Equine Medicine encompasses the study and application of medical practices specifically related to the health and well-being of horses. This field involves the diagnosis, treatment, and prevention of diseases and disorders affecting equine species. It covers a wide range of topics, including internal medicine, surgery, reproduction, and pharmacology. Research in equine medicine often focuses on understanding the physiological and pathological processes unique to horses, as well as developing effective therapeutic interventions. This page aggregates peer-reviewed research studies and scholarly articles that explore various aspects of equine medicine, providing insights into the latest advancements and methodologies in the care and management of horse health.
Parry BW, Gay CC, Anderson GA.The present study retrospectively examined clinical and clinicopathological findings in horses with colic to determine which variables distinguished between medically treatable cases and cases which required surgical intervention. Heart rate, haematocrit, haemoglobin concentration, blood erythrocyte count, frequency of borborygmi and degree of mental depression showed the greatest differences (P less than 0.001) between medical and surgical groups. However, some variables which primarily evaluated cardiovascular function, ie, blood pressure, oral mucosal capillary refill time and blood lactate...
Rice DA.The time it takes audible sound waves to travel across a lobe of excised horse lung was measured. Sound speed, which is the slope in the relationship between transit time and distance across the lobe, was estimated by linear regression analysis. Sound-speed estimates for air-filled lungs varied between 25 and 70 m/s, depending on lung volume. These speeds are less than 5% of sound speed in tissue and less than 20% of sound speed in air. Filling the lung with helium or sulfur hexafluoride, whose free-field sound speeds are 970 and 140 m/s, respectively, changed sound speed +/- 10% relative to a...
Heizmann CW, Berchtold MW, Rowlerson AM.The physiological role of the Ca2+-binding protein parvalbumin in skeletal muscle has been investigated by measuring the parvalbumin content by HPLC in a variety of mammalian muscles, including man, and comparing the results with the respective muscle relaxation properties and fiber type compositions. The parvalbumin concentrations were highest in the skeletal muscles of the smallest animal investigated (mouse, gastrocnemius: 4.9 g/kg), which has the highest relaxation speed, and lowest in the larger animals (horse, deep gluteal muscle: less than or equal to 0.001 g/kg) and man (vastus, tricep...
Buchanan AM, Davis DC, Pedersen NC, Beaman BL.L-phase (CWD) broth and plate media were used in parallel with conventional microbiological media during a 3-year period for culturing synovial and pleural fluids of animals. Two kinds of recoveries were obtained where parallel conventional methods were negative: (1) parent or normal bacteria, in very low numbers; and (2) Type B CWD variants in equally low numbers. Organisms in group 1 were: Streptococcus zooepidemicus from horses (2x); beta-hemolytic streptococci, Lancefield Gp. G (2x); Staphylococcus aureus; Actinobacillus, and Actinomyces viscosus. Group 2 consisted of Bacteroides sp., Prop...
van der Luer RJ, Kroneman J.This research paper discusses a rare case of biliary atresia in a foal. It provides a detailed account of the clinical and pathological features of the condition in the animal. […]
Baskerville A.Related to its potential vulnerability the respiratory tract has a very complex and effective defence apparatus. The interaction between these defence mechanisms and certain characteristics of aetiological agents results in a pattern in which initial infections by these agents tend to occur at specific sites in the tract. Infections in which the primary portal of entry is in the upper respiratory tract include Bordetella bronchiseptica and Haemophilus spp in pigs; Pasteurella spp in cattle, sheep, pigs; Mycoplasma spp in cattle, sheep, pigs and poultry; equine herpesvirus 1 in horses; infectio...
Igwe OJ, Blake JW.An analytical gas/liquid chromatographic (GLC) protocol is described for the quantitation of pemoline in biological fluids of the horse. Plasma samples containing known quantities of pemoline and its analog as an internal standard (IS) were deproteinized with 5-sulfosalicylic acid, heated at 80 degree C, and centrifuged. 5-Phenyl-2,4-oxazolidinedione, the hydrolytic product of pemoline in acid medium, was extracted with dichloromethane (DCM). The organic layer was in turn re-extracted with 1% NaHCO3. The aqueous layer was acidified with HCI, and re-extracted with DCM, which was evaporated to d...
