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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Fluid therapy.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 517-525 doi: 10.1016/s0749-0739(17)30343-7
Seahorn TL, Cornick-Seahorn J.Fluid therapy is an integral part of treatment of the equine emergency patient. In this article, general principles of fluid therapy are discussed, including formulas for calculation of fluid volumes, fluid types and their indications, and specific therapy for several emergency conditions.
Acute rhabdomyolysis.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 567-573 doi: 10.1016/s0749-0739(17)30347-4
Andrews FM.Early aggressive medical therapy in horses with acute rhabdomyolysis is essential to prevent further muscle damage and secondary complications, such as laminitis and acute renal failure. A variety of pharmacologic agents may be helpful in the treatment of this condition but may have adverse affects if hydration status is not corrected first or concurrently with oral or intravenous fluids. Early aggressive therapy will help prevent irreversible muscle damage that could lead to poor performance in the future.
Consideration of anatomic and radiographic features of the caudal pouches of the femorotibial joints of horses for the purpose of arthroscopy.
American journal of veterinary research    December 1, 1994   Volume 55, Issue 12 1682-1689 
Trumble TN, Stick JA, Arnoczky SP, Rosenstein D.Development of an arthroscopic approach to the caudal pouches of the equine stifle has been necessary because cranial approaches do not allow access to articular lesions in the caudal aspect of the joint. Therefore, the anatomy of the caudal region was examined in 52 cadaver limbs by use of gross dissection (29), x-ray-computed tomography (6), fluoroscopy (8), or arthroscopy (9). Additionally, using arthroscopic techniques developed in equine cadaver limbs, 3 stifles from 2 anesthetized horses were arthroscopically explored. Fluoroscopy was used to verify needle placement for joint injection a...
Novel force transducer for the measurement of tendon force in vivo.
Journal of biomechanics    December 1, 1994   Volume 27, Issue 12 1489-1493 doi: 10.1016/0021-9290(94)90198-8
Platt D, Wilson AM, Timbs A, Wright IM, Goodship AE.No abstract available
Acute laminitis.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 627-642 doi: 10.1016/s0749-0739(17)30351-6
Baxter GM.Laminitis is an inflammation of the sensitive laminae along the dorsal aspect of the digit and is considered to be a secondary complication of several predisposing or primary factors. Affected horses are usually very lame, have increased digital pulses, are painful to hoof testers along the toe of the foot, and have evidence of downward rotation or distal displacement of the distal phalanx present on radiographs. Treatments for acute laminitis include anti-inflammatory drugs, anti-endotoxin therapy, vasodilators, antithrombotic therapy, corrective trimming and shoeing, and surgical procedures....
Prevention of acidosis and laminitis associated with grain feeding in horses.
The Journal of nutrition    December 1, 1994   Volume 124, Issue 12 Suppl 2742S-2744S doi: 10.1093/jn/124.suppl_12.2747S
Rowe JB, Lees MJ, Pethick DW.No abstract available
A comparative study of the pharmacokinetics of intravenous and oral trimethoprim/sulfadiazine formulations in the horse.
Journal of veterinary pharmacology and therapeutics    December 1, 1994   Volume 17, Issue 6 440-446 doi: 10.1111/j.1365-2885.1994.tb00275.x
van Duijkeren E, Vulto AG, Sloet van Oldruitenborghoosterbaan MM, Mevius DJ, Kessels BG, Breukink HJ, van Miert AS.The biopharmaceutical properties of four fixed trimethoprim/sulfonamide combinations were investigated in the horse. Eight fasted horses were dosed at 1 week intervals in a sequentially designed study with one intravenous (i.v.) and three oral trimethoprim/sulfadiazine (TMP/SDZ) formulations (1, 2 and 3) administered at a dose of 5 mg/kg trimethoprim (TMP) and 25 mg/kg sulfadiazine (SDZ). Plasma concentrations of each compound were monitored for 48 h. Pharmacokinetic parameters (volume of distribution, bioavailability and total body clearance) for TMP and SDZ were calculated and compared. Afte...
Equine model of inducing ulceration in alimentary squamous epithelial mucosa.
