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Topic:Lameness

Lameness in horses is a condition characterized by an abnormal gait or stance due to pain or mechanical dysfunction affecting the limbs or spine. It is a common issue in equine practice and can result from a variety of causes, including injury, infection, or degenerative diseases. Lameness can affect a horse's performance and quality of life, making accurate diagnosis and management important for equine health. Diagnostic techniques often include physical examination, imaging, and gait analysis. This page aggregates peer-reviewed research studies and scholarly articles that explore the etiology, diagnostic methods, and management strategies for lameness in horses.
Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses.
Journal of veterinary pharmacology and therapeutics    November 13, 2008   Volume 31, Issue 6 554-561 doi: 10.1111/j.1365-2885.2008.00994.x
Schleining JA, McClure SR, Evans RB, Hyde WG, Wulf LW, Kind AJ.Lameness as a result of joint disease is a major source of decreased athletic performance in the horse. Most treatment protocols include the administration of nonsteroidal anti-inflammatory drugs (NSAIDs). Phenylbutazone, alone or in combination with other treatments, is the most commonly and widely used NSAID, however it has the potential for serious side effects. The introduction of the liposome-based formulation of the NSAID diclofenac has shown promising effect as a safe and convenient treatment for lameness associated with osteoarthritis. The purpose of this study was to evaluate the effe...
Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 200-210 doi: 10.1016/j.vetimm.2008.11.005
Noschka E, Moore JN, Peroni JF, Lewis SJ, Morrow JD, Robertson TP.Inflammation and vascular dysfunction occur concurrently during the prodromal stages of equine laminitis. The aim of this study was to provide insights into the role that thromboxane and isoprostanes may play in the development of black walnut heartwood extract (BWHE)-induced laminitis. Horses were divided into two groups, either control or BWHE-administered horses. Plasma concentrations of thromboxane increased transiently after administration of BWHE and coincided with the nadir in white blood cell counts, whereas plasma concentrations of iso-prostaglandin PGF(2alpha) (iso-PGF(2alpha)) did n...
You say lamellae, I say laminae. Let’s call … An overview of the Havemeyer workshop on laminitis pathophysiology.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 149-150 doi: 10.1016/j.vetimm.2008.11.011
Moore JN, Belknap JK.No abstract available
Extracellular matrix, leukocyte migration and laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 161-163 doi: 10.1016/j.vetimm.2008.11.010
Black SJ.The structure and dynamic nature of extracellular matrix is discussed in the context of healthy and diseased tissues particularly the equine digital laminae.
Temporal aspects of laminar gene expression during the developmental stages of equine laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 242-253 doi: 10.1016/j.vetimm.2008.11.002
Noschka E, Vandenplas ML, Hurley DJ, Moore JN.The results of recent studies indicate that inflammatory responses occurring in the early stages of equine laminitis lead to downstream events that eventually result in failure of the bond between the hoof wall and the distal phalanx. In order to gain further insights into the molecular mechanisms involved in the development of laminitis, an equine-specific cDNA microarray consisting of transcripts for more that 3000 genes was used to assess temporal changes in gene expression in laminar tissues at 1.5, 3 and 12 h after administration of either a laminitis-inducing agent (black walnut heartwoo...
Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 167-173 doi: 10.1016/j.vetimm.2008.11.009
Bailey SR, Adair HS, Reinemeyer CR, Morgan SJ, Brooks AC, Longhofer SL, Elliott J.The link between the fermentation of carbohydrate in the equine large intestine and the development of acute laminitis is poorly understood. Absorption of endotoxin (lipopolysaccharide; LPS) into the plasma has been observed in one experimental model of laminitis, but does not cause laminitis when administered alone. Thus, the potential role of endotoxin is unclear. Platelet activation has previously been demonstrated in the developmental stage of laminitis. Equine platelets are more sensitive than leukocytes to activation by endotoxin, and can be activated directly by LPS in the low pg/ml ran...
Inflammatory and redox status of ponies with a history of pasture-associated laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 216-220 doi: 10.1016/j.vetimm.2008.11.004
Treiber K, Carter R, Gay L, Williams C, Geor R.Inflammatory and redox signals could render lamellar tissue susceptible to damage and contribute to higher risk for laminitis in obese or insulin resistant ponies just as these factors contribute to health risks in humans with metabolic syndrome. This study evaluated circulating markers of inflammatory and redox status in ponies that had a history of recurrent bouts of pasture-associated laminitis (PL, n = 42) or had never developed clinical laminitis (NL, n = 34) under the current management conditions. There were no differences (P > 0.05) between PL and NL ponies for markers of antioxidan...