Gerring EL, Lees P, Taylor JB.Phenylbutazone was given orally to 2 groups of horses and the plasma levels of the drug and its 2 principal metabolites oxyphenbutazone and gamma-hydroxyphenylbutazone measured by high performance liquid chromatography. Animals in Group 1 received single oral doses in a range from 1.1 to 13.2 mg/kg and were sampled over the succeeding 24 h. Considerable individual variation was observed both in timing and magnitude of the plasma drug responses between horses, but 24 h after dosing a clear dose response relation was recorded. Group 2 horses were given the recommended therapeutic dosage regimen ...
Jandová V, Huber N, AlMheiri FG, Bábor K, Trachsel DS.Stress represents a serious health and welfare concern; however, its objective assessment remains difficult. The equine gastric ulcer syndrome (EGUS) and orthopedic diseases that cause pain are among stress associated diseases in equine medicine. The leukocyte coping capacity (LCC) quantifies oxygen radical generation of neutrophil granulocytes which is altered under stress. Therefore, LCC could be a novel biomarker for stress in horses and we hypothesized that horses with stress associated diseases would have lower LCC values in comparison to horses without these diseases. Methods: In this ob...
Brito G, Damián JP, Trigo P, Ruprechter G.The Raid Hípico Uruguayo (RHU) is the oldest equestrian endurance sport in Uruguay. A high percentage of horses fail to complete RHU rides. Therefore, the aim of this study was to investigate whether weather conditions (comfort index [CI]), horse experience, and ride distance affect horse performance (finishing ride [FR] or nonfinishing ride [NFR]) in the RHU. An additional objective was to determine whether finishing the ride affects the hematological and biochemical parameters of the horses. This study involved 17 RHU rides over distances of 60-90 km and 284 horses. Blood samples were tak...
Frey K, Perlini M, Reed R.Intravenous (IV) contrast administration during computed tomography (CT) of the equine head is routinely performed to delineate the extent of disease and differentiate between vascular and nonvascular tissue. Current equine scan protocols are extrapolated from human and canine studies. There have been no prospective equine studies describing the optimal time to image the patient after administration of contrast or the optimal site of contrast administration. Therefore, the current postcontrast times to scan and sites of contrast administration may not be appropriate for use in horses. The obje...
Southwood LL, Long A, Perez J, Daniel S, Bittinger K, Aitken M, Redding L.Based on human studies, surgical antimicrobial (AMD) prophylaxis (SAP) beyond 24 h is unnecessary and potentially detrimental. Objective: To compare clinical and microbiological outcomes in patients receiving 24- or 72-h of SAP for colic surgery. Methods: Prospective randomised clinical trial. Methods: Horses that recovered from colic surgery were considered. Exclusion criteria were (1) age <2 years; (2) Miniature Horses, pony, and draught breeds; (3) azotaemia; (4) recent hospitalisation, colic surgery, or AMDs; (5) local AMD administration. Eligible horses were randomly assigned to recei...
Otero JC, Neild DM, Ferrante AA, Gambarotta MC, Caldevilla ML.Glycerol, a penetrating cryoprotectant, is most employed for deep freezing spermatozoa. However, it can induce toxic, chemical, and osmotic effects, altering the lipid structure of the sperm membrane. Rapid glycerol addition has been demonstrated to have fewer toxic effects than its removal. Objective: To minimize both the toxic and osmotic effects of glycerol on equine sperm through post-thaw dilution using two different extenders. Methods: Samples of equine semen frozen with 5% glycerol from nine stallions were thawed, re-diluted 1:2, and incubated for 30 minutes at 22°C in Tyrodes (Tyr) an...
