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Topic:Disease Prevention

Disease prevention in horses encompasses strategies and practices aimed at minimizing the occurrence and spread of infectious and non-infectious diseases within equine populations. These practices include vaccination programs, biosecurity measures, and regular health monitoring. Vaccination helps to stimulate the horse's immune system to protect against specific pathogens, while biosecurity measures, such as quarantine and sanitation, reduce the risk of disease transmission. Regular health monitoring, including physical examinations and diagnostic testing, aids in early detection and management of potential health issues. This page compiles peer-reviewed research studies and scholarly articles that explore various methods and their effectiveness in preventing diseases in horses, as well as the development and implementation of prevention programs in different equine settings.
High intensity light increases olfactory bulb melatonin in Venezuelan equine encephalitis virus infection.
Neurochemical research    August 10, 2001   Volume 26, Issue 3 231-234 doi: 10.1023/a:1010964500370
Medina-Leendertz S, Valero N, Chacín-Bonilla L, Añez F, Giraldoth D, Arias J, Espina G, Díaz S, Bonilla E.In mice infected with the Venezuelan equine encephalomyelitis (VEE) virus and exposed to high intensity light (2500 lux) with a 12 h light: 12 h dark photoperiod, a significant increase in the levels of melatonin in the olfactory bulb was observed. The significance of these findings deserves further studies to understand the mechanisms involved in this effect since the olfactory bulbs have been proposed as first portal for VEE virus entry into the CNS. The increase in melatonin content could represent one of the mechanisms of defense against the viral attack.
Production of potent polyvalent antivenom against three elapid venoms using a low dose, low volume, multi-site immunization protocol.
Toxicon : official journal of the International Society on Toxinology    August 2, 2001   Volume 39, Issue 10 1487-1494 doi: 10.1016/s0041-0101(01)00108-8
Chotwiwatthanakun C, Pratanaphon R, Akesowan S, Sriprapat S, Ratanabanangkoon K.The purpose of this study was to prepare a potent polyvalent antivenom against three elapids namely, the Thai cobra (Naja kaouthia, NK), the King cobra (Ophiophagus hannah, OH) and the banded krait (Bungarus fasciatus, BF). Two groups of horses were immunized. Group 1, comprising five horses, was immunized twice with a mixture of postsynaptic neurotoxins followed by an additional six immunizations with a mixture of crude venoms of the three elapids. Group 2, comprising four horses, was immunized with a mixture of crude venoms throughout the course. For the first immunization, the immunogens we...
Clinical and virological evaluation of the efficacy of an inactivated EHV1 and EHV4 whole virus vaccine (Duvaxyn EHV1,4). Vaccination/challenge experiments in foals and pregnant mares.
Vaccine    July 18, 2001   Volume 19, Issue 30 4307-4317 doi: 10.1016/s0264-410x(01)00131-1
Heldens JG, Hannant D, Cullinane AA, Prendergast MJ, Mumford JA, Nelly M, Kydd JH, Weststrate MW, van den Hoven R.Pregnant mares and young foals were vaccinated with Duvaxyn EHV1,4, an inactivated and adjuvanted vaccine containing both the EHV-1 and 4 antigens. SN and CF antibody titres were induced two weeks after first vaccination. Antibody levels were boosted after second vaccination, however they never reached the levels induced after virus challenge. Young foals were challenged with virulent EHV-1 and EHV-4 field viruses. Pregnant mares were challenged with the highly abortigenic EHV-1 strain Ab4. Vaccinated animals showed a clear reduction in clinical signs and virus excretion compared to unvaccinat...
Caterpillars, cherry trees may take blame for foal deaths in Kentucky.
Journal of the American Veterinary Medical Association    July 7, 2001   Volume 219, Issue 1 13-14 
No abstract available
The effect of different quantities and compositions of pelleted diets on immune response of mares during the production of anti-tetanus sera.