Digestive diseases and sciences    December 1, 1994   Volume 39, Issue 12 2530-2535 doi: 10.1007/BF02087686
Murray MJ.Ulceration of the gastric squamous epithelial mucosa was induced in 10 horses using a feeding protocol previously shown to expose the gastric mucosa to repeated periods of high acidity. The feeding protocol consisted of alternating feed deprivation with free access to hay. Over a period of seven days, each horse was provided hay for 84 hr and deprived of hay for 84 hr. Hay was never withheld for longer than 24 hr at a time. Gastroscopy was performed on each horse at the beginning of the protocol after 12 hr of feed deprivation, and after a total of 36 hr, 60 hr, and 84 hr of feed deprivation. ...
Soft tissue emergency in adult horses.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 575-590 doi: 10.1016/s0749-0739(17)30348-6
French DA.Equine practitioners are frequently called to attend to soft tissue injuries. The majority of these cases are routine and straightforward; however, a certain percentage may present as a life-threatening situation with potentially serious complications. Client communication, adequate preparation, patient stabilization, accurate injury assessment and appropriate wound preparation are key factors to expedite recovery and achieve a favorable outcome. Understanding the limitations of field therapy and deciding when to transport the case to a clinic or referral center plays an important role in the ...
[Equestrian accidents in children and adolescents].
Der Unfallchirurg    December 1, 1994   Volume 97, Issue 12 661-662 
Schmidt B, Mayr J, Fasching G, Nöres H.The rate of pediatric equestrian injuries is relatively low, but the severity of injuries is greater than in many other pediatric sport activities. In a 4-year period the charts of 109 patients up through the age of 15 years, who were admitted for equestrian-related injuries were reviewed. Falls from horses are the most frequent cause of injuries and responsible for their anatomic localization and type of injury. In our study the upper extremity was the most common (38%) area injured and head injuries comprised the second largest group with 36%. Forty percent of all injuries were fractures, 72...
Efficacy of the new radiographic measurement method for cervical vertebral instability in wobbling foals.
The Journal of veterinary medical science    December 1, 1994   Volume 56, Issue 6 1119-1122 doi: 10.1292/jvms.56.1119
Tomizawa N, Nishimura R, Sasaki N, Kadosawa T, Senba H, Hara S, Takeuchi A.Cervical myelography and survey radiography was performed on 12 light breed wobbling foals and a new radiographic measurement method was applied for more accurate diagnosis of cervical vertebral instability. Ratios of stenosis of the spinal canal on survey radiography and myelography using relative values in an individual foal were defined on radiograms of lateral flexed position of mid-cervical region, and coincidence between the ratios and histopathological lesions in the cervical spinal cord was investigated. Five of 6 foals had ratios of stenosis on myelography more than 40% at the interve...
Endogenic nortestosterone in cattle?
The Analyst    December 1, 1994   Volume 119, Issue 12 2581-2585 doi: 10.1039/an9941902581
de Brabander HF, van Hende J, Batjoens P, Hendriks L, Raus J, Smets F, Pottie G, van Ginkel L, Stephany RW.When residues of nortestosterone (NT) were found in the urine of cattle, racehorses or bodybuilders, exogenic administration was thought to be proven. In previous literature, no records were found of the endogenic presence of this molecule. In the horse-racing world, Houghton and Courthot found that NT is normally present in the urine of the stallion. Belgian and Dutch researchers found that NT is also present in the urine and edible parts of the intact boar. Vandenbroeck et al. (1991) suggested the endogenous presence of NT (in the beta form) in the pregnant cow. Meyer (1992) reported the pre...
Determination of succinonitrile in horse urine by gas chromatography-nitrogen-phosphorus detector and gas chromatography-mass spectrometry.
The Analyst    December 1, 1994   Volume 119, Issue 12 2697-2699 doi: 10.1039/an9941902697
Pedroso RC, Salvadori MC, Andraus MH, Lopez NM.A chromatographic method was developed to detect and confirm the presence of succinonitrile (SDN) in horse urine samples, for antidoping control. The urine samples (5 ml) were extracted with diethyl ether and screened by gas chromatography-nitrogen-phosphorus detector and the confirmation of the drug's presence was accomplished by using gas chromatography-mass selective detection. The recovery of extraction was 78 and 81% for 1.0 and 2.0 micrograms ml-1 (relative standard deviation, < 10%), respectively. Urine samples collected after the administration of Energisan were positive for SDN (1-30 ...
Multifocal myositis associated with Sarcocystis sp in a horse.