van den Broek M, Chan ZYS, De Bruyne C, Garcia-Alamo K, Skotarek Loch S, Pfau T.Increased risk of musculoskeletal injury in galloping racehorses has been linked to decreased stride length and reduced speed over consecutive races prior to the injury. As racetrack curvature influences horses' maximal speed, we hypothesized it also affects stride parameters. During training sessions, twenty-eight wagon-pulling Thoroughbred Chuckwagon horses were equipped with Global Navigation Satellite System (GNSS) loggers, allowing for identification of speed, stride length (SL) and stride frequency (SF), and average speed, SL and SF were calculated for consecutive 100 m sections. Effects...
Mańkowska A, Dobraczyńska BM, Szewczak J, Chodup Z, Radzanowski B, Matychyn I, Witkowska D.Cultivated carrot ( subsp. ) is a valuable component of equine diets due to its high β-carotene content (a precursor of vitamin A) and desirable sensory properties. However, its use may be limited by short shelf life, susceptibility to spoilage, and firm texture, which can be challenging for horses with dental problems. This study aimed to evaluate horses' preferences for different physical forms of carrots. Twenty-one leisure horses aged 3-22 years were individually evaluated in a free-choice test. Each horse was simultaneously offered equal portions (150 g) of five carrot forms: raw, grated...
Simó-Martínez MS, Marco-Fuertes A, Galán-Relaño Á, Astorga Márquez RJ, Marin C, Valero Díaz A, Vega S. are zoonotic pathogens, and rising antimicrobial resistance (AMR) amplifies their public health impact. Asymptomatic horses can act as reservoirs, contributing to environmental contamination and interspecies transmission. This study aimed to estimate the prevalence of and characterize AMR patterns in healthy horses from eastern Spain. Faecal samples from 95 asymptomatic horses were collected once daily over five consecutive days (475 samples in total) and processed under for detection. Epidemiological information was obtained through owner questionnaires, and associations with shedding we...
Bolesławska-Szubartowska J, Kucharczuk M, Skrabska A, Zbysław A, Adamowicz J, Alszko A, Domagalska-Stomska K, Durska M, Dziekcierów A....Pain after giving birth is commonly observed in horses, yet there has not been a specific tool developed for assessing this pain in postpartum mares. The goal was to adapt existing equine pain scales and to preliminarily validate a practical pain scale for use by veterinarians and caregivers after foaling. Methods: The pain scale was developed by adapting items from other pain scales, including established orthopedic and colic equine pain scales, and incorporating caregiver feedback. The final scale includes eight areas for assessing pain: behavior, facial expressions, vital signs, udder exami...
Schank N, Cottone A, Wulf M, Seiter K, Thomas B, Miller LMJ, Anderson SL, Sahyoun A, Abidi AH, Kassan M, Verma A.Equine colic remains a prevalent and potentially life-threatening condition with multifactorial origins, including dietary imbalances, stress, and microbial dysbiosis. Central to equine gut health is the production of short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, generated through microbial fermentation of dietary fibers in the hindgut. These metabolites not only serve as vital energy sources but also play crucial roles in maintaining intestinal barrier integrity, modulating motility, and suppressing inflammation. This review explores the role of SCFAs in equine...
Cooper BL, Hobbs KJ, Bayless R, Stinson-Miller A, Gruber E, Hepworth-Warren K, Lavoie JP, Sheats MK.Severe equine asthma (sEA) is characterized by increased lower airway neutrophils that contribute to dysregulated inflammation through the release of cytokines, reactive oxygen species and neutrophil extracellular traps (NETs). NETs are composed of cell-free DNA (cfDNA) intercalated with enzymatic proteins and are known to be increased in the lower airway of asthmatic horses. The objectives of this study were two-fold: 1. Determine if cfDNA can be accurately measured in equine bronchoalveolar lavage fluid (BALF) and tracheal wash (TW) with a Qubit 4 fluorometer. 2. Determine whether Qubit-meas...
