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Search 66,205 equine research studies and published journal articles.
Life-threatening anaphylaxis following antivenom administration in two patients with horse dander allergy.
Clinical toxicology (Philadelphia, Pa.)    August 28, 2025   Volume 63, Issue 10 778-780 doi: 10.1080/15563650.2025.2545592
Isoardi KZ, Chiew AL, Dhital A, Isbister GK.Antivenom is used to treat systemic envenomation and is immunoglobulin G raised from animals, mainly horses, inoculated by venom. Unassigned: We report two cases of life-threatening anaphylaxis following the administration of antivenom in patients with known horse dander allergy. Unassigned: A 14-year-old boy presented with redback spider envenomation. He had a known horse dander allergy. He received antivenom to treat severe pain and developed immediate severe anaphylaxis requiring endotracheal intubation and inotropic support. A 52-year-old man with horse dander allergy presented with suspec...
Are Equine Assisted Interactions (EAI) a Dark Horse Bet? A Systematic Review on Measuring the Psychological and Physiological Effects of EAI on PTSD, Anxiety and/or Mood Disorders.
Psychiatry and clinical psychopharmacology    August 27, 2025   Volume 35, Issue Suppl 1 S90-S112 doi: 10.5152/pcp.2025.24958
Kapteijn C, Reinders N, Hueting M, Van Huffelen RA, Vermetten E, Rodenburg B, Endenburg N.Background: Conventional forms of trauma-focused psychological interventions seem to be less effective in military veterans with post-traumatic stress disorder (PTSD). Equine Assisted Interventions (EAI) have become increasingly popular as an additional treatment, resulting in increasing research on the effects of EAI. However, no systematic review on the effects of EAI has focused on PTSD, anxiety and/or mood disorders and whether the effects are reflected in psychological and physiological measures. This systematic review investigated the treatment effects, study design, population, interven...
Draft horses have similar outcomes as nondraft horses presenting for colic at a referral institution in Atlantic Canada.
Journal of the American Veterinary Medical Association    August 27, 2025   Volume 263, Issue 11 1427-1433 doi: 10.2460/javma.25.05.0320
Burns JJ, Stull J, John E, Doyle A.For horses presenting for colic to a referral hospital in Atlantic Canada, we aimed to describe clinical findings, diagnosis, treatment, and outcome for draft breeds; identify associations between clinical findings, diagnosis, treatment, and outcome for draft compared to nondraft breeds; and identify the overall impact of draft breed on mortality. Unassigned: A retrospective review of equine colic cases presenting to the Atlantic Veterinary College (2004 to 2023). Logistic regression models were used to assess associations between parameters and draft breed and mortality. Unassigned: A total o...
Genetic Diversity of Equid Herpesvirus 5 in Temporal Samples from Mares and Their Foals at Three Polish National Studs.
International journal of molecular sciences    August 27, 2025   Volume 26, Issue 17 8298 doi: 10.3390/ijms26178298
Stasiak K, Dunowska M, Rola J.Equid herpesvirus 5 (EHV-5) comprises a group of heterogeneous viruses with a worldwide distribution. Primary infection typically occurs early in life, which is followed by latency and periodic recrudescence of the virus. The aim of this study was to determine the genetic variation of EHV-5 in individual animals over time and to determine the dynamics of EHV-5 spread among selected mare-foal pairs at three horse studs. The partial glycoprotein B () gene was amplified from archival nasal swab samples. Sequences from 3-5 clones from each PCR product were compared using identity matrix, phylogeny...
Development of an In-House ELISA for Serological Detection of Equine Herpesvirus-1/4 Antibodies in Turkish Horses.
Animals : an open access journal from MDPI    August 27, 2025   Volume 15, Issue 17 2523 doi: 10.3390/ani15172523
Şahinkesen İ, Bilge-Dağalp S.Equine herpesvirus 1 (EHV-1) and Equine herpesvirus 4 (EHV-4) are major viral pathogens of horses that contribute to respiratory disease, abortion, and neurological disorders, leading to economic losses in the equine industry. Accurate serological diagnosis is critical for disease surveillance and control. This study aimed to develop and validate an in-house enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against EHV-1 and EHV-4 in horse sera. Serum samples previously confirmed by virus neutralization test (VNT) and a commercial ELISA were used to optimize the assay. Cut-off...
