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Topic:Treatment
Treatments for horses encompasses a range of medical and therapeutic interventions aimed at maintaining or restoring equine health. This field involves the use of pharmaceuticals, surgical procedures, and alternative therapies to address various conditions affecting horses. Common treatments include the administration of anti-inflammatory drugs, antibiotics, and vaccines, as well as physical therapies and nutritional management. Research in this area focuses on evaluating the efficacy, safety, and outcomes of different treatment modalities. This page collects peer-reviewed research studies and scholarly articles that explore the methods, advancements, and clinical outcomes associated with equine treatment practices.
Race Performance Following Arthroscopic Surgery for Femoropatellar and Tarsocrural Osteochondrosis in Juvenile Thoroughbreds. The objective of this study is to evaluate racing performance of Thoroughbred yearlings following arthroscopic surgery for osteochondrosis (OC) of the femoropatellar (FP) and tarsocrural (TC) joints. Unassigned: This is a retrospective study of Thoroughbreds 0.05). In both groups, no significant performance differences were found between unilateral and bilateral cases ( > 0.05). Unassigned: Racing performance after FP or TC OC surgery was comparable to that of unaffected controls. Bilateral cases performed as successfully as unilateral.
Seizures and blindness onset zone in 7 horses undergoing radiographic myelography in lateral recumbency under inhalation anesthesia. Seizures and blindness are potential complications associated with myelography. Objective: Describe, classify, and determine onset zone of seizures and blindness in horses undergoing radiographic myelography in lateral recumbency. Methods: Seven young adult horses. Methods: Retrospective study. Horses with seizures or blindness associated with myelography were included. Results: Three horses with general proprioceptive ataxia and 4 neurologically normal horses (Warmblood = 4, Thoroughbred = 3), ages 9 (range, 3-16) years old. Iohexol (300 mg I/mL) from 50 to 60 mL (0.09-0.1 mL/kg) were ...
Histological differences in the placenta of three mares treated for ascending bacterial placentitis compared to physiological pregnancies. Ascending bacterial placentitis is a frequent cause of late pregnancy loss in mares. The histology of placentitis has been described but mainly with a focus on inflammatory changes. In this study, we assessed several aspects beyond inflammatory processes between mares foaling close to term during treatment for placentitis and physiological pregnancies. We included placental tissue from physiological term pregnancies (group PP; n = 8) and clinical cases with confirmed ascending bacterial placentitis (group PL; n = 3). Samples were collected from several locations of the allantochorion (cerv...
Magnesium Dysregulation. Magnesium (Mg) is a critical intracellular cation involved in energy metabolism, neuromuscular and cardiac stability, and endocrine regulation of calcium and potassium. In horses, Mg dysregulation is common in gastrointestinal disease, systemic inflammation and critical illness, yet often remains underdiagnosed. Hypomagnesemia contributes to ileus, cardiac arrhythmias, and refractory hypocalcemia or hypokalemia, whereas hypermagnesemia is rarely reported and typically iatrogenic. This review summarizes Mg physiology, regulation, clinical manifestations of Mg dysregulation, diagnostic approache...
Surgical Management of Unilateral Maxillary Molar Teeth Impaction in a Horse. Impaction of equine permanent cheek teeth is most commonly reported in the mandible, whereas maxillary involvement is rare. This report describes an uncommon presentation of congenital impaction of 3 successive maxillary molar teeth in a 4-year-old mare. Computed tomography revealed complex spatial relationships between the impacted teeth, the sinus floor and adjacent structures, which were not fully appreciated on conventional radiography and were essential for surgical planning. Surgical extraction via a maxillary sinus bone flap permitted controlled sectioning and subsequent removal of all ...
Isolation of Moraxella spp. strains in horses. Two species of Moraxella were isolated from swabs obtained from two symptomatic horses suffering from conjunctivitis and rhinitis. The isolates were identified via MALDI-TOF as Moraxella osloensis and Moraxella equi respectively, with a good genus identification and a probable species identification score. The first one was also confirmed by BLAST sequence analysis with a high homology (99%). Antimicrobial susceptibility testing obtained by minimum inhibitory concentration method showed that the two isolates were sensitive to all the tested molecules. The therapeutic protocols applied had an e...
Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review. Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective: To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Methods: Structured scoping review. Methods: A comprehensive search was performed in accordance with the PRISMA Extension for Scoping Reviews using the terms '(paracetamol OR acetaminophen) AND (pain OR safety OR toxicosis OR pharmacokinetics) AND (horse OR pony OR donkey OR mule)' across Web of Science, Scopus, and PubMed from dat...
