Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Plasma glutamine concentrations in the horse following feeding and oral glutamine supplementation. Pharmacological benefits of glutamine supplementation have been shown in athletically and clinically stressed human subjects. In the horse, infection and intense exercise have also been shown to significantly decrease plasma glutamine concentrations, but little is known on how best to supplement. Objective: To evaluate whether ingestion of different foodstuffs, with or without L-glutamine (G) or a peptide (Pep) containing 31.5% w/w G in a water-stable form, could affect plasma glutamine concentrations (P-GC). Methods: Nine feeds (molassed sugar beet-pulp (mSB); naked oats (nO); commercial mix ...
Optimal active recovery intensity in standardbreds after submaximal work. A retrospective study concerning spontaneous active recovery intensity, i.e. at a freely chosen speed, after a submaximal exercise in trotters showed that the mean intensity demanded by trainers corresponds to 40-50% of maximal heart rate (max HR; unpublished data). However, in human athletes, optimal active recovery intensity was found to be about 60-70% of max HR. Is the spontaneous recovery optimal after a submaximal exercise in trotters? Objective: To compare different recovery intensities and define the most efficient one. Methods: Thirty-seven trotters performed a standardised exercise t...
Effect of omeprazole on markers of performance in gastric ulcer-free standardbred horses. A large percentage of performance horses develop gastric ulcers and many of those horses are treated with omeprazole. Unfortunately, no data have been published on the effects of the drug on markers of performance in animals without ulcers. Objective: Omeprazole would alter markers of aerobic and anaerobic performance. Methods: Ten unfit, healthy, ulcer free, Standardbred mares were administered either control (CON; oral apple sauce, 20 ml) or omeprazole (OP; oral paste, 4 mg/kg bwt s.i.d.) in a random crossover fashion with the investigators blind to the treatment. Treatments were administere...
Right ventricular pressure dynamics and stress echocardiography in pharmacological and exercise stress testing. There is interest in using pharmacological stress testing (PST) as a substitute for exercise stress testing (EST) to evaluate cardiac function in horses. Objective: To compare the effect of PST and EST on right ventricular pressure dynamics and stress echocardiography. Methods: Five horses completed a PST and EST in a randomised crossover design. High fidelity pressure transducers were placed in the right ventricle. Continuous pressure signals were digitally collected and stored, and dP/dtmax, dP/dtmin and tau calculated from these measurements. ECGs were recorded continuously for 20 h. Echoca...
Kernicterus in a neonatal foal. A 5-day-old Thoroughbred foal was submitted to the necropsy service at the University of Kentucky Livestock Disease Diagnostic Center. The foal had a clinical history of seizure activity and severe icterus. A complete blood count and serum chemistry analysis indicated that the foal was anemic (hematocrit, 16%), hyperbilirubinemic (45 mg/dl), and hypoglycemic. At necropsy, all tissues were discolored various shades of yellow. Microscopically, there was degeneration and necrosis of cerebral neurons and cerebellar Purkinje cells; severe hepatocellular degeneration and necrosis; and deposition of ...
Validation of a portable equine metabolic measurement system. In equine sports medicine, VO2 has been measured exclusively with stationary systems, in laboratories equipped with a treadmill. Measurement during exercise in field conditions has not previously been reported because of the lack of portable equipment designed for horses. Objective: A commercially available portable metabolic measurement system, based on breath-to-breath gas analysis and flow spirometry, was adapted to the horse's physiology and morphology (Cosmed K4b2 and Equimask) and its validity tested by (1) repeatability of the measures and (2) comparing metabolic data to those obtained ...
Observations on respiratory flow strategies during and after intense treadmill exercise to fatigue in thoroughbred racehorses. Locomotor-respiratory coupled (LRC) breath types are a feature of galloping exercise in horses. Differences in breath type have been demonstrated during exercise in particular the 'big respiratory cycle' (BRC) and 'flow hesitation'. To investigate breath types during recovery and quantitatively investigate BRCs during exercise to understanding the mechanism driving BRCs. Objective: To investigate the occurrence of different breath types during and after intense treadmill exercise, and test the hypothesis that large breaths (BRCs) were a function of respiratory frequency. Methods: Six trained a...
Trot asymmetry in relation to physical performance and metabolism in equine endurance rides. Trot is a symmetric gait and asymmetry might appear or increase during endurance rides due to lameness, pain or excessive fatigue. Objective: To assess whether trot asymmetry increases during endurance competitions, whether it is possible to discriminate between horses with different performance and also its possible relationship with metabolism. Methods: Fifty-eight horses were filmed at trot during the lameness examinations in the vet-gates, before the competition (BCO), and after phases 1 (at 29 km), 2 (at 59 km) and 3 (at the end of the ride, at 80 km) and stride duration (SD) measured in ...
