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Topic:Safety

Safety in horses encompasses practices, equipment, and protocols designed to prevent accidents and injuries to both horses and humans. It involves understanding equine behavior, proper handling techniques, and the use of protective gear. Safety measures include the correct fitting and use of tack, appropriate rider attire such as helmets and boots, and safe stable management practices. This topic also covers the design of equestrian facilities to minimize hazards and the implementation of emergency procedures. This page compiles peer-reviewed research studies and scholarly articles that explore various aspects of equine safety, including risk factors, preventive strategies, and the effectiveness of safety interventions in equestrian activities.
Topical treatment of equine aural plaques with nitric acid and zinc solution.
Equine veterinary journal    March 12, 2026   doi: 10.1002/evj.70161
Leo LK, Bergvall KE.Equine aural plaque caused by equine papilloma viruses is common worldwide and affected horses can show severe clinical signs. Due to its viral aetiology, in some countries affected horses are not allowed to compete. Since lesions persist, showing no spontaneous regression, effective and safe treatment is required. Currently, the only treatment with consistent efficacy is imiquimod. Treatment time is prolonged and adverse effects are common. In humans, papilloma warts are successfully and safely treated with topical nitric-zinc complex solutions inducing a painless caustic effect. Objective: T...
Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses.
Journal of veterinary pharmacology and therapeutics    December 3, 2025   Volume 49, Issue 2 141-149 doi: 10.1111/jvp.70037
Rangel A, Sellon DC, Sanz MG, Pinnell E, Pietras ZM, Villarino NF.Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes. In Phase 2, eight horses received 0.5 mg/kg IM. Plasma or serum concentrations of ketamine and major metabolites were determined by a validated liquid chromatography-mass spectrometry method at baseline and selected intervals post-administration. Subcutaneous administration resulted in ...
Horse-racing injuries in children before and after the introduction of safety regulations in Mongolia.
Western Pacific surveillance and response journal : WPSAR    November 24, 2025   Volume 16, Issue 4 82-88 doi: 10.5365/wpsar.2025.16.4.1195
Gunsmaa G, Gurbazar U, Badarch TU, Ichikawa M.The aim of this study was to assess the effectiveness of safety regulations governing traditional Mongolian horse racing on the frequency and severity of injuries among child jockeys. Regulations introduced in 2019 mandate the wearing of helmets and protective clothing, prohibit the participation of jockeys aged < 7 years, and ban horse racing during the cold season (November-April). National injury surveillance data were used to compare the profile of injuries that occurred among children aged < 15 years in the 4-year periods before and after the introduction of the regulations (2015-2018 ...
Traumatic injuries in polo players.
Postgraduate medical journal    November 20, 2025   qgaf200 doi: 10.1093/postmj/qgaf200
Ken-Dror G, Chua V, Sharma P.To determine the frequency of traumatic injuries in polo players in England. Methods: The survey included data on body location and reason for injury derived from accident reports using a retrospective cohort design from 26 participating English polo clubs between the years 2018 and 2024. Results: The study population included injuries in 236 polo players. The most common injury site was the limb (arm, hand, leg, wrist, shoulder) 47.9% (95% CI: 41.4-54.5), and face or head 38.6% (95% CI: 32.3-45.1), of which 12.1% (95% CI: 6.2-20.6) affected the eyes. The most common reason to require hospital...
A Multi-Site Observational Evaluation of the Equine Assisted Growth and Learning Association Model of Equine-Assisted Psychotherapy for Veteran Trauma Survivors.
International journal of environmental research and public health    October 13, 2025   Volume 22, Issue 10 1557 doi: 10.3390/ijerph22101557
Kowalski H, Van Buiten H, Hopkins P, Baldwin C, Nazarenko E, Marchand WR.The primary aim of this study was to evaluate the feasibility, safety, and preliminary outcomes of the Equine Assisted Growth and Learning Association (Eagala) model of equine-assisted psychotherapy for active-duty military and veteran trauma survivors. This was a retrospective multi-site observational study. Study participants completed four psychological instruments pre- and post-intervention. These were the PTSD Checklist for DSM-5, the Patient Health Questionnaire, the Satisfaction with Life Scale and the Sheehan Disability Scale. The Client Satisfaction Questionnaire-8 was also completed ...
