A prospective study in equine research involves the systematic observation and collection of data from a group of horses over a defined period. This type of study is designed to assess the development and outcomes of specific conditions or diseases by following the subjects forward in time. Prospective studies can provide insights into the natural progression of equine health issues, the effectiveness of treatments, or the impact of various management practices. The methodology typically includes predefined protocols for data collection and analysis, ensuring consistent and reliable results. This page compiles peer-reviewed research studies and scholarly articles that focus on the design, implementation, and findings of prospective studies in equine science.
Aarnes TK, Bednarski RM, Bertone AL, Hubbell JA, Lerche P.The objective of this study was to compare recovery from desflurane anesthesia in horses with or without post-anesthetic xylazine. Six adult horses were anesthetized on 2 occasions, 14 d apart using a prospective, randomized crossover design. Horses were sedated with xylazine, induced to lateral recumbency with ketamine and diazepam, and anesthesia was maintained with desflurane. One of 2 treatments was administered intravenously at the end of anesthesia: xylazine [0.2 mg/kg body weight (BW)] or an equivalent volume of saline. Recovery parameters were recorded and assessed by 2 blinded observe...
Hopster K, Müller C, Hopster-Iversen C, Stahl J, Rohn K, Kästner S.To compare cardiovascular effects and recovery quality and duration of total intravenous anaesthesia (TIVA) with xylazine-ketamine-midazolam or dexmedetomidine-ketamine-midazolam. Methods: Prospective, randomized experimental cross-over trial. Methods: Eight adult warmblood horses. Methods: After sedation with acepromazine and either xylazine [0.5 mg kg(-1) , intravenously (IV)] or dexmedetomidine (3.5 μg kg(-1) IV) anaesthesia was induced with ketamine and midazolam and maintained with a constant rate infusion (CRI) of xylazine (1 mg kg(-1) hour(-1) ) [XKM] or dexmedetomidine (7 μg...
Munsters CC, van den Broek J, Welling E, van Weeren R, van Oldruitenborgh-Oosterbaan MM.Eventing is generally recognized as a challenging equestrian discipline and wastage figures for this discipline are relatively high. There is a need for information that provides insight into the causes of wastage and withdrawal from competition, for animal welfare and economic reasons. The aim of the present investigation was to conduct a prospective study following the entire national selection of event horses (n = 20) and ponies (n = 9) in the Netherlands that prepared for the European Championship in 2010 (ponies) and 2011 (horses), noting causes of withdrawal and monitoring fitness using ...
Steel CM, Pannirselvam RR, Anderson GA.The aims of this study were to determine the risk of septic arthritis after intra-articular medication (IAM) and to identify potential risk factors for this complication. Methods: A retrospective and prospective descriptive study of prevalence, and matched case-control study for risk factors. Results: Of 16,624 joints injected in 1103 horses at 6695 horse-visits, septic arthritis occurred as a complication in 13 joints (13 horses). The risk of septic arthritis following IAM was 7.8 cases per 10,000 injections or 1 case per 1279 injections. Veterinarian and type of corticosteroid were identifie...
Oel C, Gerhards H, Gehlen H.Analysis of any effect of retrobulbar block during ocular surgery on heart rate variability and oculocardiac reflex. Methods: Prospective study. Methods: Horses (n = 16) undergoing eye enucleation due to chronic ophthalmologic diseases. Methods: Eye enucleation was performed under general anesthesia. The horses were randomly assigned to the first (inhalation anesthesia only, n = 10) or second group (inhalation and local retrobulbar anesthesia, n = 6). The retrobulbar block was performed using 12 mL of mepivacaine hydrochloride 2%. ECG data were taken by a Telemetric ECG before, during, and aft...
Kelly PG, Reardon RJ, Johnston MS, Pollock PJ.Endoscopic examination of Thoroughbred (TB) yearlings is performed routinely to determine the suitability of horses for racing and to ensure that the conditions of sale are satisfied. However, previous research has demonstrated that resting endoscopic examination can be inaccurate in the diagnosis of functional pathology of the upper portion of the respiratory tract (URT). Objective: To investigate the feasibility of performing dynamic overground endoscopy in a group of TB yearlings and to compare the results of resting and dynamic endoscopic examination of the URT. Methods: Prospective cohort...
