Equine Medicine encompasses the study and application of medical practices specifically related to the health and well-being of horses. This field involves the diagnosis, treatment, and prevention of diseases and disorders affecting equine species. It covers a wide range of topics, including internal medicine, surgery, reproduction, and pharmacology. Research in equine medicine often focuses on understanding the physiological and pathological processes unique to horses, as well as developing effective therapeutic interventions. This page aggregates peer-reviewed research studies and scholarly articles that explore various aspects of equine medicine, providing insights into the latest advancements and methodologies in the care and management of horse health.
Meistro F, Ralletti MV, Rinnovati R, Spadari A.Subjective lameness evaluation during lungeing is routinely performed in equine practice, but its consistency remains limited, especially in cases of mild or complex asymmetry. Objective: This study aimed to assess the agreement between subjective gait evaluations and a markerless AI-based gait analysis system (OAI-MS) in traditional racehorses during lungeing. Intra- and inter-observer agreement of subjective evaluations was also investigated. Methods: 24 traditional racehorses were assessed during routine pre-race inspections (T0) while trotting on a soft surface. Two experienced equine clin...
Scala E, Durie I, Gommeren K, Saegerman C, van Galen G.(1) Background: Ultrasonography of major vessels helps evaluate fluid status and responsiveness in critical human and canine patients. Aims: transrectal and inguinal ultrasonography of caudal vena cava (CVC), aorta (Ao), and femoral artery (FA) and vein (FV) in horses; calculate CVC collapsibility index (CI CVC) and vein-to-artery ratios; compare B- and M-mode; and evaluate repeatability and reproducibility. (2) Methods: B-mode and M-mode video loops were recorded twice by transrectal (Ao, CVC) and inguinal ultrasonography (FV, FA) by two operators on 17 healthy, sedated adult horses. Diameter...
Allen TS, Johnson S.The physical stresses on equine athletes are unique and differ across various disciplines. Recognizing these differences is essential for early detection of injuries and effective management of the competition horse's health. Equine sports medicine involves specific challenges and risks that can be reduced through proper care, careful attention to technique, and a deep understanding of the demands of each sport. Proper training, regular monitoring, and sport-specific expertise are crucial in preventing injuries and ensuring optimal performance. By focusing on these aspects, veterinarians and t...
Mazur SE, Toribio RE.Complications in critically ill equine patients are often related to the underlying disease process but can also be a consequence of diagnostic and therapeutic interventions. Complications can be specific to the affected organ or body system; however, in critically ill patients, they frequently affect the vasculature, acid-base, electrolyte, and fluid balance, energy homeostasis, and coagulation, with systemic consequences. Infrequent monitoring, late detection, failure to adapt therapies, hematologic and biochemical abnormalities, coagulopathies, and systemic inflammation can all contribute t...
Cremer J, Ross J, Paranjape V.General anesthesia in equine patients is associated with a higher risk of mortality despite improved monitoring equipments and anesthetic techniques most likely due to their large body size, unique physiology and anatomy, behavioral tendencies, and therefore the challenging recovery. Larger body mass, increased age, higher American Society of Anesthesiologists (ASA) status, out-of-hours surgery, and longer duration of anesthesia have been identified as contributing factors increasing the risk of perioperative mortality in equine patients. Especially the recovery period remains a critical time ...
Phillips NAI, Hackett ES.Respiratory surgery and procedures typically focus on conditions of the upper airway that restrict airflow at rest or exercise. This article focuses on respiratory anatomy and common surgeries of the trachea and larynx in horses. The trachea serves as the airway conduit from the larynx to the bronchi. A variety of upper airway disorders can lead to obstruction and in these instances, tracheotomy is typically utilized to bypass these obstructions and maintain airway patency. Emergency and permanent tracheotomy procedures are discussed. Other common upper airway operations, such as laryngotomy, ...