Pharmacokinetics and preliminary safety of single-dose oral fluralaner at 10 and 25 mg/kg in healthy horses revealed no adverse reactions.
American journal of veterinary research    October 3, 2025   Volume 86, Issue 12 ajvr.25.06.0200.xml doi: 10.2460/ajvr.25.06.0200
Morgan JM, Gentille SR, Goyette FD, Lehman ML, Boss AL, Cassano JM, Knych HK, White SD.To determine the safety and pharmacokinetics of a single dose of the oral ectoparasiticide fluralaner at 10 and 25 mg/kg in healthy horses. Unassigned: 12 clinically healthy university-owned horses, 9 to 17 years of age, were administered a single oral dose of fluralaner at 10 or 25 mg/kg. Physical examinations, neurological examinations, plasma samples, hematology and biochemistry panels, and skin biopsies were collected throughout the 84-day trial period. Fluralaner concentrations were measured in plasma and skin by liquid chromatography-tandem mass spectrometry, and pharmacokinetics were ev...
Feasibility and safety of intrathecal transplantation of allogeneic bone marrow mesenchymal stem cells in horses.
Veterinary research communications    September 29, 2025   Volume 49, Issue 6 333 doi: 10.1007/s11259-025-10920-8
de Oliveira Ferreira LV, Maia L, Barberini DJ, Takahira RK, de Vasconcelos Machado VM, Machado GF, de Melo GD, Amorim RM.Mesenchymal stem cells (MSCs) have emerged as a promising alternative for treating neurological disorders due to their neuroprotective, neuroregenerative, immunomodulatory, anti-inflammatory, and anti-apoptotic properties. The use of allogeneic MSCs offers advantages such as the selection of specific cells and their immediate availability. This study aimed to evaluate the safety and feasibility of intrathecal transplantation of allogeneic equine bone marrow-derived MSCs (EqBM-MSCs) in healthy horses. Ten healthy horses (five-12 years old) were randomly divided into two groups. In the control g...
Adverse Effects and Drug Reactions in Equids.
The Veterinary clinics of North America. Equine practice    September 24, 2025   Volume 41, Issue 3 653-674 doi: 10.1016/j.cveq.2025.08.011
Wilson KE, Davis JL.Adverse drug events (ADEs) are any harms caused by medical interventions used for treatment, prevention, or diagnosis. These events can happen due to human error or as unintended, harmful reactions to drugs when given at normal therapeutic doses. This review focuses on common ADEs associated with drugs frequently used in equine practice. Recognizing and understanding the manifestations of ADEs can help with early detection and more effective management, ultimately leading to better outcomes for equine patients. Additionally, knowledge of the potential harmful effects of drugs also aids in appr...
Horsing Around: A Retrospective Study of Equestrian Related Eye Injuries in the Emergency Department.
The Journal of emergency medicine    September 10, 2025   Volume 79 446-452 doi: 10.1016/j.jemermed.2025.09.009
Moran C, Harrington M, Barnett J, Wayman L, Bond J.Equestrian activities pose significant risks for ocular and ocular adnexal injuries, particularly from horse kicks and falls from horse riding. Objective: This study characterizes the spectrum of horse-related ocular trauma, analyzes outcomes, and provides recommendations for management of these injuries. Methods: A retrospective review was conducted at a large academic medical institution in the southeastern U.S. using ICD codes to identify horse-related ocular trauma cases. Demographics, injury mechanisms, clinical presentation, treatment, and long-term sequelae were analyzed. Results: Fifty...
Oral cannabidiol increases thermal threshold in horses without physiologic adverse effects.
American journal of veterinary research    August 25, 2025   Volume 86, Issue 11 ajvr.25.05.0185 doi: 10.2460/ajvr.25.05.0185
Carroll AT, Reed RA, Berghaus LJ, McNabney D, Knych HK.To investigate the effect of cannabidiol (CBD) on thermal and mechanical thresholds and physiologic variables in horses. Unassigned: 6 horses (3 geldings and 3 mares) were enrolled in a prospective, randomized, masked crossover design from March 18 through May 3, 2025. Horses received 3.48 mg/kg CBD oil or placebo (sesame oil) orally every 24 hours for 3 days. Thermal and mechanical thresholds were determined at baseline and 4 and 12 hours after treatment administration on each day. Physiologic variables, including heart rate, respiratory rate, and rectal temperature, were recorded at the same...
