Standardbred horses are a breed known for their performance in harness racing, characterized by their ability to trot or pace at high speeds. This breed is distinguished by its well-muscled build, strong legs, and calm temperament. Standardbreds are primarily used in racing but are also versatile in other equestrian activities, including riding and driving. Their genetic lineage can be traced back to the late 18th century, with the establishment of the breed registry in the United States. This page compiles peer-reviewed research studies and scholarly articles that explore the genetics, physiology, and performance characteristics of Standardbred horses, as well as their management and health considerations in various equine disciplines.
Connysson M, Essén-Gustavsson B, Lindberg JE, Jansson A.A higher forage allowance to athletic horses might be an alternative to increase health and the gut fluid reservoir. However, more forage might increase bodyweight (bwt) and could therefore be a limitation during competition. Objective: To investigate the effect of a forage-only diet (FD) compared to a 50:50 (dry matter basis) forage:oats diet (OD) on bwt, plasma protein concentration and some metabolic plasma parameters during 12 h of feed deprivation. Methods: Twelve adult Standardbred horses in training were used. The 2 diets were fed in 2 experimental periods of 3 weeks each in a crossover...
Smarsh DN, Liburt N, Streltsova J, McKeever K, Williams CA.Many nutraceuticals are used as equine supplements without their efficacy having been scientifically tested. Black tea, cranberries, orange peel and ginger are a few of those nutraceuticals that warrant further study. Objective: To test the effects of single doses of black tea, cranberry, orange peel and ginger extract on markers of oxidative stress and antioxidant status following exercise in horses. Methods: In Study 1, 9 mature, healthy but unfit Standardbred mares were administered 2 l of a control (water), orange peel extract (30 g extract) or decaffeinated black tea extract (28 g extract...
Mykkänen AK, Pösö AR, McGowan CM, McKane SA.In exercising horses, up to 50% of blood lactate is taken up into red blood cells (RBCs). Lactate transporter proteins MCT1, MCT2 and CD147 (an ancillary protein for MCT1) are expressed in the equine RBC membrane. In Standardbreds (SB), lactate transport activity is bimodally distributed and correlates with the amount of MCT1 and CD147. About 75% of SB studied have high lactate transport activity in RBCs. In other breeds, the distribution of lactate transport activity is unknown. Objective: To study whether similar bimodal distribution of MCT1 and CD147 is present also in the racing Finnhorse ...
Leleu C, Haentjens F.The demands in the Standardbred trotters industry require young, still growing horses, to be trained well above light exercise level. During that period, the risk of occurrence of energy imbalance and maladaptation to training is high. In man, the lack of energy homeostasis is considered as the basic problem in the development of chronic fatigue. Objective: To find objective biomarkers of early maladaptation to training in young racehorses under field conditions. Methods: Sixty-five 2-year-old Standardbreds were followed during their first 3 months of training in 5 different training centres. ...
Passman SN, Cheetham J, Bonassar LJ, Ducharme NG, Rawlinson JJ.Upper airway obstruction is a common problem in the performance horse as the soft tissues of the larynx collapse into the airway, yet there is a paucity of information on biomechanical properties for the structural cartilage components. Objective: To measure the geometry and compressive mechanical properties of the hyaline cartilage to improve understanding of laryngeal function and morphology. Methods: A total of 11 larynges were harvested from Thoroughbred and Standardbred racehorses. During gross dissection, linear dimensions of the cricoid were obtained. From both the cricoid and arytenoid...
Medina-Torres CE, Weese JS, Staempfli HR.Fecal samples were collected to establish the apparent prevalence of Clostridium difficile shedding in Standardbred and Thoroughbred racehorses housed at 4 racetracks and 2 breeding facilities, and in horses admitted to a referral large animal clinic. Forty-one (7.59%) of 540 racetrack horses, seven (5.83%) of 120 breeding farm horses, and four (4.88%) out of 82 horses admitted to the referral clinic were culture-positive for C. difficile. An overall fecal culture prevalence of 7.01% for C. difficile was identified in 742 fecal samples. PCR-ribotyping and toxin gene identification was performe...
van de Goor LH, van Haeringen WA, Lenstra JA.As a consequence of the close integration of horses into human society, equine DNA analysis has become relevant for forensic purposes. However, the information content of the equine Short Tandem Repeat (STR) loci commonly used for the identification or paternity testing has so far not been fully characterized. Population studies were performed for 17 polymorphic STR loci (AHT4, AHT5, ASB2, ASB17, ASB23, CA425, HMS1, HMS2, HMS3, HMS6, HMS7, HTG4, HTG6, HTG7, HTG10, LEX3 and VHL20) including 8641 horses representing 35 populations. The power of parental exclusion, polymorphic information content...