Studzińska M, Klockiewicz M, Szczepaniak K, Demkowska-Kutrzepa M, Roczeń-Karczmarz M, Tomczuk K.The resistance of strongyles to pyrantel pamoate has been reported in publications worldwide. There is no data on its efficacy in horses in Poland. Therefore, the aim of this study was to evaluate the effectiveness of pyrantel pamoate to control strongyle invasions in young horses. The study involved horses of both sexes, aged 1 to 2 years, and was conducted in two seasons (spring and the end of summer). Feces were collected 24 hours before and 14 days after deworming, and they were then examined using McMaster's and combined sedimentation-flotation methods. Results revealed that in spring, th...
Mudge M.Morbidity after equine abdominal surgery is common and post-operative complications can be costly to owners. The focus of this article is on intraoperative decision-making and current evidence, including surgical techniques and prognostic information that can prevent and predict complications. Emerging techniques for intra-operative monitoring and intestinal viability assessment, anastomotic techniques, body wall suturing, peritonitis treatment, and pain management are discussed.
Hain AM, Tretow M, Bienert-Zeit A.Outside of Iceland, the Icelandic horse is prone to the development of Equine Odontoclastic Tooth Resorption and Hypercementosis (EOTRH). The aim of this study was to determine the radiographic prevalence and clinical signs of EOTRH in elderly horses (≥15 years) in Iceland. The rostral oral cavity of 170 horses (aged 15-30 years) was examined clinically. In addition, husbandry and nutritional management history was recorded by use of a questionnaire. Radiographs (2-4 views) of 188 horses were evaluated, findings were categorized by numerical staging of the condition and collated with clinica...
Verna M, Amitrano FN, Boeder ZJ.To assess the clinical impact of the cricoarytenoideus dorsalis (CAD) myectomy in the short- and long-term postoperative abduction grade in racehorses. Unassigned: Records from horses presented for surgical treatment of recurrent laryngeal neuropathy from January 2019 through December 2023 were divided into 2 groups: horses that received standard prosthetic laryngoplasty and horses that received a complete myectomy of the CAD (modified myectomy laryngoplasty). Outcomes were compared through endoscopic evaluation after anesthetic recovery, both short term (7 to 10 days) and long term (80 to 90 ...
Wilson KE, Davis JL.Adverse drug events (ADEs) are any harms caused by medical interventions used for treatment, prevention, or diagnosis. These events can happen due to human error or as unintended, harmful reactions to drugs when given at normal therapeutic doses. This review focuses on common ADEs associated with drugs frequently used in equine practice. Recognizing and understanding the manifestations of ADEs can help with early detection and more effective management, ultimately leading to better outcomes for equine patients. Additionally, knowledge of the potential harmful effects of drugs also aids in appr...
Luštrek B, Šimon M, Turk K, Bogičević S, Potočnik K.In small, closed populations such as the Lipizzan horse, maintaining genetic diversity while limiting inbreeding is a key challenge in conservation breeding. The Lipizzan is an indigenous Slovenian breed with a small population and restricted gene flow from other subpopulations. Inbreeding is traditionally monitored with pedigree-based coefficients, but these often underestimate realised autozygosity, particularly when pedigree depth is limited. This study compared pedigree-based inbreeding (F_PED) with four genomic estimators (F_HOM, F_ROH, F_HBD, F_GRM) in 329 Slovenian Lipizzan horses genot...
Domańska-Kruppa N, Benoit P, Żukiewicz-Benoit K, Domino M, Kliczkowska K, Szubart M, Stefanik E.Limited data is available on the diagnostic and therapeutic methods for pathologies caused by scarring after castration. It is well recognized that specific behaviors or untypical hindlimb lameness may be observed in geldings with gelding scars and adhesions caused by spermatic cord remnants after castration OBJECTIVES: To describe how to diagnose movement disorders associated with excessive adhesions caused by spermatic cord remnant after castration and to present a successful surgical treatment method. Methods: To assess the impact of gelding scars on horses' movement and behavior, medical r...