Malekipour F, Whitton RC, Muir P, Lee PV.Stress fractures are common in racehorses, with the metacarpophalangeal (MCP) joint being the most frequently affected site as it is subjected to high-magnitude and high-rate cyclic loads during training and racing. These loads lead to repeated compressive stresses, resulting in subchondral bone (SCB) sclerosis, fatigue microcracks, and matrix damage that can progress to parasagittal fractures or palmar osteochondral disease (POD). The present study developed joint-specific 3D FE models and slice-based FE models using standing CT images for three trained racehorses, each presenting distinct SC...
Sohn Y, An SJ, Forbes E, Yoon J, Kim BS, Ryu SH, Lee I.Osteochondritis dissecans (OCD) is a developmental orthopedic condition in young horses. Exercise and management affect OCD development, but the impact of exercise patterns during the 6-12 months growth period remains unclear. This study examined the association between OCD lesions in Thoroughbred foals and irregular exercise patterns. Forty foals wore halter-mounted Global Positioning System devices that recorded velocity every five seconds during turnout. Foals were routinely turned out for approximately 13 h daily, except on rainy days. Radiographs were taken at six and twelve months of a...
Dantas FTDR, Canisso IF, Feijó LS, de Vasconcelos PMF, Campos ML, Ulanov AV, Li Z, Pizzi GLBL, Nogueira CEW, Curcio BR.Doxycycline is widely used in equine medicine, yet data on its pharmacokinetics and safety during late gestation are scarce. We investigated the pharmacokinetics, fetoplacental diffusion, and safety of compounded oral doxycycline in late-term pregnant mares. In the first experiment, six mares at 300 days of gestation received a single oral dose (10 mg/kg), and plasma concentrations were measured using LC-MS/MS. Pharmacokinetic analysis using non-compartmental and compartmental models showed rapid absorption, with a mean Cmax of about 6000 ng/mL reached within 0.8 h and a terminal half-life ...
Hargitaiova K, Maleas G.To describe outcomes following high-metacarpal deep digital flexor tenotomy (DDFT) combined with Steward clog application in horses and ponies with refractory chronic laminitis. Methods: Retrospective observational study. Methods: Client-owned horses and ponies (7 horses, 8 ponies) with severe refractory laminitis. Methods: Medical records (2018-2019) were reviewed. All underwent standing high-metacarpal DDFT tenotomy proximal to the accessory ligament (AL-DDFT) junction, followed by customized Steward clogs application. Preoperative assessment included radiography and venography. Postoperativ...
Sellke L, Ludewig E, Handschuh S, Witter K.In a previous study on hoof biometry, we found that mathematical correction of measuring results from radiographs did not lead to complete correspondence to computed tomography (CT) results. The present study investigates this finding by comparing 13 measures of six cadaveric equine digits collected with the following workflows: radiographs with 1 and 2 m focus-object distance (FOD) (Xray 1 m/2 m), computed tomography images in planes defined based on anatomical landmarks (CTw), simulated radiographs based on the tomography dataset (virtual 120-mm slabs, Xray Sim) and measurements based ...
Zamith Cunha R, Gobbo F, Morini M, Salamanca G, Zanoni A, Bernardini C, Gramenzi A, Chiocchetti R.Evidence suggests that the endocannabinoid system (ECS) is crucial for regulating inflammation, cell proliferation and pain. The ECS is composed of cannabinoid receptors such as type 1 (CBR1), type 2 (CBR2) and GPR55, endocannabinoids and enzymes. Proteins of ECS have previously been localized in the epidermal cells of the horse hooves. Given the physio-pathological role and cellular distribution of the ECS across species, the authors hypothesized that cannabinoid receptors are expressed within the inflammatory cells, fibroblasts and endothelial cells of the equine hoof laminae, going beyond t...