Soma LR, Uboh CE, You Y, Guan F, McDonnell S.Pennsylvania (PA) State Racing Commissions regulate the endogenous androgenic steroid, testosterone (TES), in racing intact males (RIM) by quantification of TES in post-race samples. Post-race plasma samples (2209) collected between March 2008 and November 2010 were analyzed for TES, nandrolone (NAN), and other anabolic steroids (ABS). Of the 2209 plasma samples, 2098 had quantifiable TES ≥ 25 pg/mL. Plasma (mean ± SD) concentrations of TES and NAN in RIM were 329.2 ± 266.4 and 96.0 ± 67.8 pg/mL, respectively. Only 64.6% of RIM had quantifiable concentration of NAN, and there was no relat...
Faramarzi B, Cruz AM, Sears WC.To quantify changes in hoof wall strain distribution associated with exercise and time in Standardbreds. Methods: 18 young adult Standardbreds. Methods: 9 horses were exercised 4 d/wk for 30 to 45 minutes at a medium trot for 4 months; 9 nonexercised horses served as the control group. Rosette strain gauges were used to measure the principal surface strains at the toe, lateral quarter of the hoof wall (LQ), and medial quarter of the hoof wall (MQ) of the right forefoot at the beginning and end of the experiment. Midstance maximal (msϵ1) and minimal (msϵ2) principal and peak minimal principal...
de Laat MA, van Eps AW, McGowan CM, Sillence MN, Pollitt CC.Laminitis has many triggers and comparing the histopathology of lesions induced by different causes may help to establish whether a common mechanism or multiple pathologies are involved. The aim of this study was to describe the microscopical lesions and to quantify morphometric changes in the lamellae of horses with insulin-induced (n=4) and oligofructose (OF)-induced laminitis (n=4) compared with normal controls (n=4). Archived lamellar samples collected during two previous studies were used. Laminitis was induced within 48 h in standardbred horses with either a euglycaemic, hyperinsulinaemi...
Knobbe MG, Maenhoudt C, Turner RM, McDonnell SM.2 Standardbred racehorses that had been winning races while competing as mares underwent postrace drug testing and had serum testosterone concentrations above the acceptable limit for female racehorses. Results: Initial physical examinations by the referring veterinarian revealed ambiguous external genitalia and suspected intra-abdominally located testes leading to a preliminary diagnosis of male pseudohermaphroditism. Horses were referred for further evaluation of sex. Physical examination of the external genitalia confirmed the findings of the referring veterinarian. Transrectal palpation an...
Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G.The quantification of equine left ventricular (LV) function is generally limited to short-axis M-mode measurements. However, LV deformation is 3-dimensional (3D) and consists of longitudinal shortening, circumferential shortening, and radial thickening. In human medicine, longitudinal motion is the best marker of subtle myocardial dysfunction. Objective: To evaluate the feasibility and reliability of 2-dimensional speckle tracking (2DST) for quantifying equine LV longitudinal function. Methods: Ten healthy untrained trotter horses; 9.6 ± 4.4 years; 509 ± 58 kg. Methods: Prospective study. Re...
Lavoie JP, Cesarini C, Lavoie-Lamoureux A, Moran K, Lutz S, Picandet V, Jean D, Marcoux M.There is limited information relating bronchoalveolar lavage (BAL) cytology and cytokine messenger ribonucleic acid (mRNA) expression in racehorses with inflammatory airway disease (IAD). HYPOTHESIS AND OBJECTIVE: We hypothesize that cytokine expression in BAL cells would correlate with cytology. Thus, we evaluated the mRNA expression of selected cytokines in BAL cells in racehorses with exercise intolerance and lower airway inflammation. Methods: Thirty-one client-owned Standardbred racehorses with exercise intolerance. Methods: Prospective, observational study. Cells were obtained by BAL, an...