Synovial Fluid Biomarker Profile After Intra-Articular Administration of Neosaxitoxin in Horses: A Feasibility Study.
Animals : an open access journal from MDPI    August 21, 2025   Volume 15, Issue 16 2453 doi: 10.3390/ani15162453
Dörner C, Lagos N, Oyaneder L, Menarim BC, Ramírez-Toloza G.Osteoarthritis (OA) is an inflammatory joint disease and the leading cause of musculoskeletal disability affecting human and veterinary patients. New therapeutics halting inflammation while preserving joint homeostasis remain a critical need. Voltage-gated sodium (NaV) channels regulate the pro-inflammatory response of macrophages in the synovium, the central driver of joint homeostasis. Neosaxitoxin (NeoSTX) is a phycotoxin that blocks NaV channels, conferring a unique potential to regulate joint inflammation. This study evaluated the safety of intra-articular administration of NeoSTX in hors...
Monte Carlo evaluation of occupational exposures in equine radiology procedures.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine    August 21, 2025   Volume 226 112116 doi: 10.1016/j.apradiso.2025.112116
de Souza LWG, Oliveira EA, Vieira JW, Farias WAWA, de Souza Santos W, Neves LP, Perini AP.Portable X-ray equipments are commonly used in diagnostic radiology of equine patients. Despite its benefits, the exposure to ionizing radiation can pose a health risk to workers as physical restraint of patients is typically required. In this context, the aim of this study was to apply Monte Carlo simulation to investigate occupational exposure in the diagnosis of horses. The simulations were carried out by the Monte Carlo N-Particle 6.2 (MCNP6.2) code. The workers were represented by a FASH3 (female) and MASH3 (male) virtual anthropomorphic phantoms. To simulate the horse, a realistic virtua...
Safety study of leucoreduced allogeneic pooled freeze-dried platelet-rich plasma in healthy equine joints.
Frontiers in veterinary science    July 14, 2025   Volume 12 1625431 doi: 10.3389/fvets.2025.1625431
Kooy S, Constant J, Cole R, Boone L.Clinical use of blood-derived intra-articular therapies, such as platelet-rich plasma (PRP), have increased in equine athletes due to their proposed disease-modifying effects. Need for a shelf-stable, allogeneic PRP product with known composition for standardized treatment exists. The objective of this study was to compare systemic and local effects of a single intra-articular injection of equine leucoreduced allogeneic pooled freeze-dried PRP (alloPRP) to a placebo control (saline) in normal, healthy equine joints. Unassigned: Twelve healthy horses were randomly assigned to either control (sa...
Evaluating the extent to which ataxia and responsiveness to stimuli reflect the efficacy of xylazine sedation using pharmacokinetics.
Journal of equine veterinary science    July 9, 2025   Volume 152 105652 doi: 10.1016/j.jevs.2025.105652
Bacon EK, Finno CJ, Donnelly CG, Haase B, Knych HK, Velie BD.Clinical assessments of equine sedation typically rely on subjective observations, the accuracy of which is paramount to the safety of equine veterinary procedures. Methods: To assess the degree in which subjective clinical sedative evaluations reflect pharmacokinetic measurements of equine drug metabolism, xylazine hydrochloride, an alpha-2 adrenoreceptor agonist, was administered to 36 horses of varying breed and age at a dosage of 0.5 mg/kg body weight. Subjective clinical parameters were scored at 5-, 15-, 30-, 45- and 60-minutes post xylazine administration and included responsiveness to ...
Striking a Balance: Stakeholder Perceptions of Risk in Horse Racing.