Leukocyte-derived and endogenous matrix metalloproteinases in the lamellae of horses with naturally acquired and experimentally induced laminitis.
Veterinary immunology and immunopathology    November 7, 2008   Volume 129, Issue 3-4 221-230 doi: 10.1016/j.vetimm.2008.11.003
Loftus JP, Johnson PJ, Belknap JK, Pettigrew A, Black SJ.Inflammation and dysregulation of endogenous matrix metalloproteinase (MMP) production are implicated in the development of equine laminitis. In this study, we examine quantitative relationships among levels of leukocyte-derived proMMP-9 and MMP-9, lamellar proMMP-2 and MMP-2, and expression of proMMP-2 processing enzymes, MT1-MMP/PACE4, as steps towards determining whether inflammation and dysregulation of endogenous MMP production are independent or co-dependent processes. Methods: Archived samples of lamellae from horses with naturally acquired laminitis (n = 12), and from horses administer...
Evaluation of clinical examination for differential diagnosis of lameness by navicular apparatus or heel pain in horses.
Pakistan journal of biological sciences : PJBS    September 30, 2008   Volume 11, Issue 13 1754-1756 doi: 10.3923/pjbs.2008.1754.1756
Sardari K, Kazemi H.To evaluation of clinical examination for differential diagnosis of navicular region pain from other forms of palmar heel pain in the forelimb in horses the present study was undertaken. Thirty four horses with lameness referable to the palmar aspect of the hoof based on their response to the palmar digital nerves analgesia were divided into 2 groups based on their response to both distal interphalangeal joint and navicular bursa analgesia. Horses that were profoundly improved by both analgesic blocks (distal interphalangeal joint and navicular bursa) were considered to have navicular region p...
[Frequency of diseases and injuries in the Swiss horse population].
Schweizer Archiv fur Tierheilkunde    September 10, 2008   Volume 150, Issue 8 399-408 doi: 10.1024/0036-7281.150.8.399
Knubben JM, Gygax L, Auer J, Fürst A, Staᆲher M.Through a written questionnaire, which was sent to a representatively distributed and randomly selected sample of Swiss horse owners, data of 2912 horses and ponies were acquired to extrapolate prevalence data of health disorders. General questions about the horse and associated factors of housing and use, as well as questions about the current health status and the occurrence of diseases and injuries had been asked. 718 horses (24.7% of the sample) had been examined by a veterinarian within the 12 months prior to the survey. Orthopaedic and traumatic disorders (41.5%) had the largest proporti...
[Drug interactions of phenylbutazone and phenprocoumon in a warmblood gelding].
Schweizer Archiv fur Tierheilkunde    August 22, 2008   Volume 150, Issue 7 352-358 doi: 10.1024/0036-7281.150.7.352
Cohausz O, Müntener CR, Trachsel D, Wimmershoff J, Eser MW.A 15 year old Oldenburger gelding was treated during 3 weeks for laminitis with the anticoagulant phenprocoumone (27 mg orally, once daily) and concurrent administration of phenylbutazone (2-4 g orally, twice daily). After this treatment the animal was presented to the Equine Clinic University of Zurich with a history of acute colic and advanced symptoms of shock. On the basis of the clinical signs and laboratory values, a diagnosis of combined drug induced coagulopathy was made. The horse was treated with the antidote Vitamine-K1 (0.5 mg/kg, subcutaneously). Eventually, the general condition ...
Factors affecting outcome of extensor tendon lacerations in the distal limb of horses. A retrospective study of 156 cases (1994-2003).
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    August 16, 2008   Volume 21, Issue 4 358-364 
Mespoulhès-Rivière C, Martens A, Bogaert L, Wilderjans H.Distal limb lacerations are common injuries in horses, with a better prognosis reported for extensor tendons lacerations compared to flexor tendons lacerations. The objective of the present study was to determine the influence of type and location of injury, modalities of treatment and post surgical complications on the outcome of extensor tendon lacerations. The medical records of 156 horses surgically treated for extensor tendon lacerations over a 10-year period were analysed retrospectively. Information was obtained for 124 horses with a minimum of 18 months follow-up. Statistical analysis ...
Laminitis: drink deep, or taste not the Pierian Spring.