Journal of the American Veterinary Medical Association    December 1, 1994   Volume 205, Issue 11 1574-1576 
Traub-Dargatz JL, Schlipf JW, Granstrom DE, Ingram JT, Shelton GD, Getzy DM, Lappin MR, Baker DC.Multifocal myositis was diagnosed in a 7-year-old Quarter Horse gelding on the basis of history and findings on physical examination, serum biochemical analysis, electromyography, and microscopic examination of frozen sections of muscle biopsy specimens. Histologic examination of the muscle specimen revealed multifocal accumulations of histiocytes, lymphocytes, and plasma cells, with attendant myofiber degeneration and necrosis. Parasitic cysts with morphologic characteristics of Sarcocystis sp were found in regions of myocyte degeneration and necrosis, and in regions of normal muscle. Based o...
Management of orthopedic emergencies.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 603-625 doi: 10.1016/s0749-0739(17)30350-4
Bertone AL.Initial management of injuries includes safely gaining control of the animal and assessing and treating systemic shock. If hemorrhage is life threatening, it must be controlled. If the limb is nonfunctional it should be stabilized. Any open orthopedic injury should be treated by cleaning the tissues, protecting the exposed tissues, and administering systemic antibiotics. A commercial splint is available (Equine Regular Leg Saver Splint, Kimzey Welding Works, Woodland, CA) that can immobilize and relieve weightbearing for cases of phalangeal fracture, flexor tendon rupture, fetlock breakdown, a...
Emergency analgesia and chemical restraint in the horse.
The Veterinary clinics of North America. Equine practice    December 1, 1994   Volume 10, Issue 3 503-516 doi: 10.1016/s0749-0739(17)30342-5
Hubbell JA, Muir WW.Clinical examination of the equine patient with acute abdominal pain should identify the affected body system and yield a provisional diagnosis. Determination of signalment, history, physical examination, and basic laboratory tests should assist in classification of the gastrointestinal disorder and direct the therapeutic plan. Determination of the definitive diagnosis of abdominal pain based on clinical examination is not crucial. For a successful outcome, efforts should be directed toward early recognition of the need for surgery and treatment of cardiovascular compromise in horses with seve...
Sequence analyses of the p24 gene of Borna disease virus in naturally infected horse, donkey and sheep.
Virus research    December 1, 1994   Volume 34, Issue 3 281-289 doi: 10.1016/0168-1702(94)90128-7
Binz T, Lebelt J, Niemann H, Hagenau K.By reverse transcriptase/PCR amplification and subsequent sequence determination of the p24 gene, the relatedness of Borna disease virus (BDV) in various naturally infected animal species was determined. These results are indicative of a common ancestral virus pool and a remarkably low species barrier of BDV. Comparison of 11 sequences to that of tissue culture adapted virus revealed that the homology among all isolates was at least 96.2% at the nucleotide level, and 97% at the amino acid level. Viral sequences from sheep, donkey and horse were found to be not more distantly related to each ot...
Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling.
Journal of veterinary pharmacology and therapeutics    December 1, 1994   Volume 17, Issue 6 459-469 doi: 10.1111/j.1365-2885.1994.tb00278.x
Toutain PL, Autefage A, Legrand C, Alvinerie M.The purpose of the present study was to establish in the horse the relationship between plasma concentration profiles of phenylbutazone (PBZ) and flunixin meglumine (FM) and their pharmacological effects in order to build a predictive pharmacokinetic/pharmacodynamic (PK/PD) model. In five horses, an experimental arthritis was induced by injecting Freund's adjuvant into a carpal joint. PBZ (4 mg/kg) and FM (1 mg/kg) were injected by the intravenous route as a single intravenous dose in two different trials. Five pharmacodynamic end-points were regularly measured after test article injection usi...
Fumonisin toxicosis in domestic animals: a review.
Veterinary and human toxicology    December 1, 1994   Volume 36, Issue 6 548-555 
Diaz GJ, Boermans HJ.Fumonisins are the most recently discovered group of mycotoxins with important implications in animal health. Equine leucoencephalomalacia and porcine pulmonary edema are diseases observed for many years, but their etiology was unknown. These 2 syndromes were recently reproduced experimentally after administration of purified fumonisin B1 (FB1). The main target organs for the toxic actions of FB1 are the brain in horses and the lungs in the case of swine. However, severe liver damage in both species and pancreatic lesions in swine are also observed, especially when Fusarium moniliforme culture...
