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Topic:Dexamethasone
Dexamethasone is a synthetic glucocorticoid commonly used in equine medicine for its anti-inflammatory and immunosuppressive properties. It is employed in the management of various inflammatory and allergic conditions in horses, such as arthritis, respiratory diseases, and skin disorders. Dexamethasone works by inhibiting the release of inflammatory mediators and suppressing immune responses. Its administration can be through oral, intravenous, or intramuscular routes, depending on the specific clinical situation. This page compiles peer-reviewed research studies and scholarly articles that investigate the pharmacokinetics, therapeutic applications, and potential side effects of dexamethasone in equine health.
[Aspergillus oryzae as a cause of keratomycosis in the horse]. A case of a spontaneous mycokeratitis of a previously injured cornea in a horse is described. The infection was caused by Aspergillus oryzae. After application of Chloramphenicol ophthalmic ointment a corneal clouding was found in the centre which was circularly sharply defined and which - after dispensing Dexamethason-Neomycin eye drops - expanded all over to a purulent keratitis. The demarcated and initially non purulent mycotic lesions largely improved after the application of tincture of iodine, whereas the purulent keratitis could be completely cured only by a lasting treatment with Lugol...
Morphologic and biochemical changes in cartilage of foals treated with dexamethasone. Epiphyseal and articular cartilages were examined in pony foals treated with intramuscular injections of either 0.5 mg dexamethasone per 100 kg bodyweight daily for 3, 8 or 11 months, or 5.0 mg per 100 kg for 11 months, and in horse foals treated with 5.0 mg per 100 kg for 20 weeks. The proximal femoral growth plates exhibited increased spatial separation between chondrocyte columns, narrowed zones of disorganized columnar and hypertrophic cartilage, abnormal penetration of hypertrophic cartilage by metaphyseal capillaries, retained cartilage in the spongiosa, distal terminal plate formation, ...
Sodium retention and cortisol (hydrocortisone) suppression caused by dexamethasone and triamcinolone in equids. Three ponies and 1 horse were bilaterally adrenalectomized (BADX). The initial hypoadrenal episode after BADX was reversed with 20 mg of dexamethasone (DXM) IM (n = 2) or 20 mg of triamcinolone (TMC) IM (n = 2). Nine hypoadrenal crises were reversed with 20 mg of DXM given IM (n = 4) or 20 mg of TMC given IM (n = 5). Sodium and chloride retention and potassium excretion were documented based on changes in serum electrolytes and urinary excretion. Eight intact adult horses were randomly assigned to 2 groups to study the effects of a single IM injection of DXM (0.044 mg/kg of body weight) or TMC...
The use of capillary column gas chromatography and negative ion chemical ionization mass spectrometry to confirm the administration of synthetic corticosteroids to horses. The negative ion chemical ionization mass spectra of the MO-TMS derivatives of the corticosteroids prednisolone, betamethasone and dexamethasone have been obtained using capillary column gas chromatography mass spectrometry. The spectra showed abundant diagnostic ions at m/z greater than 300 allowing for clear discrimination between the three steroid derivatives. A capillary column gas chromatographic mass spectrometric method using negative ion chemical ionization mass spectrometry has been developed to confirm the presence of the parent steroids in horse urine following the administration of...
Effects of dexamethasone on endotoxin shock in the anesthetized pony: hematologic, blood gas, and coagulation changes. The effects of dexamethasone (1 mg/kg of body weight) on hematologic, blood gas, and blood coagulation values in anesthetized ponies during endotoxin-induced shock were evaluated. Fifteen ponies were assigned to 3 groups of 5 ponies each: group 1, anesthetized nontreated and dexamethasone-treated controls; group 2, endotoxin, nontreated; group 3, endotoxin, dexamethasone treated. The hematologic changes in this endotoxin shock model included leukopenia and hemoconcentration. Significant hematologic effects were not seen in ponies after administration of dexamethasone. However, dexamethasone tr...
Dexamethasone metabolism in the horse. Dexamethasone and a metabolite, 9-fluoro-16α-methyl-6β, 11β, 16β-trihydroxy-1, 4-androstadiene-3, 17-dione, were detected in the urine of horses injected parenterally with the parent drug. The structure of the metabolite was elucidated by thin-layer chromatography, infrared spectroscopy, mass spectroscopy and nuclear magnetic resonance spectroscopy.