Suontama M, van der Werf JH, Juga J, Ojala M.Genetic correlations for body measurements and subjectively scored traits between foals and studbook horses were estimated using bivariate linear mixed models. Observations for nine foal and eleven studbook traits in Finnhorses on 6529 foals and 6596 studbook horses and in Standardbred trotters on 3069 foals and 2112 studbook horses were available from the Finnish horse breeding shows. The number of sires with progeny in both foal and studbook data was 203 in Finnhorse and 145 in Standardbred trotters. Estimates of heritability for body measurements in foals and studbook horses using univariat...
Visser MB, Pollitt CC.The timing of lamellar basement membrane (BM) changes occurring during laminitis development is incompletely understood. Objective: To determine the temporal progression of lamellar BM changes and whether laminin-332 (Ln-332) γ2 cleavage products are generated during laminitis development. Methods: Eight clinically normal Standardbred horses were allocated into treatment (n = 5) or sham (n = 3) groups. The treatment group received, via nasogastric intubation, an oligofructose (OF) bolus (10 g/kg bwt) while the sham group was given water. Laminitis induction proceeded for 48 h followed by euth...
Lacourt M, Marcoux M.To report use of a shielded hook bistoury developed for correction of epiglottic fold entrapment in standing sedated horses. Methods: Prospective clinical study. Methods: Standardbreds (n=8), 3-19 years of age. Methods: Epiglottic fold entrapment was corrected during standing sedation using a shielded hook bistoury passed nasally into the pharynx. Owners, trainers, and referring veterinarians were contacted by telephone to establish outcome. Results: Axial division of the entrapping epiglottic fold was successful in all horses. No short- or long-term complications occurred. Axial transection o...
David F, Laverty S, Marcoux M, Szoke M, Celeste C.To report a tenoscopic technique using monopolar electrosurgery to transect the accessory ligament of superficial digital flexor muscle (AL-SDFM) and outcome in 33 horses. Methods: Case series. Methods: Horses (n=33). Methods: Medical files and surgery video recordings of horses that had AL-SDFM desmotomy performed by tenoscopy with monopolar electrosurgical electrodes were reviewed. Results: Of 33 horses, 24 were Standardbred racehorses with surgery performed bilaterally for superficial digital flexor tendonitis and 9 horses had flexural deformity. Severe (n=6) and mild (6) intrathecal hemorr...
Cuniberti B, Badino P, Odore R, Girardi C, Re G.The effect of dynamic exercise on complete blood cell count, lymphocyte β-adrenergic receptor and plasma catecholamine (adrenaline and noradrenaline) levels in horses performing different disciplines were investigated during rest and after exercise. Blood samples were collected from jumping horses (n=6), Arabian Endurance horses (n=6) and Standardbred trotters (n=6) before and immediately after competition. Dynamic exercise caused a significant increase in red blood cell count (Standardbred trotters: P=0.0012), haemoglobin concentration (jumping horses: P=0.001; Standardbred trotters: P=0.01)...
Lykkjen S, Dolvik NI, McCue ME, Rendahl AK, Mickelson JR, Roed KH.Osteochondrosis (OC), a disturbance in the process of endochondral ossification, is by far the most important equine developmental orthopaedic disease and is also common in other domestic animals and humans. The purpose of this study was to identify quantitative trait loci (QTL) associated with osteochondrosis dissecans (OCD) at the intermediate ridge of the distal tibia in Norwegian Standardbred (SB) using the Illumina Equine SNP50 BeadChip whole-genome single-nucleotide polymorphism (SNP) assay. Radiographic data and blood samples were obtained from 464 SB yearlings. Based on the radiographi...
Brooks SA, Makvandi-Nejad S, Chu E, Allen JJ, Streeter C, Gu E, McCleery B, Murphy BA, Bellone R, Sutter NB.Horses, like many domesticated species, have been selected for broad variation in skeletal size. This variation is not only an interesting model of rapid evolutionary change during domestication, but is also directly applicable to the horse industry. Breeders select for complex traits like body size and skeletal conformation to improve marketability, function, soundness and performance in the show ring. Using a well-defined set of 35 measurements, we have identified and quantified skeletal variation in the horse species. We collected measurements from 1215 horses representing 65 breeds of dive...
Tseng CT, Miller D, Cassano J, Bailey E, Antczak DF.A system for identifying equine major histocompatibility complex (MHC) haplotypes was developed based on five polymorphic microsatellites located within the MHC region on ECA 20. Molecular signatures for 50 microsatellite haplotypes were recognized from typing 353 horses. Of these, 23 microsatellite haplotypes were associated with 12 established equine leucocyte antigen (ELA) haplotypes in Thoroughbreds and Standardbreds. Five ELA serotypes were associated with multiple microsatellite subhaplotypes, expanding the estimates of diversity in the equine MHC. The strong correlations between serolog...
