Healing and horses encompass the physiological processes and mechanisms by which horses recover from injuries, illnesses, and surgical procedures. This topic covers the cellular and molecular pathways involved in tissue repair, pain management, and rehabilitation strategies. Research in this area often focuses on wound healing, bone and joint recovery, and the role of various therapies such as physical rehabilitation, pharmacological interventions, and alternative treatments. Studies also investigate the influence of factors such as nutrition, genetics, and environment on the healing process. This page aggregates peer-reviewed research studies and scholarly articles that explore the biological and clinical aspects of healing in equine medicine.
Todhunter RJ, Parker JE.A recently castrated horse was examined because of preputial and ventral abdominal swelling, prolapse of the preputial fold, and serosanguinous fluid dripping from the external urethral orifice. After a poor response to initial medical management, a urethral laceration was found during exploratory surgery. Half of the ventral portion of the corpus cavernosum penis had been transected. Primary closure was followed by healing without complications.
Markel MD, Snyder JR, Hornof WJ, Meagher DM.Nuclear scintigraphy was used to evaluate healing of third metacarpal bone (MC III) fractures in 2 horses (horses 1 and 2) and a third metatarsal bone fracture in 1 horse (horse 3) after stabilization of each fracture with 2 broad dynamic compression plates. In horse 1, the fracture had uniform uptake of 99mTc methylene diphosphonate on days 1, 15, and 30 after surgery. The fracture healed, and the horse was discharged from the clinic on day 52. In horse 2, a 6-cm photopenic region (ie, area of low radioactivity) was seen over the diaphysis of MC III on day 3. The region persisted and became m...
Markel MD, Richardson GL, Peterson PR, Meagher DM.Three adult horses were admitted with chronic coronary band avulsions of 2-, 3-, and 46-month durations, respectively. The hoof had a typical appearance in all 3 horses, with a spur of coronary band and associated horn growing at right angles to the hoof wall. Each horse was anesthetized, and the coronary band was reconstructed. Follow-up evaluation of the 3 horses (12, 15, and 23 months after surgery, respectively), revealed healing of all 3 avulsed coronary bands. Mild roughening of the hoof wall distal to the previous avulsion site was observed.
Collier MA, Rendano VT, Kallfelz FA.A delayed union metacarpal stress fracture was repaired in a horse, using lag-screw fixation in conjunction with dc electrical stimulation. Twelve weeks after surgery, radiographic and scintigraphic evaluations revealed that the fracture line was not discernible and that there was a decrease in radiopharmaceutic uptake, as compared with that in previous bone imaging studies. In this horse, DC stimulation of a delayed union stress fracture in a bone resulted in a healing pattern similar to that in human beings with delayed union fractures when treated with electrical stimulation.
Leaper DJ, Foster ME, Brennan SS, Davies PW.Magnetic fields have been considered for treating many ailments over man's history. There have been many anecdotal unsupported claims for successful treatment of soft tissue injury although reports have been more substantive in the orthopaedic field. The widespread clinical and veterinary use of a light self-adhesive magnetic foil in Europe prompted this trial of experimental wound healing. One hundred and sixty Sprague-Dawley rats had a linear 2.5 cm incision or a circular 1 cm skin defect made over the mid-dorsal spine. Equal numbers were randomised to receive either a magnetic foil or a dum...
Williams IF, McCullagh KG, Goodship AE, Silver IA.The histological and morphological characteristics of the scar tissue formed during healing after traumatic equine tendon injury have been compared with those of scar tissue produced in response to an enzyme-induced pony tendon injury. Several techniques are currently in use in the treatment of equine tendon sprain and this work formed part of a study of their respective efficacy. It was concluded that the enzyme-induced lesion is resolved by a reparative process very similar in its prognosis and extent to that following a naturally occurring tendon sprain. It may therefore justifiably be used...
Wagner PC, DeBowes RM, Grant BD, Kaneps AJ, Watrous BJ.Proximal growth plate fractures of the tibia in 4 foals were treated surgically. A medial approach was utilized in 3 cases and a lateral approach in the fourth. Bone screw fixation was achieved with cancellous screws and washers. In 3 cases, the screw shaft crossed the proximal tibial growth plate with no adverse effects. In all animals, there was rapid and cosmetic healing. At 8 to 18 months after surgery, all horses were sound at a walk, trot, and canter.
Williams IF, McCullagh KG, Silver IA.During tissue response to injury the glycoproteins fibronectin and Type III collagen are synthesized in increased amounts. We have studied the distribution of these molecules in the healing tendon at various times after injury by comparison with that of the major constituent of normal tendon, Type I collagen. Immunofluorescent localization demonstrated the presence of fibronectin throughout the tendon within one week after injury. Staining was found in the matrix, both around capillaries and around fibroblast-like cells. Fibronectin was still apparent in the healing tendon at one month after i...
