veterinary research    May 31, 2013   Volume 74, Issue 6 874-887 doi: 10.2460/ajvr.74.6.874
Ley CJ, Ekman S, Dahlberg LE, Björnsdóttir S, Hansson K.To evaluate the use of CT and MRI for guidance of osteochondral sample collection for histologic detection of early osteoarthritic lesions in centrodistal (distal intertarsal) joints of horses. Methods: Right tarsal joints from the cadavers of 24 Icelandic horses aged 29 to 31 months. Methods: CT and MRI were used to evaluate the extent of suspected osteoarthritic changes in centrodistal joints, which were graded with a semiquantitative system. The anatomic regions with the highest grade of change were identified, and osteochondral samples were obtained from these regions. Samples were also ob...
Clinical snapshot: Corneal edema in a Tennessee walking horse.
Compendium (Yardley, PA)    May 30, 2013   Volume 35, Issue 2 E7 
Tirosh-Levy S.No abstract available
The use of molecular and cytogenetic methods as a valuable tool in the detection of chromosomal abnormalities in horses: a case of sex chromosome chimerism in a Spanish purebred colt.
Cytogenetic and genome research    May 30, 2013   Volume 141, Issue 4 277-283 doi: 10.1159/000351225
Demyda-Peyrás S, Membrillo A, Bugno-Poniewierska M, Pawlina K, Anaya G, Moreno-Millán M.Chromosomal abnormalities associated to sex chromosomes are reported as a problem more common than believed to be in horses. Most of them remain undiagnosed due to the complexity of the horse karyotype and the lack of interest of breeders and veterinarians in this type of diagnosis. Approximately 10 years ago, the Spanish Purebred Breeders Association implemented a DNA paternity test to evaluate the pedigree of every newborn foal. All candidates who showed abnormal or uncertain results are routinely submitted to cytogenetical analysis to evaluate the presence of chromosomal abnormalities. We s...
Decorin-PEI nanoconstruct attenuates equine corneal fibroblast differentiation.
Veterinary ophthalmology    May 30, 2013   Volume 17, Issue 3 162-169 doi: 10.1111/vop.12060
Donnelly KS, Giuliano EA, Sharma A, Tandon A, Rodier JT, Mohan RR.To explore (i) the potential of polyethylenimine (PEI) nanoparticles as a vector for delivering genes into equine corneal fibroblasts (ECFs) using green fluorescent protein (GFP) marker gene, (ii) whether PEI nanoparticle-mediated decorin (DCN) gene therapy could be used to inhibit fibrosis in the equine cornea using an in vitro model. Methods: Polyethylenimine-DNA nanoparticles were prepared at nitrogen-to-phosphate (N-P) ratio of 15 by mixing 22 kDa linear PEI and a plasmid encoding either GFP or DCN. ECFs were generated from donor corneas as previously described. Initially, GFP was introduc...
Assessment of the wind-up phenomenon in the equine nociceptive trigeminal system.
Veterinary journal (London, England : 1997)    May 30, 2013   Volume 198, Issue 1 81-87 doi: 10.1016/j.tvjl.2013.04.012
Veres-Nyéki KO, Leandri M, Spadavecchia C.Repeated sub-threshold nociceptive electrical stimulation resulting in temporal summation of the limb nociceptive withdrawal reflex is a well-established non-invasive model to investigate the wind-up phenomenon in horses. Due to structural similarities of the trigeminal sensory nucleus to the dorsal horn of the spinal cord, temporal summation should be evoked by repeated transcutaneous electrical stimulation of trigeminal afferents. To evaluate this hypothesis repeated transcutaneous electrical stimulation was applied to the supraorbital and infraorbital nerves of 10 horses. Stimulation intens...
Clinical snapshot: Hirsutism in a pony.