Human Adenovirus 36 Antibodies in Horses with Different Metabolic Statuses.
Animals : an open access journal from MDPI    August 27, 2025   Volume 15, Issue 17 2527 doi: 10.3390/ani15172527
Chwirot A, Niedźwiedź A, Stygar D, Siwińska N, Paszkowska M, Niżański W, Napierkowska S, Migdał P, Kublicka A, Marynowska M, Matczuk A....This study investigated the presence of antibodies to human adenovirus type 36 (HAdV-D36) in horses with different metabolic statuses, including normal, overweight, and those diagnosed with equine metabolic syndrome (EMS). A total of 151 serum samples were tested, of which 47.6% were positive for anti-HAdV-D36 antibodies. Although the horses were confirmed to be susceptible to HAdV-D36 infection, there was no significant correlation between infection and blood glucose or cholesterol levels. However, the triglyceride levels showed significant differences-they were particularly elevated in the s...
Molecular Detection and Prevalence of Equine Piroplasmosis and Other Blood Parasites in Equids of Western Aegean Türkiye.
Veterinary sciences    August 27, 2025   Volume 12, Issue 9 826 doi: 10.3390/vetsci12090826
Hacilarlioglu S, Bilgic HB, Karagenc T, Aydin HB, Toker H, Kanlioglu H, Pekagirbas M, Bakirci S.Equine piroplasmosis (EP), caused by and , is a tick-borne disease posing significant threats to equine health and the horse industry worldwide. Other vector-borne blood parasites, including , spp., and spp., can also infect horses; however, their prevalence remains poorly characterized in Türkiye. This study aimed to determine the molecular prevalence of , , , spp., and spp. in equids from the Western Aegean Region of Türkiye. Blood samples were collected from 388 clinically healthy equines across İzmir, Aydın, Denizli, and Muğla provinces. Species-specific PCR assays were performed...
Integration of empirical network data and agent-based modelling to examine the risk of equine influenza infection in equine athletes in Ontario, Canada.
Preventive veterinary medicine    August 26, 2025   Volume 245 106665 doi: 10.1016/j.prevetmed.2025.106665
Turcotte G, O'Sullivan TL, Rossi TM, Spence KL, Winder CB, Greer AL.Horses are frequently transported, creating opportunities for the spread of pathogens. Disease transmission models for equine infectious diseases face limitations on their generalizability due to challenges in describing equine movement and the structure of their contact networks beyond simplistic assumptions. This study aimed to combine a stochastic, agent-based, SEIR model for equine influenza disease dynamics with an observed Ontario, Canada equine contact network structure to quantify the potential magnitude of equine influenza outbreaks in Ontario competition horses under different condit...
Effect of Fluorescence Biomodulation on Dermal Healing in an Equine Experimental In Vivo Wound Model.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T    August 26, 2025   Volume 39, Issue 2 117-125 doi: 10.1055/a-2655-9312
Loyd A, Neto R, Caldwell F, Boone L, White A.This study aimed to determine the safety and macroscopic/microscopic effects of fluorescence biomodulation (FBM) on experimentally induced, full-thickness, distal limb wounds in horses.This was an experimental study ( = 6 horses). Two full-thickness wounds were created on both dorsal metacarpi of six adult horses. Each forelimb was randomly allocated to either control (no FBM) or treatment (FBM) and randomly allocated to visual or histological assessment of healing. Wounds were treated within each experimental group every 7 days for four treatments. Fluorescence biomodulation wounds were ...
Development and application of a NP-cELISA for the detection of nucleoprotein antibodies of equine influenza virus.
Microbiology spectrum    August 25, 2025   Volume 13, Issue 10 e0093925 doi: 10.1128/spectrum.00939-25
Yang Y, Guo K, Xu L, Guo W, Dong M, Liu W, Li S, Zhang Z, Chu X, Wang Y, Zhang Z, Hu Z, Wang X.Equine influenza (EI), caused by the equine influenza virus (EIV), is an acute respiratory disease that has become enzootic worldwide, resulting in frequent outbreaks and substantial economic losses within the equine industry. In this study, we developed a competitive enzyme-linked immunosorbent assay (NP-cELISA) for the detection of antibodies against the EIV nucleoprotein (NP). The assay was designed by coating plates with purified monoclonal antibodies (mAbs) against the NP protein, followed by simultaneous incubation of the test serum samples and HRP-NP antigen in a competitive binding rea...
