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Topic:Longitudinal Study

A longitudinal study in the context of equine research involves the systematic observation and data collection from the same group of horses over an extended period. This research approach aims to track changes and developments in various health parameters, behaviors, or conditions within the equine population being studied. By repeatedly assessing the same subjects, researchers can identify patterns, establish temporal sequences, and infer potential causal relationships. Longitudinal studies in horses can encompass a wide range of topics, including growth and development, disease progression, and the impact of environmental or management changes. This page gathers peer-reviewed research studies and scholarly articles that explore the methodologies, findings, and implications of longitudinal studies in equine science.
Repair of a longitudinal scapular fracture in a horse.
Veterinary surgery : VS    June 6, 2007   Volume 36, Issue 4 378-381 doi: 10.1111/j.1532-950X.2007.00278.x
Kidd JA, Lamas L, Henson FM.To report repair of a longitudinal scapular fracture in a horse. Methods: Case report. Methods: A 2-year-old Paint Horse colt. Methods: A longitudinal scapular fracture was surgically repaired using four 4.5 mm dynamic compression plates. Results: An acute longitudinal scapular fracture repaired surgically returned the horse to soundness within 6 months. Conclusions: Internal fixation of longitudinal scapular fracture is possible with multiple 3-5 hole dynamic compression plates. Conclusions: Longitudinal fractures of the scapula should be considered when there is lateral instability of the sh...
Incisional complications following exploratory celiotomy: does an abdominal bandage reduce the risk?
Equine veterinary journal    May 25, 2007   Volume 39, Issue 3 277-283 doi: 10.2746/042516407x193963
Smith LJ, Mellor DJ, Marr CM, Reid SW, Mair TS.Post operative complications following exploratory laparotomy can be potentially life-threatening, increase post operative morbidity and result in an increase in the length of hospitalisation of the affected individual. No study has evaluated the efficacy of specific strategies to reduce the incidence of post operative incisional complications. Objective: The use of an abdominal bandage following colic surgery through a celiotomy incision would significantly reduce the prevalence of post operative incisional complications. Methods: A controlled, randomised clinical trial to test the hypothesis...
Congenital colonic malformation (“short colon”) in a 4-month-old standardbred foal.
The Canadian veterinary journal = La revue veterinaire canadienne    May 15, 2007   Volume 48, Issue 4 420-422 
Koenig JB, Rodriguez A, Colquhoun JK, Stämpfli H.During exploratory laparotomy of a foal with colic, a congenital abnormally developed large colon was identified incidentally. Long-term follow-up showed that the colt was more prone to gas-colic with diet and exercise changes than were other horses, due possibly to the short colon. Malformation congénitale du côlon (côlon court) chez un poulain Standardbred âgé de 4 mois. Au cours d’une laparotomie exploratrice chez un poulain atteint de colique, une malformation congénitale du gros côlon a été identifiée de façon fortuite. Un suivi à long terme a montré que le poulain était d...
Evidence for transferrin allele as a host-level risk factor in naturally occurring equine respiratory disease: a preliminary study.
Equine veterinary journal    March 24, 2007   Volume 39, Issue 2 164-171 doi: 10.2746/042516407x166954
Newton JR, Woodt JL, Chanter N.Recurring respiratory infections can contribute to prolonged burdens of disease, especially in younger horses and better knowledge of factors and effective interventions, such as vaccines, should improve therapeutic and preventive strategies. Objective: To identify factors and infections associated with naturally occurring respiratory disease in recently weaned Welsh Mountain ponies maintained at pasture and to determine whether ponies vaccinated with an experimental inactivated bacterial vaccine had lower burdens of disease and infection compared to nonvaccinated controls. Transferrin allele,...
Immune selection of equine infectious anemia virus env variants during the long-term inapparent stage of disease.
Virology    February 27, 2007   Volume 363, Issue 1 156-165 doi: 10.1016/j.virol.2007.01.037
Sponseller BA, Sparks WO, Wannemuehler Y, Li Y, Antons AK, Oaks JL, Carpenter S.The principal neutralizing domain (PND) of equine infectious anemia virus (EIAV) is located in the V3 region of SU. Genetic variation in the PND is considered to play an important role in immune escape and EIAV persistence; however, few studies have characterized genetic variation in SU during the inapparent stage of disease. To better understand the mechanisms of virus persistence, we undertook a longitudinal study of SU variation in a pony experimentally inoculated with the virulent EIAV(Wyo). Viral RNA isolated from the inoculum and from sequential sera samples was amplified by RT-PCR, clon...
