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Topic:Horse Racing

Horse racing is a competitive equestrian sport involving horses ridden by jockeys over set distances, often on flat tracks or over obstacles. It is characterized by a variety of race types, including thoroughbred, harness, and steeplechase, each with distinct rules and traditions. The sport emphasizes speed, stamina, and strategy, with races typically categorized by distance, surface type, and horse age or breed. Horse racing plays a significant role in the equine industry, influencing breeding, training, and veterinary care practices. This page compiles peer-reviewed research studies and scholarly articles that explore the physiological demands, training methodologies, and health considerations associated with horse racing.
The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses.
PloS one    October 14, 2015   Volume 10, Issue 10 e0140673 doi: 10.1371/journal.pone.0140673
Turło A, Cywińska A, Czopowicz M, Witkowski L, Niedźwiedź A, Słowikowska M, Borowicz H, Jaśkiewicz A, Winnicka A.Training-induced muscle, skeletal and joint trauma may result in acute phase response reflected by the changes in the blood concentration of serum amyloid A (SAA) in racehorses. It remains yet unclear if such systemic reaction could be triggered by sport injuries and what is the impact of different types of musculoskeletal trauma on SAA concentrations in racehorses. This study aimed to determine changes in the SAA blood concentration in racehorses with different types of injuries of musculoskeletal system. Methods: The study involved 28 racehorses diagnosed after the race with bone fractures (...
Detection of the selective androgen receptor modulator andarine (S-4) in a routine equine blood doping control sample.
Drug testing and analysis    October 12, 2015   Volume 8, Issue 2 257-261 doi: 10.1002/dta.1867
Cawley AT, Smart C, Greer C, Liu Lau M, Keledjian J.No abstract available
Analysis of metronidazole in equine plasma using liquid chromatography/tandem mass spectrometry and high-resolution accurate mass spectrometry.
Rapid communications in mass spectrometry : RCM    September 26, 2015   Volume 29, Issue 8 753-763 doi: 10.1002/rcm.7158
Ilomuanya M, Uboh C, Ciallella J, Li X, Liu Y, Ifudu N, Azubuike C, Igwilo C.Treatment of racehorses with bicarbonate solutions to manage acidosis and muscle cramps prior to competition is banned in Pennsylvania (PA). Use of excess bicarbonate in horses causes diarrhea, requiring treatment with an antibiotic such as metronidazole (MTNZ). At present no method exists for detecting MTNZ in equine plasma. Thus, a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the detection, quantification and confirmation of MTNZ was developed. Methods: The analyte was recovered from plasma by liquid-liquid extraction using methyl tert-butyl ether and separated on an ...
The detection of a synthetic Interleukin-1 receptor antagonist peptide in a seized product from a racing stable.
Drug testing and analysis    September 11, 2015   Volume 8, Issue 9 957-965 doi: 10.1002/dta.1869
Levina V, Timms M, Vine J, Steel R.A synthetic Interleukin-1 receptor antagonist peptide with the sequence Acetyl-Phe-Glu-Trp-Thr-Pro-Gly-Tyr-Trp-Gln-Pro-Tyr-Ala-Leu-Pro-Leu-OH has been identified in a vial seized during a stable inspection. The use of peptide-based Interleukin-1 receptor antagonists as anti-inflammatory agents has not been previously reported, making this peptide the first in a new class of sports doping peptides. The peptide has been characterized by high-resolution mass spectrometry and a detection method developed based on solid-phase extraction and liquid chromatography - triple quadrupole mass spectrometr...
A Genome-wide Scan for Selective Sweeps in Racing Horses.
Asian-Australasian journal of animal sciences    September 4, 2015   Volume 28, Issue 11 1525-1531 doi: 10.5713/ajas.14.0696
Moon S, Lee JW, Shin D, Shin KY, Kim J, Choi IY, Kim J, Kim H.Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2)...
Whips in racing: is it time to take a stronger stand?
Australian veterinary journal    September 1, 2015   Volume 93, Issue 7 N26 doi: 10.1111/avj.12344
Hart T.No abstract available
Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses.