Dart AJ, Dart CM, Dudhia J, Perkins N, Canfield P, Smith RK.To evaluate whether wound type or site influence the production of cartilage oligomeric matrix protein (COMP) and transforming growth factor β1 (TGF-β1), and determine if there is a correlation between TGF-β1and COMP during healing. Methods: Experimental. Methods: Standardbred horses (n=6), 4-8 years old. Methods: Six, standardized, full-thickness skin wounds (open, straight, and elliptical) were surgically created on the neck (n=3) and metacarpus (3) on each horse. Wounds were randomly allocated to site and side. Tissue samples were collected before creating wounds and on days 7, 14, and 4...
Vengust M, Kerr C, Staempfli HR, Pringle J, Heigenhauser GJ, Viel L.Frusemide (Fru) is widely prescribed for management of racehorses experiencing EIPH. The effect of Fru in the lung appears to be a reduction in transcapillary pressures and inhibition of the erythrocyte anion exchange, which may lead to attenuation of transpulmonary fluid fluxes during exercise. Objective: Treatment with Fru will attenuate transpulmonary fluid fluxes in horses during high intensity exercise. Methods: In a crossover study, 6 race-fit Standardbred horses were treated with 250 mg of Fru i.v. (FruTr) or placebo (Con) 4 h before exercise on a high speed treadmill until fatigue. Art...
Westermann CM, Dorland L, Wijnberg ID, de Sain-van der Velden MGM, van Breda E, Barneveld A, de Graaf-Roelfsema E, Keizer HA, van der Kolk JH.The objective of this study is to assess the influence of acute exercise, training and intensified training on the plasma amino acid profile. In a 32-week longitudinal study using 10 Standardbred horses, training was divided into four phases, including a phase of intensified training for five horses. At the end of each phase, a standardized exercise test, SET, was performed. Plasma amino acid concentrations before and after each SET were measured. Training significantly reduced mean plasma aspartic acid concentration, whereas exercise significantly increased the plasma concentrations of alanin...
Schroderus E, Ojala M.The aim of this study was to estimate genetic parameters for conformation measures and scores in the Finnhorse and the Standardbred foals presented in foal shows. Studied traits included height at withers and at croup, six subjectively evaluated conformation traits and overall grade. Data were from 10-year period (1995-2004) and consisted of 5821 Finnhorse foals (1-3 years old) with 7644 records and 2570 Standardbred foals (1-2 years old) with 2864 records. Variance components were estimated with REML - animal model using VCE4 program. The model included age class, year of judging, sex and...
Ragnarsson S, Jansson A.The aim of the present study was to compare digestibility and metabolic response in Icelandic and Standardbred horses fed two grass haylages harvested at different stages of maturity. Six horses of each breed were used in a 24-day change-over design. A total collection of faeces was made on days 15-17 and 22-24. Blood samples were collected on day 24 of each period and analysed for total plasma protein (TPP), plasma urea, non-esterified fatty acids, cortisol and insulin concentration. There were no differences in digestibility coefficients of crude protein, neutral detergent fibre or energy be...
Vilar JM, Santana A, Espinosa J, Spinella G.The assessment of a normal range for cross-sectional area (CSA) of tendons in the tarsal region is important in order to use them as reference values in the identification of pathological changes of dimensions. Objective: To provide normal reference values for the CSA of the tendons of the tarsus of Standardbred trotter horses (STH) by means of ultrasonography. Methods: Transverse echographic images of the tendons were obtained at different levels proximodistally; these images were digitised and CSA values (mean ± s.d.) were obtained for each structure. Results: The largest structure correspo...
Curtis GC, Grove-White D, Ellis RN, Argo CM.Standard and modified measuring sticks were used to record height at the withers and a 'non-contact' laser was used to measure withers and loin heights. Sixty horses and ponies, ranging in height (115 to 155 cm) and body condition score (BCS) (moderate to obese) were measured by each method at 10-minute intervals for 40 minutes. Measurement series were repeated over three successive days. Unique regression models were constructed for method-specific data. Coefficients of variation were similar for stick and laser methods (0.002 to 0.004 per cent). Models were not influenced by day of measureme...
