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Topic:Safety

Safety in horses encompasses practices, equipment, and protocols designed to prevent accidents and injuries to both horses and humans. It involves understanding equine behavior, proper handling techniques, and the use of protective gear. Safety measures include the correct fitting and use of tack, appropriate rider attire such as helmets and boots, and safe stable management practices. This topic also covers the design of equestrian facilities to minimize hazards and the implementation of emergency procedures. This page compiles peer-reviewed research studies and scholarly articles that explore various aspects of equine safety, including risk factors, preventive strategies, and the effectiveness of safety interventions in equestrian activities.
Safety, Tolerability, and Pharmacokinetics of NTM-1632, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin B.
Antimicrobial agents and chemotherapy    June 17, 2021   Volume 65, Issue 7 e0232920 doi: 10.1128/AAC.02329-20
Guptill JT, Raja SM, Juel VC, Walter EB, Cohen-Wolkowiez M, Hill H, Sendra E, Hauser B, Jackson P, Swamy GK.Botulism is a rare, life-threatening paralytic disease caused by Clostridium botulinum neurotoxin (BoNT). Available treatments, including an equine antitoxin and human immune globulin, are given postexposure and challenging to produce and administer. NTM-1632 is an equimolar mixture of 3 human IgG monoclonal antibodies, B1, B2, and B3, targeting BoNT serotype B (BoNT/B). This first-in-human study assessed the safety, tolerability, pharmacokinetics (PK), and immunogenicity of NTM-1632. This double-blind, single-center, placebo-controlled dose escalation study randomized 3 cohorts of healthy vol...
Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer’s disease treatment.
Bioorganic chemistry    May 21, 2021   Volume 112 104974 doi: 10.1016/j.bioorg.2021.104974
Makhaeva GF, Lushchekina SV, Kovaleva NV, Yu Astakhova T, Boltneva NP, Rudakova EV, Serebryakova OG, Proshin AN, Serkov IV, Trofimova TP, Tafeenko VA....We synthesized eleven new amiridine-piperazine hybrids 5a-j and 7 as potential multifunctional agents for Alzheimer's disease (AD) treatment by reacting N-chloroacetylamiridine with piperazines. The compounds displayed mixed-type reversible inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Conjugates were moderate inhibitors of equine and human BChE with negligible fluctuation in anti-BChE activity, whereas anti-AChE activity was substantially dependent on N4-substitution of the piperazine ring. Compounds with para-substituted aromatic moieties (5g, 5h, and bis-amirid...
Anesthesia techniques used for field castration of 10 intractable horses.
The Canadian veterinary journal = La revue veterinaire canadienne    May 11, 2021   Volume 62, Issue 5 501-504 
Stover BC, Caulkett NA.Dealing with an intractable horse is a reality for nearly every equine or mixed animal veterinarian. Establishing an adequate level of sedation prior to induction of anesthesia for various clinical procedures involves little margin for error regarding the safety of the veterinarian, handler, and patient. This is further compounded by the extreme difficulty of gaining venous access required to obtain rapid and reliable results. This case series describes a technique of intramuscular sedation used for field castration of 10 captive, formerly wild horses, which may be useful for various other typ...
Safety and efficacy of an additive consisting of synthetic vitamin K1 (phytomenadione) for horses (JARAZ Enterprises GmbH & Co. KG).
EFSA journal. European Food Safety Authority    April 30, 2021   Volume 19, Issue 4 e06538 doi: 10.2903/j.efsa.2021.6538
Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B....Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of vitamin K1 (phytomenadione) produced by chemical synthesis when used as a nutritional additive in complementary feed of horses at a maximum supplemental level of 14 mg vitamin K1/horse per day. The use of vitamin K1 is safe when used as a feed additive for horses under the proposed conditions of use. The use of vitamin K1 in nutrition of horses under the proposed co...
Radiation safety practices among Canadian equine veterinary workers during diagnostic procedures with portable X-ray equipment.