Bolwell CF, Rogers CW, French NP, Firth EC.Few studies have investigated the effect of having interruptions during training on future training and racing performance in Thoroughbred racehorses. The aim of this paper was to investigate the effect of having an interruption before the first trial on starting in a trial or a race. A prospective cohort study was used to record the training activity of a cohort of Thoroughbred racehorses, over two racing seasons. Fourteen racehorse trainers recorded information on the distances worked at canter and at fast speeds (<15s/200 m) and provided reasons for horses not training, or for having int...
Eckert V, Lockemann U, Püschel K, Meenen NM, Hessler C.To analyze horse-related accidents caused by hoof kicks. Methods: Prospective study to evaluate hoof kick-related accidents. Methods: Multicenter study, including 9 trauma centers in Hamburg, Germany. Methods: Patients who were treated as the result of a hoof kick between January 1, 2010, and May 1, 2010, were included in the study. Methods: Horse and rider qualifications, riders' use of protective equipment, location and activity at time of accident, mechanism of injury, injuries sustained, and treatment required for these injuries. Results: Twenty-four equestrians received hoof kicks. The av...
Wagner AE, Mama KR, Contino EK, Ferris DJ, Kawcak CE.To evaluate the sedative and analgesic effects of subanesthetic doses of ketamine in horses sedated with xylazine, with or without butorphanol. Methods: Prospective, randomized, controlled study. Methods: 10 adult horses. Methods: Each horse was sedated multiple times by administration of xylazine (treatment X), xylazine and butorphanol (treatment XB), xylazine with 1 of 2 dosages of ketamine (treatment XK1 or XK2), or xylazine and butorphanol with 1 of 2 dosages of ketamine (treatment XBK1 or XBK2). Head height and various behaviors, including responses to noise, insertion of a dental float, ...
Wylie CE, Proudman CJ, McGorum BC, Newton JR.Equine grass sickness (EGS) remains a frequently fatal disease of equids in Great Britain (GB). The first nationwide surveillance scheme for EGS was developed to obtain information on the occurrence of EGS and to help facilitate future proposed intervention studies, such as vaccine trials. Objective: To collect both retrospective and prospective data on cases of EGS occurring in GB since 2000 and to assess potential risk factors for categories of EGS and survival after chronic EGS. Methods: Prospective data were collected using a nationwide surveillance scheme for EGS that was developed and in...
Tóth F, Schumacher J, Schramme M, Hecht S.To describe the anatomic features of the equine trochanteric bursa and to evaluate 4 techniques for bursa centesis. Methods: Prospective, randomized design. Methods: Equine cadavers (n=2) and 20 live horses. Methods: The trochanteric bursae of 2 equine cadavers were injected with latex to identify the boundaries of the bursae. Four techniques for centesis of the trochanteric bursa were evaluated by attempting to inject dye into both trochanteric bursae of 20 live horses. Techniques included injection of the bursa with the limb-bearing weight and injection with the limb nonweight bearing and su...
Gardner RB, White GW, Ramsey DS, Boucher JF, Kilgore WR, Huhtinen MK.To determine whether sublingual detomidine gel administration to horses would be effective in providing an appropriate degree of sedation and restraint to facilitate completion of veterinary and husbandry procedures under field conditions. Methods: Multicenter, prospective, randomized, blinded, placebo-controlled clinical study. Methods: 270 client-owned horses known to require sedation or strong restraint to enable veterinary and husbandry procedures to be performed. Methods: Horses randomly received a single dose of detomidine gel (0.04 mg/kg [0.018 mg/lb]) or placebo gel administered sublin...
Jackson M, Kummer M, Auer J, Hagen R, Fuerst A.This prospective study describes a series of 18 olecranon fractures in 16 horses that were treated with locking compression plates (LCP). Twelve of the 18 fractures were simple (type 2), whereas six were comminuted (type 4). Six fractures were open and 12 were closed. Each horse underwent LCP osteosynthesis consisting of open reduction and application of one or two LCP. Complete fracture healing was achieved in 13 horses. Three horses had to be euthanatized: two because of severe infection and one because of a comminuted radial fracture 11 days after fixation of the olecranon fracture. Complic...