Isgren CM, Upjohn MM, Fernandez-Fuente M, Massey C, Pollott G, Verheyen KL, Piercy RJ.Exertional rhabdomyolysis syndrome is recognised in many athletic horse breeds and in recent years specific forms of the syndrome have been identified. However, although Standardbred horses are used worldwide for racing, there is a paucity of information about the epidemiological and performance-related aspects of the syndrome in this breed. The objectives of this study therefore were to determine the incidence, risk factors and performance effects of exertional rhabdomyolysis syndrome in Standardbred trotters and to compare the epidemiology and genetics of the syndrome with that in other bree...
Physick-Sheard PW, McGurrin MK.A lack of information on normal heart rhythm at maximal effort hampers investigation of poor performance and sudden death in Standardbred racing. Objective: To characterize rhythm variations during scheduled racing in clinically normal Standardbred horses. Methods: Two hundred and eighty-eight Standardbred horses competing in 40 scheduled races at a Southern Ontario racetrack. Methods: Observational study, convenience sampling: Heart rhythm was monitored by ECG from harnessing to postrace recovery and assessed visually and by examining heart rate intervals. Rhythm variations were used as respo...
Hogan PM, Bramlage LR.Medical records and lifetime race results were obtained for 61 Standardbred racehorses treated consecutively from 1985 to 1992 with transection of the accessory ligament of the superficial digital flexor tendon (AL-SDF) for tendinitis of one or both forelimbs. A clinical diagnosis of tendinitis was confirmed in all cases by ultrasonographic examination. After surgery, 50 (82%) horses raced and 42 (69%) completed 5 or more starts. Eight horses (13%) failed to start and/or complete 5 or more races due to a recurrence of tendinitis. Six (10%) horses did not start and/or complete 5 or more starts ...
Gerard MP, Hodgson DR, Rose RJ, Walsh WR.To determine whether recombinant equine growth hormone (rEGH) would alter the in vitro biomechanical properties of the forelimb superficial digital flexor tendon (SDFT) in exercising young Standardbred horses. Methods: Randomized complete block design. Methods: Twelve Standardbred yearlings. Methods: Horses were trained for 12 weeks on a high-speed treadmill (10% positive incline). rEGH was administered intramuscularly (IM) daily (10 microg/kg during week 4; 20 microg/kg for weeks 5-9) to 6 horses (treated group), whereas 6 horses (control group) were administered an equivalent daily volume of...
Vengust M, Kerr C, Staempfli HR, Pringle J, Heigenhauser GJ, Viel L.Frusemide (Fru) is widely prescribed for management of racehorses experiencing EIPH. The effect of Fru in the lung appears to be a reduction in transcapillary pressures and inhibition of the erythrocyte anion exchange, which may lead to attenuation of transpulmonary fluid fluxes during exercise. Objective: Treatment with Fru will attenuate transpulmonary fluid fluxes in horses during high intensity exercise. Methods: In a crossover study, 6 race-fit Standardbred horses were treated with 250 mg of Fru i.v. (FruTr) or placebo (Con) 4 h before exercise on a high speed treadmill until fatigue. Art...
McCoy AM, Lopp CT, Kooy S, Migliorisi AC, Austin SM, Wilkins PA.Diseases affecting the internal umbilical remnant are common in foals. Ultrasound is used to diagnose abnormalities of these structures, and to monitor treatment. However, little is known about the progression of normal internal umbilical remnant regression. Objective: To document normal regression of the umbilical remnant in foals over the first 6 weeks of life. Methods: Prospective, longitudinal cohort study. Methods: Weekly ultrasound examinations were performed beginning at 1 day of age in 34 healthy Standardbred foals. The umbilical vein was measured in cross section just cranial to the...
Steel CM, Bond BM, Morrice-West AV.To determine swimming training practices in Australian harness racing horses and potential targets for future research. Methods: An online survey of Australian Standardbred trainers and telephone interviews with 20 leading trainers were conducted. Questions relating to swimming facility and protocol, perceived benefits and contraindications were included. Descriptive data analysis was performed. Results: Data were collected from 270 trainers: 250 by online survey (250/1770, response rate 14.1%) and 20 by interview. Of these, 103 trainers (38.1%), including 91 surveyed trainers (91/250, 36.4%) ...