Tucker-Retter EK, Yamagata M, Gilger B, Oh A.To assess whether topical carbonic anhydrase inhibitors (CAIs) with or without episcleral brinzolamide implants control intraocular pressure (IOP) in horses with glaucoma. Methods: 12 client-owned horses diagnosed with glaucoma. Methods: Medical records of horses treated with topical CAIs for ≥ 14 days, with a subset receiving episcleral brinzolamide implants, were reviewed. Diagnosis, signalment, concurrent ocular disease, medications, IOP, visual status, and additional procedures were recorded. Treatment failure was defined as horses with IOP > 30 mmHg resulting in phthisis bulbi o...
In light of the increasing reports of anthelmintic (AH) resistance in equids, a national survey on helminth control practices was distributed to 42 528 keepers. A total of 4 344 responses was obtained. Respondents implemented preventive pasture practices with varying frequency according to the age of the animals, such as pasture rotations (78.1-80.6 %), excrement removal from pastures several times a year (15.9-27.2 %) and/or mixed or rotational grazing with ruminants (14.5-18.1 %). A majority of keepers routinely used AH treatments even though they did not perceive any major risk to the...
Kozłowska N, Borowska M, Jasiński T, Wierzbicka M, Domino M.In human medicine, computer-aided diagnosis (CAD) is increasingly employed for screening, identifying, and monitoring early endoscopic signs of various diseases. However, its potential-despite proven benefits in human healthcare-remains largely underexplored in equine veterinary medicine. This study aimed to quantify endoscopic signs of pharyngeal lymphoid hyperplasia (PLH) as digital data and to assess their effectiveness in CAD of PLH in comparison and in combination with clinical data reflecting respiratory tract disease. Endoscopic images of the pharynx were collected from 70 horses clinic...
Merle R, Feuer L, Frenzer K, Plenio JL, Bethe A, Sarnino N, Lübke-Becker A, Bäumer W.: A mandatory monitoring of the use of antibiotics in horses in the European Union will come into force from 2027 on. The aim of the study was to explore the potential implementation of a monitoring system and to provide an overview of antibiotic use in horses in Germany. : Data on all consultations from 57 German practices between 2018 and 2023 were obtained. The dataset included basic data about the horse, free-text diagnoses (allocated to one of 20 categories), and treatments. Information on the administered or dispensed pharmaceutical product was recorded for antibiotic treatment consultat...
Buschmann E, Van Steenkiste G, Vernemmen I, Demeyere M, Schauvliege S, Decloedt A, van Loon G.Detailed characterization of arrhythmias can be performed by multiple catheter mapping; but this has not yet been explored in horses. Objective: Perform ultrasound-guided multiple catheter mapping of the right heart during sinus rhythm and right and left atrial pacing to identify activation patterns characteristic of the origin of ectopy. Obtain His signals and effective refractory periods (ERP). Methods: Eight healthy adult horses. Methods: Experimental study. Recording catheters were placed at the terminal crest, intervenous tubercle, caudal vena cava, and coronary sinus. Right atrial pacing...
Cloteau C, Delcourt V, Loup B, Chabot B, Pescher M, Susdorf E, Kaabia Z, Garcia P, Popot MA, Le Bizec B, Dervilly G, Bailly-Chouriberry L.Biomarker identification by mass spectrometry represents a key step in the workflow of nontargeted metabolomic studies. Given the complexity of the data, this step, which must be carried out by a trained specialist, is time-consuming, and the biomarkers discovered are not always identified. While this stage is not an obstacle to the development of new screening and classification tools, it is nonetheless crucial to a better understanding of the results obtained. For this reason, the aim of this study was to perform structural elucidation of candidate biomarkers, which had previously been displ...
Lugo T, Myers S, Nguyen TA.In vitro models have revolutionized our understanding of biological pathways and mechanisms, offering a viable alternative to direct patient testing. However, there is a significant lack of models for different animals, particularly equine models. This study presents a novel primary cell culture extracted from a 3-year-old horse diagnosed with multisystemic eosinophilic epitheliotropic disease. Tissue samples were collected from lymph nodes at various locations. Growth curves of extracted primary cells were analyzed and the optimal conditions were assessed. Biomarkers, such as CD31, ZO-1, CD79...