Equine veterinary journal    August 6, 2008   Volume 40, Issue 5 431-432 doi: 10.2746/042516408X320870
Silver IA.No abstract available
Rupture of collateral ligaments in metacarpophalangeal and metatarsophalangeal joints in horses: 17 cases (1999–2005).
Journal of the American Veterinary Medical Association    August 5, 2008   Volume 233, Issue 3 456-462 doi: 10.2460/javma.233.3.456
Tenney WA, Whitcomb MB.To characterize ruptures of collateral ligaments (CLs) in metacarpophalangeal and metatarsophalangeal joints in horses. Methods: Retrospective case series. Methods: 17 horses with ruptured CLs. Methods: Data were obtained from medical records, including signalment, history, clinical signs, ultrasonographic and radiographic findings, treatment, and outcome. Additional follow-up information was obtained from owners or referring veterinarians. Results: The lateral CL was ruptured in 11 horses; the medial CL was ruptured in 6 horses. Ultrasonography revealed ipsilateral rupture of the short and lo...
Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses.
American journal of veterinary research    July 3, 2008   Volume 69, Issue 7 886-890 doi: 10.2460/ajvr.69.7.886
Valdés-Martínez A, Seiler G, Mai W, Bolt DM, Mudge M, Dukti SA, Hubert JD.To develop a quantitative method of interpreting tibial scintigrams of Thoroughbred racehorses with tibial stress fractures that may facilitate diagnosis of fractures and to provide prognostic information regarding future performance of affected horses. Methods: 35 Thoroughbred racehorses. Methods: Static bone-phase scintigrams of tibial stress fractures were quantitatively analyzed by use of ratios of the mean radionuclide counts per pixel in a region of interest (ROI) drawn around the area of increased uptake of radiopharmaceutical to mean counts per pixel in a second ROI drawn around an app...
Microbial ecology of the equine hindgut during oligofructose-induced laminitis.
The ISME journal    June 26, 2008   Volume 2, Issue 11 1089-1100 doi: 10.1038/ismej.2008.67
Milinovich GJ, Burrell PC, Pollitt CC, Klieve AV, Blackall LL, Ouwerkerk D, Woodland E, Trott DJ.Alimentary carbohydrate overload is a significant cause of laminitis in horses and is correlated with drastic shifts in the composition of hindgut microbiota. Equine hindgut streptococcal species (EHSS), predominantly Streptococcus lutetiensis, have been shown to be the most common microorganisms culturable from the equine caecum prior to the onset of laminitis. However, the inherent biases of culture-based methods are estimated to preclude up to 70% of the normal caecal microbiota. The objective of this study was to evaluate bacterial population shifts occurring in the equine caecum throughou...
Compressive damage to the deep branch of the lateral plantar nerve associated with lameness caused by proximal suspensory desmitis.
Veterinary surgery : VS    June 20, 2008   Volume 37, Issue 4 328-335 doi: 10.1111/j.1532-950X.2008.00385.x
Tóth F, Schumacher J, Schramme M, Holder T, Adair HS, Donnell RL.To describe pathologic changes in the deep branch of the lateral plantar nerve (DBLPN) of horses determined to be lame because of proximal suspensory desmitis (PSD), and to report the outcome after treatment by excision of a segment of the horses' DBLPN. Methods: Retrospective case series. Methods: Adult horses (n=16). Methods: Horses determined to be lame on one or both pelvic limbs because of PSD were treated by excision of a segment of the DBLPN, and 30 nerves were examined histologically. Owners were contacted to obtain information about the horses >or=6 months after surgery. Results: H...
Desmitis of the distal digital annular ligament in seven horses: MRI diagnosis and surgical treatment.
Veterinary surgery : VS    June 20, 2008   Volume 37, Issue 4 336-344 doi: 10.1111/j.1532-950X.2008.00386.x
Cohen JM, Schneider RK, Zubrod CJ, Sampson SN, Tucker RL.(1) To describe the clinical signs and abnormalities observed on magnetic resonance imaging (MRI) in 7 horses with desmitis of the distal digital annular ligament (DDAL); (2) to describe the normal magnetic resonance (MR) appearance and thickness of the DDAL in health; and (3) to describe a tenoscopic surgical technique for treating horses with desmitis of the DDAL. Methods: Retrospective study. Methods: Horses (n=7) with desmitis of the DDAL. Methods: MR examinations of 20 sound horses were reviewed to determine the normal appearance of the DDAL. Dimensions obtained from these images were com...