Drug testing and analysis    September 1, 2015   Volume 8, Issue 1 141-147 doi: 10.1002/dta.1834
Knych HK, Harrison LM, White A, McKemie DS.The use of isoflupredone acetate in performance horses and the scarcity of published pharmacokinetic data necessitate further study. The objective of the current study was to describe the plasma pharmacokinetics of isoflupredone acetate as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racing-fit adult Thoroughbred horses received a single intra-articular administration (8 mg) of isoflupredone acetate into the right antebrachiocarpal joint. Blood, urine and synovial fluid samples were collected prior to and at various tim...
Peri-anaesthetic complications in an equine referral hospital: Risk factors for post anaesthetic colic.
Equine veterinary journal    August 26, 2015   Volume 47, Issue 6 635-640 doi: 10.1111/evj.12475
Jago RC, Corletto F, Wright IM.Peri-anaesthetic complications are relatively common in equine patients and further investigations are warranted to identify manageable risk factors. Objective: To report morbidity and mortality rates and identify associated risk factors for horses undergoing general anaesthesia, within a predominantly racing Thoroughbred (TB) population. Methods: Single centre retrospective observational study. Methods: Anaesthetic and case records of all horses ≥12 months old undergoing general anaesthesia at Newmarket Equine Hospital between August 2010 and April 2012 were analysed, excluding emergency ab...
Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development.
Berliner und Munchener tierarztliche Wochenschrift    August 19, 2015   Volume 128, Issue 7-8 335-339 
Dierks C, Sieme H, Piechotta M, Lehner S, Merkt JC, Uphaus H, Klug E, Distl O.A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n = 64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicul...
Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses.
The Journal of heredity    August 18, 2015   Volume 106, Issue 6 734-740 doi: 10.1093/jhered/esv062
Jäderkvist Fegraeus K, Johansson L, Mäenpää M, Mykkänen A, Andersson LS, Velie BD, Andersson L, Árnason T, Lindgren G.Previous studies showed a positive effect of the DMRT3 "gait keeper" mutation on harness racing performance in Standardbreds, French-, and Nordic trotters. The mutation has also been shown to influence riding traits in multiple breeds. This study investigated the effect of the DMRT3 mutation on harness racing performance and riding traits in Finnhorses. Finnhorses used for harness racing (n = 180) and for riding (n = 59) were genotyped for the DMRT3 mutation. For the trotters the genotypes were evaluated for association with racing performance (number of starts, victories, placings, earnings, ...
Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis.
Mitochondrion    July 26, 2015   Volume 24 99-104 doi: 10.1016/j.mito.2015.07.006
Houben R, Leleu C, Fraipont A, Serteyn D, Votion DM.This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by means of respirometric parameters did not correlate with racing performance registered over the following racing season. However, altered mitochondrial energy metabolism was associated with higher risk of developing exertional rhabdomyolysis, a common cause of exercise intolerance in racehorses. These data represent a first step towards establishing reference values for muscle OXPHOS capacity...
Relationship between serum biomarkers of cartilage and bone metabolism and joint injury in young Thoroughbred racehorses in training.
American journal of veterinary research    July 26, 2015   Volume 76, Issue 8 679-687 doi: 10.2460/ajvr.76.8.679
Jackson BF, Reed SR, Price JS, Verheyen KL.To compare serum concentrations of biomarkers of cartilage and bone metabolism between racehorses with a carpal or metacarpophalangeal or metatarsophalangeal (ie, fetlock) joint injury and matched uninjured control horses, determine changes in biomarker concentrations following joint injury, and establish the biomarkers' diagnostic test performance. Methods: 50 Thoroughbred racehorses with a carpal or fetlock joint injury and 50 matched uninjured horses (control horses). Methods: Serum concentrations of 2 cartilage synthesis biomarkers (carboxy-terminal propeptide of type II collagen [CPII] an...
Musculoskeletal Health, Kidney and Liver Function in Retired Jockeys.
