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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses.
American journal of veterinary research    November 1, 1994   Volume 55, Issue 11 1501-1504 
Sweeney CR, Rossier Y, Ziemer EL, Lindborg SR.Bronchoalveolar lavage (BAL) was performed on 16 horses to determine whether it caused local or diffuse inflammation in the lungs. In 7 horses, BAL was performed in both lungs twice, 48 hours apart. Although total cell counts of the BAL samples did not change significantly, there were increased numbers and percentage of neutrophils in the second lavage fluid samples. In 5 horses, BAL was performed in 1 lung and repeated 48 hours later in the same lung and in the corresponding airway in the contralateral lung. The absolute cell count and percentage of neutrophils were significantly (P = < 0....
Antral follicle development and in-vitro maturation of oocytes from macaques stimulated with a single subcutaneous injection of pregnant mare’s serum gonadotrophin.
Human reproduction (Oxford, England)    November 1, 1994   Volume 9, Issue 11 2130-2134 doi: 10.1093/oxfordjournals.humrep.a138404
Younis AI, Sehgal PK, Biggers JD.A single s.c. injection of 1000 IU of pregnant mare's serum gonadotrophin (PMSG) stimulates the growth of multiple antral follicles in cynomolgus monkeys (Macaca fascicularis). The number of cumulus-enclosed oocytes (CEO) from six non-stimulated controls was 36 (mean = 6). In contrast, a total of 95 CEO (mean = 31.7) were recovered from three animals stimulated and ovariectomized 3 days later, while 385 CEO (mean = 128.3) were obtained from three animals stimulated and ovariectomized 4 days later. A comparison of the effects of highly purified human follicle-stimulating hormone (FSH), human lu...
Comparative analysis of phagocytosis of fungal cells by insect hemocytes versus horse neutrophils.
Developmental and comparative immunology    November 1, 1994   Volume 18, Issue 6 455-466 doi: 10.1016/s0145-305x(06)80001-7
Mazet I, Pendland J, Boucias D.In this study, the phagocytic ability of Spodoptera exigua hemocytes was compared to horse neutrophils. In vitro assays showed that the insect granulocytes and horse neutrophils actively phagocytose FITC-labeled Paecilomyces farinosus blastospores opsonized with S. exigua hemolymph lectin or horse serum, respectively. Killing of fungal cells by the neutrophils and hemocytes was analyzed under in vitro conditions. Neutrophils reduced the growth of P. farinosus up to 65% whereas no fungicidal activity was observed with hemocyte monolayers. The production of oxygen metabolites by both phagocytic ...
An algorithm to describe the oxygen equilibrium curve for the thoroughbred racehorse.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 500-502 doi: 10.1111/j.2042-3306.1994.tb04058.x
Smale K, Anderson LS, Butler PJ.An algorithm to describe the oxygen equilibrium curve (OEC) of the Thoroughbred horse was derived from raw oxygen equilibrium curve data obtained under standard conditions of temperature, pH and PCO2 (Smale and Butler, 1994). This algorithm was derived by a curve-fitting procedure based on the algorithm for human blood produced by Kelman (1966). The temperature, fixed acid and net CO2 coefficients were then incorporated in the algorithm to enable the accurate calculation of % saturation from any combination of PO2, temperature, pH and PCO2. The algorithm was checked using blood gas data obtain...
Models for assessing the relationship between drug concentration and drug effect in performance horses.
The British veterinary journal    November 1, 1994   Volume 150, Issue 6 507-525 doi: 10.1016/S0007-1935(94)80034-0
Kamerling SG, Owens JG.The actions of most drugs are dependent upon achieving adequate plasma concentrations. Plasma concentrations are influenced by the degree to which a drug is absorbed, distributed, metabolized and excreted. Pharmacokinetic assessment reflects changes in these variables as a function of time. Pharmacodynamics refers to specific drug effects or mechanisms of drug action. Individual drug pharmacokinetics provides information on which to base a therapeutic dose, route of administration and dosing interval. However, not all drug actions temporally correlate with plasma kinetics. To resolve this disc...