Use of magnetic resonance imaging to diagnose the cause of proximal metacarpal pain in a standardbred trotter.
The Veterinary record    June 17, 2008   Volume 162, Issue 24 790-792 doi: 10.1136/vr.162.24.790
Coudry V, Denoix JM, Didierlaurent D, Rossignol F, Audigié F.No abstract available
Clinical and scintigraphic findings in horses with a bone fragility disorder: 16 cases (1980-2006).
Journal of the American Veterinary Medical Association    June 4, 2008   Volume 232, Issue 11 1694-1699 doi: 10.2460/javma.232.11.1694
Anderson JD, Galuppo LD, Barr BC, Puchalski SM, Macdonald MM, Whitcomb MB, Magdesian KG, Stover SM.To describe clinical and scintigraphic abnormalities in horses with a bone fragility disorder. Methods: Retrospective case series. Methods: 16 horses with scintigraphic evidence of multiple sites of increased radiopharmaceutical uptake (IRU). Procedures-Medical records were reviewed for information on signalment; history; clinical, clinicopathologic, and diagnostic imaging findings; and treatment. Follow-up information was obtained through telephone interviews with owners. Results: Horses ranged from 4 to 22 years old; there were 8 castrated males and 8 females. Foci of IRU most commonly invol...
Quantitative morphology of the equine laminar junction in relation to capsule shape in the forehoof of Standardbreds and Thoroughbreds.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 5 473-480 doi: 10.2746/042516408X313652
Thomason JJ, Faramarzi B, Revill A, Sears W.Differences in hoof morphology have largely been underappreciated in the literature until recently, and it is these that hold the key to interpreting functional adaptation in the hoof. Objective: Primary laminar morphology correlates with hoof capsule shape; and breeds with different hoof shapes and loadings show different patterns of correlation. Methods: Seventeen measurements of capsule shape and 3 of primary epidermal laminae (PEL) morphology (spacing, orientation and curvature) were made on right and left front hooves from 27 Standardbred and 25 Thoroughbred horses, and tested for breed d...
The collateral ligaments of the distal interphalangeal joint: magnetic resonance imaging and post mortem observations in 25 lame and 12 control horses.
Equine veterinary journal    May 20, 2008   Volume 40, Issue 6 538-544 doi: 10.2746/042516408X313661
Dyson S, Blunden T, Murray R.Magnetic resonance imaging (MRI) is used with increasing frequency to diagnose injuries of the collateral ligaments (CLs) of the distal interphalangeal (DIP) joint, but the results have not been verified by histology and the mechanism of injury is poorly understood. Objective: Abnormal signal intensity and tissue contour represents change in tissue structure detected on histology. Objective: To compare results in horses free from and those with chronic lameness and to describe possible progression of lesions. Methods: One or both feet of horses free from lameness (Group N: n = 12) and with foo...
Diagnostic imaging of the equine fetlock region using radiography and ultrasonography. Part 2: the bony disorders.
Veterinary journal (London, England : 1997)    May 7, 2008   Volume 181, Issue 2 123-136 doi: 10.1016/j.tvjl.2008.01.017
Vanderperren K, Saunders JH.The metacarpophangeal/metatarsophalangeal (fetlock) joint in the horse is commonly associated with equine lameness and diagnostic imaging is routinely used to investigate disorders of the joint and its surrounding tissues. This review describes the osseous disorders of the fetlock as well as the technical aspects of taking radiographic and ultrasonographic images of the different lesions. In current clinical practice, a combination of radiography and ultrasonography is still the most frequently used approach to arrive at a diagnosis.
[Animal welfare in prevention and therapy of laminitis].
DTW. Deutsche tierarztliche Wochenschrift    May 1, 2008   Volume 115, Issue 3 106-113 
Winkelsett S, Vervuert I.Laminitis is a systemic disease which is manifested as a non infectious condition in the foot. The management of feeding and housing conditions is necessary to treat the endocrinological and metabolic disturbances of laminitic horses. The Equine Metabolic Syndrome (EMS) is predisposing for developing laminitis, and it is characterised by obesity, insulin resistance, hypertension and dyslipidaemia. A genetical predisposition is supposed and EMS is accompanied by a lack of exercise and inadequate energy intake. Laboratory examinations are of great importance for diagnosis. Analyses of insulin, g...
Diagnostic imaging of the equine fetlock region using radiography and ultrasonography. Part 1: Soft tissues.