Equine veterinary journal    July 7, 2025   doi: 10.1111/evj.14561
McCarthy J, Cameron-Whytock HA, Bennet ED.Thoroughbred racing is a major industry, and in recent years, public concerns about equine safety have become more prominent, particularly in relation to on-track injuries and fatalities. This has challenged the industry's social licence to operate (SLO). Objective: To investigate and elucidate how UK and Irish racing stakeholders perceive risks to racehorses on race day and how those risks should be managed. Methods: Qualitative analysis of stakeholder perspectives using a constructionist approach. Methods: Twelve stakeholders from veterinary, communication and regulatory sectors within racin...
Frequent location and severity of sports-related fractures in children in a tertiary care-center. A retrospective observational cohort study.
Orthopaedics & traumatology, surgery & research : OTSR    July 4, 2025   104327 doi: 10.1016/j.otsr.2025.104327
Cordonnier T, Germon V, Lemé C, Jouve JL, Launay F, Pesenti S.Despite benefits in children, sport practice has been reported with higher risk of fractures. Our objective was to report the characteristics of sport-related fractures in children and to compare them to fractures sustained in a domestic context. Our hypothesis was that sports-related fractures more frequently required surgical treatment, and could therefore be considered more severe METHODS: We conducted a retrospective cohort study including patients under 16 years old, diagnosed with a fracture at the emergency department, excluding skull and face fractures. Demographic data, context of inj...
Pharmacokinetics of cannabidiol and its two main phase I metabolites in Connemara ponies.
Frontiers in veterinary science    June 27, 2025   Volume 12 1599934 doi: 10.3389/fvets.2025.1599934
Wermer K, Korbacska-Kutasi O, Berkecz R, Csupor D, Ágh N, Sztojkov-Ivanov A, Cserhalmi D.Cannabidiol (CBD) has shown potential therapeutic benefits in veterinary medicine, but further investigations are needed to establish its pharmacokinetics and therapeutic dosing in horses and ponies. The present study aimed to investigate the pharmacokinetic properties of CBD in Connemara ponies following oral administration of CBD oil. Unassigned: Ten healthy ponies received a single oral dose of CBD oil at 2 mg/kg. Blood samples were collected before dosing and up to 16 days post-administration, with physical examinations conducted at baseline and at 8, 12, and 24 h post-dose. Addition...
Evaluation of use of respiratory physiotherapy in treatment of young foals with pneumonia.
Journal of equine veterinary science    June 25, 2025   105637 doi: 10.1016/j.jevs.2025.105637
Rossi HS, Mykkänen AK, Teppo AM, Junnila JJT, Hyytiäinen HK.Pneumonia is a common condition in young, hospitalized foals, causing accumulation of inflammatory secretions to the airways. In humans, respiratory physiotherapy is commonly used as a supplementary treatment for pneumonia with varying results regarding its efficacy, but the efficacy in foals has not been assessed to date. Objective: This study aimed to evaluate the safety and efficacy of respiratory physiotherapy as a supplementary therapy method for young foals with pneumonia. Methods: A total of 44 foals with pneumonia aged under a month were used. The prospective intervention group receivi...
Equine Bone Imaging, Part 1: Establishing an Equine Nuclear Medicine Facility.
Journal of nuclear medicine technology    June 24, 2025   jnmt.125.270049 doi: 10.2967/jnmt.125.270049
Tually P, Currie G.While the establishment and operation of an equine nuclear medicine department share several principles with those of human nuclear medicine departments, they require an additional skill set to ensure safe and effective operation. This article explores the practical aspects of equine nuclear medicine facility location and design and details important considerations for safe and practical operation. Key considerations associated with the differences in physical and radiation safety and imaging approaches are explored. Specific adaptations of γ-camera gantries to allow either planar imaging or ...
Equine Standing Multidetector Computed Tomography of the Distal Thoracic Limb and Tarsus Has a Lower Cumulative Radiation Dose than Digital Radiography. Gaida JL, Steinberg T, Stieger-Vanegas SM, Merle R, Lischer CJ.Recent technological advancements in CT have improved the ability to scan standing sedated horses. However, the impact of radiation exposure on veterinary staff while scanning the extremities of standing horses using this technique, compared with digital radiography (DR), remains unknown. This study compares the radiation exposure of imaging technicians assisting with multidetector CT (MDCT) and DR of the distal thoracic limb and tarsus in standing horses. Personal dose equivalent was measured on four body locations: thyroid gland, gonads, hand, and feet. Images of the distal thoracic limb (n ...
Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid.
Equine veterinary journal    May 13, 2025   Volume 57, Issue 5 1245-1254 doi: 10.1111/evj.14531
Luque RM, Henderson B, McCorkell TC, Alizadeh AH, Russell KA, Koch TG, Koenig J.Mesenchymal stromal cells (MSCs) are widely used to treat osteoarthritis (OA). Optimising dose, timing, and safety while comparing efficacy with standard therapies like hyaluronic acid (HA) is essential for their standardisation. Objective: To assess the safety and efficacy of equine umbilical cord-derived (eCB) MSCs in client-owned horses with fetlock or carpus OA. Methods: Prospective single-blinded randomised clinical study. Methods: Horses diagnosed with fetlock or carpus OA via intra-articular (IA) anaesthesia were randomly assigned to receive either 10 or 20 million eCB-MSCs in HA or 3...
Transfusion of rhodococcal hyperimmune plasma to newborn foals does not markedly alter serum electrolyte or protein concentrations.
Journal of the American Veterinary Medical Association    April 30, 2025   Volume 263, Issue 7 859-865 doi: 10.2460/javma.25.02.0115
Volding DM, Flores-Ahlschwede P, Cramer MJ, Landrock KK, Sayre KC, Welsh TH, Bordin AI, Piccione J, Cohen ND.To determine the effects of transfusion of Rhodococcus equi hyperimmune plasma (REHIP) on serum electrolyte and protein concentrations in neonatal foals. Unassigned: A prospective observational study of 355 privately owned Thoroughbred foals from 13 farms in New York and cross-sectional study of REHIP samples. Blood was collected immediately before and after transfusion of either 1 or 2 L of REHIP to foals, and serum samples were separated and frozen until tested for concentrations of sodium (Na), potassium (K), chloride (Cl), total protein (TP), albumin, and globulins. Samples (n = 90) of REH...
Equestrian STAR: Development of an Experimental Methodology for Assessing the Biomechanical Performance of Equestrian Helmets.
Annals of biomedical engineering    April 28, 2025   Volume 53, Issue 9 2309-2332 doi: 10.1007/s10439-025-03723-0
Duma LA, Begonia MT, Miller B, Jung C, Wood M, Duma BG, Rowson S.The current equestrian helmet standards set minimal requirements for passing helmets, highlighting the need for a rating system that differentiates helmets based on their impact performance. This study's objectives were to compare equestrian helmet impact response kinematics between linear-driven and oblique impact conditions and then to evaluate the effect of incorporating oblique drop tests into a previously established equestrian helmet rating system, Equestrian STAR. Methods: Oblique drop tests were conducted with 45 equestrian helmet models at two impact locations, front boss and rear bos...
Population pharmacokinetics and clinical evaluation of intravenous acetaminophen and its metabolites in Andalusian horses.
Veterinary journal (London, England : 1997)    April 24, 2025   Volume 312 106357 doi: 10.1016/j.tvjl.2025.106357
Granados MM, Medina-Bautista F, Navarrete-Calvo R, Argüelles D, Domínguez-Pérez JM, Priego-Capote F, Muñoz-Rascón P, Serrano-Rodríguez JM.To date, no intravenous pharmacokinetics (PK) studies have assessed acetaminophen or its major metabolites (acetaminophen-glucuronide and acetaminophen-sulphate) in horses. The influence of sex on acetaminophen metabolism in horses is unclear, and Monte Carlo simulations have not been applied to explore potential clinical applications. This study aimed to determine the intravenous PK and safety of acetaminophen in Andalusian horses at 10 and 20 mg/kg, evaluate sex as a covariate, and simulate clinical regimens. Twenty mares and twenty stallions received intravenous acetaminophen, and plasma ...
‘It’s only a flesh wound’ – Understanding the safety culture in equine, production animal and mixed veterinary practices.
