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Topic:Fractures

Fractures in horses refer to the disruption in the continuity of a bone, often resulting from trauma, excessive stress, or pathological conditions. These injuries can vary in severity, from simple, non-displaced fractures to complex, comminuted fractures involving multiple bone fragments. Fractures can affect any bone in a horse's body, but they are most commonly observed in the limbs due to the high mechanical loads these structures endure. Diagnosis typically involves clinical examination and imaging techniques such as radiography or ultrasound to assess the extent and nature of the fracture. Treatment strategies depend on the type and location of the fracture and may include rest, immobilization, surgical intervention, or a combination of these approaches. This page aggregates peer-reviewed research and scholarly articles focusing on the etiology, diagnosis, management, and outcomes of fractures in horses, providing insights into current veterinary practices and advancements in equine orthopedic care.
A method for fatigue testing of equine McIII subchondral bone under a simulated fast workout training programme.
Equine veterinary journal    September 11, 2019   Volume 52, Issue 2 332-335 doi: 10.1111/evj.13163
Shaktivesh , Malekipour F, Whitton C, Lee PVS.Standard fatigue testing of bone uses a single load and frequency applied until failure. However, in situ, the subchondral bone of Thoroughbred racehorses is subjected to a combination (or a spectrum) of loads and frequencies during training and racing. Objective: To investigate the use of a fatigue testing method for equine third metacarpal (McIII) subchondral bone under a spectrum of loading conditions which a racehorse is likely to experience during a fast workout. Methods: In vitro biomechanical experimental study. Methods: McIII subchondral bone specimens (n = 12) of racehorses were ha...
Long-term clinical and radiographic results after lag screw ostheosynthesis of short incomplete proximal sagittal fractures of the proximal phalanx in horses not used for racing.
Veterinary surgery : VS    August 21, 2019   Volume 49, Issue 1 88-95 doi: 10.1111/vsu.13314
Bryner MF, Hoey SE, Montavon S, Fürst AE, Kümmerle JM.To determine long term outcomes of nonracing equines athletes treated for short incomplete proximal sagittal fractures of the proximal phalanx (SIPSFP1) by lag screw fixation. Methods: Retrospective study. Methods: Thirty-one horses. Methods: Medical records from horses with an SIPSFP1 (2008-2014) were reviewed. Long-term (≥12 months) outcomes were assessed with telephone interviews and clinical and radiographic examinations. Results: Warmblood was the predominant breed in cases included in the study. Among horses with long-term interview information, 27 of 31 returned to previous athletic...
Radiographic and arthroscopic features of third carpal bone slab fractures and their impact on racing performance following arthroscopic repair in a population of racing Thoroughbreds in the UK.
Equine veterinary journal    August 19, 2019   Volume 52, Issue 2 213-218 doi: 10.1111/evj.13155
Baldwin CM, Smith MRW, Allen S, Wright IM.Slab fractures of the third carpal bone (C3) are a common injury of Thoroughbred racehorses. Results of arthroscopically guided repair have not been reported since the initial description of the technique in 1986. Additionally, fracture details and racing outcomes in a population of Thoroughbreds racing under UK jurisdiction have not previously been described. Objective: To report the frequency distribution of C3 slab fractures and to determine the impact on racing performance following arthroscopically guided repair in a population of Thoroughbred racehorses. Methods: Retrospective case serie...
Letter to the Editor: Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses?
Equine veterinary journal    August 3, 2019   Volume 51, Issue 5 706-707 doi: 10.1111/evj.13138
Pease A, Marr C.No abstract available
Risks and Outcomes of Equine Flat Bone Fractures.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    July 18, 2019   Volume 32, Issue 4 v doi: 10.1055/s-0039-1693467
Johnson KA.No abstract available
Outcome of Pelvic Fractures Identified in 75 Horses in a Referral Centre: A Retrospective Study.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    July 18, 2019   Volume 32, Issue 4 274-281 doi: 10.1055/s-0039-1688774
Moiroud CH, Coudry V, Denoix JM. The aim of this study was to evaluate the reliability of fracture location and horse sporting discipline as prognostic indicators after a pelvic fracture in a referral centre caseload. Methods:  Data were collected for the short- and long-term follow-up of all cases with a diagnosis of pelvic fracture in a 7-year period. Information was obtained for 75 horses through a postal and internet survey. The proportion of horses returning to competition following fractures was compared between groups according to the competition discipline and the characteristics of the fracture. Results:  Fort...