Comparison of theophylline pharmacokinetics in yearling and 4-year-old horses.
Journal of veterinary pharmacology and therapeutics    December 1, 1994   Volume 17, Issue 6 473-476 doi: 10.1111/j.1365-2885.1994.tb00280.x
Perez Y, Puigdemont A, Cristofol C, De Mora F, Arboix M.No abstract available
Ventricular tachycardia and myocardial dysfunction in a horse.
Journal of the American Veterinary Medical Association    December 1, 1994   Volume 205, Issue 11 1569-1573 
Traub-Dargatz JL, Schlipf JW, Boon J, Ogilvie GK, Bennett DG, Wingfield WE, Hutchison JM.Ventricular tachycardia develops less frequently than supraventricular dysrhythmias and generally is more indicative of cardiac disease. The horse in this report had clinical signs of lethargy and hypophagia and was determined to have sustained ventricular tachycardia. Echocardiography was a valuable diagnostic tool and revealed an echodense area in the left ventricle that had subnormal ventricular performance. A primary heart problem of an inflammatory nature was suspected. The horse responded favorably to treatment with lidocaine, antimicrobials, and aspirin, as well as stall rest. The horse...
Evidence that the agent of equine grass sickness may reach neurons by retrograde axonal transport.
The Veterinary record    November 26, 1994   Volume 135, Issue 22 520-523 doi: 10.1136/vr.135.22.520
Griffiths IR, Smith S, Doxey DL, Whitwell K, Love S.Sera from acute and chronic cases of natural grass sickness or normal horses were injected into the parotid salivary gland of ponies. This gland receives its sympathetic innervation from the ipsilateral cranial cervical ganglion. None of the ponies showed any local or systemic signs of illness. After one week the cranial cervical ganglia, stellate and coeliaco-mesenteric ganglia were removed for histological study. Pathological changes were found only in the cranial cervical ganglion ipsilateral to a parotid salivary gland which had received an injection of grass sickness serum. Four out of fi...
Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992).
Journal of the American Veterinary Medical Association    November 15, 1994   Volume 205, Issue 10 1432-1436 
Garber JL, Reef VB, Reimer JM.Sonographic findings correlated with necropsy findings in 8 of 9 horses in which the cranial portion of the mediastinum was evaluated by use of both methods. Cranial mediastinal masses were imaged as multilobular and homogeneously hypoechoic; a complex echogenic pattern was observed with necrosis within the mass. Pleural effusion was a common finding in horses with mediastinal lymphosarcoma. Cytologic evaluation of pleural fluid samples was useful in diagnosis of lymphosarcoma in 10 of 12 horses that had thoracentesis. Sonographic examination of the thorax and cranial portion of the mediastinu...
[Renal tubular acidosis (type 2) in a Friesian mare].
Tijdschrift voor diergeneeskunde    November 15, 1994   Volume 119, Issue 22 675-676 
van der Kolk JH.A 2-year-old Friesian mare was examined because she had been sluggish for a few weeks. Blood biochemistry showed that concentrations of creatinine (136 mumol.L-1) and urea nitrogen (6.1 mmol.L-1) in plasma were within their normal limits. Severe metabolic acidosis was apparent; the venous pH was 7.154 and the bicarbonate concentration was 13 mmol.L-1. The base excess amounted to -15.3 mmol.L-1 and the venous pCO2 measured 5.1 kPa. Plasma sodium was normal (135 mmol.L-1) and plasma chloride (113 mmol.L-1) was slightly elevated, but there was a hypokalaemia (2.9 mmol.L-1). The urine had a specif...
Management of perianal squamous cell carcinoma with permanent colostomy in a mare.
Journal of the American Veterinary Medical Association    November 15, 1994   Volume 205, Issue 10 1430-1431 
Wilson DA.A 28-year-old Pinto mare was evaluated for multiple recurrences of a perianal squamous cell carcinoma. Clinical signs included lethargy, inappetence, weight loss, dyschezia, and hematochezia. The tumor involved the proximal portion of the vulvar labia, the perineum, and the anus, and there was a rectal fistula just left of the anus. Permanent end-on colostomy without further treatment of the carcinoma was the management option chosen. The colostomy functioned satisfactorily, and the mare's condition was stable for the next 14 months. Recurrence of lethargy and inappetence and development of we...
Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates.
Virology    November 15, 1994   Volume 205, Issue 1 17-23 doi: 10.1006/viro.1994.1615
Connor RJ, Kawaoka Y, Webster RG, Paulson JC.The receptor specificity of 56 H2 and H3 influenza virus isolates from various animal species has been determined to test the relevance of receptor specificity to the ecology of influenza virus. The results show that the receptor specificity of both H2 and H3 isolates evaluated for sialic acid linkage specificity and inhibition of hemagglutination by horse serum correlates with the species of origin, as postulated earlier for H3 strains based on a limited survey of five human, three avian, and one equine strain. Elucidation of the amino acid sequence of several human H2 receptor variants and a...
Investigations on naturally occurring Trypanosoma evansi infections in horses, cattle, dogs and capybaras (Hydrochaeris hydrochaeris) in Pantanal de Poconé (Mato Grosso, Brazil).
Acta tropica    November 1, 1994   Volume 58, Issue 2 159-169 doi: 10.1016/0001-706x(94)90055-8
Franke CR, Greiner M, Mehlitz D.The prevalence of Mal de Cadeiras--Portuguese for Trypanosoma (T.) evansi infections in horses--as well as the prevalence of T.evansi infections in cattle, dogs and free-ranging capybaras (Hydrochaeris hydrochaeris) was investigated in Pantanal de Poconé (Mato Grosso, Brazil). In 0.3, 8.6 and 8.0% of the horses, dogs and capybaras, respectively, infection was detected using standard parasitological methods. A seroprevalence of 4.1, 2.3, 7.1 and 22.0% was found in horses, cattle, dogs and capybaras, respectively, using an enzyme-linked immunosorbent assay for the detection of T.evansi antigen ...
Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro.
Research in veterinary science    November 1, 1994   Volume 57, Issue 3 317-324 doi: 10.1016/0034-5288(94)90124-4
Jarvis GE, Evans RJ.Endotoxaemia is a leading cause of death among horses. Thrombocytopenia is a common finding in clinical and experimentally-induced cases of endotoxaemia and can lead to coagulopathies, including disseminated intravascular coagulopathy which is usually fatal. In this study it was shown that endotoxin (3 ng ml-1 to 25 micrograms ml-1) can aggregate equine platelets in heparinised whole blood in vitro. The endotoxin-induced aggregation (EIA) was shown to be dependent on the presence of leucocytes in the blood and did not occur when detoxified endotoxin was used, suggesting that lipid A was necess...
Modulation of K(+)-Cl- cotransport in equine red blood cells.
Experimental physiology    November 1, 1994   Volume 79, Issue 6 997-1009 doi: 10.1113/expphysiol.1994.sp003824
Gibson JS, Godart H, Ellory JC, Staines H, Honess NA, Cossins AR.Potassium transport was measured in equine red blood cells, using 86Rb+ influx as a convenient assay. A significant component of volume- and pH-sensitive K(+)-Cl- cotransport to the overall K+ flux was observed in all blood samples studied, although fluxes were variable between animals, and within individuals when measured at intervals over a period of weeks. The aryloxyacetic acid [(dihydroindenyl)oxy]alkanoic acid (DIOA), at a final concentration of 100 microM, inhibited most (> 95%) of the Cl(-)-dependent K+ flux, and DIOA sensitivity was therefore used to define the activity of the K(+)...
Observations on the anatomy and pathology of the palmar intercarpal ligaments in the middle carpal joints of thoroughbred racehorses.
Equine veterinary journal    November 1, 1994   Volume 26, Issue 6 486-491 doi: 10.1111/j.2042-3306.1994.tb04055.x
Phillips TJ, Wright IM.Ten carpi from juvenile Thoroughbred horses were dissected in detail to record the anatomy of the palmar intercarpal ligaments (PICLs). These were found not to be substantially attached to the palmar carpal ligament. The lateral PICL was sited at the convergence of the palmar aspects of the third, fourth, intermediate and ulnar carpal bones and aligned predominantly in a proximodistal direction. The medial PICL had a large origin distally on the lateral aspect of the radial carpal bone (Cr) and attached to third (C3) and second (C2) carpal bones with apparently separate fibre orientations. Fib...