Arevalo-Turrubiarte M, Edling CE, Moller-Levet C, Forbes B, Kemp V, Weir J, Marr C, Lewis R, Jeevaratnam K.The initiation and maintenance of atrial fibrillation have been associated with physiological alterations in myocardial sleeves of the pulmonary veins (PVs). Gene expression profiles of the myocardial sleeves of the PVs in healthy (n = 3) and paroxysmal atrial fibrillation (PAF) (n = 6) thoroughbred horses (Equus caballus) were studied. Tissue collected from the left superior PV, adjacent to the left atrium, was analyzed by RNA sequencing. Gene Set Enrichment Analysis demonstrated positive enrichment of gene ontology biological processes related to muscle and endothelial cell development, cell...
A Quarter Horse mare was presented with a history of imidocarb intoxication. During the initial evaluation, the patient presented an initial episode of syncope, in addition to a Grade III/IV diastolic murmur. On the basis of the observed condition, the animal underwent echocardiographic evaluation, in which artifacts were detected and subsequently characterized as air bubbles, restricted to the right cardiac chambers. A diagnosis of venous air embolism resulting from right jugular venocatheterization was made. This is the first reported case of venous air embolism secondary to jugular venocath...
Corrigan RH, Pierard M, Davies E, Marlin D, Evans S, Williams JM.Human-horse relationships encompass diverse roles, from companion to competition partner. The impact of such bonds informs owner decision-making regarding horse management and veterinary care, yet standardised instruments to measure these unique bonds are limited. Objective: To develop the Human-Equine Attachment Scale (HEAS), a novel instrument to measure the multi-faceted dimensions of human-horse attachment. Methods: Cross-sectional design using a self-administered psychometric instrument. Methods: Initial items were developed through a systematic review of human and animal attachment resea...
Dobbs EC, Acutt EV, Scharf AM, Manzi TJ, Stefanovski D, Bills KW.To investigate the effects of varied feed consistency and administration of xylazine or N-butylscopolammonium bromide on 3 phases of swallowing and characterize esophageal motility following barium administration via nasoesophageal tube. Unassigned: 8 healthy horses were enrolled for 2.5 consecutive weeks. Horses underwent experimental videofluoroscopic swallow studies before and after sedated and anticholinergic interventions. Esophageal motility was assessed with barium administered via nasoesophageal tube and with barium-admixed feedstuffs of 3 consistencies with increasing viscosity. Phase...
Leibeck R, Lehman J, Birmingham S.Whole-body vibrational therapy (WBV) is well-studied in people, but there is a paucity of research regarding its effect on horses. It is suggested that the use of WBV in horses increases performance, aids in recovery, and stimulates nerves, bones, and muscles in ways that normal exercise does not. Objective: The purpose of this pilot study was to determine if frequent WBV therapy sessions affect mechanical nociceptive thresholds based on pressure algometry in horses without clinical signs of lameness or back pain. Methods: The mechanical nociceptive thresholds (MNTs) were measured for 5 horses...
Parker M, Arnade H, Parker JL, Gordon J, Peroni JF.Investigation of alternative antibiotic therapies is critical for the future of medicine. Platelet lysate (PL) is a blood product that has shown antibiotic potential, which could be used to augment or replace current antibiotics. Objective: To compare the effects of equine PL versus antibiotics on growth of clinically isolated antibiotic resistant bacteria. We hypothesized that PL would exert an antimicrobial effect on equine bacterial isolates resistant to antibiotics. Methods: In vitro experimental study. Platelets were collected via apheresis from nine donor horses and underwent two freeze-...
Briefer-Freymond S, Dalla Costa E, Jolivald A, Bruckmaier RM, Atallah E, Giorgia Riva M, Ijichi C.Personality affects both experience and expression of pain and the welfare impact of castration on horses is poorly understood. Therefore, the current study observed 19 horses to determine: the welfare impact of standard castration on horses; whether individuals consistently vary in their behavioural and emotional responses to pain; the influence of personality on behavioural and physiological responses to pain; whether Horse Grimace Scale (HGS) indicates how individuals feel about painful experiences. Eye temperature (IRT), salivary cortisol, HGS and a pain ethogram were measured at intervals...