Oral cannabidiol increases thermal threshold in horses without physiologic adverse effects.
American journal of veterinary research    August 25, 2025   Volume 86, Issue 11 ajvr.25.05.0185 doi: 10.2460/ajvr.25.05.0185
Carroll AT, Reed RA, Berghaus LJ, McNabney D, Knych HK.To investigate the effect of cannabidiol (CBD) on thermal and mechanical thresholds and physiologic variables in horses. Unassigned: 6 horses (3 geldings and 3 mares) were enrolled in a prospective, randomized, masked crossover design from March 18 through May 3, 2025. Horses received 3.48 mg/kg CBD oil or placebo (sesame oil) orally every 24 hours for 3 days. Thermal and mechanical thresholds were determined at baseline and 4 and 12 hours after treatment administration on each day. Physiologic variables, including heart rate, respiratory rate, and rectal temperature, were recorded at the same...
Inflammatory response following intra-articular injection of decellularized porcine amnion/chorion in horses.
Veterinary surgery : VS    August 25, 2025   Volume 54, Issue 7 1454-1462 doi: 10.1111/vsu.70005
Cormier KV, Fontenot RL, Eddy A, Williams ML, Wills RW, Jumper WI, Mochal-King CA.The objective of the study was to evaluate effects of intra-articular decellularized porcine amnion/chorion suspension (dPACLS) in horses. Methods: Controlled, randomized, prospective study. Methods: A total of 10 adult horses. Methods: One randomly selected radiocarpal joint (RCJ) was injected with a high dose (HD) of 50 mg (n = 5) or low dose (LD) of 5 mg of dPACLS (n = 5). The contralateral RCJ received saline as control. Systemic serum amyloid A (SAA), synovial fluid analysis (including SAA) and subjective lameness evaluation were performed prior to injection (time 0) and 24, 4...
Are Immune-Integrative Biomarkers Predictors of Systemic Inflammation in Show Jumping Horses?
Veterinary clinical pathology    August 25, 2025   Volume 54, Issue 3 271-280 doi: 10.1111/vcp.70034
Alves-Junior CDB, Ferreira TC, Nunes-Pinheiro DCS.This study evaluated the dynamics of blood immune-inflammatory biomarkers in response to exercise-induced changes in jumping horses. Methods: For this purpose, adult Brazilian Sport Horses (n = 9), aged 10.1 years, both sexes, underwent a specific training test consisting of warm-up, flatwork, and jumping exercises, and recovery on a 900 m sand track over 40 min. Clinical examinations and blood collections were performed at three time points: before (T0), immediately after (T1), and 1 h after (T2) the final exercise. Hematologic and biochemical parameters, such as total protein, gl...
Born to run? Associations between gestational and early-life exposures and later-life performance outcomes in Thoroughbreds.
Equine veterinary journal    August 25, 2025   doi: 10.1111/evj.70084
Mouncey R, de Mestre AM, Arango-Sabogal JC, Verheyen KL.Gestational and early-life exposures may modulate development during growth and influence future athletic performance. Objective: To investigate associations between gestational and early-life exposures in Thoroughbreds and (i) likelihood of racing, (ii) total number of runs and (iii) total prizemoney by the end of the 3-year-old year. Methods: Prospective cohort. Methods: Daily records were kept on the location and duration of turnout, management and veterinary-attended episodes of disease or injury from birth until leaving the farm or study exit for 129 Thoroughbred foals on six stud farms. ...
Administration study of somapacitan, a long-acting growth hormone derivative, in horse for doping control purpose. Shimizu Y, Sugai-Bannai M, Tanabe H, Saito K, Ito H, Tokushige H, Kamiya K, Hirano-Kodaira M, Yamada M, Leung GN.Somapacitan is the second generation of recombinant human growth hormone (rhGH) medication that retains the pharmacological effects of rhGH but exhibits a longer duration of action due to its reversible albumin-binding in the body. In general, the use of all recombinant growth hormone (rGH) analogues is banned by the human and animal sports regulatory authorities due to their anabolic and lipolytic effects. However, little is known about the elimination kinetics and biological effects of the newly introduced long-acting rhGH, somapacitan, in horses. This paper describes the administration stud...
Airborne detection of Equid alphaherpesvirus 1 at international equestrian events.