In vitro development of day 2 embryos obtained from young, fertile mares and aged, subfertile mares.
Journal of reproduction and fertility    November 1, 1994   Volume 102, Issue 2 371-378 doi: 10.1530/jrf.0.1020371
Brinsko SP, Ball BA, Miller PG, Thomas PG, Ellington JE.This study was designed to investigate the development of day 2 embryos obtained from young and aged mares, co-cultured with oviductal epithelial cells obtained from mares in each age group in a 2 x 2 crossover design. Young, fertile mares (n = 19; 2-7 years of age) and aged, subfertile, mares (n = 16; 17-24 years of age) were used as embryo and oviductal epithelial cell donors. Embryos (n = 37) were collected from the oviducts 2 days after ovulation and were paired (embryos obtained from young mares with embryos obtained from aged mares) so that eight pairs were co-cultured with young mare ov...
The aetiopathogenesis of infectious keratitis in the horse.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 432-433 doi: 10.1111/j.2042-3306.1994.tb04044.x
Matthews AG.No abstract available
Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development.
Anatomy and embryology    November 1, 1994   Volume 190, Issue 5 469-477 doi: 10.1007/BF00235494
Sonea IM, Bowker RM, Robinson NE, Holland RE.The lungs of neonatal foals contain many nerves immunoreactive for substance P and calcitonin gene-related peptide. These nerves are closely associated with the epithelium, bronchial and pulmonary vessels and the airway smooth muscle of all intrathoracic airways, including non-cartilaginous bronchioles. Activation of sensory nerves in the respiratory epithelium could thus potentially affect, via local axon reflexes, vascular and respiratory smooth muscle in neonatal equine airways. Nerves immunoreactive for these peptides are much more widely distributed within the lung than in adult horses; t...
Pulmonary vascular pressures of thoroughbreds increase rapidly and to a higher level with rapid onset of high-intensity exercise than slow onset.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 496-499 doi: 10.1111/j.2042-3306.1994.tb04057.x
Manohar M.Previous studies of pulmonary vascular pressures have utilised gradual incremental step exercise protocols, but in competitive racing at the track, horses perform rapid acceleration high-intensity exercise. The rate of rise in pulmonary vascular pressures under conditions of quick onset high-intensity exercise is unknown. Catheter mounted manometers, whose in vivo signals were matched with pressure signals obtained via transducers connected to fluid-filled lumens from same cardiovascular sites, were used to compare right heart and pulmonary vascular pressures in 8 healthy Thoroughbreds perform...
Blood lactate disappearance after maximal exercise in trained and detrained horses.
Research in veterinary science    November 1, 1994   Volume 57, Issue 3 325-331 doi: 10.1016/0034-5288(94)90125-2
Rainger JE, Evans DL, Hodgson DR, Rose RJ.The influence of training on blood lactate concentrations during treadmill exercise and a 40-minute inactive recovery period was examined in seven trained and seven detrained thoroughbred horses. Lactate concentrations were measured in venous blood collected at the end of each exercise state, and at intervals for 40 minutes afterwards. Measurements were made of maximum oxygen uptake (VO2max, ml kg-1 min-1), VLA4 (velocity at which blood lactate concentration was 4 mmol litre-1); LA8 (lactate concentration [mmol litre-1] during exercise at 8 m sec-1), peak lactate (highest lactate concentration...
Effect of sample handling on measurement of plasma glucose and blood lactate concentrations in horses before and after exercise.
American journal of veterinary research    November 1, 1994   Volume 55, Issue 11 1497-1500 
Ferrante PL, Kronfeld DS.Collection of a satisfactory blood sample requires special procedures to prevent changes in glucose and lactate content after the sample has been obtained. Changes in measured plasma glucose and blood lactate concentrations attributable to anticoagulants and storage procedures, respectively, were examined in blood samples obtained from horses at rest and after exercise. To evaluate the effect of anticoagulants on measured plasma glucose concentration, blood was preserved with either sodium fluoride/potassium oxalate or lithium heparin. Measured plasma glucose concentration in blood obtained at...
Unintentional duplicate reporting of equine enterocutaneous fistulae.