Thomson GW, McCready R, Sanford E, Gagnon A.In the foaling season of 1977, five vaccinated horses in a Standardbred breeding stable were affected with herpesvirus myeloencephalitis. Respiratory and abortigenic forms also occurred in other individuals on the premises. Equine herpesvirus type 1 was isolated from the brain of one case of myeloencephalitis and from lungs of two aborted fetuses. Twelve of 16 horses demonstrated fourfold or greater increases in titres to equine herpesvirus type 1.
Tetens J, Derksen FJ, Stick JA, Lloyd JW, Robinson NE.To evaluate the efficacy of prosthetic laryngoplasty with and without bilateral ventriculocordectomy for treatment of experimentally induced left laryngeal hemiplegia (LLH). Methods: 15 adult Standardbreds. Methods: Horses were allotted to 3 equal groups. Sham operation (group 1), prosthetic laryngoplasty (group 2), or prosthetic laryngoplasty with bilateral ventriculocordectomy (group 3) was performed after induction of LLH. Upper airway function testing was performed prior to left recurrent laryngeal neurectomy (LRLN), 14 days after LRLN, and 60 and 180 days after surgical treatment. Measure...
Valberg S, Gustavsson BE, Lindholm A, Persson SG.Eight standardbred horses trotted on a treadmill for 55 mins at a sub-maximal speed of 5m/sec and subsequently performed an exercise test consisting of 2 min intervals at increasing speed. Heart (HR) and respiratory (Rf) rates and venous blood samples were obtained before, during and for 5 mins after exercise. Gluteus medius muscle biopsies and rectal temperatures were taken before and after exercise. The mean HR was 132/min and the mean Rf was 156/min during the 5m/sec trotting. With 5m/sec exercise, plasma free fatty acids (FFA), glucose, creatinine and cortisol concentrations increased mark...
Drevemo S, Fredricson I, Dalin G, Björne K.A high-speed cinematographic analysis of interlimb time and linear gait characteristics was carried out at racing speed (12.0 m/sec; 1:23.6 min/km) in 30 clinically sound Standard-bred trotters. In respect of the whole group of horses the racing trot was found to be a very regular and symmetric gait. The variation coefficient between different horses ranged from 8 to 21 per cent depending on the particular characteristic being investigated. The variations recorded in individual animals were about 60 per cent less than those found for the whole group. The most stable characteristics were the du...
Wilson BD, Neal RJ, Howard A, Groenendyk S.Standardbred pacers have been studied under race conditions to describe the gait of the pacer, and to determine relationships between stage of the race, finish order and selected gait kinematics. Overlap increased with the stage of the race while pacing speed decreased marginally for low order pacers and increased for high order finishers. High order finishing pacers appear to have greater stance and stride lengths than do low order finishers. Pacers could be separated into low order and high order groups on the basis of their movement patterns. High order pacers exhibited greater ranges of li...
Szymanski CM.Enlargement of the left eye, corneal opacification, and blindness were clinical signs of a teratoid medulloepithelioma in a 5-year-old Standardbred mare. Diagnosis was made on histologic examination of the enucleated eye. Medulloepitheliomas are congenital intraocular tumors arising from primitive ciliary body epithelium. Their development is rare in domestic animals.
Westermann CM, Dorland B, de Sain-van der Velden MG, Wijnberg ID, Van Breda E, De Graaf-Roelfsema E, Keizer HA, Van der Kolk JH.To evaluate alterations in skeletal muscle carnitine metabolism during exercise and training by measuring changes in plasma acylcarnitine concentrations in Standardbreds. Methods: 10 Standardbred geldings with a mean +/- SD age of 20 +/- 2 months and weight of 384 +/- 42 kg. Methods: In a 32-week longitudinal study, training on a treadmill was divided into 4 phases as follows: phase 1, acclimatization for 4 weeks; phase 2, 18 weeks with alternating endurance and high-intensity exercise training; phase 3, increased training volume and intensity for another 6 weeks; and phase 4, deconditioning f...
Nostell KE, Essén-Gustavsson B, Bröjer JT.The branched chain amino acid leucine is a potent stimulator of insulin secretion. Used in combination with glucose it can increase the insulin response and the post exercise re-synthesis of glycogen in man. Decreased plasma amino acid concentrations have been reported after intravenous or per oral administration of leucine in man as well as after a single per oral dose in horses. In man, a negative correlation between the insulin response and the concentrations of isoleucine, valine and methionine have been shown but results from horses are lacking. This study aims to determine the effect of ...