Hormonal, clinical, and survival outcomes in horses and ponies diagnosed with pituitary pars intermedia dysfunction in primary care practice. Variables associated with hormonal, clinical, and survival outcomes of equids with pituitary pars intermedia dysfunction (PPID) are incompletely investigated. Objective: Evaluate the effect of initial hormone concentrations, clinical signs, treatment, and owner-related variables on outcomes in horses and ponies with PPID. Methods: Medical records from 213 horses and ponies diagnosed with PPID by 2 university-based primary care practices. Methods: Analytical observational cohort study. Variables associated with adrenocorticotropic hormone normalization, clinical improvement, and survival after ...
[Puncture wounds of the equine hoof – a retrospective study of 96 cases – Part 2: Management and prognosis]. Puncture wounds are a common and potentially life-threatening injury in equine veterinary practice. The aim of this study was to systematically analyze data from horses presenting to the clinic with a puncture wound. Unassigned: A retrospective study was conducted on patient data from horses with a puncture wound in the period from September 2008 to August 2024. Analyzed data included medical management and surgical treatment, complications, duration and costs of hospitalization, short-term survival rate and treatment success. Unassigned: A total of 96 horses met the inclusion criteria. Seven ...
Osteosynthesis of bilateral, displaced incisive bone fracture in a horse. A nine-year-old Trakehner mare was presented three days after an episode of severe epistaxis, showing intermittent foul-smelling nasal discharge with feed material and rostral displacement of the upper incisor teeth. Radiographic and computed tomography examinations revealed a complete comminuted fracture of the right side and an oblique complete fracture of the left side nasal processes of the incisive bone and maxillary bone, as well as open fractures of the nasal septum and palatine bone with displacement of the incisor part rostrally and development of an oronasal communication. The fractu...
Disorders of Water and Tissue Perfusion (Diabetes Insipidus, Renin-Angiotensin-Aldosterone Axis, and Anhidrosis). This review highlights disorders of water and tissue perfusion in equids, specifically diabetes insipidus, the renin-angiotensin-aldosterone axis, and anhidrosis. The differences in renal versus central diabetes insipidus is discussed, as well as diagnosis and treatment of diabetes insipidus in equids. The physiology of the renin-angiotensin-aldosterone axis is reviewed, and recent research in the role of the renin-angiotensin-aldosterone axis in equids in certain states is emphasized. The proposed pathophysiology of anhidrosis in horses is discussed, as well as potential therapies.
Guttural pouch tympany or empyema in 38 ٍStraight Egyptian Arabian foals: clinical presentation, diagnostic features and outcome. As a breed, Straight Egyptian Arabian horses are susceptible to many disorders that mostly affect the head, such as guttural pouch (GP) tympany and empyema. This retrospective study evaluated the findings of clinical examination, ultrasonography, endoscopy, laboratory analyses and outcome of treatment of 38 Straight Egyptian Arabian foals with GP tympany and empyema. Methods: Data from medical records of foals diagnosed with GP tympany or empyema over a 2-year period (2024-2025) were reviewed. Foals with verified GP tympany or empyema who had complete medical records and had not previously rec...
Equine Fungal Keratitis due to Cladorrhinum bulbillosum. To describe the case details and treatment of an equine fungal keratitis case caused by Cladorrhinum bulbillosum. Methods: A 14-year-old Bashkir Curly gelding with a complicated corneal ulcer of the left eye. Methods: Corneal cytology was performed, and intraoperative samples were collected for polymerase chain reaction and for aerobic and mycologic cultures. Under general anesthesia, an inferior eyelid subpalpebral lavage system (SPL) was placed to facilitate postoperative therapy. Anterior stromal keratectomy was performed followed by cryotherapy of the keratectomy bed. A biological scaffold...
Epidural 0.125% ropivacaine is safe but insufficient for induced tibiotarsal joint pain. Epidural injection of a low concentration of the local anaesthetic ropivacaine produces analgesia without neurological deficits or ileus in people. Objective: To determine if epidural 0.125% ropivacaine mitigates induced hindlimb lameness in horses while preserving neurological function and gastrointestinal (GI) motility. Methods: Randomised, blinded, controlled, crossover study. Methods: Eight healthy, sound horses underwent two treatments in random order, separated by at least 3 weeks: epidural saline or epidural ropivacaine. For each treatment, an epidural catheter was inserted at the fir...