Compendium (Yardley, PA)    May 30, 2013   Volume 35, Issue 3 E6 
Stern A.No abstract available
Comparison between standard ultrasonography, angle contrast ultrasonography, and magnetic resonance imaging characteristics of the normal equine proximal suspensory ligament. Werpy NM, Denoix JM, McIlwraith CW, Frisbie DD.Previous studies have proposed that standard ultrasonography may not adequately represent the pertinent anatomic characteristics of the equine proximal suspensory ligament. The purpose of the study was to compare the use of standard ultrasonography, angle contrast ultrasonography, MRI, and histology for identification of the anatomic characteristics of the normal equine suspensory ligament in the forelimb. Horses free from forelimb lameness with no palpable abnormalities in the region of the suspensory ligament were included in the study. The proximal suspensory ligaments in 20 forelimbs were ...
Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys.
Toxicon : official journal of the International Society on Toxinology    May 29, 2013   Volume 71 113-120 doi: 10.1016/j.toxicon.2013.05.007
Pessoa CR, Pessoa AF, Maia LA, Medeiros RM, Colegate SM, Barros SS, Soares MP, Borges AS, Riet-Correa F.The effects and susceptibility of donkeys to Crotalaria juncea and Crotalaria retusa poisoning were determined at high and low doses. Seeds of C. juncea containing 0.074% of dehydropyrrolizidine alkaloids (DHPAs) (isohemijunceines 0.05%, trichodesmine 0.016%, and junceine 0.008%) were administered to three donkeys at 0.3, 0.6 and 1 g/kg body weight (g/kg) daily for 365 days. No clinical signs were observed and, on liver and lung biopsies, the only lesion was a mild liver megalocytosis in the donkeys ingesting 0.6 and 1 g/kg/day. Two other donkeys that received daily doses of 3 and 5 g seed/...
Development of an enzyme-linked immunosorbent assay using a recombinant LigA fragment comprising repeat domains 4 to 7.5 as an antigen for diagnosis of equine leptospirosis.
Clinical and vaccine immunology : CVI    May 29, 2013   Volume 20, Issue 8 1143-1149 doi: 10.1128/CVI.00245-13
Yan W, Saleem MH, McDonough P, McDonough SP, Divers TJ, Chang YF.Leptospira immunoglobulin (Ig)-like (Lig) proteins are a novel family of surface-associated proteins in which the N-terminal 630 amino acids are conserved. In this study, we truncated the LigA conserved region into 7 fragments comprising the 1st to 3rd (LigACon1-3), 4th to 7.5th (LigACon4-7.5), 4th (LigACon4), 4.5th to 5.5th (LigACon4.5-5.5), 5.5th to 6.5th (LigACon5.5-6.5), 4th to 5th (LigACon4-5), and 6th to 7.5th (LigACon6-7.5) repeat domains. All 7 recombinant Lig proteins were screened using a slot-shaped dot blot assay for the diagnosis of equine leptospirosis. Our results showed that Li...
Fast and sensitive analysis of dermorphin and HYP6-dermorphin in equine plasma using liquid chromatography tandem mass spectrometry.
Drug testing and analysis    May 29, 2013   Volume 6, Issue 4 342-349 doi: 10.1002/dta.1487
Wang CC, Hartmann-Fischbach P, Krueger TR, Wells TL, Feineman AR, Compton JC.Dermorphin and HYP(6) -dermorphin are hepta-peptides and natural opioids originally isolated from the skin of South American frogs. They are more potent than morphine but less likely to produce drug tolerance and addiction. These properties make them ideal candidates for the doping of racehorses to enhance performance during competition. Dermorphin was recently classified as a Class I drug by Racing Commissioners International (RCI), indicating that it is a banned substance in equine athletes. To enforce this ban, a fast and sensitive method was developed for dermorphin and HYP(6)-dermorphin a...
Anatomical location and culture of equine corneal epithelial stem cells.
Veterinary ophthalmology    May 28, 2013   Volume 17, Issue 2 106-112 doi: 10.1111/vop.12050
Moriyama H, Kasashima Y, Kuwano A, Wada S.To identify morphologically the locations of equine corneal epithelial stem cells (CESCs) and to culture these cells. Methods: We studied the eyes of 12 adult thoroughbred horses. Methods: Eye tissues were immunostained for two positive stem cell markers (p63, CK14) and one negative marker (CK3) to identify the locations of CESCs, so we could compare their immunostaining patterns with those of human stem cells previously reported. We compared the proliferation rates and morphological features of epithelial cells isolated from the corneal limbus and central cornea. Results: Undifferentiated cel...