Marcilla MG, Schauvliege S, Duchateau L, Gasthuys F.To evaluate the cardiopulmonary effects of two different constant rate infusions (CRI) of dexmedetomidine (1 and 1.75 microg kg(-1 )hour(-1)) in experimental ponies. Methods: Six healthy ponies (mean 306 +/- SD 71 kg, 7.0 +/- 1.6 years). Methods: Prospective, randomized, experimental study. Methods: After premedication with intravenous (IV) dexmedetomidine (3.5 microg kg(-1)), anaesthesia was induced (T0) with ketamine (2.2 mg kg(-1) IV) and midazolam (0.06 mg kg(-1) IV) and maintained with isoflurane (Fe'ISO 1.50%) in 55% oxygen for 150 minutes. Normocapnia was maintained using artificial ven...
Belda E, Blissitt KJ, Duncan JC, Laredo FG, Escobar Gil de Montes M, Clutton RE.To record the bispectral index (BIS) when horses moved during either halothane or sevoflurane anaesthesia and when they made volitional movements during recovery from these anaesthetics. Methods: Randomized prospective clinical study. Methods: Twenty-five client-owned horses undergoing surgery aged 8.8 (+/- 5.3; 1-19) years (mean +/- SD; range). Methods: Baseline BIS values were recorded before pre-anaesthetic medication (BIS(B)) and during anaesthesia (BIS(A)) maintained with halothane (group H; n = 12) or sevoflurane (group S; n =13) at approximately 0.8-0.9 x minimum alveolar concentrations...
Nolen-Walston RD, Kuehn H, Boston RC, Mazan MR, Wilkins PA, Bruns S, Hoffman AM.Inflammatory airway disease has a high prevalence in horses, but is often a diagnostic challenge. Flowmetric plethysmography and histamine bronchoprovocation (FP/HBP) is a simple and effective tool for diagnosis, but reproducibility of these measurements made over time has not been established. Objective: We hypothesize that the measurement of airway responsiveness in horses using FP/HBP is consistent over both short and long periods of time. Methods: Twenty-nine healthy adult horses from 2 university herds. Methods: In this prospective experimental study, airway responsiveness was determined ...
Schwesig R, Neumann S, Richter D, Kauert R, Becker S, Esperer HD, Leuchte S.Hippotherapy has become an important therapeutic option in patients suffering from motoric dysfunction. The physiologic basis of this approach is the three-dimensional transmission of the horse's motion onto the patients body. These motion stimuli are believed to exert possitve effects on the patients's postural control systems. Objective: To test the hypothesis that hippotherapy has both positive short- and lang-term effects on gait and posture control of persons suffering from motoric disabilities. Methods: Twenty-two children and adolescents aged 9.69 +/- 4.01 years (range: 9.69 +/- 4.01 ye...
Tobari H, Yamagishi K, Noda H, Tanigawa T, Iso H.Prevention of horse-related injuries is considered difficult because horse behavior is unpredictable. Therefore, risk factors for injuries related to professional horse racing need to be investigated. We conducted a study to determine whether body mass index (BMI) and gamma-glutamyltransferase (GGT) levels are associated with professional horse racing-related injuries. Methods: A baseline healthy survey of 546 male grooms and exercise riders aged 40-70 yr working at Miho Training Center, the largest racing-horse training facility in Japan, was performed in May 2003. A total of 93 occupational ...
Schauvliege S, Van den Eede A, Duchateau L, Pille F, Vlaminck L, Gasthuys F.To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Methods: Prospective randomized experimental cross-over trial. Methods: Six ponies aged 5.0 +/- 1.6 (4-6.5) years and weighing 286 +/- 53 (212-368) kg. Methods: After sedation (romifidine) and induction (midazolam + ketamine), anaesthesia was maintained with isoflurane in oxygen. After 90 minutes (= T0), one of four treatments was administered: saline 0.1 mL kg(-1...
Murphy J.Eight horses were tested in a Y-maze to see if they would approach the side on which they had seen and heard food being delivered into a food trough. The horses were tested in five experimental contexts: immediate release (IR), delayed release 3s (3DR), 6s (6DR), 9s (9DR) and 12s (12DR) after food delivery. Individual subjects performed five IR trials, followed by five each of 3DR, 6DR, 9DR and 12DR trials. A re-rest was performed 1 week later. Data were analysed by log-linear analysis of frequencies. The results showed that the horses were capable of achieving the correct choice during IR tri...