Sharma M, Singh A, Kumar V, Olla N, Arora R, Sharma R, Mohan NH, Ahlawat S.The genus Equus, encompassing horses, donkeys, and extinct relatives, has evolved over approximately 55 million years from small, multi-toed ancestors to the modern horse. Selective breeding has produced over 600 distinct horse breeds optimized for diverse traits such as size, conformation, performance, and adaptability. In the past two decades, rapid advances in equine genomics have significantly deepened our understanding of the molecular basis of these traits. The integration of high-throughput sequencing, genome-wide association studies (GWAS), and single-nucleotide polymorphism (SNP) geno...
Ibrahim L, Cornillie P, Buschmann E, Demeyere M, van Loon G.The coronary sinus (CS) and great cardiac vein (GCV) are crucial in cardiac electrophysiology and can be arrhythmogenic in humans. In horses, CS/GCV catheterisation is increasingly performed for arrhythmia diagnosis and treatment. Improved anatomical understanding of these structures is needed to clarify relationships to surrounding structures. Methods: Postmortem examinations of 64 adult warmblood equine hearts were carried out. Middle cardiac vein and vein of Marshall ostia locations were described. Right atrial myocardial sleeve (MS) length was measured from the CS ostium. In 23 horses, CS/...
Bonhomme MM, Boisdenghien L, Couroucé A, Votion DM.Public scrutiny of racehorse welfare is increasing. The preparatory training phase preceding the racing season is potentially a critical period for physical and mental development. Structured welfare assessment protocols have recently been developed, but their use in field conditions remains limited. Objective: (1) To evaluate the field applicability of a racehorse-specific welfare assessment protocol in a professional French jump racing yard; and (2) to explore whether it can detect relevant physical and behavioural changes in young horses during season preparation. Methods: Longitudinal obse...
Strompfová V, Štempelová L, Bujňáková D, Karahutová L, Gondoľová D, Nagyová M, Siegfried L.In order to develop non-antibiotic therapies to treat dermatological diseases it is urgent to spread knowledge on composition and properties of skin bacteria in healthy animals. Since horses are popular companions of humans, it is necessary to know what risk skin bacteria pose to humans. Therefore the aim of this work was to analyse species composition of staphylococci isolated from skin swabs of 50 healthy horses using MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight) spectrometry and to characterize their virulence properties. Swabs were collected from five body areas (n...
Decoster C, Lefère L, Raes E, van Loon G, Dufourni A.Leptospirosis is a widespread zoonotic, infectious disease associated with abortion, stillbirth, as well as liver and kidney failure. Leptospiral Pulmonary Haemorrhage Syndrome (LPHS) has increasingly been reported in human and canine patients infected by Leptospira and is associated with a high fatality rate. In equine medicine, pulmonary haemorrhage has mainly been described in foals with leptospiral infections, but rarely in adult horses. Objective: To characterise the clinicopathological features of pulmonary haemorrhage as a distinct disease entity in adult horses with leptospirosis, term...
Friedlund AM, Bracamonte JL, Koziy RV, Epp T, Thomas KL.To evaluate if high-volume lavage results in a negative bacterial culture of egress fluid, regardless of pathogen in an experimental model of equine septic arthritis. Methods: Experimental study. Methods: A total of 11 horses in three groups (lipopolysaccharide [LPS] Group 1, n = 4; Escherichia coli [E. coli] Group 2, n = 4; Staphylococcus aureus [S. aureus] Group 3, n = 3). Methods: A middle carpal joint of each horse was injected with LPS (synovitis Group 1), E. coli (septic arthritis Group 2) or S. aureus (septic arthritis Group 3). Arthroscopic lavage of the middle carpal joint...