The effect of conformation on orthopaedic health and performance in a cohort of National Hunt racehorses: preliminary results.
Equine veterinary journal    January 19, 2007   Volume 38, Issue 7 622-627 doi: 10.2746/042516406x159034
Weller R, Pfau T, Verheyen K, May SA, Wilson AM.There is a lack of scientific data and studies on the effect of conformation on performance or on orthopaedic health. Objective: To investigate the relationship between conformation, injury and performance in racehorses used for racing over fences. Methods: Over 2 years, 108 National Hunt racehorses were followed and their medical and performance data recorded. Conformation was measured in 3D with a computerised motion analysis system. Linear multiple regression models were used to evaluate the effect of conformation on measures of race performance and stepwise forward logistic regression mode...
Prevalence, heritability and significance of musculoskeletal conformational traits in Thoroughbred yearlings.
Equine veterinary journal    January 19, 2007   Volume 38, Issue 7 597-603 doi: 10.2746/042516406x159016
Love S, Wyse CA, Stirk AJ, Stear MJ, Calver P, Voute LC, Mellor DJ.The assessment of belief that equine conformation is associated with performance and durability is a fundamental concept of horsemanship. Surprisingly, there is almost no quantitative evidence to support these beliefs. Objective: To assess the prevalence and heritability of conformational traits in Thoroughbred yearlings, and investigate their significance for subsequent turf flat-racing performance and durability. Methods: Nine selected conformational traits were assessed in a consistent, qualitative manner by a single veterinary observer and entered into a database together with details of p...
Carpal and fetlock conformation of the juvenile Thoroughbred from birth to yearling auction age.
Equine veterinary journal    January 19, 2007   Volume 38, Issue 7 604-609 doi: 10.2746/042516406x159025
Santschi EM, Leibsle SR, Morehead JP, Prichard MA, Clayton MK, Keuler NS.There is little information available about conformational changes in the forelimbs of growing foals. Objective: To describe the conformation of the carpus and fetlock of Thoroughbred foals from birth to yearling sale age. Methods: Subjective assessments of the fetlock and carpal conformation of 119 Thoroughbred foals were made within the first month of life and then at 30 day intervals until at least age 120 days. At least 70 subjects were examined further at 60 day intervals until September of their second year. Conformation grades are reported for 5 age groups: first 7 days and at a mean of...
Uneven feet in a foal may develop as a consequence of lateral grazing behaviour induced by conformational traits.
Equine veterinary journal    January 19, 2007   Volume 38, Issue 7 646-651 doi: 10.2746/042516406x159070
van Heel MC, Kroekenstoel AM, van Dierendonck MC, van Weeren PR, Back W.Conformational traits are important in breeding, since they may be indicative for performance ability and susceptibility to injuries. Objective: To study whether certain desired conformational traits of foals are related to lateralised behaviour while foraging and to the development of uneven feet. Methods: Twenty-four Warmblood foals, born and raised at the same location, were studied for a year. Foraging behaviour was observed by means of weekly 10 min scan-sampling for 8 h. A preference test (PT) was developed to serve as a standardised tool to determine laterality. The foals were evaluated...
Equine piroplasmoses at the reintroduction site of the Przewalski’s horse (Equus ferus przewalskii) in Mongolia.
Journal of wildlife diseases    November 10, 2006   Volume 42, Issue 3 518-526 doi: 10.7589/0090-3558-42.3.518
Rüegg SR, Torgerson PR, Doherr MG, Deplazes P, Böse R, Robert N, Walzer C.Piroplasmosis has been identified as a possible cause of mortality in reintroduced Przewalski's horses (Equus ferus przewalskii) in the Dsungarian Gobi (Mongolia). A cross-sectional and a longitudinal study were conducted in a representative sample (n = 141) of the resident domestic horse population and in 23 Przewalski's horses to assess the prevalence of Theileria equi and Babesia caballi. Piroplasms were detected in blood by light microscopy in 6.7% (95% confidence interval [CI]: 3.6-12.2%) of the domestic horse samples. Antibody prevalence was 88.6% (95% CI: 82.4-92.9%) for T. equi and 75....