Thermographic analysis of chiropractic care on the back health of Mangalarga Marchador horses. Poor saddle fit can cause back pain and lesions in horses, highlighting the need for preventive therapies. Objective: To evaluate the effects of chiropractic treatment on the backs of Mangalarga Marchador horses using infrared thermography to monitor thermal changes associated with saddle-induced overload. Methods: Physiological, environmental, thermographic, and chiropractic parameters were evaluated in 13 horses subjected to a standardized 25-min exercise session. Animals were assigned to either a control group (GC, n = 6) or a chiropractic treatment group (GT, n = 7). Assessments were c...
Quantifying the Equine Pain Response to Paracetamol Administration in Horses With Chronic Lameness Already Receiving Non-Steroidal Anti-Inflammatories. Paracetamol is used in horses alongside non-steroidal anti-inflammatories (NSAIDs) for multi-modal analgesia; however to date there are few studies published which have investigated its analgesic effect in the horse. Horses were recruited to this study from a population of geriatric horses at The Horse Trust. Horses were selected based on the following inclusion criteria; documented naturally occurring chronic lameness and being treated with an NSAID at the licensed dose and dosing interval. This population was assessed with a five-point subjective lameness grading system performed live by two...
Pharmacokinetic/Pharmacodynamic Analysis of Quinidine-Induced Dominant Frequency Reduction in Thoroughbred Horses With Atrial Fibrillation. Quinidine has long been used for the pharmacological treatment of atrial fibrillation (AF) in horses; however, the plasma concentration required for conversion to sinus rhythm remains unclear. Dominant frequency (DF), derived from surface electrocardiograms, reflects atrial activation rate during AF. This study aimed to quantify the relationship between plasma quinidine concentration and DF using a pharmacokinetic/pharmacodynamic (PK/PD) approach. Ten Thoroughbred horses with naturally occurring AF received quinidine sulfate via a nasogastric tube. Plasma quinidine concentrations and DF values...
Efficiency of a Combination of Polyethylene Glycol and Psyllium on the Evacuation of Sand Compared to Established Treatment Regimes in Sand Enteropathy of the Horse. The accumulation of sand in the abdomen is a rising risk for colic in horses. Sand mainly accumulates in the ascending colon in the cranioventral abdomen. Evacuation of sand is facilitated by the application of psyllium supported with a laxative via nasogastric intubation. Laxatives currently used are either sodium sulfate/magnesium sulfate or mineral oil. The aim of this study was to compare the efficiency of polyethylene glycol, a laxative already used in human medicine for chronic constipation, with that of the above-described, established therapy options. Therefore, 44 horses diagnosed wit...
Use of extracorporeal hemoperfusion in a 2-day-old foal with neonatal sepsis. A 2-day-old Miniature Horse filly presented with severe clinical and clinicopathologic findings consistent with neonatal sepsis, failure of transfer of passive immunity, and aspiration pneumonia. The filly initially was treated with broad spectrum antimicrobials, hemodynamic support, and hyperimmune plasma. Because of a lack of improvement within the first 24 h, extracorporeal blood purification and cytokine removal were implemented. The foal underwent hemoperfusion (HP) using a polymer-based device (VetResQ). Reported notable changes during and after treatment included improved physical exam...
The effects of clomiphene citrate on reproductive parameters in the mare. Clomiphene citrate (CC) is a longstanding human fertility drug that has yet to be investigated in horses. The objective was to evaluate effects of CC on mare reproduction. After follicle ablation on Day 0, treatment mares (n=5) received 2 grams of CC intravenously on Days 1-5 while control mares (n=4) received no treatment. Transrectal ultrasonography was performed on Days 1-5 and 8, and transvaginal oocyte aspiration occurred on Day 8. Hormones were analyzed on Days 0-5, 8, 11, and 15. Mares receiving CC exhibited higher uterine edema grades compared to control mares (P=0.009). Antral follicl...
The Impact of a Horse Kick: A Systematic Review of Horse-Related Maxillofacial Trauma. : To systematically review the evidence on horse-related maxillofacial trauma, with emphasis on horse-kick injuries, anatomical patterns, associated injuries, management, outcomes, and prevention. : This systematic review followed the PRISMA 2020 statement. PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library were searched for original clinical studies reporting facial, craniofacial, orbital, dental, or maxillofacial injuries related to horse-associated activities. Data were extracted on study characteristics, demographics, mechanism, mounted/unmounted status, anatomical site, asso...