Calcium metabolism in glucocorticoid-treated pony foals. Pony foals were injected intramuscularly with 0, 0.5, or 5.0 mg dexamethasone per 100 kg body weight daily for up to 11 months. True absorption of dietary calcium was inhibited by treatment at 18 days (57% versus 14% of intake; P less than .01) and 10 months (72% versus 55% versus 43%: P less than .01), but not at 2 or 7 months, and was independent of age and treatment related decreases in intestinal calcium binding protein activities. Uninary excretion of calcium was increased by treatment through 7 months but decreased at 10 months. Treatment for 18 days resulted in total calcium excretions ...
Glucocorticoid suppression of oestrus, follicles, LH and ovulation in the mare. Dexamethasone, a synthetic glucocorticoid, was administered (30 mg/day) from Day 10 after ovulation to assess the involvement of the adrenal glands in the ovulatory cycle. Only 1 of 8 mares treated in this way exhibited behavioural oestrus, compared to 7 of 8 control mares. Mean maximum LH concentration and follicle size were significantly reduced. Ovulation occurred in 1 and possibly in 2 other treated mares, compared to all 8 control mares. The results demonstrated that dexamethasone can interfere with ovulation and associated events in the mare, but the mechanism of action is uncertain.
Glucocorticoid-induced inhibition of osteolysis and the development of osteopetrosis, osteonecrosis and osteoporosis. Changes in the developing femoral epiphysis, especially those concerning the osteocytes, were examined in pony foals systemically treated with daily intramuscular injections of either 0.5 or 5.0 mg of dexamethasone per 100 kg bodyweight for either 3, 8 or 11 months. Midsagittal sections of proximal femur from animals treated for 3 months contained significantly more bone tissue subchondrally and epiphyseally than did sections from untreated ponies. Large portions of the bone tissue appeared necrotic, although osteoblasts and patent capillaries were abundant. After 8 months the bone sections re...
The use of combined high performance liquid chromatography negative ion chemical ionization mass spectrometry to confirm the administration of synthetic corticosteroids to horses. Negative ion chemical ionization mass spectra of some corticosteroids have been obtained by direct syringe introduction on to the Finnigan moving belt high-performance liquid chromatography-mass spectrometer interface. Proprietary preparations based upon dexamethasone, betamethasone and prednisolone were administered to horses at therapeutic dose level. Urine samples were extracted, the extracts purified by Sephadex LH-20 chromatography and the presence of the parent steroids in the eluates was confirmed by combined high-performance liquid chromatography negative ion chemical ionization mass s...
Experimentally induced toxicoinfectious botulism in horses and foals. Four experiments were performed to elucidate the pathogenesis of toxicoinfectious botulism in horses and foals. Groups of horses and foals were inoculated with one of the following: (1) crude toxin of Clostridium botulinum, type B, given IV, (2) C botulinum spores, given IM, (3) C botulinum spores, given IM, in necrotic lesions, and (4) C botulinum spores, given orally with and without dexamethasone. Toxin of C botulinum in minute amounts is toxic to horses. Clostridium botulinum spores produced toxicosis only when necrotic lesions were present. When C botulinum spores were given orally, they ...
A critical review of current methods for induction of parturition in the mare. The efficacy and safety of oxytocin, dexamethasone and prostaglandin, used alone or in combination as inducing agents, are discussed. It is contended that insufficient evidence exists to support the routine application of any of these methods in practice. Oxytocin has been the most widely used and it is claimed by some to be free from side effects. However, the synthetic prostaglandin analogue, fluprostenol, seems to pose the least risk to the foetus and dexamethasone appears to be either ineffective, or too dangerous to use at all. The main indications for induced foaling are managerial conve...
Recrudescence of equine infectious anemia by treatment with immunosuppressive drugs. Horses which had passed a few months to a few years asymptomatically after the last recurrence of equine infectious anemia (EIA) showed a typical febrile response after treatment with the immunosuppressive agent, dexamethasone (DM) or cyclophosphamide (CY). In horses showing a febrile response, EIA virus which had not been neutralized by neutralizing antibody previously produced was propagated. In DM-treated horses it disappeared from the blood soon after pyretolysis and antibody against the virus was produced promptly. In contrast, detectable viremia persisted in CY-treated horses for 10 to 8...
The effect of a corticosteroid (dexamethasone), progesterone, oestrogen and prostaglandin F2alpha on gestation length in normal and ovariectomized mares. Dexamethasone (100 mg/day) injected from Days 318 to 324 of pregnancy induced parturition. Progesterone (500 mg/day) administered daily from Day 318 of pregnancy also shortened gestation while oestrogen (50 mg/day) administered on the same schedule as progesterone had no such effect. Dexamethasone treatment superimposed on the oestrogen or progesterone treatments shortened gestation. Prostaglandin F2alpha alone did not induce parturition, unlike PGF2alpha with dexamethasone, or PGF2alpha given to ovariectomized mares.