International journal of sports medicine    July 24, 2015   Volume 36, Issue 12 968-973 doi: 10.1055/s-0035-1548889
Cullen S, Donohoe A, McGoldrick A, McCaffrey N, Davenport C, Byrne B, Donaghy C, Tormey W, Smith D, Warrington G.The long-term implications of making-weight daily on musculoskeletal health and functioning of the kidney and liver remain unknown. This study aimed to investigate musculoskeletal health and kidney and liver function in a group of retired jockeys. 28 retired male jockeys (age 50-70 years) provided fasting blood samples for markers of bone metabolism and kidney and liver function. A dual-energy x-ray absorptiometry (DXA) scan was performed for the assessment of bone mineral density (BMD). Established reference ranges were used for interpretation of results. Comparisons were made between retired...
Bar shoes and ambient temperature are risk factors for exercise-induced pulmonary haemorrhage in Thoroughbred racehorses.
Equine veterinary journal    July 14, 2015   Volume 48, Issue 4 438-441 doi: 10.1111/evj.12458
Crispe EJ, Lester GD, Robertson ID, Secombe CJ.Ambient temperature has been identified as a risk factor for exercise-induced pulmonary haemorrhage (EIPH) in racing Thoroughbreds. This warranted a more expansive investigation of climatic conditions on the incidence and severity of EIPH. The impact of other variables such as the type of bit used, tongue ties and nonstandard shoes has not been reported and also warrant investigation. Objective: To examine the effect of various climatic variables as contributing risk factors for EIPH. Other previously uninvestigated variables as well as standard track and population factors will also be examin...
A genetic approach to improving the lives of racing Thoroughbreds.
Equine veterinary journal    July 1, 2015   Volume 48, Issue 3 270-271 doi: 10.1111/evj.12454
Velie B.No abstract available
Racehorses are getting faster.
Biology letters    June 26, 2015   Volume 11, Issue 6 20150310 doi: 10.1098/rsbl.2015.0310
Sharman P, Wilson AJ.Previous studies have concluded that thoroughbred racehorse speed is improving very slowly, if at all, despite heritable variation for performance and putatively intensive selective breeding. This has led to the suggestion that racehorses have reached a selection limit. However, previous studies have been limited, focusing only on the winning times of a few elite races run over middle and long distances, and failing to account for potentially confounding factors. Using a much larger dataset covering the full range of race distances and accounting for variation in factors such as ground softnes...
Putative regulation mechanism for the MSTN gene by a CpG island generated by the SINE marker Ins227bp.
BMC veterinary research    June 23, 2015   Volume 11 138 doi: 10.1186/s12917-015-0428-3
van den Hoven R, Gür E, Schlamanig M, Hofer M, Onmaz AC, Steinborn R.A single nucleotide polymorphism (SNP) in the first intron of the myostatin gene (MSTN) is associated with aptness of elite Thoroughbreds to race over sprint, middle or long distances. This intronic marker (g.66493737 T ≻ C), a short interspersed nuclear element (SINE) of 227 bp (Ins227bp) insertion polymorphism in the MSTN promoter, and the adjacent SNP BIEC2-417495 have not been studied for their association with racing aptness of the average Thoroughbreds raced in countries with lower status of the racing industry. This study investigated these markers regarding their prevalence and assoc...
Liquid chromatography-mass spectrometry analysis of five bisphosphonates in equine urine and plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences    June 20, 2015   Volume 998-999 1-7 doi: 10.1016/j.jchromb.2015.06.020
Wong AS, Ho EN, Wan TS, Lam KK, Stewart BD.Bisphosphonates are used in the management of skeletal disorder in humans and horses, with tiludronic acid being the first licensed veterinary medicine in the treatment of lameness associated with degenerative joint disease. Bisphosphonates are prohibited in horseracing according to Article 6 of the International Agreement on Breeding, Racing and Wagering (published by the International Federation of Horseracing Authorities). In order to control the use of bisphosphonates in equine sports, an effective method to detect the use of bisphosphonates is required. Bisphosphonates are difficult-to-de...
A longitudinal study of poor performance and subclinical respiratory viral activity in Standardbred trotters.
Veterinary record open    June 17, 2015   Volume 2, Issue 1 e000107 doi: 10.1136/vetreco-2014-000107
Back H, Penell J, Pringle J, Isaksson M, Ronéus N, Treiberg Berndtsson L, Ståhl K.While clinical respiratory disease is considered a main cause of poor performance in horses, the role of subclinical respiratory virus infections is less clear and needs further investigation. Objective: In this descriptive longitudinal study the relationship of markers of subclinical respiratory viral activity to occurrence of poor performance in racing Standardbred trotters was investigated. Methods: 66 elite Standardbred trotters were followed for 13 months by nasal swabs analysed with qPCR for equine influenza virus, equine arteritis virus, equine rhinitis B virus (ERBV), equine herpesvi...