Comparative Stiffness of an Equine Distal Sesamoid Bone Fracture Model Stabilized with 3.5-mm versus 4.5-mm Cortical Bone Screws in Lag Fashion.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    July 6, 2019   Volume 32, Issue 6 440-446 doi: 10.1055/s-0039-1692979
Mampe JR, Tatarniuk DM, Suarez-Fuentes DG, Kraus KH. The aim of this study was to to determine the comparative stiffness following repair of an axial sagittal fracture model in equine distal sesamoid bones using either a single 3.5-mm or 4.5-mm cortical bone screw placed in lag fashion. Methods:  The present study was an biomechanical study. Results:  The mean (±standard deviation) stiffness value for the 4.5-mm screw-bone construct (522.49 N/mm ± 168.21) was significantly greater than the 3.5-mm screw-bone construct (408.46 N/mm ± 131.13) ( = 0.047). This represents a 28% difference in mean stiffness. Conclusions:  ...
Standing MRI for surgical planning of equine fracture repair.
Veterinary surgery : VS    July 3, 2019   Volume 48, Issue 8 1372-1381 doi: 10.1111/vsu.13272
Genton M, Vila T, Olive J, Rossignol F.To report the feasibility of standing MRI (sMRI) and document the value of sMRI in surgical planning for surgical repair of limb fractures in the horse. Methods: Retrospective case series. Methods: Thirty-one horses with preoperative sMRI. Methods: Medical records were reviewed for fracture type, application of a polyester cast, sMRI sequences performed, technical variables, and image quality. Fracture geometry and concomitant lesions were compared between sMRI and radiography. The relative value of sMRI with regard to surgical planning was classified as minor (sMRI did not provide additional ...
Bisphosphonate use in the horse: what is good and what is not?
BMC veterinary research    June 24, 2019   Volume 15, Issue 1 211 doi: 10.1186/s12917-019-1966-x
Mitchell A, Watts AE, Ebetino FH, Suva LJ.Bisphosphonates (BPs) are a family of molecules characterized by two key properties: their ability to bind strongly to bone mineral and their inhibitory effects on mature osteoclasts and thus bone resorption. Chemically two groups of BPs are recognized, non-nitrogen-containing and nitrogen-containing BPs. Non-nitrogen-containing BPs incorporate into the energy pathways of the osteoclast, resulting in disrupted cellular energy metabolism leading to cytotoxic effects and osteoclast apoptosis. Nitrogen-containing BPs primarily inhibit cholesterol biosynthesis resulting in the disruption of intrac...
Incomplete fracture of the talus secondary to maladaptive stress remodeling in a horse.
Journal of the American Veterinary Medical Association    June 14, 2019   Volume 255, Issue 1 102-108 doi: 10.2460/javma.255.1.102
Katzman SA, Spriet MP, Beck BR, Barrett MF, Hendrickson DA.A 6-year-old Quarter Horse gelding used for barrel racing was evaluated for acute onset of non-weight-bearing lameness of the left hind limb following strenuous exercise. Nuclear scintigraphic imaging revealed focal increased radiopharmaceutical uptake centrally within the left talus. Subsequent standard radiographic and ultrasonographic examinations of the tarsus failed to identify the cause of the increased radiopharmaceutical uptake; however, the lameness was definitively localized to the tarsocrural joint by intra-articular anesthesia. Subsequent MRI sequences of the left tarsus revealed a...
Surgical site infection associated with equine orthopedic internal fixation: 155 cases (2008-2016).
Veterinary surgery : VS    April 16, 2019   Volume 48, Issue 5 685-693 doi: 10.1111/vsu.13216
Curtiss AL, Stefanovski D, Richardson DW.To determine the prevalence of surgical site infection (SSI) after internal fixation and to identify risk factors for SSI and nonsurvival. Methods: Retrospective study. Methods: One hundred fifty-five horses with long bone fractures or arthrodesis treated by internal fixation at 1 hospital between 2008-2016. Methods: Signalment, diagnosis, surgical repair, surgeon, surgical time, antimicrobial use, SSI onset, bacterial identification, and adjunct treatments were recorded. Perioperative variables were analyzed to identify risk factors associated with outcomes. Results: Surgical-site infection w...