Sharshar A, Hammad A, Salem M, El-Sunsafty M.This study was carried out to evaluate a rectal pull-back one-stage technique, which is a modification of the one-stage Goetz technique, for treating third-degree perineal laceration or rectovestibular fistula. Methods: This study was performed on 12 mares, ten of whom suffered from third-grade perineal laceration, and two suffered from rectovestibular fistula and were included in this study. After incision of the vestibular shelf horizontally, the dissected rectal flap was pulled caudally and sutured to the anal sphincter during its reconstruction at the final stage. While the vestibular shel...
Riahi Z, Naeini AT, Zare R.Dareshuri horses are the predominant breed in Fars Province, Iran. Although disorders affecting their maxillary cheek teeth and maxillary sinuses are relatively common, limited fundamental data are available on the dimensions and relationships of these structures at different ages. Given the significant anatomical changes in the heads of young horses as they mature, this study aimed to evaluate age-related changes in the position and anatomical relationships of individual maxillary cheek teeth within the rostral and caudal maxillary sinuses (RMS and CMS, respectively), as well as changes in th...
Olakojo TA, Akinniyi OO, Dansu EO, Adeoye AO, Adah O, Nwufoh OC, Adeoye BO, Oridupa OA, Saba AB.Dexamethasone is a common drug used in equine medicine, but when administered inappropriately, it can lead to serious health complications. There is a dearth of data on horse caregivers' knowledge, attitudes, and practices regarding dexamethasone use in Nigeria. Understanding current dexamethasone usage patterns is necessary for developing educational interventions which will then improve equine welfare. This study aimed to assess the knowledge, attitudes, and practices (KAP) of horse caregivers regarding dexamethasone use in Ibadan, Nigeria. A cross-sectional study was conducted amongst a tot...
Smith R, Perkins L, Pinchbeck G, Ireland J.The decisions made by horse owners on behalf of their animal, including decisions to involve a veterinarian, play an important role in the management of pain. This study explored horse owners' experiences to understand how they conceptualised chronic pain within the context of their horse-human relationship, what led them to seek veterinary involvement, and how veterinary interactions shaped their perceptions of pain and its management. An ethnographic approach using constructivist grounded theory methods was adopted. This paper draws upon field notes generated through 200 h of observation und...
Wood AD, Parker RA.To describe a tenoscopically guided technique for desmotomy of the proximal digital annular ligament (PDAL). Methods: Ex vivo study and clinical case series. Methods: A total of 10 normal cadaver equine hindlimbs and five clinical cases of PDAL desmitis. Methods: The digital flexor tendon sheath (DFTS) was approached via a lateral basisesamoid portal and a palmar/plantar annular ligament (PAL) desmotomy was performed to improve maneuverability in the DFTS. Additional proximolateral and distal midline instrument portals were created to facilitate transection of the proximolateral attachment, th...
Bouverat VMA, Pradervand N, Wichert BA, Greim E, Dolf GJ, Gerber V.Hay quality is a key factor in equine respiratory health, with microbiological contaminants in inhaled organic dust posing significant risks. Sensory assessment has been used to evaluate hay hygiene, but its value to identify deficiencies remains unclear. This study aimed to explore the potential of sensory assessment to predict both particulate matter (PM) dust concentrations and microbiological contamination. Fifty hay samples were collected from horse owners and evaluated using a structured sensory examination, microbiological analyses, and dust concentration measurements obtained with the ...
Pilati N, Pressanto MC, Palumbo Piccionello A, De Angelis Corvi F, Beccati F.The term overriding spinous processes (ORSPs), commonly known as "kissing spine syndrome," refers to a skeletal abnormality in horses that is characterized by the narrowing (<4 mm) of the interspinous space and touching or overlapping of the spinous processes (SPs). This condition primarily affects the mid- and caudal thoracic vertebrae; however, ORSP can also affect the lumbar SPs. In the veterinary community, kissing spine is widely recognized as a common condition in sport horses, as it is often associated with chronic back pain and contributes to poor performance. Despite its significant c...