Relave F, Meulyzer M, Alexander K, Beauchamp G, Marcoux M.Lesions located on the medial malleolus of the tarsocrural joint can be difficult to image radiographically. Ultrasonography allows evaluation of articular cartilage and subchondral bone. Objective: To compare dorso30 degrees lateral-plantaromedial-oblique (DL-PIMO) and dorso45 degrees views to detect lesions on the medial malleolus, to validate the use of ultrasonography to show lesions in the tarsocrural joint and to compare its sensitivity to radiography. Methods: Tarsocrural joints (n=111) with osteochondrosis were evaluated ultrasonographically and radiographically prior to arthroscopic l...
Bentz AI, Palmer JE, Dallap BL, Wilkins PA, Boston RC.Coagulopathy is a potentially underrecognized complication of sepsis and septic shock in critically ill neonatal foals. Objective: Critically ill neonatal foals have abnormalities in coagulation that are associated with disease severity and outcome. Methods: Foals <72 hours old admitted to a neonatal intensive care unit. Methods: Prospective, observational study. Blood was collected at admission, 24, and 48 hours for platelet count, prothrombin time, activated partial thromboplastin time, antithrombin activity and concentrations of fibrin degradation products, and fibrinogen in plasma from all...
Clark L, Clutton RE, Blissitt KJ, Chase-Topping ME.To investigate the effects of peri-operative morphine on the quality and duration of recovery from halothane anaesthesia in horses. Methods: Prospective randomized study. Methods: Twenty-two client owned horses, ASA category I or II. Methods: Horses undergoing elective surgical procedures were divided into two groups and paired according to procedure, body position during surgery, body mass and breed. Group M+ received morphine by intravenous injection (0.15 mg kg(-1)) before induction of anaesthesia and then by infusion (0.1 mg kg(-1) hour(-1)) during anaesthesia. Group M- received the same a...
Driessen B, Nann L, Benton R, Boston R.To study whether hemodynamic function in horses, particularly mean arterial blood pressure (MAP), is better maintained with sevoflurane than isoflurane, thus requiring less pharmacological support. Methods: Prospective randomized clinical investigation. Animals Thirty-nine racehorses undergoing arthroscopy in lateral recumbency. Methods: Horses were assigned to receive either isoflurane (n = 20) or sevoflurane (n = 19) at 0.9-1.0 minimum alveolar concentration (MAC) for maintenance of anesthesia. Besides routine clinical monitoring, cardiac output (CO) was measured by lithium dilution. Hemodyn...
Newton AM, Nielsen AM.The literature contains many studies on the types of injuries sustained in horseback riding incidents. Most advocate the use of equestrian helmets to prevent head trauma. However, information is limited on other specific prevention strategies. Methods: A 4-year, retrospective, and prospective review of medical records pertaining to horse-related injuries in a southwestern Colorado hospital yielded a sample of 85 patients who had been injured while riding or tending to horses. In addition to the record review, patients were interviewed during ED discharge, inpatient treatment, or in a follow-up...
Xie H, Colahan P, Ott EA.To evaluate use of electroacupuncture for treatment of horses with signs of chronic thoracolumbar pain. Methods: Prospective study. Methods: 15 horses with signs of chronic thoracolumbar pain. Methods: Horses were randomly allocated to 1 of 3 treatment groups. Horses in group 1 received electroacupuncture stimulation (once every 3 days for 5 treatments), those in group 2 received phenylbutazone (2.2 mg/kg [1 mg/lb], PO, q 12 h, for 5 days), and those in group 3 received saline (0.9% NaCl) solution (20 mL, PO, q 12 h, for 5 days). Thoracolumbar pain scores (TPSs) were evaluated before (baseline...
Zubrod CJ, Farnsworth KD, Oaks JL.To evaluate the effectiveness of four methods of povidone-iodine preparation on skin bacterial flora of arthrocentesis sites, in horses, with and without evidence of skin contamination. Methods: Prospective randomized study. Methods: Twenty-four adult horses. Methods: Horses were assigned to either the clean or contaminated group based on housing environment and visual evidence of contamination. Using a moist sterile swab, microbial culture samples were obtained from the skin over the distal interphalangeal joints immediately before and after preparation. Each site was aseptically prepared wit...