Lindholm A, Ronéus B, Lindblad G, Jones B.The biological turnover of hyaluronan (sodium hyaluronate) of different molecular weights (0.6 x 10(6) and 2.5 x 10(6) Daltons) was studied in the synovial fluid of the middle carpal and metacarpophalangeal joints of 6 clinically healthy Standardbred horses. The hyaluronan was radioactively labelled with 14C. The biological half-life (t1/2) was calculated from repeated synovial samples after injection of the labelled hyaluronan. The mean t1/2 in the metacarpophalangeal joints was 9.7 h for low molecular weight hyaluronan and 8.9 h for high molecular weight hyaluronan and in the middle carpal j...
Revold T, Mykkänen AK, Karlström K, Ihler CF, Pösö AR, Essén-Gustavsson B.Muscular changes caused by training are breed-specific and studies on the Norwegian-Swedish Coldblooded Trotter (NSCT) are limited. Knowledge about lactate-transporters in muscle in this light draught breed used for harness racing is lacking. Objective: To identify muscular changes associated with training in young NSCTs and investigate muscular distribution of the monocarboxylate transporter 1 (MCT1) and its ancillary protein CD147, which facilitate lactate transport across membranes. Methods: Nine horses were followed from the start of their training period until the end of their 3-year-old ...
Chen JW, Uboh CE, Soma LR, Li X, Guan F, You Y, Liu Y.Proper identification of racehorses competing in an official race and maintenance of defensible chain of custody are important in doping control regulations. The purpose of this study was to develop a reliable multiplex PCR method for providing genetic evidence for matching donors to test samples by using short tandem repeat (STR) loci. Amplification of 21 STR loci from blood, urine or hair root was achieved in a single tube and STR length polymorphism was analyzed using fluorescent labeled capillary electrophoresis. This novel approach showed an allele confidence interval of 0.19-0.43 bp and ...
Persson SG, Funkquist P, Nyman G.The purposes of this study were to elucidate the influences of age and sex on the mass specific blood volume parameters: total blood volume (TBV/BW, ml/kg), plasma volume (PV/ BW, ml/kg), total red cell volume (CV/BW, ml/kg) and maximal packed cell volume (PCV, l/l, i.e. after total mobilisation of the splenic red cell reservoir) and to establish reference values for these in normally performing Standardbred trotting race horses. In total 205 horses were studied. They were all, according to their owners and/or trainers, performing satisfactorily in racing or training for shortly impending raci...
Geor RJ, McCutcheon LJ, Hinchcliff KW.To compare effects of low and high intensity warm-up exercise on oxygen consumption (VO2) and carbon dioxide production (VCO2) in horses. Methods: 6 moderately conditioned adult Standard-breds. Methods: Horses ran for 2 minutes at 115% of maximum oxygen consumption (VO2max), 5 minutes after each of the following periods: no warm-up (NoWU); 10 minutes at 50% of VO2max (LoWU); or 7 minutes at 50% VO2max followed by 45-second intervals at 80, 90, and 100% VO2max (HiWU). Oxygen consumption and VCO2 were measured during exercise, and kinetics of VO2 and VCO2 were calculated. Accumulated O2 deficit ...
Schneider RK, Bramlage LR, Gabel AA, Barone LM, Kantrowitz BM.The medical records and radiographs of all horses with a third carpal bone fracture admitted to The Ohio State University Veterinary Hospital from 1979 to 1987 were reviewed. Three hundred and seventy-one fractures were found in 313 horses; 57 percent were Standardbreds, 41 per cent were Thoroughbreds, and only 1.6 per cent were Quarterhorses. All were young racehorses (average age = 3.1 years). Third carpal fractures occurred more frequently in the right limb (60 percent) than the left limb (40 percent); Thoroughbreds had a greater right-left disparity (67.5 percent R, 27.1 per cent L). Fract...
Whitton RC, Kannegieter NJ.The clinical presentation and outcome of treatment is presented for 26 cases of osteochondral fragmentation of the plantar/palmar proximal aspect of the proximal phalanx. Twenty-three were racing Standardbreds and three were racing Thoroughbreds. The most common reason for presentation was an inability to run straight at high speed. Only eight horses presented for lameness, although on examination 19 were lame. A positive flexion test was recorded in 90% of affected fetlock joints and effusion in 48%. Arthroscopic fragment removal was performed on 23 occasions in 21 horses and arthrotomy in on...