Selecky ME, Louie EW, Donnelly C, Finno CJ, Morgan JM.Echocardiographic reference intervals for Quarter Horses are infrequently reported. Objective: To provide standard echocardiographic measurements for sedentary Quarter Horses and evaluate the relationship between physical characteristics (body weight, age, sex) and echocardiographic measurements. Methods: Forty-one sedentary Quarter Horses, free of cardiac disease, from a university research herd. Methods: A cross-sectional study evaluating standardized echocardiograms performed on sedentary Quarter Horses (41) between 2020 and 2022. Reference intervals were calculated for raw and weight-corre...
Robel M, Grest P, Riond B, Zablotski Y, Schoster A.Limited data are available on immune cells in the intestinal wall of healthy horses, hampering interpretation of results in case of disease. Objective: Characterize and quantify the immune cell populations and their distribution in duodenal and rectal biopsies of horses without gastrointestinal disease; compare immune cell counts (ICCTs) between full thickness- and mucosal biopsies. Methods: Twenty horses fit for slaughter, slaughtered for meat production. Methods: Full-thickness and endoscopic forceps obtained mucosal biopsies were taken within 30 min after slaughter from the duodenum and rec...
Aragona F, Rizzo M, Arfuso F, Arrigo F, Fazio F, Giudice E, Faggio C, Piccione G, Giannetto C.Homeostasis and inflammation are two opposing physiological processes that are driven by the circadian clock. Objective: The study aim was to investigate the biological rhythm of the C-reactive protein (CRP) and Interleukin-6 (IL-6) in horses. Methods: Eight clinically healthy Italian saddle gelding horses, housed in individual boxes and subjected to a natural 12/12 L/D cycle, were enrolled. Blood samples were performed every 4 hours over a 48-hour period. Results: A positive correlation was found between CRP and IL-6 on both days of monitoring. Both parameters showed a daily rhythm; CRP acrop...
Middlebrooks B, McCue P, Nelson B, May E, Divine C, Barton C, Conley A.Disorders of sexual development (DSD) are associated with atypical chromosomal, gonadal, or phenotypic sex. It is likely that the number of cases of DSD are underestimated in the equine population. Monorchidism in the horse is very rare. This case report describes the clinical assessment of a phenotypic mare with stallion-like behavior which led to the diagnosis of a DSD. A 4-year-old Quarter Horse mare presented in good body condition, with normal external genitalia for a mare, and normal mammary glands with two bilaterally symmetric teats. No uterus, cervix, or gonads were detected on transr...
Fachal MV, Furlan M, Clark R, Card CE, Chedrese PJ.The objective of this investigation was to clone and express the elk and horse common alpha-subunit and FSH beta-subunit cDNAs, and to produce recombinant FSH from both species in vitro. The RNAs extracted from elk and horse pituitary glands were reverse-transcribed and amplified by polymerase chain reaction. The cDNAs corresponding to both subunits of elk and horse were cloned into the expression vector pBudCE4.1 and transfected into CRL-9096 cells. Expression of both genes was determined in the transfected cells by Northern and Western blot analysis. Recombinant elk and horse FSH secreted in...
Giorgi M, De Vito V, Poapolathep A, Rychshanova R, Sgorbini M, Owen H.Flupirtine (FLU) is a non-opioid analgesic drug, with no antipyretic or anti-inflammatory effects, used in the treatment of a wide range of pain states in human beings. It does not induce the side effects associated with the classical drugs used as pain relievers. The aim of this study was to evaluate the pharmacokinetic profiles of FLU after IV and PO administration in healthy horses. Six mixed breed adult mares were randomly assigned to two treatment groups using an open, single-dose, two-treatment, two-phase, paired, cross-over design (2 × 2 Latin-square). Group 1 (n = 3) received ...