Natalini CC, Alves SD, Guedes AG, Polydoro AS, Brondani JT, Bopp S.To evaluate the analgesic, physiologic, and behavioral effects of the epidural administration of tiletamine/zolazepam in horses. Methods: Prospective, double-blind, randomized experimental study. Methods: Five adult, healthy horses aged 10-16 years and weighing (mean +/- SD) 400 +/- 98 kg. Methods: The horses were sedated with 1.0 mg kg(-1) intravenous (IV) xylazine, and an epidural catheter was placed into the first intercoccygeal intervertebral space. After a 48-hour resting period, epidural tiletamine/zolazepam, 0.5 mg kg(-1) (treatment I) or 1.0 mg kg(-1) (treatment II), diluted up to 5 mL...
Verheyen KL, Wood JL.Musculoskeletal injury is the major cause of days lost from training and wastage in Thoroughbred racehorses. Little scientific information is available on the majority of injuries occurring in training. Objective: To estimate the incidence of fractures in British racehorses in training and describe the occurrence of different fracture types and bones involved. Methods: Thirteen UK racehorse trainers participated in a prospective study, providing data on horses in their care for 2 years. Details on horses, their daily exercise and fracture occurrence were recorded. Results: A total of 1178 hors...
Stein FJ, Geller SC, Carter JC.To determine whether microchips used for identification migrate after implantation in horses, donkeys, and mules. Methods: Prospective study. Methods: 53 horses, donkeys, and mules. Methods: Twenty horses that had had microchips implanted in the nuchal ligament at a veterinary teaching hospital from 1996 through early 2000 were included (group 1), and the poll-to-withers distance and location of the microchip were determined, measured, and recorded. Additionally, the poll-to-withers distance was measured in 16 horses, 12 donkeys, and 5 mules (group 2), and microchips were implanted in the nuch...
Scharner D, Gittel C, Winter K, Blaue D, Schedlbauer C, Vervuert I, Brehm W.Development of incisional complications following ventral median celiotomy might depend on suture pattern for skin closure. Methods: In this prospective study, 21 healthy male horses underwent celiotomy. Skin closure was either performed via a continuous percutaneous pattern (CO group; 5 warmbloods/5 ponies) or an intradermal pattern (ID group; 5 warmbloods/6 ponies). Follow-up examination of the incisional site included daily monitoring for edema, dehiscence, and drainage. Transcutaneous ultrasound was performed at Days 3, 6, and 10 as well as on Week 8 and 12 to evaluate size of edema and pr...
Salem SE, Sinnott A, Roach JM, Verheyen KLP, de Mestre AM.Multiple pregnancies (MPs) are commonly diagnosed during breeding management of mares. Whilst some studies have reported on factors associated with the risk of MPs, few have utilised multivariable data analysis to control for confounding variables. A prospective cohort study of Thoroughbred broodmares was conducted with information collected on 27 factors. Mixed-effects logistic regression was used to determine risk factors for MPs. Mare, stallion, stud, and veterinarian were evaluated as random effects. The prevalence of MPs in 1754 mares and 2245 pregnancies was 16.06% (95% confidence interv...
Hodgson C, Pinchbeck G.Despite the regularity with which castration is performed, the types of complications and current best practice are unknown. Objective: The objective of this study was to perform a prospective audit of routine equine castrations performed in general practice to determine complication rates and factors associated with them. Methods: Multicentre, prospective audit of castrations. Methods: Data on castrations were collected on the day of surgery from 18 veterinary practices; 30-days post-operatively follow-up was obtained and complications recorded. Frequency of complications was reported, and mu...
Crosignani N, Luna SP, Dalla Costa T, Pimenta EL, Detoni CB, Guterres SS, Puoli Filho JN, Pantoja JC, Pigatto MC.We investigated the thermal, electrical and mechanical antinociceptive and physiological effects (heart rate, respiratory rate, arterial blood pressure, head height and abdominal auscultation score), and pharmacokinetics, of 0.5 mg/kg of the injectable formulation (ORAL) or nanoparticulated methadone (NANO) given orally, in six adult mares, using a crossover, blind and prospective design. Repeated-measure models were used to compare parametric data between and within treatments, followed by Tukey's test. Nonparametric data were analysed with Wilcoxon signed-rank, adjusted by Bonferroni tests....