Veterinary surgery : VS    November 1, 1994   Volume 23, Issue 6 534 doi: 10.1111/j.1532-950x.1994.tb00515.x
Bristol DG.No abstract available
GRASP: a novel heparin-binding serum glycoprotein that mediates oligodendrocyte-substratum adhesion.
Journal of neuroscience research    November 1, 1994   Volume 39, Issue 4 457-473 doi: 10.1002/jnr.490390413
Schirmer EC, Farooqui J, Polak PE, Szuchet S.Cell-substratum adhesion plays a crucial part in the cascade of events that control growth or turn on and consummate a differentiation program. We are investigating the molecular basis of oligodendrocyte (OLG) cytodifferentiation, employing pure cultures of OLGs isolated from postmyelination brains. We have shown that such OLGs will regenerate in vitro and reenact the ontogenic development of myelin, but to do so they need a signal. Adherence to a polylysine surface in the presence of 20% horse serum generates such a signal. Among the events that are turned on upon OLG adhesion is the phosphor...
Structural protein relationships among eastern equine encephalitis viruses.
The Journal of general virology    November 1, 1994   Volume 75 ( Pt 11) 2897-2909 doi: 10.1099/0022-1317-75-11-2897
Strizki JM, Repik PM.We have re-evaluated the relationships among the polypeptides of eastern equine encephalitis (EEE) viruses using SDS-PAGE and peptide mapping of individual virion proteins. Four to five distinct polypeptide bands were detected upon SDS-PAGE analysis of viruses: the E1, E2 and C proteins normally associated with alphavirus virions, as well as an additional more rapidly-migrating E2-associated protein and a high M(r) (HMW) protein. In contrast with previous findings by others, the electrophoretic profiles of the virion proteins of EEE viruses displayed a marked correlation with serotype. The pro...
Experimentally-induced synovitis as a model for acute synovitis in the horse.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 492-495 doi: 10.1111/j.2042-3306.1994.tb04056.x
Palmer JL, Bertone AL.The use of extremely small dosages of intra-articular E. coli lipopolysaccharide (LPS) endotoxin can create a model of synovitis that mimics acute synovitis in horses. Dosages of 5000 ng, 25 ng, 0.5 ng, 0.25 ng, 0.17 ng and 0.125 ng per joint were injected into various joints of a total of 6 horses. The dose response of LPS on clinical signs and synovial fluid parameters was evaluated at baseline and 12, 24, 36 and 48 h after LPS injection. Peripheral venous blood analysis was performed at baseline and at 0, 4, and 12 h after LPS injection. Dosages greater than 0.5 ng/joint resulted in clinica...
Equine echocardiography.
The British veterinary journal    November 1, 1994   Volume 150, Issue 6 503-506 doi: 10.1016/S0007-1935(94)80033-2
Bonagura JD.No abstract available
Studies on the presence of magnesium in visceral amyloid.
Zentralblatt fur Pathologie    November 1, 1994   Volume 140, Issue 4-5 309-315 
Müller W, Firsching R.The Magneson and Titan yellow tests were used to detect Mg in amyloid deposits in primary and secondary amyloidosis, in a pituitary tumour and in a case of equine cutaneous amyloidosis. Especially vascular amyloid deposits turned out to contain high levels of Mg. The significance of these findings remains unclear at present. Competition between Mg and Ca, the relationship between Mg in elastic fibres and amyloid P-component, and the high water content of amyloid along with the interaction of Mg with water are discussed.
Presence of African horse sickness virus in equine tissues, as determined by in situ hybridization.
Veterinary pathology    November 1, 1994   Volume 31, Issue 6 689-694 doi: 10.1177/030098589403100609
Brown CC, Meyer RF, Grubman MJ.In a retrospective study, a negative-sense digoxigenin-labeled RNA probe, corresponding to the gene encoding nonstructural protein-1 of African horse sickness virus (AHSV) serotype 4, was applied to formalin-fixed, paraffin-embedded tissue taken from horses in the terminal stages of infection with AHSV. Fifteen infected ponies and one noninfected control were studied. Ponies exhibited a range of clinical signs and lesions. Thirteen ponies were infected with serotype 4, one with serotype 1, and one with serotype 2. Ponies were monitored clinically and euthanatized when severely clinically ill. ...