Equine veterinary journal    August 24, 2025   Volume 58, Issue 2 630-637 doi: 10.1111/evj.70078
Khan A, Jose-Cunilleras E, Hyde E, Olajide E, Polo MC, Goehring LS.Equid alphaherpesvirus 1 (EHV-1) remains a major concern for the equine industry, with recent outbreaks at international equestrian events highlighting the need for improved surveillance during competitions. Objective: To investigate EHV-1 and -4 presence in shared airspaces and environmental surfaces in direct contact with horses at international equestrian events; and to evaluate air sampling as a surveillance alternative to individual horse testing. Methods: Cross-sectional field study. Methods: Air (37) and surface samples (205) were collected from temporary stabling facilities across six ...
Retrospective Evaluation of Cryptorchid Sidedness at Colorado State University Between 1984 and 2014 and Oakridge Equine Hospital Between 2008 and 2023.
Veterinary sciences    August 23, 2025   Volume 12, Issue 9 796 doi: 10.3390/vetsci12090796
Fain H, Hendrickson DA, Buesing MT, Griffenhagen G.Cryptorchidism is a common congenital disorder in male horses characterized by the failure of one or both testes to descend into the scrotum. This developmental anomaly has important clinical, surgical, and economic implications, particularly in breeding animals. This retrospective study investigates the prevalence and laterality of cryptorchidism in a large equine population presented to two veterinary referral hospitals-Colorado State University Veterinary Teaching Hospital (CSU VTH, 1984-2014) and Oakridge Equine Hospital (OEH, 2008-2023). Medical records were reviewed to identify affected ...
Long-Term Changes of Physiological Reactions in Young Lipizzan Stallions During Exercise Testing.
Animals : an open access journal from MDPI    August 23, 2025   Volume 15, Issue 17 2479 doi: 10.3390/ani15172479
Čebulj-Kadunc N, Frangež R, Kruljc P.The aim of the study was to determine the fluctuations of selected physiological parameters in young Lipizzan stallions ( = 10) during the initial phase of their training as indicators of adaptation to a graded exercise load and stress exposure. For this purpose, four exercise tests (ExT) with lunging were carried out over a period of one year. Physiological parameters (gait speed, heart and respiratory rate (HR and RR), rectal and body surface temperature (RT and BST), and cortisol and lactate concentration (CORT and LAC)) were measured before and after training. In all ExT, gait speeds incre...
Global survey on the utilisation and experiences with different retrobulbar anaesthesia techniques in horses.
Equine veterinary journal    August 23, 2025   doi: 10.1111/evj.70082
Lieberth S, Thieme K, Dancker C, Merle R, Eule JC.Retrobulbar anaesthesia (RBA) is relevant for ocular surgery in standing sedated horses. Objective: Gathering insights on experiences with RBA techniques. Methods: Cross-sectional survey. Methods: An online survey collected information on the respondents' professional background, indications, injection methods, use of ultrasound assistance, medication, and complications associated with RBA in horses. Results: Two-hundred and thirty-eight veterinarians from 25 countries contributed. 86.1% were members of veterinary specialty colleges. RBA indications were enucleation (97.8%), corneal surgery (2...
Isolation and characterization of mesenchymal stromal cells derived from equine ovarian follicular aspirates.
Theriogenology    August 22, 2025   Volume 249 117636 doi: 10.1016/j.theriogenology.2025.117636
Muñoz-García CC, Soriano-Campos MP, Luis-Calero M, Gallardo-Soler A, González-Fernández L, Macías-García B.The use of mesenchymal stromal cells (MSCs) in equine reproduction is increasing its interest in the treatment of specific pathologies. MSCs have been isolated from follicular aspirates obtained during transvaginal oocyte aspiration in women, offering a novel source for autologous therapies in reproductive treatments. However, this approach has not been tested in mares despite the common use of transvaginal oocyte aspiration for oocyte collection to produce equine embryos in vitro. Our study aimed to investigate the feasibility of isolating MSCs from equine ovarian follicular aspirates obtaine...
High-field magnetic resonance imaging enables diagnosis of central tarsal bone fractures in performance horses with lameness localized to the proximal metatarsus and tarsus.