Evaluation of race distance, track surface and season of the year on exercise-induced pulmonary haemorrhage in flat racing thoroughbreds in Brazil. To our knowledge no studies evaluating risk factors to EIPH have been undertaken with such a population of horses in Brazil, which is one of the few countries in the racing community to accept the use of frusemide (FUR) as a prerace medication for bleeders. We also compared national results with those already in the literature. Objective: To verify the influence of variables such as distance of the race, racetrack surface, going and season of the year in the recurrence and severity of EIPH and its effect on the finishing position of flat racing Thoroughbreds in Brazil. Methods: 2118 post race ...
Oral vitamin E supplementation on oxidative stress, vitamin and antioxidant status in intensely exercised horses. Vitamin E is the most commonly supplemented antioxidant in horses; however, previous research is not conclusive as to the recommended level for exercising horses. Objective: To evaluate the effects of 3 levels of vitamin E supplementation on oxidative stress and vitamin/antioxidant status in intensely exercised horses to determine the optimal level of vitamin E supplementation. Methods: Twelve unfit Standardbreds were divided into 3 groups, supplemented orally with 0 (CON), 5000 (MOD), or 10,000 (HI) iu/day of DL-alpha-tocopheryl acetate. The 3 x 3 Latin square design consisted of three 4 week...
Raising heels of hind hooves changes the equine coffin, fetlock and hock joint angle: a kinematic evaluation on the treadmill at walk and trot. Raised heels are commonly recommended for various equine orthopaedic conditions. However, the simultaneous effect of raised heels on the different joint angles of the equine hindlimb throughout the motion cycle has not been previously evaluated. Objective: To document the simultaneous effect of raised heels on the joint angles of the equine hindlimb coffin, fetlock and hock joints. Methods: Eight sound, adult, Warmblood horses were evaluated barefoot and with a heel wedge of 8 or 16 degrees, walking and trotting on a horizontal treadmill. Markers placed on the dorsal and cranial aspect of the ...
A comparison of cross-country recovery rates at CCI 2* with and without steeplechase competitions. Short format 3-day events were introduced in 2004. Anecdotal reports suggested that horses were more tired on completion of the cross-country phase of short format events when compared with horses completing the cross-country phase of long format competitions, despite the absence of Phases A, B and C. Objective: To compare the physiological parameters and haematological parameters of horses that had completed the cross-country phase of a short format (SF) and a long format (LF) CCI 2* competition. Methods: During a CCI 2* competition 69 competitors took part in the short format and 74 in the l...
The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses. Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species. Objective: To determine if guanabenz induces measurable signs of adrenergic suppression on fit Thoroughbred horses undergoing intense exercise. Methods: In a random crossover design, 12 exercise conditioned Thoroughbred horses...
Correlations between exercising arterial blood gas values, tracheal wash findings and upper respiratory tract abnormalities in horses presented for poor performance. There are limited data on the correlations between arterial blood gas (ABG) values, tracheal wash (TW) cytology and upper respiratory tract (URT) abnormalities. Objective: To identify horses with abnormal exercising ABG, and compare the proportions of horses with abnormal ABG and TW cytology, mucus or URT dysfunction with those with normal ABG results and abnormal TW cytology, mucus or URT dysfunction. Methods: Medical records of 813 horses presenting to the treadmill facility that had a complete treadmill examination, including ABG analysis, TW and URT endoscopy were selected. Diagnoses, ABG ...
Study of gelatin supplemented diet on amino acid homeostasis in the horse. Gelatin supplementation is a common measure in an attempt to assist cartilage repair, but little scientific evidence exists to support its efficacy. Objective: To investigate the effects of gelatin administration on post prandial homeostasis. Methods: Twelve Standardbred horses (mean 404 kg bwt) were fed a hay-concentrate diet supplemented by soy bean meal and oil (control [C], n = 6) or with the addition of 60 g gelatin/day (G, n = 6). The horses were trained by an alternate order of interval and prolonged exercise every second day. The velocities of the treadmill corresponding to 2 and 10 mm...
