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Home / Equine Research Bank / Animals (Basel) / Regenerative Medicine for Equine Musculoskeletal Diseases.
Animals : an open access journal from MDPI2021; 11(1); 234; doi: 10.3390/ani11010234

Regenerative Medicine for Equine Musculoskeletal Diseases.

Abstract: Musculoskeletal injuries and chronic degenerative diseases commonly affect both athletic and sedentary horses and can entail the end of their athletic careers. The ensuing repair processes frequently do not yield fully functional regeneration of the injured tissues but biomechanically inferior scar or replacement tissue, causing high reinjury rates, degenerative disease progression and chronic morbidity. Regenerative medicine is an emerging, rapidly evolving branch of translational medicine that aims to replace or regenerate cells, tissues, or organs to restore or establish normal function. It includes tissue engineering but also cell-based and cell-free stimulation of endogenous self-repair mechanisms. Some regenerative medicine therapies have made their way into equine clinical practice mainly to treat tendon injures, tendinopathies, cartilage injuries and degenerative joint disorders with promising results. However, the qualitative and quantitative spatiotemporal requirements for specific bioactive factors to trigger tissue regeneration in the injury response are still unknown, and consequently, therapeutic approaches and treatment results are diverse. To exploit the full potential of this burgeoning field of medicine, further research will be required and is ongoing. This review summarises the current knowledge of commonly used regenerative medicine treatments in equine patients and critically discusses their use.
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Publication Date: 2021-01-19 PubMed ID: 33477808PubMed Central: PMC7832834DOI: 10.3390/ani11010234Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article is about exploring the use of regenerative medicine, which includes cell-based techniques, to manage musculoskeletal injuries and diseases in horses with the aim of not just repairing but fully regenerating the damaged tissues.

Understanding the Scope of the Research

  • The study focuses on the problem of musculoskeletal injuries and chronic degenerative diseases among horses. These medical conditions can adversely affect the horses’ athletic careers and even their general well-being and longevity.
  • The conventional repair mechanisms often result in the formation of biomechanically inferior scar or replacement tissues instead of fully functional regeneration of injured tissues. This can lead to high reinjury rates, advancement of degenerative diseases, and lasting morbidity.

The Role of Regenerative Medicine

  • Regenerative medicine is, as stated in the article, a rapidly progressing branch of translational medicine aiming to replace or regenerate cells, tissues, or organs, and restore normal functionality. This discipline includes tissue engineering involving both cell-based and cell-free techniques stimulating self-repair mechanisms in the body.
  • Several regenerative medicine therapies have found successful application in the treatment of tendon injuries, tendinopathies, cartilage injuries, and degenerative joint disorders in horses. Such applications have yielded encouraging results.

Challenges and Future Directions

  • Despite these achievements, there are still gaps in our understanding. For instance, scientists do not yet fully understand the exact spatiotemporal requirements for the bioactive factors that trigger tissue regeneration following an injury.
  • This leads to diverse therapeutic approaches and results, which, while they can be effective, might not be as efficient or consistent as they would be with better understanding.
  • The uncertain and varied outcomes suggest the need for additional research in this emerging field to exploit its potential fully and refine treatment protocols for equine patients.

Objectives of the Review

  • The article demonstrates a review of the current state of knowledge regarding commonly utilized regenerative medicine treatments in equine healthcare.
  • Additionally, it critically discusses the implementation of these approaches, suggesting not just a need for further research, but also a careful re-evaluation of current methods to ensure the best possible outcomes for the horse patients involved.

Cite This Article

APA
Ribitsch I, Oreff GL, Jenner F. (2021). Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel), 11(1), 234. https://doi.org/10.3390/ani11010234

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 1
PII: 234

Researcher Affiliations

Ribitsch, Iris
  • Equine Surgery Unit, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Oreff, Gil Lola
  • Equine Surgery Unit, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Jenner, Florien
  • Equine Surgery Unit, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Conflict of Interest Statement

The authors declare no conflict of interest.

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