Altered homeostasis of extracellular matrix proteins in joints of standardbred trotters during a long-term training programme.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    October 24, 2006   Volume 53, Issue 9 445-449 doi: 10.1111/j.1439-0442.2006.00877.x
Skiöldebrand E, Heinegård D, Olofsson B, Rucklidge G, Ronéus N, Ekman S.This study evaluates how strenuous training, age and lameness influence the release of cartilage oligomeric matrix protein (sf-COMP), aggrecan and collagen type II into synovial fluid in 28 (19.5-40 months) Standardbred trotters (STB), during a long-term training programme (24 months). All the horses were trained by the same trainer and were healthy on entering the training programme. Synovial fluid (sf) from the left middle carpal joint in each subject was sampled every third month. Enzyme-linked immunosorbent assay was used to determine the concentrations of sf-COMP, sf-aggrecan and sf-colla...
Postoperative effects of anesthesia and surgery on resting energy expenditure in horses as measured by indirect calorimetry.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire    October 18, 2006   Volume 70, Issue 4 257-262 
Cruz AM, Coté N, McDonell WN, Geor RJ, Wilson BA, Monteith G, Li R.In this study, we aimed to define the effects of anesthesia and surgery on the resting energy expenditure of horses in experimental conditions. Six horses were used in a longitudinal study with 2 study periods: before and after anesthesia and surgery. Every horse underwent a standard 90-min ventral midline exploratory laparotomy. Oxygen uptake (VO2) and carbon dioxide output (VCO2) were measured, with the use of a closed-circuit spirometry system, on 5 consecutive days immediately before and after the surgery. In 3 consecutive 5-min periods each day, the expired air was collected in a Collins ...
Use of a synthetic bone substitute to retard molariform tooth drift after maxillary tooth loss in ponies.
Veterinary surgery : VS    October 10, 2006   Volume 35, Issue 7 589-595 doi: 10.1111/j.1532-950X.2006.00195.x
Vlaminck LE, Huys L, Maes D, Steenhaut ML, Gasthuys F.To evaluate the effect of alveolar bone substitute on post-extraction drift of maxillary cheek teeth in ponies. Methods: In vivo longitudinal experimental study. Methods: Five ponies (5-7 years) with a healthy dentition. Methods: Both maxillary 4th premolar teeth (Triadan 08) were surgically removed. One alveolus was filled with a biocompatible non-resorbable bone substitute (Bioplant 24), whereas the other healed by second intention. A polyvinylsiloxane plug and spring wire isolated the bone substitute from the oral environment. Pathologic changes to dentition and adjacent soft tissue were re...
Surgical treatment of extensive chondroid formation in the guttural pouch of a Warmblood horse.
Australian veterinary journal    August 17, 2006   Volume 84, Issue 8 297-300 doi: 10.1111/j.1751-0813.2006.00017.x
Schaaf KL, Kannegieter NJ, Lovell DK.A Warmblood horse presented with a purulent nasal discharge that had failed to respond to antibiotic therapy. Radiography and endoscopy confirmed a large number of chondroid masses (over 200) in the left guttural pouch. Despite the large number of chondroids present, there was no external swelling evident. The masses were surgically removed via a hyovertebrotomy approach that provided excellent exposure, and no postoperative complications were encountered. Long term follow-up (3 years) confirmed a successful outcome.
What is the likelihood that a horse treated for septic digital tenosynovitis will return to its previous level of athletic function?
Equine veterinary journal    July 27, 2006   Volume 38, Issue 4 337-341 doi: 10.2746/042516406777749155
Smith LJ, Mellor DJ, Marr CM, Mair TS.Septic digital tenosynovitis is a serious problem in the horse, with a poor prognosis being reported for recovery. Objective: The occurrence of septic digital tenosynovitis would significantly reduce the likelihood of a horse returning to its previous level of athletic function. Methods: Medical records of 90 horses treated for septic digital tenosynovitis were reviewed. Data retrieved included age, sex, location of inciting cause of sepsis, time from onset of clinical signs to presentation for treatment, and whether the horse survived to be discharged. Long-term outcome was determined through...
Long-term follow-up on a large number of horses that underwent transarterial coil embolisation (TCE) for guttural pouch mycosis (GPM).
Equine veterinary journal    May 19, 2006   Volume 38, Issue 3 271 
Freeman DE.No abstract available
The efficacy of intratumoural 5-fluorouracil for the treatment of equine sarcoids.
Australian veterinary journal    March 25, 2006   Volume 84, Issue 3 101-106 doi: 10.1111/j.1751-0813.2006.tb12239.x
Stewart AA, Rush B, Davis E.To document the efficacy of intratumoural injections of 5-fluorouracil for the treatment of equine sarcoids. Methods: A prospective study that included 13 horses and one donkey. Methods: Sarcoids were confirmed by histological examination and treated with intratumoural 5-fluorouracil every 2 weeks. If the sarcoids did not resolve after seven treatments, treatment was considered a failure. All cases were re-examined 6 months after treatment commenced and owners were telephoned 3 years after commencement of treatment to report on tumour recurrence. Outcome comparisons were performed to determine...