Comparison of Fogarty and Vollmar thrombectomy for chronic jugular thrombosis in horses. Chronic jugular vein thrombosis may result in persistent venous obstruction and impaired head drainage. Although surgical thrombectomy is performed in selected cases, experimental comparisons between mechanical techniques for chronic thrombus removal in horses are lacking. Objective: To compare Fogarty catheter thrombectomy alone with a combined Vollmar ring-Fogarty technique for restoration and maintenance of luminal patency in experimentally induced chronic jugular thrombosis. Methods: Randomised in vivo study. Methods: Chronic right jugular thrombosis was induced in 10 healthy adult horses....
Eight Weeks of 448 kHz Radiofrequency Therapy Increases Multifidus Muscle Cross-Sectional Area and Modulates Thoracolumbar Range of Motion in Horses with Chronic Back Pain. We aimed to investigate the effects of an 8-week 448 kHz radiofrequency (RF) on multifidus cross-sectional area (CSA) and thoracolumbar differential range of motion (ROM). Eight Thoroughbred horseball horses received four RF treatments (T9-L6) at 2-week intervals. Multifidus CSA (T10-L5) and differential spinal ROM between the withers (W), T13, T18, L3 and sacrum (S) were measured before treatment, immediately after the first session, 24 h after the first session, and at 8 weeks (15 days after the last session). Linear mixed models with Tukey post hoc comparisons were used. Significant effects...
Neosaxitoxin Downregulates Inflammation in an Equine In Vivo Model of Osteoarthritis. Chronic synovial inflammation is a hallmark of osteoarthritis progression and is tightly regulated by synovial macrophages. Recently, voltage-gated sodium channels (NaV) have emerged as potent modulators of macrophage-driven inflammation, positioning them as novel therapeutic targets. Among selective NaV channel blockers, neosaxitoxin exerts remarkable anesthetic and immunomodulatory effects; however, its effects on joint inflammation upon intra-articular delivery remain unexplored. Using an equine model of bilateral carpal osteoarthritis, this study evaluated the immunomodulatory and tissue-p...
Short-term effects of pulsed electromagnetic field therapy on subjective flexion-associated lameness responses and circulating cytokines in horses with distal tarsal osteoarthritis. Pulsed electromagnetic field (PEMF) therapy is commonly used in equine sports medicine for its proposed anti-inflammatory effects; however, limited controlled studies have evaluated its physiologic effects in horses. Objective: The objective of this study was to investigate the effects of PEMF therapy on flexion-induced lameness and circulating cytokines in horses with radiographic evidence of distal tarsal osteoarthritis. Methods: Six mares were enrolled in a repeated-measures crossover design in which each horse served as its own control. Horses were evaluated at baseline (sham PEMF) and at ...
Russell’s viper envenomation in a 9-month pregnant mare saved with high-dose antivenom: a first-in-world case report. Snakebite during pregnancy is an uncommon but potentially catastrophic event, with maternal and foetal outcomes closely related to the severity of envenomation. While snakebite in pregnant women has been sporadically reported and is known to be associated with significant obstetrical complications, envenomation in animals, particularly in pregnant horses, is exceedingly rare. Only a few isolated cases of snakebite in horses have been documented, and to the best of our knowledge, snakebite in a pregnant mare has not been previously reported in the medical or veterinary literature. Russell's vip...
Cryopreserved umbilical allograft (equicenta® CTM) improves clinical outcomes compared with clinician-selected standard of care in performance horses: a pragmatic prospective controlled trial. This multicenter, prospective, controlled clinical study and client survey evaluated the safety and effectiveness of an equine umbilical tissue suspension (equicenta® CTM; eCTM, 2:1) compared with clinician-selected standard of care (SOC) for treating lame performance horses. Unassigned: This pragmatic, real-world, open-label study enrolled horses diagnosed with appendicular musculoskeletal conditions affecting the joints, tendons, or ligaments under owner consent and an intention-to-treat design with an optional crossover after no improvement at 12 weeks and per-protocol analyses at 26 ...
Cold Atmospheric Plasma-Aerosol Treatment of Equine Antibiotic-Resistant Wound Infection: A Preliminary Case Series. Wound infections are common sequelae of wound treatment in horses. Secondary bacterial colonization with antimicrobial resistant microorganisms is of particular concern and is of crucial importance regarding the "One Health Concept". Due to frequent antimicrobial resistance (AMR), conventional treatments often involve determining resistance and sensitivity using time-consuming antibiograms. Infections with multi-resistant pathogens are especially challenging. This case series presents studies of four horses evaluating the efficacy of Cold Atmospheric Plasma-Aerosol (CAP-A) as a standalone trea...