Infertility in the mare.
Journal of comparative pathology    November 1, 1994   Volume 111, Issue 4 333-351 doi: 10.1016/s0021-9975(05)80093-3
Watson ED.No abstract available
Eosinophilic keratoconjunctivitis in a horse.
Journal of the American Veterinary Medical Association    November 1, 1994   Volume 205, Issue 9 1308-1311 
Ramsey DT, Whiteley HE, Gerding PA, Valdez RA.An 11-year-old Quarter Horse gelding was evaluated because of a persistent, raised band of 1- to 2-mm subepithelial plaques of the left cornea. Cytologic examination of corneal scrapings revealed numerous eosinophils and segmented neutrophils, with few mast cells, plasma cells, and lymphocytes. Bacteriologic culture yielded sparse growth of alpha-hemolytic Streptococcus and Staphylococcus spp. Histologically, the plaques consisted of subepithelial foci of fragmented and degenerated collagen fibers infiltrated by eosinophils and neutrophils, with few lymphocytes, plasma cells, and macrophages. ...
Equilibrium unfolding studies of horse muscle acylphosphatase.
European journal of biochemistry    November 1, 1994   Volume 225, Issue 3 811-817 doi: 10.1111/j.1432-1033.1994.0811b.x
Taddei N, Buck M, Broadhurst RW, Stefani M, Ramponi G, Dobson CM.The stability and equilibrium unfolding behaviour of horse muscle acylphosphatase have been studied by denaturing the protein under various conditions of temperature, pH, and urea concentration. Far-ultraviolet circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy indicate that this small monomeric protein unfolds reversibly and cooperatively. Thermodynamic parameters, the Gibbs free energy delta G and enthalpy delta H of unfolding, have been estimated for denaturation of the protein from NMR and CD data as 19 kJ mol-1 and 350 kJ mol-1, respectively. CD and 1H-NMR results s...
In vitro mechanical properties of the accessory ligament of the deep digital flexor tendon in horses in relation to age.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 454-459 doi: 10.1111/j.2042-3306.1994.tb04049.x
Becker CK, Savelberg HH, Barneveld A.The material properties of the accessory ligament of the deep digital flexor tendon (AL) of 21 forelimbs from horses between ages one day and 15 years were determined. The force (634-11416 N), failure stress (45-138 N/mm2), failure strain (7-24%) and tangent modulus (33-1639 MPa) are presented in relation to age. Tangent modulus did not indicate changes in elasticity due to age. The results demonstrate that complete ligament failures (CLF) of ALs of older horses (mean 7835 N) occur at lower forces than ALs of young adult horses (mean 8894 N). Sudden decreases, 'dips', in the force-time curves ...
Distribution of equid herpesvirus-1 (EHV-1) in respiratory tract associated lymphoid tissue: implications for cellular immunity.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 470-473 doi: 10.1111/j.2042-3306.1994.tb04052.x
Kydd JH, Smith KC, Hannant D, Livesay GJ, Mumford JA.Twelve adult ponies and 2 conventional foals were exposed intranasally to EHV-1, strain Ab4 (TCID50 10(-6.6) and samples of respiratory tract associated lymphoid tissues were recovered between 12 h and 13 days after infection. Infectious virus was detected in tissue homogenates using susceptible cell monolayers and expression of viral antigens was monitored using indirect immunoperoxidase histochemistry on paraffin sections. The results showed both infectious EHV-1 and viral antigens in respiratory tract associated lymph nodes 12 h after exposure. Infected leucocytes were identified morphologi...
Induction of superovulation in DD mice at different stages of the oestrous cycle.