Effects of chronic acetazolamide administration on fluid flux from the pulmonary vasculature at rest and during exercise in horses. Horses develop high pulmonary pressures during exercise, which force fluid out of pulmonary capillaries. Specific airway diseases in horses, especially those associated with hypoxaemia, hypercapnoea and acidosis may influence pulmonary haemodynamics and pulmonary interstitial fluid equilibrium. Objective: This study was designed to determine fluid flux (J(V-A) l/min) across the lung in exercising horses treated chronically with acetazolamide. Methods: Six horses were exercised on a treadmill until fatigue without (Con) and with chronic carbonic anhydrase (CA) inhibition (AczTr) and associated ...
Effects of egg-bar shoes on the 3-dimensional kinematics of the distal forelimb in horses walking on a sand track. Understanding of the biomechanical effects of egg-bar shoes remains incomplete because kinematic studies are usually performed on hard tracks and with skin markers that do not measure the actual 3-dimensional (3D) movements of the 3 digital joints. Objective: To quantify the effects of egg-bar shoes on the 3D kinematics of the distal forelimb in horses walking on a sand track. Methods: Four healthy horses were equipped with ultrasonic markers fixed surgically to the 4 distal segments of the left forelimb. The 3D movements of these segments were recorded while the horses were walking on a sand ...
Influence of training on plasma adrenaline and noradrenaline kinetics in untrained standardbreds. Catecholamines (CAT) play an important role in modulating the response to exercise. But the kinetics of CAT changes during exercise are difficult to study due to their short biological half-life. Objective: Learning about variations in plasma CAT levels during training could furnish new information regarding sweating, redistribution of blood flow and energy metabolism. Methods: Four untrained Standardbreds, adapted to treadmill work, were used to determine the influence of training on plasma adrenaline (A) and noradrenaline (NA) kinetics. Horses underwent a standardised exercise test (SET) on ...
Determination of mechanical loading components of the equine metacarpus from measurements of strain during walking. The mechanical environment of the distal limb is thought to be involved in the pathogenesis of many injuries, but has not yet been thoroughly described. Objective: To determine the forces and moments experienced by the metacarpus in vivo during walking and also to assess the effect of some simplifying assumptions used in analysis. Methods: Strains from 8 gauges adhered to the left metacarpus of one horse were recorded in vivo during walking. Two different models - one based upon the mechanical theory of beams and shafts and, the other, based upon a finite element analysis (FEA) - were used to ...
Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in standardbred horses. Increased insulin sensitivity occurs after a period of exercise training, but the mechanisms underlying this training-associated increase in insulin action have not been investigated. Objective: To examine the effects of short-term endurance training (7 consecutive days) and a subsequent period of inactivity (5 days) on whole body insulin sensitivity and GLUT-4 protein and the activities of glycogen synthase (GS) and hexokinase (HK) in skeletal muscle. It was hypothesised that training would increase insulin sensitivity in association with increased GLUT-4 protein and activities of GS and HK, ...
Abnormal radiographic findings in 865 French standardbred trotters and their relationship to racing performance. Developmental orthopaedic lesions are commonly found in French Standardbred horses. One of the main questions asked by trainers, owners and veterinarians is what impact these lesions have on the racing career and racing performances of horses. Objective: To study the prevalence and distribution of developmental orthopaedic lesions in young French Standardbred trotters and to relate them to racing performance. Methods: Feet, fetlock, tarsus and stifle regions were radiographed in 865 two-year-old French Standardbred trotters. Abnormal radiographic findings (ARF) were evaluated for 12 anatomical...
Effect of exercise on blood oxidant/antioxidant markers in standardbred horses: comparison between treadmill and race track tests. Interest in establishing oxidant/ antioxidant profiles in competition horses is increasing. Earlier studies performed in horses have mainly been performed under laboratory conditions using a treadmill and it is not known to what extent laboratory results of oxidant/antioxidant studies might be transposed to field conditions. Objective: To compare the impact on the blood oxidant/ antioxidant status of a standardised exercise test including a run up to fatigue performed on a treadmill (TM) and on a racetrack (RT) in healthy and trained Standardbred horses. Methods: During TM and RT tests the fol...
Exercise-induced pulmonary haemorrhage during submaximal exercise. Maximally exercising horses achieve mean pulmonary artery pressures (Ppa(mean)) that exceed the minimum threshold (75 mmHg) estimated for pulmonary capillary rupture and exercise-induced pulmonary haemorrhage (EIPH). EIPH is not expected to occur during moderate submaximal exercise (i.e. 40-60% VO2max) since Ppa(mean) remains well below this threshold. Objective: Prolonged submaximal exercise (trotting) would precipitate locomotory respiratory uncoupling and cause EIPH. This would be present as a result of the most negative intrapleural pressures (as estimated by the minimum oesophageal pressu...