Leduc L, Leclère M, Lavoie JP.Although horses with asthma share similar clinical signs, the heterogeneity of the disease in terms of severity, triggering factors, inflammatory profile, and pathological features has hindered our ability to define biologically distinct subgroups. The recognition of phenotypes and endotypes could enable the development of precision medicine, including personalized, targeted therapy, to benefit affected horses. While in its infancy in horses, this review outlines the phenotypes of equine asthma and discusses how knowledge gained from targeted therapy in human medicine can be applied to evaluat...
Bishop RC, Jonk KM, Migliorisi A, Austin SM, Mullins EC, Wilkins PA.Polycythaemia and coagulopathy are identified risk factors for non-survival in critically ill horses. Assessment of coagulation is recommended for critical care monitoring but may be affected by concurrent polycythaemia. Objective: To evaluate the effects of induced polycythaemia on coagulation parameters as measured by a point-of-care viscoelastic coagulation device (VCM Vet™). Methods: Prospective interventional study. Methods: Healthy adult horses (n = 7) were given 6 mcg/kg of phenylephrine IV over 15 min to induce transient polycythaemia. Samples for packed cell volume (PCV), to...
Sponseller BT, Wong DM, Ruby R, Ware WA, Wilson S, Haynes JS.A 9-year-old Quarter Horse gelding was presented for lethargy, decreased appetite, polyuria and polydipsia (PU/PD), and severe muscle wasting suggestive of immune-mediated myositis. Results: The horse displayed lethargy, fever, tachyarrhythmia, inappetence, PU/PD, and severe epaxial and gluteal muscle wasting. Clinicopathologic findings were consistent with previously reported cases of systemic calcinosis in horses, including increased muscle enzyme activity, hyperphosphatemia, increased calcium-phosphorus product, hypoproteinemia, and an inflammatory leukogram. A diagnosis of systemic calcino...
Ortolani F, Nannarone S, Scilimati N, Gialletti R.Pararectal abscesses are life-threatening conditions that can rupture and cause septic peritonitis. The objective of this case report is to describe aggressive treatment of a pararectal abscess to allow a quick return to competitions. A 14-year-old pony was admitted to the Veterinary Teaching Hospital (VTH) of the University of Perugia because of a suspected intra-abdominal mass. Two weeks earlier, it exhibited clinical signs compatible with colic which was treated medically; however, because of the persistence of a firm mass on the right side of the abdomen noted on rectal palpation, the pony...
Weiss DJ, Evanson OA, MacLeay J, Brown DR.To determine whether mucosal permeability is altered during the prodromal stages of alimentary laminitis. Methods: 15 healthy adult ponies. Methods: intestinal permeability was evaluated for control ponies (n = 5) and for ponies 4 to 12 (n = 5) and 20 to 28 (n = 5) hours after administration of carbohydrate overload. Mucosal permeability was determined by measuring the percentage of orally administered technetium Tc99m diethylenetriaminopentaacetate (99mTc-DTPA) excreted in urine during an 8-hour period, then measuring blood radioactivity at hourly intervals. Plasma endotoxin-like activity was...
Clarke EJ, Gillen A, Turlo A, Peffers MJ.Horses are used in a variety of equestrian disciplines predisposing them to musculoskeletal injury or disease including osteoarthritis and tendinopathy. As a result, a number of preventative measures are used within equine medicine and husbandry, ranging from therapeutic shoeing to the use of nutraceuticals. Despite their popularity and routine use evidence base and clinical outcomes are variable, bringing into question the efficacy of these prophylactic measures. In recent years a small number of studies have been performed examining the effect of specific strategies in order to quantify the ...
Fielding CL.With advances in technology and owner education, field management in equine veterinary medicine continues to evolve. Equine gastrointestinal disease is one of the most common types of emergencies evaluated by equine practitioners, and many of these patients can be effectively managed in the field. Although the equine veterinarian must make numerous decisions, fluid therapy, pain management, and antimicrobial use are 3 of the major choices that must be addressed when initiating field treatment of equine gastrointestinal disease. This article addresses the practical use of these 3 treatment cate...