Zarghooni K, Hub L, Bredow J, Yagdiran A, Hackenberg RK, Scheyerer M, Westermann L, Eysel P, Siewe J.Equestrian vaulting is a sport, particularly popular among children and adolescents, in which gymnastic and dance routines are performed on horseback. Current data regarding injuries and thus, the risks of this sport, is meager and based only on retrospective studies. Methods: In the current prospective study, 233 active members of a vaulting club were questioned monthly from November 2014 until October 2015. In addition to general information (training, competitions), the questionnaire collected the number of competitions, the competitive class, the discipline (single, team, Pas-de-Deux), and...
Tobari H, Yamagishi K, Noda H, Tanigawa T, Iso H.Prevention of horse-related injuries is considered difficult because horse behavior is unpredictable. Therefore, risk factors for injuries related to professional horse racing need to be investigated. We conducted a study to determine whether body mass index (BMI) and gamma-glutamyltransferase (GGT) levels are associated with professional horse racing-related injuries. Methods: A baseline healthy survey of 546 male grooms and exercise riders aged 40-70 yr working at Miho Training Center, the largest racing-horse training facility in Japan, was performed in May 2003. A total of 93 occupational ...
Willmund G, Zimmermann P, Alliger-Horn C, Varn A, Fischer C, Parent I, Sobottka A, Bering R, Rose C, Ströhle A, Köhler K.Many traumatised individuals suffering from deployment related PTSD report severe problems in their relationships. Up until now, the therapeutic interventions used by the German Armed Forces have rarely targeted these problems through the integration of partners. For this reason, a Program designed specifically for couples was developed. In this prospective study equine-assisted psychotherapy was applied to soldiers and their spouses. The study population consisted of n = 36 couples, divided in n = 20 therapy group with a inpatient equine-assisted intervention and a 16-couples control grou...
Aarnes TK, Bednarski RM, Bertone AL, Hubbell JA, Lerche P.The objective of this study was to compare recovery from desflurane anesthesia in horses with or without post-anesthetic xylazine. Six adult horses were anesthetized on 2 occasions, 14 d apart using a prospective, randomized crossover design. Horses were sedated with xylazine, induced to lateral recumbency with ketamine and diazepam, and anesthesia was maintained with desflurane. One of 2 treatments was administered intravenously at the end of anesthesia: xylazine [0.2 mg/kg body weight (BW)] or an equivalent volume of saline. Recovery parameters were recorded and assessed by 2 blinded observe...
Duarte PC, Paz CFR, Oliveira APL, Maróstica TP, Cota LO, Faleiros RR.To investigate the nociceptive and clinical effects of buffering a lidocaine-epinephrine solution with sodium bicarbonate in caudal epidural block in mares. Methods: Prospective randomized controlled trial. Methods: Six mixed-breed mares weighing 350-440 kg. Methods: Each animal was administered two caudal epidural injections, 72 hours apart, using different solutions prepared immediately before injection. The control solution was 7 mL 2% lidocaine hydrochloride with epinephrine hemitartrate (1:200,000) added to 3 mL sterile water for injection (pH 2.9). The alkalinized solution was 7 mL o...
Grossman JA, Kulund DN, Miller CW, Winn HR, Hodge RH.In a prospective study involving 110 injured equestrians, there were no noteworthy correlations between age, sex, or experience of the amateur riders and injury occurrence. Tack failure caused several injuries. Among fox hunters the incidence was related only to frequency of hunts. The most common severe injury was to the head, associated with lack of headgear. Fewer than 20% of the 110 riders used a protective helmet. There were four renal contusions and one bladder laceration. The most frequent injuries were fractures of the upper extremities. Wearing a good-quality protective helmet and che...
Acutt EV, Zhou T, Mama K, Nelson BB, Selberg KT, Barrett MF.Delivery of mesenchymal stem cells (MSC) via intravascular techniques to treat diffuse and/or inaccessible soft tissue injuries has grown in popularity. The purpose of the current prospective, analytical pilot study was to utilize CT to validate this novel technique and provide additional evidence to support its use for injectate delivery to specific soft tissue structures. Of particular interest was the proximal suspensory ligament, which presents a challenging injection target. Six adult horses without lameness underwent CT of the distal hindlimbs. Scans were obtained prior to ultrasound-gui...
