The Course of Experimental Infection of the Chick Embryo with the Virus of Equine Encephalomyelitis. The titration curve for the virus of Eastern equine encephalomyelitis inoculated into the 10 day old chick embryo shows that the maximum increase in virus content continues until shortly before the generalized destruction of the embryo is apparent. This is followed by a stationary phase. Histological studies of infected embryos fail to demonstrate selective tissue destruction, and titrations show the virus to be distributed throughout the egg, although concentrated in the embryo. The chorioallantoic membrane gradually becomes increasingly resistant with age to both the Eastern and Western viru...
Equine Encephalomyelitis: Its Relationship to Man in California. The research article discusses an investigation of equine encephalomyelitis or horse brain inflammation and its potential, though rare, transmission to humans in California during the early 20th century. Background and […]
Studies on Eastern Equine Encephalomyelitis: III. Intraocular Infection with Fixed Virus in the Guinea Pig. The behavior of a fixed strain of Eastern equine encephalomyelitis virus was studied in guinea pigs after intraocular inoculation. Such inoculation concerns the central and not the peripheral nervous system. The susceptibility to intraocular injection lies midway between the highly virulent intracerebral and the quite avirulent peripheral routes. The virus must act for 10 to 13 hours in order to induce a fatal infection. Removal of the inoculated eyeball before this interval almost always prevents fatality although it may allow immunity to develop. The virus, at suitable intervals after inject...
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