Preventive veterinary medicine    April 22, 2025   Volume 241 106541 doi: 10.1016/j.prevetmed.2025.106541
Tulloch JSP, Schofield I, Jackson R, Whiting M.The veterinary industry has some of the highest rates of non-fatal work-related injuries, yet safety culture remains unexplored. Utilising a survey distributed to all UK employees of a consolidated group of veterinary practices, this study aimed to describe the prevalence of work-related injuries in equine, production animal, and mixed veterinary practices, and to understand the behaviours of injured persons. There were 144 respondents. Over 90 % of clinicians experienced injury during their careers, versus a third of non-clinical staff. Injuries to equine veterinarians were predominately ki...
Efficacy of Platelet-Rich Plasma in the Treatment of Equine Tendon and Ligament Injuries: A Systematic Review of Clinical and Experimental Studies.
Veterinary sciences    April 18, 2025   Volume 12, Issue 4 doi: 10.3390/vetsci12040382
Carmona JU, López C.(1) Background: Tendon and ligament injuries are a leading cause of lameness in horses, with significant economic implications. Platelet-rich plasma (PRP) has gained attention for its regenerative potential, but its efficacy remains uncertain due to inconsistent study designs and reporting. (2) Methods: This systematic review, following the PRISMA guidelines, evaluated 22 studies (clinical and experimental) to assess the safety and efficacy of PRP in treating equine tendon and ligament injuries. The risk of bias was analyzed using the ROBINS-I and RoB 2.0 tools. (3) Results: PRP demonstrated a...
Immunoaffinity chromatography for the preparation of equine tetanus immunoglobulin F(ab’)2 for enhanced safety and efficacy.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences    April 15, 2025   Volume 1259 124591 doi: 10.1016/j.jchromb.2025.124591
Gao X, Liu J, Xu K, Hu J, Xiao C, Wang D, Li C, Ji C, Yao X, Wang PG, Jing Y, He Y, Shen CK.Typically, the antigen-specific antibodies constitute a small fraction-often estimated to be around 2-10 %-of the total IgG in the serum after immunization. This low percentage necessitates the use of purification techniques to enrich the antigen-specific antibodies for therapeutic or research purposes. This study introduces an affinity chromatography column using NHS-activated Sepharose as a matrix and the tetanus toxin subunit C, TeNT-Hc-C869A, as a ligand, enabling the purification of polyclonal antibodies with high specificity. This process improves antitoxin purity to over 95 %, effecti...
Distribution of Alprazolam Into the Milk of Lactating Mares and Subsequent Absorption by Nursing Foals.
Journal of veterinary pharmacology and therapeutics    April 14, 2025   doi: 10.1111/jvp.13509
Quattrini C, Knych HK, Magdesian KG.Alprazolam is used to facilitate mare-foal bonding in aggressive or anxious postpartum mares. In humans, alprazolam crosses the blood-milk barrier, but the amount transferred into milk is minor and compatible with breastfeeding as the relative infant dose is < 10%. Similar data are not available for horses. The aim of this study was to measure alprazolam in serum and milk of mares (milk: serum ratio) administered alprazolam, and to determine alprazolam serum concentrations in nursing foals to estimate the extent of absorption. This was a prospective observational study involving 7 healthy...
[Correction: Statement on the efficacy and immunological safety of EHV vaccines in horses].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere    March 26, 2025   Volume 53, Issue 1 e1 doi: 10.1055/a-2560-3065
No abstract available
Systemic, hemodynamic and neurological effects of caudal epidural administration of Neosaxitoxin in horses.
Toxicon : official journal of the International Society on Toxinology    March 5, 2025   Volume 257 108303 doi: 10.1016/j.toxicon.2025.108303
Oyaneder L, Lagos N, Dörner C.The present study was conducted to evaluate the safety and the long-lasting anesthetic properties of Neosaxitoxin (NeoSTX) when injected into the intercoccygeal space in standing horses. A group of eighteen (n = 18) healthy client-owned mature crossbreed horses were enrolled in this study. Caudal epidural injection was ascertained by two methods, the "hanging drop" technique and radiographs. Horses were allocated into three groups (n = 6) each group receiving different dosages of NeoSTX. To assess the onset of action and duration of anesthesia, six horses received 20 μg in 2 mL, six 20...
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