Journal of the American Veterinary Medical Association    August 22, 2025   Volume 264, Issue 1 96-103 doi: 10.2460/javma.25.05.0346
Myers TJ, Sampson SN, Glass KP, Russell LA.Central tarsal bone (CTB) fractures are challenging to diagnose, and cross-sectional imaging is required for definitive characterization and surgical planning. This retrospective case series aims to provide the first description of high-field (3-T) MRI characteristics of CTB fractures, concurrent pathology, and clinical presentation in 8 performance horses. Unassigned: 8 horses (9 limbs) diagnosed with a CTB fracture on high-field MRI at one tertiary referral hospital between 2013 and 2023 were identified via electronic medical records search. Unassigned: Quarter Horses (6 of 8) used for Weste...
Refinement of the Lipopolysaccharide-Induced Synovitis Model in Equine Middle Carpal Joints.
Animals : an open access journal from MDPI    August 22, 2025   Volume 15, Issue 17 2474 doi: 10.3390/ani15172474
Duggan MJS, Kearney C, Baltrimaite M, Labberté MC, Gibney R, Brama PAJ.The aim of this study was to refine the lipopolysaccharide (LPS)-induced synovitis model in normal carpal joints of Thoroughbred horses by comparing two low LPS doses. A further aim was to investigate the relationship between the induced synovitis and lameness. The study design consisted of two phases using nine horses with a unilateral crossover design and a within-animal saline control. Synoviocentesis was performed at post-injection hour (PIH) 0, 8, 24, 72 and 168, allowing for synovial fluid cytology and biomarker analysis. Objective gait and thermographic analysis were used to objectively...
Incidence of Bacterial Colonization of Intravenous Non-Permanent Venous Catheters in Hospitalized Equine Patients.
Veterinary sciences    August 22, 2025   Volume 12, Issue 9 788 doi: 10.3390/vetsci12090788
Vitale V, Bindi F, Bertelloni F, Sala G, Cingottini D, Bonelli F, Sgorbini M.Bacterial contamination of intravenous catheters in hospitalized horses may pose risks for both patient care and public health due to potential antimicrobial resistance and zoonotic transmission. This prospective clinical study aimed to evaluate the incidence of catheter contamination in equine patients admitted to a Veterinary Teaching Hospital between 2020 and 2021. All horses requiring intravenous catheterization were included, and data were collected on patient signalment, clinical status, duration of catheterization, treatments, and outcomes. Two catheter types were used: 5 cm polytetrafl...
Bovine and ovine deltapapillomavirus coinfection associated with equine sarcoid.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]    August 22, 2025   Volume 56, Issue 4 2901-2908 doi: 10.1007/s42770-025-01759-x
Pereira EL, Pereira GR, Osório ML, Terra JLA, Gayger JB, Gularte JS, Demoliner M, Pereira VMAG, Filippi M, de Matos QS, Tessman A, Canal CW, Daudt C....Papillomaviruses (PV) are significant agents capable of inducing simple, multiple, and/or proliferative lesions in the dermis and epidermis of animals, known as cutaneous papillomatosis. These lesions can be benign or malignant and have been identified in various hosts, including mammals, birds, reptiles, and fish. PVs are strictly species- and tissue-specific, although some established and unusual cases of cross-infection, such as BPV in equine sarcoids, have been reported. Sarcoids are horses' most common skin tumors, which can be locally aggressive and cause significant clinical signs. It i...
Exploratory Study of the Urine Protein-to-Creatinine Ratio in Apparently Healthy Horses.
Veterinary sciences    August 21, 2025   Volume 12, Issue 8 783 doi: 10.3390/vetsci12080783
Kovarikova S, Blahova J, Steffenova V, Vaskova N, Jahn P.Currently, there is relatively little published information on the urine protein-to-creatinine (UPC) ratio in horses, a parameter commonly used in dogs and cats. The aim of this study was to determine the reference range of UPC in urine samples of apparently healthy horses and to assess the influence of age and sex. Urinalysis and the determination of urinary protein and creatinine concentrations and ratios were performed. A total of 118 urine samples from apparently healthy horses were included in the study: 10 from foals younger than 6 months and 108 from horses older than 1 year. The median...
Optimizing equine standing sedation: continuous infusion of detomidine and butorphanol enhances stability but prolongs ataxia.