Dicken M, Gee EK, Rogers CW, Mayhew IG.To examine the gestation lengths and occurrence of daytime foaling of Standardbred mares foaling outdoors at stud farms in Southland, New Zealand (latitude 45˚S). Methods: Data were collected prospectively at two commercial Standardbred stud farms (Farms A and B), during the 2008/9 and 2009/10 breeding seasons (October to February). For each foaling, the identity of the mare, date and time of foaling, gender of foal, time the mare passed the fetal membranes, time the foal stood, and foaling problems including dystocias, were recorded. The effect of farm, season, gender of foal, month of artif...
Koho NM, Hyyppä S, Pösö AR.Monocarboxylate transporters (MCT) facilitate the transport of lactate across membranes. In red blood cells (RBC) the transport activity varies interindividually due to differences in the amount of an ancillary protein CD147. Similar variations in muscles could have a great influence on lactate accumulation during exercise. Objective: To study the expression of MCT isoforms and CD147 in the middle gluteal muscle. Methods: Venous blood and muscle biopsy samples were taken from 14 Standardbred horses. Lactate transport activity in RBC and the amounts of MCT1, 2, 4 and CD147 were measured. Result...
Moshage SG, McCoy AM, Polk JD, Kersh ME.Bone adaptation is in part driven by mechanical loading, and exercise during youth has been shown to have life-long benefits for bone health. However, the development of early exercise-based interventions that reduce the incidence of fractures in racing horses is limited by the lack of characterization of normal development in growing bone. Previous efforts to quantify bone development in the horse have relied on repeated radiographs or peripheral quantitative computed tomography scans, which are limited in their assessment of the entire bone. In this study, we acquired computed tomography sca...
Trachsel DS, Calloe K, Mykkänen AK, Raistakka P, Anttila M, Fredholm M, Tala M, Lamminpää K, Klaerke DA, Buhl R.Exercise-associated sudden deaths (EASDs) are deaths occurring unexpectedly during or immediately after exercise. Sudden cardiac death (SCD) is one cause of EASD. Cardiac arrhythmias caused by genetic variants have been linked to SCD in humans. We hypothesize that genetic variants may be associated with SCD in animals, including horses. Genetic variants are transmitted to offspring and their frequency might increase within a family. Therefore, the frequency of such variants might increase with the inbreeding factor. Higher inbreeding could have a negative impact on racing performance. Pedigree...
Heath SE, Peter AT, Janovitz EB, Selvakumar R, Sandusky GE.A 2-year-old Standardbred gelding was examined because of prolapse of the third eyelid; myoclonus of the muscles of the head, neck, and forelimbs; and persistent tail swishing. The horse had a high plasma sodium concentration but was not drinking water. The hypernatremia could not be corrected by means of IV administration of fluids, and the horse became worse and, 6 days later, died. At necropsy, a tumor was found to be compressing the neurohypophysis and the area in the brain in which the thirst centers are believed to be located. It is believed that hypernatremia in this horse was a result ...
Kraus M, Physick-Sheard P, Brito LF, Sargolzaei M, Schenkel FS.Admissions of Standardbred racehorses (Std) to the Ontario Veterinary College Teaching Hospital (OVCTH) for treatment of atrial fibrillation (AF) began to increase in the early 1990s. The arrhythmia has been shown to have a modest heritability (h2 ≃ 0.15), with some stallions appearing as sires or sires of mares used in breeding (broodmares) of affected horses more frequently than others. The objective of this study was to determine the marginal genetic contributions of ancestors to cohorts of Std affected with AF and their contemporary control groups, and whether these ancestors contribute ...
Bröjer J, Holm S, Jonasson R, Hedenström U, Essén-Gustavsson B.The degradation of glycogen and its two forms, proglycogen (PG) and macroglycogen (MG) has been studied in horses performing different types of exercise, but no information is available about the resynthesis of PG and MG after exercise. Objective: To determine the resynthesis of PG and MG in skeletal muscle after intermittent uphill exercise. Methods: At a training camp 9 well-trained Standardbred trotters performed a training session comprising a warm-up period, 7 repeated 500 m bouts of exercise on an uphill slope and a recovery period. Muscle biopsies (m. gluteus medius) for analysis of PG,...