Berliner und Munchener tierarztliche Wochenschrift    June 21, 2001   Volume 114, Issue 5-6 188-192 
Rupić V, Bacar-Huskić L, Lojkić M, Habe F, Ergotić N.Research was carried out into the effect that different quantities and compositions of concentrated portions of meal had on certain haematological properties and on the immune response of mares in the course of hyper-immune antitetanus sera production. The experiment involved 24 Nonius and Lipizzaner cross-bred mares divided into two groups of 12 animals each, a control group and a trial group. The experiment lasted 12 months, with haematological and immunological tests being carried out every 30 days. During the course of the experiment each mare was subjected to 11 immunisation cycles, and i...
Equine grass sickness website.
The Veterinary record    June 2, 2001   Volume 148, Issue 19 608 
McGorum B, Milne E.No abstract available
Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding.
Fertility and sterility    June 1, 2001   Volume 75, Issue 6 1080-1087 doi: 10.1016/s0015-0282(01)01792-7
Archer DF, Dorin M, Lewis V, Schneider DL, Pickar JH.To evaluate vaginal bleeding profiles with lower doses of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) as continuous combined therapy. Methods: The Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) study, a randomized, double-blind, placebo-controlled trial. Methods: Study centers across the United States. Methods: Two thousand six hundred seventy-three healthy, postmenopausal women. Methods: Women received CEE, 0.625 mg/d; CEE, 0.625 mg/d, plus MPA 2.5 mg/d; CEE, 0.45 mg/d; CEE, 0.45 mg/d, plus MPA, 2.5 mg/d; CEE 0.45 mg/d, plus MPA, 1.5 mg/d; CEE, 0....
Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horses.
Veterinary immunology and immunopathology    May 18, 2001   Volume 79, Issue 1-2 101-114 doi: 10.1016/s0165-2427(01)00258-6
Hines MT, Paasch KM, Alperin DC, Palmer GH, Westhoff NC, Hines SA.Rhodococcal pneumonia is an important disease of young horses that is not seen in immunocompetent adults. Since all foals are normally exposed to Rhodococcus equi in their environment, we hypothesized that most develop protective immune responses. Furthermore, these antigen-specific responses were hypothesized to operate throughout adult life to prevent rhodococcal pneumonia. A better understanding of the mechanisms of immune clearance in adult horses would help define the requirements for an effective vaccine in foals. Adult horses were challenged with virulent R. equi by intrabronchial inocu...
A long-term study of 277 cases of equine sinonasal disease. Part 2: treatments and results of treatments.
Equine veterinary journal    May 16, 2001   Volume 33, Issue 3 283-289 doi: 10.2746/042516401776249787
Tremaine WH, Dixon PM.The treatments of 277 horses with equine sinonasal disease (1984-1996), described by Tremaine and Dixon (2001), are reported here. Long-term (median duration 24 months) outcomes of treatment of the more common disorders were good, with 92% of horses with sinonasal mycosis, 84% with primary sinusitis, 82% with sinus cysts, 78% with dental sinusitis and 75% with sinonasal trauma reported to have complete remission of clinical signs. However, only 33% of horses with progressive ethmoidal haematoma (PEH) and 12% with sinonasal neoplasia reported long term remission of clinical signs.
Intranasal immunogenicity of a Deltacya Deltacrp-pabA mutant of Salmonella enterica serotype Typhimurium for the horse.
Vaccine    May 12, 2001   Volume 19, Issue 25-26 3591-3599 doi: 10.1016/s0264-410x(01)00072-x
Sheoran AS, Timoney JF, Tinge SA, Sundaram P, Curtiss R.The aim of this study was to investigate the intranasal immunogenicity for the horse of a Deltacya Deltacrp-pabA mutant (MGN-707) of Salmonella enterica serotype Typhimurium (S. typhimurium). MGN-707 caused no sign of disease, was not detected in feces and a single administration induced strong Salmonella-specific serum and nasal mucosal antibody responses. All ponies had made strong salmonella specific serum IgGa, IgGb, IgA and IgM antibody responses by day 25 after the first immunization. IgM responses to salmonella lipopolysaccharide (LPS) were short lived whereas salmonella specific serum ...