Stick JA, Slocombe RF, Derksen FJ, Scott EA.Esophageal healing was studied in 12 ponies after cervical esophagotomy. The esophagus was sutured, feed and water were withheld for 48 hours, and then all ponies were permitted to eat. In group I (n = 6), a longitudinal esophagotomy was made. In group II (n = 6), a rotational esophagotomy was made with the mucosal incision 180 degrees away from the incision in the esophageal muscle. Three ponies in each group were fed a soft diet ad libitum for 9 days, and then were allowed access to hay and grain. The remaining ponies were fed hay and grain. The esophagotomies of all hay-fed ponies dehisced ...
Lindsay WA, McMartin RB, McClure JR.Five cases of fracture of the third tarsal bone in racehorses are reported. A method of surgical correction employing a cortical bone screw is described in 2 cases. Healing of the fractures was followed radiographically. Surgical repair permitted both horses to return to competition. The 3 cases treated conservatively suffered a prolonged healing time and excessive new bone formation. They were unable to return to training due to persistent lameness.
Silver IA.This paper discusses the factors which affect the healing of wounds at the tissue and organ levels. It covers some of the problems which complicate the sequence of healing and considers the mechanisms involved in regeneration and repair of tissues. The factors associated with the stimulus and sequence of healing and their interactions are also reviewed.
Frankland AL, Morris PG, Spreull JS.Seven pieces of autologous skin were transplanted onto freshly created, full thickness skin defects on the limbs and back of a one-year-old, male, piebald, Shetland pony. The transplantations were completed in two operative sessions, the transplants on the left side were done in the first session and the right side in the second. The sizes of the transplants varied from 20 sq cm to 2 sq cm and their thicknesses from whole skin to very thin, split skin. Donor sites were both rumps and the right side of the neck. Six of the seven grafts and two thirds of the remaining graft, were accepted. Both ...
Orsini JA, Buonanno AM, Richardson DW, Nunamaker DN.A Salter-Harris type-II fracture of the distal portion of the femur in a 1-year-old Pony of America was repaired by use of lateral plating combined with interfragmentary compression. The configuration of the fracture and the method of internal fixation with a condylar buttress plate were unique and resulted in primary bone healing, seen at the 5-month follow-up examination.
Ross C, Haussler KK, Kenney JD, Marks D, Bertone JJ, Henneman K, May KJ.Vigorous and prolonged effort is required to gain true mastery of the healing arts. Conventional and complementary medicine have complementary strengths and weaknesses. Like the yin and yang of traditional Chinese medicine, they naturally flow into one another by a process of induction, creating balance. Integrative medicine is the frontier; it is the future. If we are to progress beyond our current understanding and ability to heal, we must work with theoretic models that allow us and our perception to operate "outside the box." For some, this understanding is intuitive. It is through coopera...
Hackett ES, Bruemmer J, Hendrickson DA, McCue PM.Description-An 11-year-old Quarter Horse stallion was admitted for intermittent hemospermia of 4 years' duration. Results: A linear vertical defect had been detected endoscopically following multiple episodes of hemospermia on the caudodorsal convex surface of the urethra at the level of the ischial arch. Results: When sexual rest alone did not result in complete healing of the urethral defect, a subischial urethrotomy and buccal mucosal urethroplasty were performed. The surgical site healed without complication. Four months of sexual rest was recommended after surgery. Repeat endoscopy at 4 m...
Todhunter RJ, Parker JE.A recently castrated horse was examined because of preputial and ventral abdominal swelling, prolapse of the preputial fold, and serosanguinous fluid dripping from the external urethral orifice. After a poor response to initial medical management, a urethral laceration was found during exploratory surgery. Half of the ventral portion of the corpus cavernosum penis had been transected. Primary closure was followed by healing without complications.
Reiners SR, Jann HW, Stein LE, Good JK, Claypool PL.To compare the healing and mechanical strength of a multiple split autologous tendon graft (MG) to a whole autologous tendon graft (WG) in the deep digital flexor tendon of ponies. Methods: In vitro evaluation of two different tendon-grafting techniques. Methods: Six ponies of mixed gender and age. Methods: Tenotomies performed in forelimb deep digital flexor tendons (DDFT) distal to the insertion of the accessory ligament (AL-DDFT) were repaired with free autologous grafts from the hindlimb lateral digital extensor tendon (LDET). Grafts were either whole (WG) or split into three longitudinal ...