Journal of reproduction and fertility    November 1, 1994   Volume 102, Issue 2 263-267 doi: 10.1530/jrf.0.1020263
Redina OE, Amstislavsky SYa , Maksimovsky LF.This study examined the developmental capacity of oocytes in DD mice after they had been injected with pregnant mares' serum gonadotrophin at different stages of the oestrous cycle. The superovulation of mature DD mice at pro-oestrus, oestrus and metoestrus resulted in a large yield of viable embryos. The proportion of abnormal embryos was highest after injection of pregnant mares' serum gonadotrophin at dioestrus. The pool of viable oocytes was most synchronized with normal development after the hormone was injected at oestrus. The results demonstrate that oocytes of different morphology coul...
Hyperthermia during isoflurane anaesthesia in a horse with suspected hyperkalaemic periodic paralysis.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 511-514 doi: 10.1111/j.2042-3306.1994.tb04061.x
Cornick JL, Seahorn TL, Hartsfield SM.No abstract available
Effect of phenylephrine on hemodynamics and splenic dimensions in horses.
American journal of veterinary research    November 1, 1994   Volume 55, Issue 11 1570-1578 
Hardy J, Bednarski RM, Biller DS.Pharmacologically induced splenic contraction might be useful during certain medical or surgical procedures in horses. The effects of phenylephrine, an alpha 1-adrenergic receptor agonist, on hemodynamic function and splenic dimensions were examined in 6 healthy adult horses. Phenylephrine infusion (1, 3, or 6 micrograms/kg of body weight/min for 15 minutes) resulted in a dose-related increase in mean pulmonary artery pressure; right atrial pressure; systolic, mean, and diastolic arterial pressures; and packed cell volume (P = 0.0001). Concurrent decreases in heart rate and specific cardiac ou...
Three-dimensional sonographic imaging of the equine superficial digital flexor tendon.
American journal of veterinary research    November 1, 1994   Volume 55, Issue 11 1505-1508 
Wood AK, Sehgal CM, Reef VB.In a feasability study, a technique for constructing 3-dimensional sonographic images of the superficial digital flexor tendon (SDFT) was established in 6 clinically normal horses and applied to 7 horses with injured SDFT. Two-dimensional B-mode sonographic images were recorded on videotape as the sonographic transducer was manually moved along the palmar aspect of the metacarpal region. Selected videofields were digitized, and 3-dimensional images were constructed, using a computer work station and dedicated software program. The 3-dimensional images were of high quality and presented qualita...
Sevoflurane and oxygen anaesthesia following administration of atropine-xylazine-guaifenesin-thiopental in spontaneously breathing horses.
Zentralblatt fur Veterinarmedizin. Reihe A    November 1, 1994   Volume 41, Issue 9 700-708 doi: 10.1111/j.1439-0442.1994.tb00138.x
Hikasa Y, Takase K, Ogasawara S.The effects of sevoflurane-oxygen anaesthesia at a light-surgical depth on clinically important features were evaluated in spontaneously breathing horses that received atropine, xylazine, and guaifenesin-thiopental. Mean end-tidal concentrations of sevoflurane ranged from 1.6 to 2.3% during 90 min maintenance. Recovery from anaesthesia was extremely rapid and smooth. Heart rates did not significantly change after anaesthesia. Arrhythmia was not observed. Mean arterial pressure (mean +/- SD) ranged from 86 +/- 17 to 98 +/- 5 mmHg during anaesthesia. Minute ventilation was low due to decreased r...
Equine motor neuron disease and grass sickness.
The Veterinary record    October 29, 1994   Volume 135, Issue 18 440 doi: 10.1136/vr.135.18.440-b
Gerber H.No abstract available
Artificially dehydrated lucerne for horses.
The Veterinary record    October 29, 1994   Volume 135, Issue 18 426-429 doi: 10.1136/vr.135.18.426
Cí·¯ord D.Artificially dehydrated lucerne produced in the United Kingdom has been shown to be a better source of nutrients for horses than grass hay. Horses eat more lucerne when it is pelleted, and the processing has little effect on its nutritive value. Lucerne does not appear to contain any antinutritional factors of significance to horses. Lucerne contains readily available calcium and protein and can thus be used as a cereal-balancer or to upgrade poor quality roughages. Because lucerne is a good source of digestible nutrients it has therapeutic applications, including the correction of electrolyte...