Loftus L, Asher L, Leach M.Over the last twenty years the definition of good animal welfare has advanced from the 'absence of negative welfare states' to the aim of identifying the presence of positive welfare states; however, research on positive animal welfare is relatively new. Consequently, through expert consultation, this study aimed to synthesise knowledge regarding domesticated equine emotional state, specifically methods to induce and measure positive affective states, which could be of significant benefit to equine welfare across sectors. A Delphi consultation of experts in the field of equine behaviour, welfa...
Haarhuis JC, Muijtjens AM, Scherpbier AJ, van Beukelen P.Interest in the areas of food animals (FA) and veterinary public health (VPH) appears to be declining among prospective students of veterinary medicine. To address the expected shortage of veterinarians in these areas, the Utrecht Faculty of Veterinary Medicine has developed an admissions procedure to select undergraduates whose aptitude and interests are suited to these areas. A study using expert meetings, open interviews, and document analysis identified personal characteristics that distinguished veterinarians working in the areas of FA and VPH from their colleagues who specialized in comp...
Allen WR.Fertilized eggs reach the uterus of the mare by the sixth day after ovulation whereas unfertilized eggs remain lodged in the fallopian tubes for many months. However, embryo removal studies indicate that the fetal message for luteal maintenance in the pregnant mare is not transmitted until Days 14-16. The equine endometrial cups comprise a series of small, ulcer-like endometrial outgrowths which are present in the pregnant horn of the uterus between 40 and 150 days of gestation. Each cup consists of a discrete colony of large, gonadotropin-secreting, trophoblast cells derived from a specialize...
Dumasia MC, Houghton E.A method for the screening and confirmatory analysis of beta-agonists and -antagonists in equine urine is described. Following initial enzymic hydrolysis, the basic drugs and metabolites are extracted using Clean Screen DAU or Bond Elut Certify cartridges, and analysed as their trimethylsilyl ether or 2-(dimethyl) silamorpholine derivatives by capillary gas chromatography-mass spectrometry. The method proved to be very sensitive and selective for basic drugs. After administration of therapeutic doses of propranolol, metoprolol, timolol, isoxsuprine and clenbuterol to thoroughbred horses, the p...
Scott JS, Garon H, Broadstone RV, Derksen FJ, Robinson NE.We examined the response of five ponies with recurrent airway obstruction (principals) and five age- and gender-matched controls to the aerosol alpha-adrenergic agonist phenylephrine after blockade with propranolol and atropine. Measurements were made with principal ponies in clinical remission (period A) and during acute airway obstruction (period B). The blockade had no effect on base-line pulmonary mechanics in control ponies during periods A and B or in the principal ponies during period A. However, in the principal ponies during period B, blockade increased dynamic compliance (Cdyn) and d...
Pesko B, Habershon-Butcher J, Muir T, Gray B, Taylor P, Fenwick S, Hincks P, Scarth J, Paine S.Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the drug in the horse. The aim of the research was to determine the pharmacokinetics of paracetamol in equine plasma and urine to inform treatment of Thoroughbred racehorses. In this multi-dose study, paracetamol was administered orally at 20 mg/kg to six Thoroughbred horses. Pre- and post-administration urine and plasma samples were collected and analys...
Wong DM, Alcott CJ, Wang C, Bornkamp JL, Young JL, Sponseller BA.To determine agreement between indirect measurements of end-tidal partial pressure of carbon dioxide (PetCO(2)) and saturation of hemoglobin with oxygen as measured by pulse oximetry (SpO(2)) with direct measurements of PaCO(2) and calculated saturation of hemoglobin with oxygen in arterial blood (SaO(2)) in conscious healthy and ill foals. Methods: Validation study. Methods: 10 healthy and 21 ill neonatal foals. Methods: Arterial blood gas analysis was performed on healthy and ill foals examined at a veterinary teaching hospital to determine direct measurements of PaCO(2) and PaO(2) along wit...