Influence of plate type and placement on the immobilization of bilateral equine mandibular osteotomies: Ex vivo study.
Veterinary surgery : VS    April 5, 2019   Volume 48, Issue 8 1450-1455 doi: 10.1111/vsu.13198
Durket E, Kersh K, Dembek K, Riedesel E, Silverstone A, Kraus KH.To determine the influence of plate fixation (locking or dynamic compression) and the site of application (ventral [V] or ventrolateral [VL]) on the resistance to bending of transverse mandibular fractures. Methods: Ex vivo, simple randomized study. Methods: Mandibles harvested from adult equine cadavers (n = 18). Methods: Bilateral osteotomies were created 1 cm caudal to the mental foramen and perpendicular to the long axis of each mandible. Mandibles were fixed with 1 of 3 methods: (1) VL dynamic compression plate (DCP), (2) V-DCP, or (3) VL locking compression plating (LCP). Construct...
Hypoxia and mesenchymal stromal cells as key drivers of initial fracture healing in an equine in vitro fracture hematoma model.
PloS one    April 4, 2019   Volume 14, Issue 4 e0214276 doi: 10.1371/journal.pone.0214276
Pfeiffenberger M, Bartsch J, Hoff P, Ponomarev I, Barnewitz D, Thöne-Reineke C, Buttgereit F, Gaber T, Lang A.Fractures in horses-whether simple fractures with just one clean break, or incomplete greenstick with stress fractures, or complications such as shattered bones can all be either minimal or even catastrophic. Thus, improvement in fracture healing is a hallmark in equine orthopedics. The fracture healing process implements a complex sequence of events including the initial inflammatory phase removing damaged tissue, re-establishment of vessels and mesenchymal stromal cells, a soft and hard callus phase closing the fracture gap as well as the remodeling phase shaping the bone to a scar-free tiss...
A Thoroughbred racehorse with a unicortical palmar lateral condylar fracture returned to training 14 days after surgery: a hypothesis on the role of a single bone screw on crack propagation.
Journal of equine science    April 3, 2019   Volume 30, Issue 1 7-12 doi: 10.1294/jes.30.7
Brown HR, Peloso JG, Werner WC, Mecholsky JJ, Cohen ND, Vogler JB.A 2-year-old Thoroughbred racehorse had LF lameness that began post high-speed exercise and persisted for two days before the horse once again became sound. Diagnostic analgesia localized the lameness to the LF distal metacarpus, and a standing MRI identified a unicortical condylar fracture. A single 5.5 mm cortical screw was placed in lag fashion. The horse began hand walking at 14 days, racetrack jogging at 30 days, and racing at 5 months after the day of surgery. Placement of a single lag screw ahead of the tip of the crack in unicortical condylar fracture may be useful for reducing the rec...
Markers for oxidative stress in the synovial fluid of Thoroughbred horses with carpal bone fracture.
Journal of equine science    April 3, 2019   Volume 30, Issue 1 13-16 doi: 10.1294/jes.30.13
Tsuzuki N, Kanbayashi Y, Kusano K.Arthritis is thought to cause oxidative stress in synovial fluid in humans, but there have been few reports in horses. To evaluate oxidative stress in synovial fluid in horses, this study used 19 horses with unilateral fracture of the carpal joint bone. Synovial fluid was collected from the carpal joint on the fracture (arthritis group) and contralateral (control group) sides. Diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were then measured, and the oxidative stress index (OSI) was calculated. d-ROMs and OSI of the arthritis group were significantly hi...
Prevalence, radiographic resolution and outcomes of slab fractures of the third and central tarsal bones in juvenile Thoroughbred horses.