Authors do not believe article provides evidence of vaccine efficacy.
American journal of veterinary research    May 9, 2001   Volume 62, Issue 5 648 
Morley PS, Townsend HG, Haines DM.No abstract available
One percent sodium carboxymethylcellulose prevents experimentally induced abdominal adhesions in horses.
Veterinary surgery : VS    May 8, 2001   Volume 30, Issue 3 223-227 doi: 10.1053/jvet.2001.17849
Hay WP, Mueller PO, Harmon B, Amoroso L.To evaluate the efficacy of 1% sodium carboxymethylcellulose (SCMC) for prevention of experimentally induced abdominal adhesions in horses. Methods: Prospective, controlled, experimental study. Methods: Twelve healthy adult horses. Methods: The effect of 1% SCMC on adhesion formation was evaluated in 12 healthy horses by using an established model of serosal trauma to induce intraabdominal adhesions. After ventral median celiotomy, 2 separate areas of the jejunum were abraded, and three 2-0 chromic gut sutures were placed in each abraded area. Jejunal resection and end-to-end anastomosis was p...
Risk factors to tick infestations and their occurrence on horses in the state of São Paulo, Brazil.
Veterinary parasitology    May 5, 2001   Volume 97, Issue 1 1-14 doi: 10.1016/s0304-4017(01)00387-9
Labruna MB, Kerber CE, Ferreira F, Faccini JL, De Waal DT, Gennari SM.From December 1998 to March 1999, 40 stud farms were studied in the state of São Paulo, Brazil. During visits to farms, horses reared under grazing conditions were examined for the presence of ticks. On each farm visit, horse pastures were closely inspected and a questionnaire was given to the farm supervisor with the purpose of gaining information about ecological and management variables (independent variables) that could be associated with the presence and infestation levels of ticks on the farm (dependent variables). Three tick species were found during the study. Anocentor nitens, Amblyo...
Large envelope glycoprotein and nucleocapsid protein of equine arteritis virus (EAV) induce an immune response in Balb/c mice by DNA vaccination; strategy for developing a DNA-vaccine against EAV-infection.
Virus genes    April 28, 2001   Volume 22, Issue 2 187-199 doi: 10.1023/a:1008175525254
Tobiasch E, Kehm R, Bahr U, Tidona CA, Jakob NJ, Handermann M, Darai G, Giese M.Equine arteritis virus (EAV) is a member of the Arteriviridae family, that includes lactate dehydrogenase-elevating virus (LDV), porcine reproductive and respiratory syndrome virus (PRRSV), and simian haemorrhagic fever virus (SHFV). Equine arteritis is a contagious disease of horses and is spread via respiratory or reproductive tract. The objective of the present study is to evaluate the possibility for developing a model system for prevention horses against an EAV infection by DNAvaccination. A cDNA bank from the RNA of EAV was established. This gene library contains the translation unit of ...
FMD and horses: industry guidance for owners and event organisers.
The Veterinary record    April 21, 2001   Volume 148, Issue 10 290-291 
No abstract available
Understanding equine stereotypies.
Equine veterinary journal. Supplement    April 21, 2001   Issue 28 20-25 doi: 10.1111/j.2042-3306.1999.tb05151.x
Nicol C.It is frequently asserted that equine stereotypies, such as crib-biting, wind-sucking and weaving, are caused by boredom. However, this explanation is too general to be of practical use in discerning the causes of each stereotypy or in devising management practices to prevent their occurrence. The majority of equine stereotypes start within one month of weaning when both the nutritional and social environment of the foal are substantially altered. Epidemiological research has revealed that the provision of low quantities of forage and minimal opportunities for social contact are associated wit...
Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies.
Journal of virology    April 20, 2001   Volume 75, Issue 10 4570-4583 doi: 10.1128/JVI.75.10.4570-4583.2001
Leroux C, Craigo JK, Issel CJ, Montelaro RC.A primary mechanism of lentivirus persistence is the ability of these viruses to evolve in response to biological and immunological selective pressures with a remarkable array of genetic and antigenic variations that constitute a perpetual natural experiment in genetic engineering. A widely accepted paradigm of lentivirus evolution is that the rate of genetic variation is correlated directly with the levels of virus replication: the greater the viral replication, the more opportunities that exist for genetic modifications and selection of viral variants. To test this hypothesis directly, we ex...