Viral load of equine herpesviruses 2 and 5 in nasal swabs of actively racing Standardbred trotters: Temporal relationship of shedding to clinical findings and poor performance.
Veterinary microbiology    June 11, 2015   Volume 179, Issue 3-4 142-148 doi: 10.1016/j.vetmic.2015.06.002
Back H, Ullman K, Treiberg Berndtsson L, Riihimäki M, Penell J, Ståhl K, Valarcher JF, Pringle J.The equine gamma herpesviruses 2 and 5 (EHV-2 and -5) have frequently been observed in the equine population and until recently presumed low to nonpathogenic. However, recent reports linking presence of equine gamma herpesviruses with clinical signs of mild to severe lung disease, suggest that the role of these viruses in respiratory disease and poor performance syndrome is still unclear. Moreover, baseline data regarding the temporal pattern of shedding of EHV-2 and EHV-5 within stables and within individual actively racing horses have been lacking. In a prospective longitudinal study, we fol...
Heritability of racing durability traits in the Australian and Hong Kong Thoroughbred racing populations.
Equine veterinary journal    May 26, 2015   Volume 48, Issue 3 275-279 doi: 10.1111/evj.12436
Velie BD, Hamilton NA, Wade CM.Many attempts have been made to improve the well-being of racing Thoroughbreds through improvements in management and veterinary care. However, these attempts are often limited by the industry's ability to regulate a large number of environmental variables and as a result have arguably had limited success in providing long-lasting change for the breed. Objective: To identify heritable durability traits for Thoroughbred horses racing in Australia and Hong Kong. Methods: Heritability analysis of a longitudinal dataset. Methods: Performance data on the Thoroughbred populations racing in Australia...
Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement.
Journal of veterinary internal medicine    May 23, 2015   Volume 29, Issue 3 743-758 doi: 10.1111/jvim.12593
Hinchcliff KW, Couetil LL, Knight PK, Morley PS, Robinson NE, Sweeney CR, van Erck E.Published studies of exercise-induced pulmonary hemorrhage (EIPH), when assessed individually, often provide equivocal or conflicting results. Systematic reviews aggregate evidence from individual studies to provide a global assessment of the quality of evidence and to inform recommendations. Objective: Evaluate evidence to determine: if EIPH adversely affects the health, welfare or both of horses; if EIPH affects the athletic capacity of horses; the efficacy of prophylactic interventions for EIPH; and if furosemide affects the athletic capacity of horses. Methods: None. Methods: Systematic re...
Potential role of maternal lineage in the thoroughbred breeding strategy.
Reproduction, fertility, and development    May 5, 2015   doi: 10.1071/RD15063
Lin X, Zhou S, Wen L, Davie A, Yao X, Liu W, Zhang Y.Many studies have focused on identifying the genes or single nucleotide polymorphisms associated with the athletic ability of thoroughbreds, but few have considered differences in maternal and paternal heritability of athletic ability. Herein, we report on our association study of career race performances of 675 Australian thoroughbreds with their pedigrees. Racing performance data (prize money per start) were collected from the Bloodhound database. The performance of all horses was categorised as either poor or elite athletic achievement. Then, 675 foals were divided by their parents' perform...
Physiological Demands of Flat Horse Racing Jockeys.
Journal of strength and conditioning research    May 2, 2015   Volume 29, Issue 11 3060-3066 doi: 10.1519/JSC.0000000000000977
Cullen S, OʼLoughlin G, McGoldrick A, Smyth B, May G, Warrington GD.The physiological demands of jockeys during competition remain largely unknown, thereby creating challenges when attempting to prescribe sport-specific nutrition and training guidelines. The purpose of this study was to evaluate the physiological demands and energy requirements of jockeys during flat racing. Oxygen uptake (V[Combining Dot Above]O2) and heart rate (HR) were assessed in 18 male trainee jockeys during a race simulation trial on a mechanical horse racing simulator for the typical time duration to cover a common flat race distance of 1,400 m. In addition, 8 male apprentice jockeys ...
Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds.
Asian-Australasian journal of animal sciences    May 1, 2015   Volume 28, Issue 6 771-781 doi: 10.5713/ajas.14.0008
Shin DH, Lee JW, Park JE, Choi IY, Oh HS, Kim HJ, Kim H.Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively...
Post-exercise dynamics of serum amyloid A blood concentration in thoroughbred horses classified as injured and non-injured after the race.
Research in veterinary science    April 22, 2015   Volume 100 223-225 doi: 10.1016/j.rvsc.2015.04.008
Turlo A, Cywinska A, Czopowicz M, Witkowski L, Szarska E, Winnicka A.The aim of this study was to evaluate serum amyloid A (SAA) concentration in horses with orthopedic injuries acquired during racing and in healthy ones after completing the race. Injuries of bone and tendon did not cause radical increase in SAA concentration observed in other inflammatory conditions. SAA concentration correlated positively with white blood cell count (WBC) on the 3rd-4th days after race being significantly higher in the injured horses than in the control group in that time. It was suggested that racing effort may cause increase in SAA level, more pronounced in horses manifesti...
Cobalt chloride doping in racehorses: Concerns over a potentially lethal practice.
Veterinary journal (London, England : 1997)    April 9, 2015   Volume 205, Issue 3 335-338 doi: 10.1016/j.tvjl.2015.04.005
Mobasheri A, Proudman CJ.No abstract available
Non-fatal injury occurrence in Southern California Thoroughbred racehorses 2009-2010.
Veterinary journal (London, England : 1997)    April 9, 2015   Volume 205, Issue 1 98-100 doi: 10.1016/j.tvjl.2015.04.001
Hill AE, Blea JA, Arthur RM, McIlwraith CW.Private-practice racetrack veterinarians in southern California recorded non-fatal injuries meeting defined criteria in Thoroughbreds for 1 year. Injury incidence was 2.29 injury events per 100 horse-months, which was lower than other studies where trainer reported injury data were collected. Of 477 injuries recorded, 344 (72.1%) were acute and 133 (27.9%) were chronic. Fractures were common (47.6% of injuries), with stress fractures accounting for 14% of injuries. Superficial digital flexor tendonitis and suspensory ligament desmitis accounted for 15.3 and 11.5% of injuries, respectively. Agr...
Risk factors for epistaxis in jump racing in Great Britain (2001-2009).
Veterinary journal (London, England : 1997)    April 9, 2015   Volume 205, Issue 1 44-49 doi: 10.1016/j.tvjl.2015.04.003
Reardon RJ, Boden LA, Mellor DJ, Love S, Newton RJ, Stirk AJ, Parkin TD.The aim of this study was to evaluate risk factors associated with developing epistaxis in jump racing in Great Britain (GB). A retrospective analysis of records from horses running in all hurdle and steeplechase races in GB between 2001 and 2009 identified diagnoses of epistaxis whilst still at the racecourse. Data were used from 603 starts resulting in epistaxis (event) and 169,065 starts resulting in no epistaxis (non-event) in hurdle racing, and from 550 event starts and 102,344 non-event starts in steeplechase racing. Two multivariable logistic regression models to evaluate risk factors a...
Opiorphin analysis in equine plasma and urine using hydrophilic interaction LC-MS.
Bioanalysis    April 1, 2015   Volume 7, Issue 5 593-603 doi: 10.4155/bio.14.289
Wang CC, Hartmann-Fischbach P, Krueger TR, Wells TL, Simonson A, Compton JC.Due to opiorphin's analgesic and antidepressant functions, its illicit use is rumored in some racing jurisdictions. Opiorphin is very difficult to detect due to its hydrophilic nature and rapid degradation in plasma and urine samples. METHODOLOGY & RESULTS: We have developed a sensitive, reliable method for opiorphin detection and confirmation in equine samples, using EDTA to inhibit analyte degradation between the time of collection and analysis. Opiorphin was extracted by weak cation exchange followed by analysis using HILIC-MS/MS. The method was validated and the LOD was determined to b...
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