Australian veterinary journal    March 29, 2019   Volume 97, Issue 4 108-115 doi: 10.1111/avj.12790
Steel CM, Collins VL, Hance SR, Adkins AR, Hitchens PL.Veterinarians are required to interpret the significance of radiographic findings for sale, soundness and future racing performance of weanling and yearling Thoroughbreds. We investigated the prevalence and radiographic appearance of slab fractures of the third (T3) and central tarsal (Tc) bones. Methods: Weanling and yearling horses with complete or incomplete T3 or Tc fracture were identified by searching a database of radiographs. The prevalence and radiographic appearance at initial diagnosis and after continued pasture turnout, as well as prognosis for racing, of fractures of T3 and Tc we...
Epoxy-Pin External Skeletal Fixation for Management of Open Bone Fractures in Calves and Foals: A Review of 32 Cases.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    March 28, 2019   Volume 32, Issue 3 257-268 doi: 10.1055/s-0039-1678736
Aithal HP, Kinjavdekar P, Pawde AM, Dubey P, Kumar R, Tyagi SK, Madhu DN. The aim of this study was to evaluate epoxy-pin external skeletal fixation technique for the treatment of open fractures in calves and foals. Methods:  Twenty-eight calves and four foals (weighing 45-105 kg) with fractures distal to the stifle or elbow made the subject for the retrospective study. The pins (2.0-3.0-mm Kirschner wires, crossed at 60-90°) were fixed at least at two locations in both proximal and distal bone fragments as per the case situation. The pins in the same plane were bent (∼2 cm from the skin) towards the fracture site or joint and were joined using an adhesive t...
Distribution of Pelvic Fractures in Racing and Non-racing Sport Horses: A Retrospective Study of 86 Cases Examined in a Referral Centre.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    March 28, 2019   Volume 32, Issue 3 215-221 doi: 10.1055/s-0039-1683403
Moiroud CH, Coudry V, Denoix JM. The aim of this study was to analyse the pelvic fracture distribution and location in a referral centre caseload. Methods:  Medical records of 6,717 horses examined in a referral centre over a 7-year period were reviewed to identify all horses diagnosed with a pelvic fracture. Eighty-six horses were identified and divided into three disciplines, namely Thoroughbred racehorses (TBR), Standardbred trotter racehorses (STR) and non-racing sport horses (NRSH). Results:  A pelvic fracture was diagnosed in 1.3% of the cases examined during the study period. Prevalence was significantly higher ...
Temporal changes in synovial fluid composition and elastoviscous lubrication in the equine carpal fracture model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society    March 28, 2019   Volume 37, Issue 5 1071-1079 doi: 10.1002/jor.24281
Feeney E, Peal BT, Inglis JE, Su J, Nixon AJ, Bonassar LJ, Reesink HL.The objective of this study was to examine temporal variations in synovial fluid composition and lubrication following articular fracture. Post-traumatic osteoarthritis (PTOA) was induced by creating an osteochondral fracture in the middle carpal joint of four horses while the contralateral limb served as a sham-operated control. Horses were exercised on a high-speed treadmill, and synovial fluid was collected pre-operatively and at serial timepoints until 75 days post-operatively. Lubricin and hyaluronic acid (HA) concentrations were measured using sandwich ELISAs, and the molecular weight di...
Erythrocytosis and fatigue fractures associated with hepatoblastoma in a 3-year-old gelding.
Journal of the South African Veterinary Association    March 28, 2019   Volume 90 e1-e5 doi: 10.4102/jsava.v90i0.1708
Tirosh-Levy S, Perl S, Valentine BA, Kelmer G.Hepatoblastoma was diagnosed in a 3-year-old Thoroughbred gelding presented with forelimb lameness with bilateral fatigue fractures of the proximal third metacarpal bones. An abdominal mass was detected on ultrasound examination of the abdomen. Absolute erythrocytosis was diagnosed after clinical and haematological evaluation. The fractured metacarpal bones were surgically removed but complications after surgery were fatal. The liver mass was diagnosed as a hepatoblastoma based on histology and immunochemical staining. The combination of hepatoblastoma and fatigue fractures has not been descri...
Standing magnetic resonance imaging of distal phalanx fractures in 6 cases of Thoroughbred racehorse.