Leaper DJ, Foster ME, Brennan SS, Davies PW.Magnetic fields have been considered for treating many ailments over man's history. There have been many anecdotal unsupported claims for successful treatment of soft tissue injury although reports have been more substantive in the orthopaedic field. The widespread clinical and veterinary use of a light self-adhesive magnetic foil in Europe prompted this trial of experimental wound healing. One hundred and sixty Sprague-Dawley rats had a linear 2.5 cm incision or a circular 1 cm skin defect made over the mid-dorsal spine. Equal numbers were randomised to receive either a magnetic foil or a dum...
Heuerman J, Haiub H, Cull E, Lupatini R, Shrum B, Sidhu R.In this case report, we highlight the benefits of Medisca CopaSil application for scar healing in a horse having sustained second-degree burn injuries covering most of its back. The application of CopaSil started three months after sustaining the burn injury when silver sulfadiazine topical cream treatment showed no significant improvement. CopaSil is formulated with ingredients that may help in reducing inflammation and accelerate healing by modulating the immune response. After using CopaSil for six months, the horse's back was healed, and the hair began to regrow. The complete healing...
Imposimato I, Mariella J, Freccero F, Gialletti R.Riboflavin/UV-A corneal cross-linking (CXL) has been applied to treat corneal ulcers in adult horses, but its use in critically ill neonatal foals has not been described. Five cases of hospitalized, critically ill neonatal foals that were in intensive care with corneal ulcers, the ophthalmic treatment, and their outcome up to 1 year are described. A single treatment of CXL phototherapy was performed in three of five foals (five eyes). The application of a riboflavin ophthalmic solution for 20 minutes was followed by the UV-A light irradiation at 30 mW/cm2 for 3 minutes. Topical antibiotic admi...
Collier MA, Haugland LM, Bellamy J, Johnson LL, Rohrer MD, Walls RC, Bartels KE.This study was performed to investigate the effects of holmium:yttrium-aluminum-garnet (Ho:YAG) laser energy on articular cartilage and subchondral bone adjacent to traumatically created cartilage lesions in a continuous weight-bearing model. The 2.1-microns wavelength was delivered efficiently and precisely in hand-controlled contact and near-contact hard tissue arthroscopic surgery in a saline medium. Bilateral arthroscopy was performed on normal antebrachiocarpal and intercarpal joints of four adult horses. One hundred twenty traumatic lesions were created on three weight-bearing articular ...
Barton CK, Samol MA, Nelson BB, Piquini G, Smanik LE, Goodrich LR.To raise awareness of the potential for intra-articular subchondral bone sequestrum formation secondary to a traumatic or septic process to enable more rapid identification of this uncommon but possible outcome in future cases. Methods: A client-owned 12-year-old Appaloosa mare. Unassigned: The mare had a wound to the lateral aspect of the fourth metatarsal bone (MT4) that communicated with the distal tarsal joints. Radiographs revealed a displaced, comminuted fracture of MT4. Results: The horse underwent aggressive debridement of the wound and MT4 as well as, on 2 occasions, needle joint lava...
Labens R, Raidal S, Borgen-Nielsen C, Pyecroft S, Pant SD, De Ridder T.Topical wound treatments rely on carrier formulations with little to no biological impact. The potential for a common vehicle, a propylene glycol (PG) gel, to affect wound healing measures including microbiota is not known. Microbiome characterization, based on next generation sequencing methods is typically performed on tissue or directly obtained wound fluid samples. The utility for primary wound dressings to characterize equine wound microbiota in the context of topical treatments is currently unknown. This investigation reports the topical effect of an 80% PG based gel on wound healing and...
Wilcox CV, Knych HK, Katzman SA, Arthur RM, Rodriguez V, Finno CJ.There are two FDA-approved bisphosphonate products, clodronate (Osphos®) and tiludronate (Tildren®), for use in horses. It is hypothesized that bisphosphonates can produce analgesic effects and prevent proper healing of microcracks in bone. Therefore, bisphosphonate use is banned in racehorses. However, bisphosphonates have a short detection window in the blood before sequestration in the skeleton, making the reliability of current drug tests questionable. Seven exercising Thoroughbred horses were administered clodronate (1.8 mg/kg i.m.), and four were administered saline. RNA was isolated...
Menzies-Gow NJ, Shurlock T.Feedstuffs are often recommended to mitigate potential damage from acid associated with equine squamous gastric disease (ESGD). In acidic conditions, pectin alters its structure to one like mucus and binds the stomach mucosa, whilst alfalfa has a strong intrinsic acid buffering capacity. The study aimed to determine whether feeding a commercial beet pulp/alfalfa/oat fibre mix aids ESGD healing and/or prevention of recurrence. Ten adult horses with naturally occurring ESGD were included. All animals were treated with omeprazole as per the attending veterinarian's recommendation and randomly all...