The effect of long-term exercise on glucose metabolism and peripheral insulin sensitivity in standardbred horses. To study the possible long-term effect of improved glucose tolerance in horses after long-term training, as the impact of exercise training on glucose metabolism is still unclear in the equine species. It is not known whether there is a direct long-term effect of training or if the measurable effect on glucose metabolism is the residual effect of the last exercise session. Objective: To determine the chronic effect on glucose metabolism and peripheral insulin sensitivity of long-term training in horses by use of the euglycaemic hyperinsulinaemic clamp technique. Methods: Eleven Standardbred ho...
Pre-exercise hypervolaemia is not detrimental to arterial oxygenation of horses performing a prolonged exercise protocol simulating the second day of a 3-day equestrian event. Hyperhydration, prior to prolonged moderate-intensity exercise simulating the 2nd day of a 3-day equestrian event (E3DEC), may induce arterial hypoxaemia detrimental to performance. Objective: Because moderate-intensity exercise does not induce arterial hypoxaemia in healthy horses, the effects of pre-exercise hypervolaemia on arterial oxygenation were examined during a prolonged exercise protocol. Methods: Blood-gas studies were carried out on 7 healthy, exercise-trained Thoroughbred horses in control and hyperhydration experiments. The study conformed to a randomised crossover design. The se...
Effects of prior exercise on components of insulin signalling in equine skeletal muscle. Exercise is an important stimulus for the regulation of numerous metabolic functions in muscle, but there has been little investigation of the mechanism of exercise-enhanced glucose utilisation. Objective: To examine the effects of exercise on the signalling components Akt and glycogen synthase kinase-3 (GSK3) involved in insulin regulation of glycogen synthase (GS) activity. It was hypothesised that hyperinsulinaemia and prior exercise would alter the extent of Akt phosphorylation and GSK3beta deactivation and increase insulin stimulation of GS activity in skeletal muscle. Methods: Eight Stan...
Body composition in young standardbreds in training: relationships to body condition score, physiological and locomotor variables during exercise. Body composition is an essential factor in athletic performance of human sprinters and long distance runners. However, in horses, many questions remain concerning relationships between body composition and performance in the different equine activities. Objective: To determine relationships between body composition, body score, physiological and locomotor variables in a population of young Standardbreds in training. Methods: Twenty-four 2-year-old Standardbreds were studied, body condition on a scale 0-5 and bodyweight recorded, and height at withers measured. Percentage of fat (%F), fat mass ...
Is the distribution of selenium and zinc in the sublocations of spermatozoa regulated? In the sperm nuclei, of mammalian species selenium has been found only in the form of sperm nuclei glutathione peroxidase (snGPx) where it is most likely bound to the chromatin of spermatozoa. Over 80% of selenium in sperm is bound to the selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) in the midpiece of rat sperm. Zinc in sperm is mainly contained in the outer dense fiber (ODF) proteins of the flagella of mammalian spermatozoa. In the sperm nuclei, zinc is predominately located in the chromatin to the protamine proteins. In order to investigate if the insertion of zinc...
Correlation of race earnings with velocity at maximal heart rate during a field exercise test in thoroughbred racehorses. Running ability of Thoroughbred racehorses is correlated with maximal oxygen uptake, and the velocity at maximal oxygen uptake is highly correlated with the velocity at maximal heart rate (VHRmax). Objective: To investigate the relationship between VHRmax and racing performance, expressed as 'peak dollars earned per race start'. Methods: Heart rate (HR) and velocity were recorded in 25 Thoroughbred racehorses during trotting and subsequent fast gallops in the field at velocities of 15-16 m/sec. Velocity was recorded by a global positioning system (GPS). Maximal HR (HRmax) and maximal velocity ...
Effect of conditioning horses with short intervals at high speed on biochemical variables in blood. There is limited published work on the effect of training using intensive and short intervals of exercise to condition horses for racing. Objective: To examine the effect of conditioning horses 1, 2 or 3 x a week using 2 short fast exercise intervals on blood lactate (LA), plasma ammonia (NH3) and urea (urea) as well as creatine kinase (CK) activity. Methods: Thoroughbreds (age 4-5 years) were conditioned at near maximal speed (12-14 m/sec) over 100 m, on 2 occasions separated by a 10 min period at walk, on dirt track (conditioning exercise; CE) during a 6 week conditioning period (CP). The CE...
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