The Journal of veterinary medical science    March 21, 2019   Volume 81, Issue 5 689-693 doi: 10.1292/jvms.18-0183
Mizobe F, Nomura M, Kanai K, Ishikawa Y, Yamada K.Six Thoroughbred racehorses with palmar process fractures of the distal phalanx were evaluated with standing magnetic resonance imaging (sMRI). In all the cases, the fractures were detectable on T1-weighted images and fat-suppressed images. Furthermore, multi-planar reconstruction images were useful for assessing the articular involvement of the fractures. Follow-up sMRI was obtainable in 3 cases, which revealed that the area of high signal intensity on fat-suppressed images decreased over time as symptoms improved. Our findings support the use of sMRI for the detailed evaluation of distal pha...
Return to racing after surgical management of third carpal bone slab fractures in thoroughbred and standardbred racehorses.
Veterinary surgery : VS    March 18, 2019   Volume 48, Issue 4 513-523 doi: 10.1111/vsu.13193
Doering AK, Reesink HL, Luedke LK, Moore C, Nixon AJ, Fortier LA, Ducharme NG, Ross MW, Levine DG, Richardson DW, Stefanovski D, Ortved KF.To determine the prognosis for racing of horses surgically treated for slab fractures of the third carpal bone (C3). Methods: Retrospective case study. Methods: Horses (n = 125) surgically treated for C3 slab fractures. Methods: Medical records of horses surgically treated for dorsal or sagittal C3 fractures were reviewed for age, sex, breed, limb, fracture type, degree of cartilage damage, and surgical treatment. Radiographs were evaluated to determine fracture depth, width, and displacement. Osteophytes, C3 lysis, and fragmentation were scored. Racing performance was obtained from online...
The Risk of a Shod and Unshod Horse Kick to Create Orbital Fractures in Equine Cadaveric Skulls.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    March 18, 2019   Volume 32, Issue 4 282-288 doi: 10.1055/s-0039-1683368
Joss R, Baschnagel F, Ohlerth S, Piskoty G, Fürst A, Bischofberger AS. The aim of this study was to compare the potential of an unshod and shod hoof to cause an orbital fracture in the event of a kick. Methods:  Thirty-four equine cadaveric orbitae were exposed to a steel or horn impactor in a dropping test set-up. An impactor velocity of 7 m/s was used for both materials. Testing was repeated on the same orbit at a velocity of 10 m/s with the horn impactor if no damage occurred. A high-speed camera was used to analyse the impact process. Physical parameters (peak force and impact duration) were calculated based on quantitative video-tracking. Computed tomog...
Biocompatible Three-Dimensional Printed Thermoplastic Scaffold for Osteoblast Differentiation of Equine Induced Pluripotent Stem Cells.
Tissue engineering. Part C, Methods    March 6, 2019   Volume 25, Issue 5 253-261 doi: 10.1089/ten.TEC.2018.0343
Baird A, Dominguez Falcon N, Saeed A, Guest DJ.Horses, like humans, can experience bone fractures and due to their large size and the need to bear weight on all limbs during the recovery period, they can be difficult to treat. Surgical techniques to improve fracture repair are improving, but to date, regenerative medicine technologies to aid fracture healing are not commonly applied in horses. We have previously demonstrated that equine induced pluripotent stem cells (iPSCs) can be differentiated into bone forming osteoblasts in 2D culture. In this study, we report on the use of a thermoplastic, 3D-printed polymer to provide a scaffold for...
Associations between pre-injury racing history and tibial and humeral fractures in Australian Thoroughbred racehorses.
Veterinary journal (London, England : 1997)    March 5, 2019   Volume 247 44-49 doi: 10.1016/j.tvjl.2019.03.001
Whitton RC, Walmsley EA, Wong ASM, Shannon SM, Frazer EJ, Williams NJ, Guerow JF, Hitchens PL.Long bone fractures in racehorses may present as stress fractures which have a good prognosis, or complete fractures, which often result in a fatal outcome. In order to identify differences in modifiable management practices that may contribute to these outcomes, racing histories of horses with humeral or tibial fractures and of matched controls were examined. A retrospective case-control study of Australian Thoroughbred racehorses diagnosed with a fracture of the humerus or tibia by scintigraphy or at post-mortem between 2002 and 2016 was undertaken. Control horses were matched from the same ...