Charlotte C P, Benoit B, Olivier M L.To evaluate secondary intention wound healing in the horse's limbs when treated with the synthetic epidermis spray (Novacika®, Cohesive S.A.S, France) or with a standard bandaging technique. Methods: Six Standardbred mares were included in the study. Four 2.5 x 2.5 cm full-thickness skin wounds were created on each thoracic limb. Two wounds were located on the dorsoproximal aspect of the cannon bone and the other two at the dorsoproximal aspect of the fetlock. Six hours after creation, wounds were randomly treated with synthetic epidermis spray or standard bandaging. The wounds were assessed ...
Jugant S, Regnier A, Douet JY.To evaluate the safety and effectiveness of diamond burr debridement (DBD) for the treatment of calcific band keratopathy (CBK) in horses. Methods: Medical records from horses with CBK were reviewed over a period of 4 years. Diagnosis of CBK was based on slit-lamp examination findings, and DBD was performed on standing sedated horses. Follow-up was obtained by clinical reevaluation of the treated eyes or a telephone survey with the referring veterinarian. Results: Twenty-two horses of different ages (median: 11 years; range: 5-23) representing 24 CBK-affected eyes (14 left eyes and 10 righ...
King MR, Colla S.Successful rehabilitation of muscle injury requires a comprehensive understanding of the injury process, healing phases, and resources to be employed. The initial phase is characterized by acute inflammatory signs, followed by the regenerative and remodeling phases. Therapeutic exercises can be utilized in all 3 phases, progressing from isometric exercises to aquatic therapies. The classification and phase of injury and the individual response to the applied therapies will guide the progression of the therapeutic exercises through the rehabilitation program.
Kamm JL, Odegaard J, Gaida J, King N.This tutorial aims to illustrate and instruct on the technique of punch skin grafting in the horse. Unassigned: A 10-year-old paint gelding with a 9 X 6-cm chronic granulating wound to the left forelimb was utilized for this tutorial. Unassigned: The chronic wound was debrided with sharp dissection, and the limb was pressure bandaged overnight. Twenty-four hours later, the horse was sedated for punch skin grafting. The ventral pectoral region was aseptically prepared for skin harvest and locally anesthetized. An 8-mm biopsy punch was used to harvest the grafts. The subcutaneous tissue was then...
Rosa MCB, Campos MEST, Albuquerque AS, Braz MS, Mapele RO, de Oliveira MCG, Toma HS, Ferraz PFP, Pereira RN, Raymundo DL.Skin wounds in horses, particularly in the distal extremities, often heal slowly due to mechanical stress, compromised perfusion, and excessive fibroplasia. This study evaluated the effects of topical Croton lechleri (CL) cream, alone or in combination with nitroglycerin, on the healing of skin wounds in the metatarsal region of horses. Six mares received six standardized wounds in each region and were treated with: saline solution, nitroglycerin (0.1 or 1 mg/mL), CL (1 or 10 µg/mL), or CL + nitroglycerin (10 µg/mL + 1 mg/mL). Wound contraction, histology, and bacterial culture were evaluate...
Zhang Z, Li J, Mai Z, Yang Y, Fu H, Cao X, Li T, Guo Q, Ma Y.The incidence of sports injuries in horses is increasing, thus accurate assessment, diagnosis, and treatment are critical. Among common sports-related injuries, proximal sesamoid bone fractures (PSBFs) are one of the most frequent types. To investigate the effects of low-intensity pulsed ultrasound (LIPUS) on imaging and hematological parameters of PSBFs, providing a clinical reference for the diagnosis and treatment of PSBFs in racehorses. After clinical diagnosis and radiographic examination confirmed the disease and its location, the affected horses were randomly divided into two groups: th...
McCoy AM, Lopp-Schurter CT, Bishop RC, Narotsky A, Grogger K, Kemper AM.To determine the natural progression of tarsal osteochondrosis (OC) in a cohort of Standardbred foals and assess the impact of gait preference (trotting vs. pacing). Methods: Longitudinal observational cohort study. Methods: Client-owned Standardbred foals (n = 148). Methods: Tarsal radiographs were taken every 2 months from 2 to 12 months of age and foals were video monitored to document time spent pacing or trotting. Differences between groups were assessed using χ analysis. Survival analysis was used to determine if lesion healing differed between groups over time. Results: Of 148 ...
Donard LA, Vinardell T, Boussauw B, Pollaris E.Sinus osteotomy is currently performed in equine surgery with conventional surgical methods, such as trephines and oscillating bone saw, leading to subsequent trauma to the bone during cutting. Piezoelectric devices are now used in maxillofacial surgery in humans as a standard tool as it is less traumatic than the oscillating bone saw and shortens the healing period. The aim of this study was to show that the piezoelectric device can be used for equine sinus surgery, compare its use with the oscillating bone saw, and describe the outcome of cases involving osteotomy performed with a piezoelect...