Hoeberg E, Haga HA, Lervik A.To investigate whether morphine causes a change in mean arterial blood pressure (MAP) heart rate (HR) and oxygen extraction (OE) rate in healthy horses anesthetized with isoflurane and a dexmedetomidine infusion. Unassigned: The study design was prospective clinical, randomized, blinded two groups including 33 horses. All horses were sedated with romifidine IV, and anesthesia was induced with midazolam IV and ketamine IV and maintained with isoflurane in oxygen and medical air and a dexmedetomidine infusion. As a baseline venous and arterial blood, HR and MAP were sampled. Thereafter either mo...
Jarosinski SK, Simon BT, Hatfield R, Matthews NS, Arnold CE.The purpose of this prospective, blinded, randomized clinical trial was to compare the effects of low dose detomidine to xylazine on recovery quality and duration in a castration procedure. Horses were administered either detomidine [0.015 mg/kg body weight (BW)] or xylazine (1.1 mg/kg BW) intravenously (IV) before IV induction with ketamine (2.2 mg/kg BW) and diazepam (0.05 mg/kg BW). Two anesthesiologists who were unaware of treatment allocation scored the recoveries using a simple descriptive scale (with a low number representing the most desirable recovery) and recoveries were timed. Horse...
Natalini CC, Alves SD, Guedes AG, Polydoro AS, Brondani JT, Bopp S.To evaluate the analgesic, physiologic, and behavioral effects of the epidural administration of tiletamine/zolazepam in horses. Methods: Prospective, double-blind, randomized experimental study. Methods: Five adult, healthy horses aged 10-16 years and weighing (mean +/- SD) 400 +/- 98 kg. Methods: The horses were sedated with 1.0 mg kg(-1) intravenous (IV) xylazine, and an epidural catheter was placed into the first intercoccygeal intervertebral space. After a 48-hour resting period, epidural tiletamine/zolazepam, 0.5 mg kg(-1) (treatment I) or 1.0 mg kg(-1) (treatment II), diluted up to 5 mL...
White KL, Hird JFR, Taylor PM.Isoflurane is the only volatile anaesthetic agent licensed for equine use in the United Kingdom, but sevoflurane is also commonly used. The two agents have rarely been compared for use in clinical elective surgery. Methods: This single centre, prospective, randomised, blinded clinical investigation recruited 101 healthy client owned horses undergoing elective surgery. Anaesthesia was standardised and horses randomly assigned to receive isoflurane (I) or sevoflurane (S) for maintenance of anaesthesia in 100% oxygen. Horses were ventilated to normocapnia and received intravenous fluid therapy an...
Figueras F, Castelo-Branco C, Pons F, Sanjuán A, Vanrell JA.The aim of the present study was to determine whether assignment to continuous estrogen-progestin therapy is more effective in protecting against bone loss than assignment to a sequential regimen. Methods: A total of 104 postmenopausal women were randomly assigned to one of two groups of treatment, Conjugated Equine Estrogens and Medroxyprogestin without interruption (continuous group) and Conjugated Equine Estrogens over 25 days with Medroxyprogestin beyond the 14th day (sequential group). Bone mineral density (BMD) was measured at inclusion, 12 and 24 months later by dual energy X-ray absorp...
Benmansour P, Billinsky J, Duke-Novakovski T, Alcorn J.To determine blood remifentanil concentration in isoflurane-anesthetized horses during and after a 1h remifentanil and dexmedetomidine infusion. Methods: Prospective study. Methods: Six adult mixed breed horses with (mean±SD) bodyweight of 507±61kg and 14±4years of age. Methods: Following sedation with xylazine IV, anesthesia was induced with ketamine IV mixed with diazepam IV. Anesthesia was maintained with isoflurane in oxygen. After 52±7min for instrumentation, dexmedetomidine (0.25μgkg(-1) followed by 1.0μg(-1)kg(-1)h(-1)) and remifentanil infusions (6μgkg(-1)h(-1)) were administere...
Valberg SJ, Nicholson AM, Lewis SS, Reardon RA, Finno CJ.To report a novel exertional myopathy, myofibrillar myopathy (MFM) in Warmblood (WB) horses. Objective: To 1) describe the distinctive clinical and myopathic features of MFM in Warmblood horses and 2) investigate the potential inheritance of MFM in a Warmblood family. Methods: Retrospective selection of MFM cases and prospective evaluation of a Warmblood family. Methods: Retrospectively, muscle biopsies were selected from Warmblood horses diagnosed with MFM and clinical histories obtained (n = 10). Prospectively, muscle biopsies were obtained from controls (n = 8) and a three generation WB...