Risk factors for musculoskeletal injuries in 2-year-old Thoroughbred racehorses.
Preventive veterinary medicine    February 14, 2006   Volume 74, Issue 1 36-43 doi: 10.1016/j.prevetmed.2006.01.005
Cogger N, Perkins N, Hodgson DR, Reid SW, Evans DL.Musculoskeletal injuries (MSI) in racehorses have been identified as the most common cause of lost training days and weeks spent resting at pasture. Several training-, track- and horse-related risk factors have been identified. However, there is no clear understanding of the inter-relationship between these factors. The aim of this longitudinal cohort study was to investigate risk factors for MSI in 2-year-old Thoroughbred racehorses. Australian Thoroughbred trainers were convenience sampled and enrolled in a 27-month longitudinal cohort study. The study population consisted of all 2-year-old ...
Spine fractures caused by horse riding. Siebenga J, Segers MJ, Elzinga MJ, Bakker FC, Haarman HJ, Patka P.Retrospective study and review of literature. Objective: Study of demographic data concerning spinal fractures caused by horse riding, classification of fractures according to the AO and Load Sharing classifications, evaluation of mid-term radiological results and long-term functional results. Methods: A review of medical reports and radiological examinations of patients presented to our hospital with horse riding-related spine fractures over a 13-year period; long-term functional follow-up is performed using the Roland Morris Disability Questionnaire (RMDQ-24). Results: Thirty-six spine fract...
Indications, surgical technique, and long-term experience with laparoscopic closure of the nephrosplenic space in standing horses.
Veterinary surgery : VS    December 14, 2005   Volume 34, Issue 6 637-641 doi: 10.1111/j.1532-950X.2005.00098.x
Röcken M, Schubert C, Mosel G, Litzke LF.To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses. Methods: Retrospective study. Methods: Forty-four horses with LDDLC. Methods: Laparoscopic portals were located in the left flank region. After administration of etilefrin intravenously to contract the spleen, the dorsal splenic margin was sutured to the nephrosplenic ligament to obliterate the nephrosplenic space. Horses were re-examined (< or = 3 years) for history of recurrence. In addition, medical...
Improvement of the lung function of horses with heaves by treatment with a botanical preparation for 14 days.
The Veterinary record    December 6, 2005   Volume 157, Issue 23 733-736 doi: 10.1136/vr.157.23.733
Anour R, Leinker S, van den Hoven R.The effects of an oral preparation containing a mixture of extracts from yellow gentian, garden sorrel, cowslip, verbena and common elder on the lung function of nine horses suffering from heaves were determined in a longitudinal crossover study. The horses were divided at random into a group of five (group 1) and a group of four (group 2). The horses in group 1 were each given 15 tablets of the preparation twice daily, while the horses in group 2 were left untreated. Fourteen days later, the horses in group 2 were given the same course of treatment while the horses in group 1 were left untrea...
Use of color Doppler echocardiography to assess the development of valvular regurgitation in Standardbred trotters.
Journal of the American Veterinary Medical Association    November 30, 2005   Volume 227, Issue 10 1630-1635 doi: 10.2460/javma.2005.227.1630
Buhl R, Ersbøll AK, Eriksen L, Koch J.To evaluate the incidence and development of valvular regurgitation and its effect on racing performance in Standardbred trotters from 2 to 3.5 years of age. Methods: Longitudinal observational study. Methods: 103 horses. Methods: Horses were examined via echocardiographic imaging 4 times at 6-month intervals. Two-dimensional and M-mode echocardiographic examinations were performed in each horse, and color Doppler imaging was used to detect and evaluate regurgitant blood flow at each valve. Results: For all cardiac valves, the frequency of valvular regurgitation increased significantly during ...
Double blind, you are the weakest link–goodbye!
Equine veterinary journal    November 22, 2005   Volume 37, Issue 6 557-558 doi: 10.2746/042516405775314916
Devereaux PJ, Bhandari M, Montori VM, Manns BJ, Ghali WA, Guyatt GH.No abstract available
Prevalence of osseous fragments in distal and proximal interphalangeal, metacarpo- and metatarsophalangeal and tarsocrural joints of Hanoverian Warmblood horses.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine    September 24, 2005   Volume 52, Issue 8 388-394 doi: 10.1111/j.1439-0442.2005.00753.x
Stock KF, Hamann H, Distl O.The prevalence of osseous fragments in different limb joints was analysed in 3749 young Warmblood riding horses, which were pre-selected for sale at auction from 1991 to 1998 by the Association of Hanoverian Warmblood Breeders (Verband hannoverscher Warmblutzüchter e.V.) in Verden (Aller), Germany. The evaluation of these horses was based on a standardized radiological examination, including the distal interphalangeal (DIJ), the proximal interphalangeal (PIJ), the metacarpo- and metatarsophalangeal (MC/MTJ) and the tarsocrural joints (TCJ). In 32% of all horses at least one osseous fragment w...