West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.
Journal of virology    April 5, 2001   Volume 75, Issue 9 4040-4047 doi: 10.1128/JVI.75.9.4040-4047.2001
Davis BS, Chang GJ, Cropp B, Roehrig JT, Martin DA, Mitchell CJ, Bowen R, Bunning ML.Introduction of West Nile (WN) virus into the United States in 1999 created major human and animal health concerns. Currently, no human or veterinary vaccine is available to prevent WN viral infection, and mosquito control is the only practical strategy to combat the spread of disease. Starting with a previously designed eukaryotic expression vector, we constructed a recombinant plasmid (pCBWN) that expressed the WN virus prM and E proteins. A single intramuscular injection of pCBWN DNA induced protective immunity, preventing WN virus infection in mice and horses. Recombinant plasmid-transform...
Equine influenza vaccine performance: still learning lessons from the field.
Veterinary journal (London, England : 1997)    March 13, 2001   Volume 161, Issue 2 107-109 doi: 10.1053/tvjl.2000.0540
Newton JR.No abstract available
Postexposure rabies prophylaxis protocol for domestic animals and epidemiologic characteristics of rabies vaccination failures in Texas: 1995-1999.
Journal of the American Veterinary Medical Association    March 7, 2001   Volume 218, Issue 4 522-525 doi: 10.2460/javma.2001.218.522
Wilson PJ, Clark KA.To determine whether postexposure rabies prophylaxis (PEP) in domestic animals, as mandated by the state of Texas, has continued to be effective and to evaluate PEP and preexposure rabies vaccination failures from 1995 through 1999. Methods: Retrospective study. Methods: 830 unvaccinated domestic animals (621 dogs, 78 horses, 71 cats, and 60 cattle) that received PEP and 4 animals (3 dogs and 1 horse) that had preexposure rabies vaccination failure. Methods: Zoonotic incident case reports from 1995 through 1999 were reviewed for information regarding unvaccinated domestic animals that received...
Putting theory into practice.
Equine veterinary journal. Supplement    February 24, 2001   Issue 32 6-7 doi: 10.1111/j.2042-3306.2000.tb05326.x
Proudman CJ.No abstract available
Antimicrobic and anthelmintic resistance.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 515-x doi: 10.1016/s0749-0739(17)30093-7
Dargatz DA, Traub-Dargatz JL, Sangster NC.Antimicrobial and anthelmintic resistance are growing issues for the equine practitioner. The development of antimicrobial or anthelmintic resistance is a source of significant concern because of increased frequency of treatment failures and increased treatment costs. In addition, antimicrobial resistance may have important consequences for public health. Only through judicious use can the efficacy of antimicrobials and anthelmintics be prolonged. This article discusses the development of resistance and suggestions for control.
Incidence of the endothelin receptor B mutation that causes lethal white foal syndrome in white-patterned horses.
American journal of veterinary research    February 24, 2001   Volume 62, Issue 1 97-103 doi: 10.2460/ajvr.2001.62.97
Santschi EM, Vrotsos PD, Purdy AK, Mickelson JR.To determine incidence of the Ile118Lys endothelin receptor B (EDNRB) mutation responsible for overo lethal white syndrome (OLWS) and its association with specific types of white patterning. Methods: 945 horses of white-patterned bloodlines and 55 solid-colored horses of other breeds. Methods: Horses were genotyped by use of allele-specific polymerase chain reaction to determine incidence of the Ile118Lys EDNRB mutation. Results: Genotypes detected were homozygous Ile118, homozygous Lys118, and heterozygous. All foals with OLWS were homozygous for the Ile118Lys EDNRB mutation, and adults that ...
Improving the predictability of performance by prerace detection of dorsal metacarpal disease in thoroughbred racehorses.