Halvorsen K, Johnston C, Back W, Stokes V, Lanshammar H.Motion capture for biomechanical applications involves in almost all cases sensors or markers that are applied to the skin of the body segments of interest. This paper deals with the problem of estimating the movement of connected skeletal segments from 3D position data of markers attached to the skin. The use of kinematic constraints has been shown previously to reduce the error in estimated segment movement that are due to skin and muscles moving with respect to the underlying segment. A kinematic constraint reduces the number of degrees of freedom between two articulating segments. Moreover...
Smith BP.The science of control of infectious diseases in hospitals was born in 1847 when Semmelweis, a physician, ordered his medical students to scrub their hands in chlorinated lime water between patients and demonstrated that this simple procedure resulted ina dramatic decline in patient morbidity and mortality. In the late nineteenth century came huge breakthroughs in the understanding that microorganisms cause many disorders, and methods to eliminate and control these microorganisms were attempted. By 1910, sterile instruments, gowns, masks, and gloves had become standard for surgical procedures ...
Epe C, Woidtke S, Pape M, Heise M, Kraemer F, Kohlmetz C, Schnieder T.Two groups of 10 first-year grazing cattle were either left untreated as controls (group 1) or treated with eprinomectin as a pour-on application at turnout and eight weeks later (group 2). The control group developed a mild infection with gastrointestinal nematodes and lungworms during the season, whereas the treated animals remained healthy. The interval between the treatments allowed the establishment of adult worms, but the egg counts remained negligible. The total number of eggs shed by the treated cattle during the grazing season was significantly smaller than by the controls.
van Dam KG, van Breda E, Schaart G, van Ginneken MM, Wijnberg ID, de Graaf-Roelfsema E, van der Kolk JH, Keizer HA.To investigate the expression and localization of glucose transporter 4 (GLUT4) and fatty acid translocase (FAT/CD36) in equine skeletal muscle. Methods: Muscle biopsy specimens obtained from 5 healthy Dutch Warmblood horses. Methods: Percutaneous biopsy specimens were obtained from the vastus lateralis, pectoralis descendens, and triceps brachii muscles. Cryosections were stained with combinations of GLUT4 and myosin heavy chain (MHC) specific antibodies or FAT/CD36 and MHC antibodies to assess the fiber specific expression of GLUT4 and FAT/CD36 in equine skeletal muscle via indirect immunofl...
Salami F, Ghodrati M, Parham A, Mehrzad J.Bone marrow mesenchymal stem cells (BM-MSCs), as multipotent cells with self-renewal and plastic-adherent properties, have immunomodulatory effects on immune cells, including neutrophils. These cells are in close proximity in bone marrow (BM) sinusoids with non-multiplicative immature neutrophils. BM-MSCs exert their immunomodulatory effects on adjacent cells both directly (cell-to-cell contact) and indirectly (secretion of soluble factors). The aim of this study was to evaluate the effect of equine bone marrow mesenchymal stem cells (BM-MSCs) on the expression of some pro- and anti-apoptotic ...
Hudson NP, Prince DP, Mayhew IG, Watson ED.Four at-risk Highland ponies on the same premises all retained their fetal membranes in the same breeding season. The ponies were treated with a combination of oxytocin, infusion and distension of the allantochorionic sac with fluid, gentle traction in one case, and supportive therapy. The possible causes of the condition were investigated with clinicopathological tests and analyses of the herbage for its species composition and fungal contamination. No obvious possible causative abnormalities were identified apart from a low total serum calcium level in one case. No fescue grass was found and...
Grondin TM, DeWitt SF, Keeton KS.A 9-year-old Arabian mare was evaluated for a 7-day history of malaise. Results of a CBC included a leukocyte concentration within the reference interval (8.4 x 10(3)/microL, reference interval 6.0-14.0 x 10(3)/microL) with an apparent degenerative left shift (segmented neutrophils 1.2 x 10(3)/microL, reference interval 2.5-7.5 x 10(3)/microL; hyposegmented neutrophils 1.8 x 10(3)/microL, reference interval 0.0-0.2 x 10(3)/microL). Serum clinical chemistry results included increased aspartate transaminase, alkaline phosphatase, and gamma-glutamyltransferase activities. A presumptive diagnosis ...