Frontiers in veterinary science    August 21, 2025   Volume 12 1606585 doi: 10.3389/fvets.2025.1606585
Arantes JA, Rabelo IP, Bermudes L, Lacerenza MD, Mendes RP, Corrêa RR, Yamada DI, Valadão CAA, Dória RGS.This study aimed to compare the sedation quality and cardiorespiratory and behavioral effects of detomidine administered intravenously, either in intermittent boluses or as a continuous rate infusion, with butorphanol in horses pre-medicated with acepromazine for odontoplasty procedures. Unassigned: A prospective clinical study was conducted with fifteen adult horses randomly assigned to two groups: Bolus group (BG, = 7) and Infusion group (IG, = 8). Both groups received acepromazine premedication, followed by detomidine administration (bolus or infusion). Butorphanol was administered either...
Molecular diversity of cox1 and LSU rDNA sequences of Sarcocystis bertrami (syn. S. fayeri) (Apicomplexa: Eucoccidiorida: Sarcocystidae) in horses.
Parasitology international    August 21, 2025   Volume 110 103144 doi: 10.1016/j.parint.2025.103144
Toda J, Miyasaka J, Osako H, Murata K, Yunus M, Amalia R, Soe BK, Sato H.Food poisoning caused by consuming raw horsemeat contaminated with Sarcocystis is a significant public health concern. Two morphotypes of sarcocysts in horsemeat, characterized by upright and folded villar protrusions, are typically identified as Sarcocystis fayeri and S. bertrami, respectively. However, recent molecular studies focusing on the ribosomal RNA gene (rDNA) and mitochondrial cytochrome c oxidase subunit I gene (cox1) have indicated a conspecific relationship between these two morphotypes using a limited number of specimens. To explore further genetic diversity in equid sarcocysts,...
Spatial Modeling of Equine Herpesviruses 1 (EHVs-1) Risks in Kazakhstan Using 2017-2024 Surveillance Data.
Transboundary and emerging diseases    August 21, 2025   Volume 2025 5536099 doi: 10.1155/tbed/5536099
Mukhanbetkaliyev Y, Yessembekova G, Mukhanbetkaliyeva A, Akmambayeva B, Kadyrov A, Uskenov R, Bostanova S, Ashirbek A, Korennoy F, Abdrakhmanov S.Equine herpesvirus 1 (EHV-1) is one of the most dangerous viral diseases affecting ungulates, and is characterized by a wide range of clinical manifestations in horses, including rhinopneumonia, abortion, neonatal death, and myeloencephalopathy. It is well known for causing mass abortions in mares and respiratory diseases in young animals. Once introduced into a horse breeding farm of any type, EHV-1 tends to establish as a persistent infection. The disease is reported on nearly all continents and causes substantial annual economic losses to horse breeding operations. In Kazakhstan, 34 EHV-1 o...
A longitudinal study of radiodensity and radiographic appearance of the proximal sesamoid bones in Thoroughbred racehorses.
Equine veterinary journal    August 21, 2025   doi: 10.1111/evj.70075
Boros K, Dyson S, Pollard D, Nagy A.There are limited data on long-term follow-up of radiographic changes of the proximal sesamoid bones (PSBs) in Thoroughbred racehorses. The effect of training and racing on radiodensity of the PSBs in live Thoroughbreds has not been described. Objective: To follow radiographic changes of the PSBs in racehorses over 2 years and describe alterations in overall radiodensity. Methods: Prospective cohort study. Methods: Forty yearlings were enrolled at the first examination (T0). Re-examinations were performed four times, approximately 6 months apart, on 31 (T1), 23 (T2), 13 (T3) and 8 (T4) horse...
Flow-controlled expiration improves gas exchange in anaesthetised horses undergoing orthopaedic surgery.
Equine veterinary journal    August 21, 2025   doi: 10.1111/evj.70079
Hopster K, Soares JHN, Levine D, Ortved K, Driessen B, Araos J.Flow-controlled expiration (FLEX) has been shown to significantly enhance oxygenation in horses under laboratory conditions. Objective: This study aims to corroborate these findings by evaluating the effects of FLEX on gas exchange in a randomised clinical trial involving a large population of clinical horses undergoing orthopaedic surgery. Methods: Prospective randomised clinical trial. Methods: A total of 406 healthy adult horses scheduled for elective orthopaedic procedures were recruited for this prospective clinical trial. Horses were randomly assigned to FLEX or VCV (volume-controlled ve...