Veterinary journal (London, England : 1997)    April 28, 2008   Volume 181, Issue 2 111-122 doi: 10.1016/j.tvjl.2008.03.005
Vanderperren K, Saunders JH.The equine fetlock is the joint most commonly associated with lameness. Although the fetlock is regarded as a simple joint, diagnosis of a fetlock disorder can be a challenge and various imaging modalities are routinely used to arrive at an accurate diagnosis. This review describes the principal disorders affecting the soft tissues of the fetlock region and addresses some of the technical aspects involved in taking radiographic and ultrasonographic images of the different soft tissue lesions. A combination of radiography and ultrasonography is still the most commonly used diagnostic approach i...
Effects of topical application of pirfenidone ointment on thermoplasty-induced acute lameness in a double-blind and acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial in horses.
Research communications in molecular pathology and pharmacology    April 23, 2008   Volume 117-118 47-63 
Giri SN, Margolin SB.The effectiveness of pirfenidone ointment against thermoplasty-induced acute foreleg lameness in a double-blind study, and against acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial was evaluated in this study. Thermoplasty was performed on both inner forelegs at designated locations of each horse under anesthetics. A 10% pirfenidone or placebo ointment was topically applied starting 24 hours after the thermoplasty three times daily for 7 days. For acute and chronic lameness of musculoskeletal origin, pirfenidone ointment was also applied one to three ti...
Conservative treatment of a comminuted cervical fracture in a racehorse.
Irish veterinary journal    April 1, 2008   Volume 61, Issue 4 244-247 doi: 10.1186/2046-0481-61-4-244
Vos Nj.The 'classical' or 'Hangman' neck fracture involves the odontoid peg (process) of the second cervical vertebra (C2), and is described as an axial, dens or odontoid peg fracture in both the veterinary and human literature. Possible surgical treatment in both foals and adult horses requires a technique that allows decompression, anatomical alignment and stabilisation of the odontoid fracture. A limited number of surgical cases in foals have been reported in literature, but never in an adult horse. A mature Irish Thoroughbred racehorse was diagnosed with a type 2a odontoid peg fracture. Clinical ...
Suspected primary scapulohumeral osteoarthritis in two Miniature ponies.
Australian veterinary journal    March 28, 2008   Volume 86, Issue 4 153-156 doi: 10.1111/j.1751-0813.2008.00260.x
Parth RA, Svalbe LS, Hazard GH, Church S.Two cases of severe scapulohumeral osteoarthritis in Miniature ponies are described, one bilateral and the other unilateral. The condition is thought to occur in miniature breeds as a result of scapulohumeral dysplasia. The presentation in one of the ponies was unusal: it refused to pick up either fore limb, with progression to a uniquely bizarre gait with narrow forelimb placement, an arched back and widely placed hindlimbs camped well forward under the body. The other pony was presented for an acute unilateral non-weight bearing forelimb lameness. Response to analgesia in both cases was poor...
Retrospective analysis of exploratory laparotomies in 192 Andalusian horses and 276 horses of other breeds.
The Veterinary record    March 11, 2008   Volume 162, Issue 10 303-306 doi: 10.1136/vr.162.10.303
Muñoz E, Argüelles D, Areste L, Miguel LS, Prades M.The medical records of 468 horses that underwent 490 exploratory laparotomies for the correction of gastrointestinal diseases were reviewed to search for differences between Andalusian horses and other breeds. The seasonal distribution of surgical colics and their outcome and complications were also investigated. Bivariant analysis was used to compare the horses' age, gender and breed with the type of surgery, the bowel affected and the type of colic, and all these variables were compared in relation to euthanasia during surgery, complications, short-term survival and seasonal distribution. A ...
Basic farriery for the performance horse.
The Veterinary clinics of North America. Equine practice    March 4, 2008   Volume 24, Issue 1 203-218 doi: 10.1016/j.cveq.2007.12.002
O'Grady SE.Proper farriery promotes a healthy functional foot and biomechanical efficiency and prevents lameness. Because the equine veterinarian is responsible for the soundness of the horse, a working knowledge of farriery becomes essential. A thorough knowledge of traditional horseshoeing enables the veterinarian to interact with the farrier at the farrier's level; this ultimately enhances and promotes quality hoof care. This article focuses on fundamental farriery and recognizing subtle changes in hoof conformation that can be used to preserve the integrity of the hoof capsule, along with the structu...
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