Australian veterinary journal    February 24, 2001   Volume 78, Issue 11 784 doi: 10.1111/j.1751-0813.2000.tb10454.x
Lloyd A.No abstract available
Equine protozoal myeloencephalitis.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 405-425 doi: 10.1016/s0749-0739(17)30086-x
MacKay RJ, Granstrom DE, Saville WJ, Reed SM.Recent advances in the understanding of the parasite life cycle, epidemiology, clinical signs, diagnosis, treatment, and prevention of EPM are reviewed. The NAHMS Equine '98 study and a controlled retrospective study from The Ohio State University College of Veterinary Medicine identified a number of risk factors associated with development of the disease. The national annual incidence of EPM was 1% or less depending on the primary use of the animals. Increased disease risk was associated with age (1-5 and > 13 years of age), season (lowest in winter months and increasing with ambient tempe...
Improving the predictability of performance by prerace detection of dorsal metacarpal disease in thoroughbred racehorses.
Australian veterinary journal    February 24, 2001   Volume 78, Issue 11 784 doi: 10.1111/j.1751-0813.2000.tb10454.x
Lloyd A.No abstract available
Emergent causes of placentitis and abortion.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 443-viii doi: 10.1016/s0749-0739(17)30088-3
Donahue JM, Williams NM.The clinical signs, laboratory findings, diagnosis, epidemiology, treatment, and prevention and control of two emerging causes of placentitis and abortion in horses are described in this article. Leptospirosis has been reported as a significant cause of fetal loss in horses in Kentucky, Northern Ireland, and England. Most abortions result from infection by serovars kennewicki or bratislava. Nocardioform placentitis has become the most common cause of placentitis in central Kentucky horses. Nocardioform placentitis is associated with infection by unnamed, gram-positive, filamentous, branching b...
Vesicular stomatitis and other vesicular, erosive, and ulcerative diseases of horses.
The Veterinary clinics of North America. Equine practice    February 24, 2001   Volume 16, Issue 3 457-ix doi: 10.1016/s0749-0739(17)30089-5
McCluskey BJ, Mumford EL.Physical trauma, dietary factors, certain toxins, immune mediated disorders, and vesicular stomatitis virus (VSV) infection are known causes of stomatitis in horses. There is evidence that some outbreaks of equine stomatitis are caused by as yet unidentified infectious agents. It remains to be determined whether stomatitis is an emerging equine infectious disease, or if the increase in reported cases is simply the result of greater public awareness as a consequence of widespread outbreaks of VSV in the southwestern United States in recent years. Focused laboratory and epidemiological studies a...
The increasing significance of international trade in equids and its influence on the spread of infectious diseases.
Annals of the New York Academy of Sciences    February 24, 2001   Volume 916 55-60 doi: 10.1111/j.1749-6632.2000.tb05274.x
Timoney PJ.Expansion in international trade in equids and equine semen has been especially notable over the past 10-15 years among those countries historically identified as having significant breeding and performance horse industries. The continuing trend towards globalization of the horse industry received additional impetus in January, 1995, following establishment of the World Trade Organization (WTO), whose primary goal is to promote freer economic exchange between member countries through the reduction or elimination of protectionist barriers to trade. Continued growth in international trade, close...
Animal trypanosomiasis in South America. Current status, partnership, and information technology.
Annals of the New York Academy of Sciences    February 24, 2001   Volume 916 199-212 doi: 10.1111/j.1749-6632.2000.tb05291.x
Dávila AM, Silva RA.Animal trypanosome species of economical importance in South America include T. vivax and T. evansi. Both species are described in Brazil, Bolivia, Colombia, French Guyana, Peru, Suriname, and Venezuela. In Argentina and Guyana, only T. evansi and T. vivax are found, respectively. Our studies on T. vivax indicated that the parasite was spreading around 1.3 km per day in Bolivia. We found severe leukopenia in bovines from Pantanal (Brazil) and the Department of Santa Cruz (Bolivia). Because it can cause immunosuppression, the importance of trypanosomiasis control in ensuring success of vaccinat...
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