Natural killer cell receptor genes in the family Equidae: not only Ly49.
PloS one    May 28, 2013   Volume 8, Issue 5 e64736 doi: 10.1371/journal.pone.0064736
Futas J, Horin P.Natural killer (NK) cells have important functions in immunity. NK recognition in mammals can be mediated through killer cell immunoglobulin-like receptors (KIR) and/or killer cell lectin-like Ly49 receptors. Genes encoding highly variable NK cell receptors (NKR) represent rapidly evolving genomic regions. No single conservative model of NKR genes was observed in mammals. Single-copy low polymorphic NKR genes present in one mammalian species may expand into highly polymorphic multigene families in other species. In contrast to other non-rodent mammals, multiple Ly49-like genes appear to exist ...
Lethargy, fever, and anorexia in a thoroughbred weanling.
Compendium (Yardley, PA)    May 28, 2013   Volume 34, Issue 4 E1 
Page A.No abstract available
Management of zebras and zebra hybrids (zebroids).
Compendium (Yardley, PA)    May 28, 2013   Volume 34, Issue 9 E4 
Wiedner EB, Lindsay WA, Isaza R.Equine practitioners are sometimes asked to treat zebras or zebra-horse or zebra-donkey hybrids. Although these equids are subject to many of the same health issues as domestic horses, they cannot be handled like horses and generally require heavy sedation to full anesthesia, even for minor procedures. This usually necessitates the use of ultrapotent narcotics administered by remote delivery systems. This article discusses the handling, sedation, anesthesia, and common medical issues of zebras and zebra hybrids.
Standing open-flank approach for removal of enlarged pathologic ovaries in mares.
The Veterinary record    May 28, 2013   Volume 172, Issue 26 687 doi: 10.1136/vr.101380
Kelmer G, Raz T, Berlin D, Steinman A, Tatz AJ.No abstract available
Design and validation of a simulator for equine joint injections.
Journal of veterinary medical education    May 28, 2013   Volume 40, Issue 2 152-157 doi: 10.3138/jvme.0912-083R1
Fox V, Sinclair C, Bolt DM, Lowe J, Weller R.Joint injections are commonly used in equine practice for diagnosis and treatment of joint disorders. Performing joint injections is hence an essential skill for equine practitioners. However, opportunities for veterinary students to practice this skill are often scarce in veterinary curricula. The aim of this study was to design and validate an equine joint injection simulator. We hypothesized that the simulator will enhance student ability and confidence in performing joint injections. The simulator was constructed around an equine forelimb skeleton with soft tissues rebuilt using building f...
Advanced imaging in equine dental disease.
The Veterinary clinics of North America. Equine practice    May 28, 2013   Volume 29, Issue 2 397-vi doi: 10.1016/j.cveq.2013.04.009
Selberg K, Easley JT.Dental and sinus disorders are relatively common and of major clinical importance in equine medicine. Advanced diagnostic imaging has become an integral part of equine veterinary medicine. Advanced imaging has progressed the understanding, diagnosis, and treatment of dental- and sinus-related diseases. As a clinician, it is important to realize the value of advanced diagnostic imaging. Although computed tomography and magnetic resonance imaging are both significantly more expensive compared with other diagnostic tools, the financial cost of inaccurate diagnosis and treatment can often result i...
Region-specific expression of aquaporin subtypes in equine testis, epididymis, and ductus deferens.
Anatomical record (Hoboken, N.J. : 2007)    May 27, 2013   Volume 296, Issue 7 1115-1126 doi: 10.1002/ar.22709
Klein C, Troedsson MH, Rutllant J.The process of water movement in the excurrent duct system of the male reproductive tract is pivotal for establishment of male fertility. The objective was to elucidate expression of aquaporin (AQP) water channels in the stallion reproductive tract. Real-time RT-PCR detected expression of AQP0-5 and AQP7-11 in testis, epididymis, and ductus deferens of mature stallions. There were two main expression patterns: (1) higher expression in testis than in epididymis and ductus deferens (AQP0, -4, -5, -8, -10, and -11); and (2) lower expression in testis than in epididymis and ductus deferens (AQP1, ...