Vinardell T, David F, Galezowski AM, Ali M, Qasim M, Massie SL, McCrae P, Filho S, Leguillette R.Swimming is used for rehabilitation of musculoskeletal injuries and for conditioning to improve equine fitness. However, there are anecdotal reports that suggest that tethered swimming can induce epistaxis, likely secondary to exercise-induced pulmonary hemorrhage (EIPH). The objective of this observational, prospective study was to investigate if EIPH occurs during intensive free-swimming training sessions (5 × 70m) using 15 endurance horses. On tracheo-bronchoscopic evaluations following swimming, low grade mucus scores were observed, but no tracheal blood was observed. Bronchoalveolar la...
Bentz AI, Palmer JE, Dallap BL, Wilkins PA, Boston RC.Coagulopathy is a potentially underrecognized complication of sepsis and septic shock in critically ill neonatal foals. Objective: Critically ill neonatal foals have abnormalities in coagulation that are associated with disease severity and outcome. Methods: Foals <72 hours old admitted to a neonatal intensive care unit. Methods: Prospective, observational study. Blood was collected at admission, 24, and 48 hours for platelet count, prothrombin time, activated partial thromboplastin time, antithrombin activity and concentrations of fibrin degradation products, and fibrinogen in plasma from all...
Schauvliege S, Van den Eede A, Duchateau L, Pille F, Vlaminck L, Gasthuys F.To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Methods: Prospective randomized experimental cross-over trial. Methods: Six ponies aged 5.0 +/- 1.6 (4-6.5) years and weighing 286 +/- 53 (212-368) kg. Methods: After sedation (romifidine) and induction (midazolam + ketamine), anaesthesia was maintained with isoflurane in oxygen. After 90 minutes (= T0), one of four treatments was administered: saline 0.1 mL kg(-1...
Xie H, Colahan P, Ott EA.To evaluate use of electroacupuncture for treatment of horses with signs of chronic thoracolumbar pain. Methods: Prospective study. Methods: 15 horses with signs of chronic thoracolumbar pain. Methods: Horses were randomly allocated to 1 of 3 treatment groups. Horses in group 1 received electroacupuncture stimulation (once every 3 days for 5 treatments), those in group 2 received phenylbutazone (2.2 mg/kg [1 mg/lb], PO, q 12 h, for 5 days), and those in group 3 received saline (0.9% NaCl) solution (20 mL, PO, q 12 h, for 5 days). Thoracolumbar pain scores (TPSs) were evaluated before (baseline...
Gierup J, Larsson M, Lennquist S.A prospective one-year study of horse-riding accidents was performed in an area with a very high frequency of amateur riding. Totally 174 patients with riding injuries were registered--66% children--making an incidence of only 0.7 per thousand riding occasions. However, many of these injuries were of a severe nature, one leading to death and 27 of the patients reporting persisting symptoms at follow-up one year after the accident. Eleven per cent of the accidents lead to cerebral injuries and 44% to fractures, mainly of the upper extremities. Eleven per cent required hospitalization and 17% op...
Niinistö KE, Ruohoniemi MO, Freccero F, Raekallio MR.Enteropathy associated with sand accumulation in the large colon of horses has been reported worldwide. Intestinal sand accumulations are commonly treated medically, but randomised controlled clinical trials on horses are scarce. This prospective study evaluated the efficacy of an enterally administered combination of psyllium and magnesium sulphate (MgSO4) for the removal of large colonic sand accumulations in horses without clinical signs of acute colic. The two groups comprised 20 untreated control horses and 20 horses treated with 1g/kg bodyweight (bwt) of psyllium and 1g/kg bwt of MgSO4 a...
McElligott EM, Sommardahl CS, Cox SK.OBJECTIVE To determine the pharmacokinetics of chloramphenicol base after PO administration at a dose of SO mg/kg (22.7 mg/lb) in adult horses from which food was not withheld. DESIGN Prospective crossover study. ANIMALS 5 adult mares. PROCEDURES Chloramphenicol base (SO mg/kg) was administered PO to each horse, and blood samples were collected prior to administration (0 minutes) and at 5, 10, 15, and 30 minutes and 1, 2, 4, 8, and 12 hours thereafter. Following a washout period, chloramphenicol sodium succinate (25 mg/kg [11.4 mg/lb]) was administered IV to each horse, and blood samples were ...