Assessing allocation concealment and blinding in randomised controlled trials: why bother?
Equine veterinary journal    September 17, 2005   Volume 37, Issue 5 394-395 doi: 10.2746/042516405774479979
Schulz KF.No abstract available
Training-related factors associated with dorsometacarpal disease in young Thoroughbred racehorses in the UK.
Equine veterinary journal    September 17, 2005   Volume 37, Issue 5 442-448 doi: 10.2746/042516405774480085
Verheyen KL, Henley WE, Price JS, Wood JL.Dorsometacarpal disease (DMD) is common in young Thoroughbred (TB) racehorses, often interfering with their training programme. No reports exist on incidence rate or associated risk factors in the UK. Objective: To estimate the incidence rate of DMD in TB horses in training for flat racing in the UK and identify associated risk factors, particularly in relation to training regimens. Methods: Data were drawn from a large prospective study in which TB horses in 13 training yards were monitored for a period of up to 2 years, recording daily training information and details of musculoskeletal inju...
Transarterial coil embolisation in 31 horses (1999-2002) with guttural pouch mycosis: a 2-year follow-up.
Equine veterinary journal    September 17, 2005   Volume 37, Issue 5 430-434 doi: 10.2746/042516405774479960
Lepage OM, Piccot-Crézollet C.There have been no previously published large case series describing short- and long-term outcome of transarterial coil embolisation (TCE) in horses with guttural pouch mycosis (GPM). Objective: To describe the clinical and surgical features of horses with GPM presented at the Veterinary School of Lyon during a 28 month period; and to evaluate immediate to long-term results of TCE as a treatment. Methods: Medical records of all horses with GPM treated with TCE between February 1999 and July 2002 were analysed. To be included in the study, no other surgical or medical treatment for the mycosis ...
Can jumping capacity of adult show jumping horses be predicted on the basis of submaximal free jumps at foal age? A longitudinal study.
Veterinary journal (London, England : 1997)    September 1, 2005   Volume 170, Issue 2 212-221 doi: 10.1016/j.tvjl.2004.06.009
Bobbert MF, Santamaría S, van Weeren PR, Back W, Barneveld A.The purpose of this study was to quantify performance characteristics of good jumping horses, and to determine whether these were already detectable at foal age. Kinematic data were collected of horses performing free jumps over a 0.60 m high fence at six months of age and of these same horses jumping with a rider over a 1.15 m high fence at five years of age. At five years of age the horses were divided into three groups on the basis of a puissance competition: a group of seven best jumpers that made no errors and in the end cleared a 1.50 m high fence, a group of nine worst jumpers that were...
Factors affecting long-term survival of horses recovering from surgery of the small intestine.
Equine veterinary journal    July 21, 2005   Volume 37, Issue 4 360-365 doi: 10.2746/0425164054529481
Proudman CJ, Edwards GB, Barnes J, French NR.Epiploic foramen entrapment (EFE) has been associated with a particularly poor post operative prognosis for equine colic cases, but the reasons for this are unknown. Objective: To identify variables associated with post operative survival following surgery for small intestinal disease; develop a model describing long-term post operative survival; and identify reasons for the poor prognosis associated with EFE. Methods: Data from 382 horses undergoing surgery were used to identify variables associated with survival. A multivariable Cox proportional hazards model for post operative survival was ...
Modelling long-term survival of horses following surgery for large intestinal disease.
Equine veterinary journal    July 21, 2005   Volume 37, Issue 4 366-370 doi: 10.2746/0425164054529328
Proudman CJ, Edwards GB, Barnes J, French NP.Large intestinal diseases are an important cause of equine colic that require surgical management, but there is little published information about long-term survival of such cases. Objective: To identify variables associated with post operative mortality and to develop a model for post operative survival following surgery for large intestinal disease. Methods: Clinical data and long-term follow-up information from 275 horses undergoing surgery for large intestinal disease were used. A multivariable, Cox proportional hazards model for post operative death was developed and the fit of the model ...
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