Bone marrow oedema-type signal in the proximal phalanx of Thoroughbred racehorses.
The Journal of veterinary medical science    March 4, 2019   Volume 81, Issue 4 593-597 doi: 10.1292/jvms.18-0530
Mizobe F, Nomura M, Ueno T, Yamada K.This study focused on 8 Thoroughbred racehorses showing bone marrow oedema-type signal in the proximal sagittal groove of the proximal phalanx, with the aim of understanding its clinical significance. Standing magnetic resonance imaging played an important role in assessing osseous abnormalities that were not radiographically identifiable. Further, a histopathological result from one of the cases showed there was oedema surrounding adipose tissues with increase in density of trabecular scaffolding. This may indicate presence of osseous injury within the area of decreased elasticity due to subc...
Catastrophic musculoskeletal injuries in Thoroughbred racehorses on racetracks in Gauteng, South Africa.
Journal of the South African Veterinary Association    February 28, 2019   Volume 90 e1-e5 doi: 10.4102/jsava.v90i0.1640
Spargo KE, Rubio-Martinez LM, Wheeler DP, Fletcher L, Carstens A.The incidence and types of catastrophic musculoskeletal injuries in Thoroughbreds that resulted in euthanasia on selected racetracks in South Africa between 1998 and 2012 were investigated by an observational retrospective investigation. Data from the National Horseracing Authority of Southern Africa for these racetracks were used to calculate incidence rates in Thoroughbreds (n = 114) that sustained catastrophic musculoskeletal injuries during racing that required immediate euthanasia, based on the diagnosis made by the on-site veterinarian as well as on fetlock radiographs and dissections o...
Heritability estimates of fractures in Japanese Thoroughbred racehorses using a non-linear model.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie    February 21, 2019   Volume 136, Issue 3 199-204 doi: 10.1111/jbg.12387
Tozaki T, Miyake T, Kikuchi M, Kakoi H, Hirota KI, Kusano K, Ishikawa Y, Nomura M, Kushiro A, Nagata SI.Thoroughbred racehorses are produced by mating small numbers of Arabian stallions and native British mares, and have been improved by selection of horseracing performance for about 300 years. While these improvements led to good performance as racehorses, they exposed horses to numerous medical disorders, aggravated by extensive exercise. Fractures are frequent medical disorders in Thoroughbred racehorses. In this study, fracture heritability was estimated using 3,927 Japanese Thoroughbred racehorses to elucidate the risk of racehorse fractures. The heritability estimates of all examined frac...
The dangers of pets and horses, animal related injuries in the Emergency department.
Trauma case reports    February 21, 2019   Volume 20 100179 doi: 10.1016/j.tcr.2019.100179
van Delft EAK, Thomassen I, Schreuder AMM, Sosef NL.Every year patients present to the emergency department due to bites, scratches and falls caused by animals. Although bite and scratch injuries have been described in literature, the exact number of patients that visit the emergency department due to all animal related injuries has never been described before. Methods: A retrospective analysis of all emergency department visits throughout a 1-year period was performed from April 2015 until March 2016. Results: 516 Patients were treated at the emergency department because of animal related injuries. Most were female and the median age was 38 ...
Genetic modification of scAAV-equine-BMP-2 transduced bone-marrow-derived mesenchymal stem cells before and after cryopreservation: An “off-the-shelf” option for fracture repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society    February 21, 2019   Volume 37, Issue 6 1310-1317 doi: 10.1002/jor.24209
Ball AN, Phillips JN, McIlwraith CW, Kawcak CE, Samulski RJ, Goodrich LR.Optimizing the environment of complex bone healing and improving treatment of catastrophic bone fractures and segmental bone defects remains an unmet clinical need both human and equine veterinary medical orthopaedics. The objective of this study was to determine whether scAAV-equine-BMP-2 transduced cells would induce osteogenesis in equine bone marrow derived mesenchymal stem cells (BMDMSCs) in vitro, and if these cells could be cryopreserved in an effort to osteogenically prime them as an "off-the-shelf" gene therapeutic approach for fracture repair. Our study found that transgene expressio...
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