The Canadian veterinary journal = La revue veterinaire canadienne    April 20, 2021   Volume 62, Issue 4 349-356 
Belotta AF, Mayer MN, Waldner CL, Robinson K, Sidhu N, Carmalt J, Bell CD, Koehncke NK.The objective of this study was to report observed radiation safety practices among equine workers using portable X-ray units at 3 veterinary practices in Canada. Practice 1 was comprised of equine field service workers from an academic institution, whereas Practices 2 and 3 were comprised of workers from private equine referral practices. Out of 2969 exposure-worker observations, protective aprons were worn for > 99% (2968/2969), thyroid shields for 87% (2584/2969), and eyeglasses for 10% (310/2969). The cassette was held by hand for 97% (1078/1114) of observations, and the X-ray unit was ...
[Rescue of injured horses, cattle and pigs from manure and cesspools by the large animal rescue service Switzerland and Liechtenstein (GTRD CH/FL)®].
Schweizer Archiv fur Tierheilkunde    April 7, 2021   Volume 163, Issue 4 281-290 doi: 10.17236/sat00297
Moser M, Keller R, Blaser C, Fürst AE.One of the varied tasks of the Large Animal Rescue Service Switzerland and Liechtenstein (GTRD CH/FL)® is the recovery of animals from manure and cesspools. The aim of the present retrospective study was the evaluation of the rescue protocols of the GTRD CH/FL from such operations and the documentation of a rescue procedure. In the past 25 years, a total of 176 animals have been rescued from manure and cesspools. These included 113 cattle, 51 horses and 12 pigs. All animals could be safely rescued with the animal rescue and transport net (TBTN) or the large animal vertical rescue set (GTVBS)....
Pharmacokinetics and bioavailability of tildipirosin following intravenous and subcutaneous administration in horses.
Journal of veterinary pharmacology and therapeutics    February 20, 2021   Volume 44, Issue 4 544-551 doi: 10.1111/jvp.12958
Abu-Basha EA, Bani Ismail Z, Ababneh MM, Hamzeh E, Gehring R.This study was designed to investigate the safety and pharmacokinetic (PK) profile of tildipirosin in horses after intravenous (i.v.) and subcutaneous (s.c.) injection of a single dose at 4 mg/kg of body weight (b.w.). A total of 12 healthy mixed breed horses were used in the study. Horses were monitored for systemic and local adverse effects, and whole blood samples were collected for hematology and plasma biochemistry analysis at time (0) and at 6, 24, and 72 h after drug administration. For PK analysis, blood samples were collected at pre-determined times before and after tildipirosin adm...
Patterns of injury following equine trauma: a non-trauma centre experience.
Scottish medical journal    February 11, 2021   Volume 66, Issue 2 73-76 doi: 10.1177/0036933021994264
Dick L, Yule M, Green J, Young J.Horse riding carries risk of injury which can result in fatality. The majority of published literature describes major trauma centre experience. We aimed to characterise injury patterns following equine trauma at a Scottish district general hospital. Methods: A retrospective review of admissions following equine trauma was undertaken from 2014 to 2019. Mechanism and nature of injuries were noted. Patient management and outcomes were recorded and analysed to determine correlation. Results: Of the 162 patients identified, 121 (74.7 per cent) were female. The commonest mechanism and injury sustai...
A Survey of Injuries That Occurred in Veterinary Teaching Hospitals during 2017.
Journal of veterinary medical education    January 11, 2021   Volume 48, Issue 4 401-416 doi: 10.3138/jvme-2019-0152
Whittem T, Woodward AP, Hoppach M.Knowing the frequency, extent or severity of injuries that occur to students and staff within veterinary teaching hospitals (VTHs) is necessary for proactive management of their safety. This study surveyed contemporaneously-captured incident reports likely to cause or causing injury to students and staff of veterinary teaching hospitals in Europe, the United States of America (USA), Canada, Australia, and New Zealand, recorded in 2017. Four different severities of incident were evaluated within four different cohorts of people, precipitated by five categories for cause. Within each cause-categ...
Is Whip Use Important to Thoroughbred Racing Integrity? What Stewards’ Reports Reveal about Fairness to Punters, Jockeys and Horses.
Animals : an open access journal from MDPI    October 29, 2020   Volume 10, Issue 11 1985 doi: 10.3390/ani10111985
Thompson K, McManus P, Stansall D, Wilson BJ, McGreevy PD.The idea that whip use is critical to thoroughbred racing integrity is culturally entrenched but lacks empirical support. To test the longstanding beliefs that whip use aids steering, reduces interference, increases safety and improves finishing times, we conducted a mixed-method analysis of 126 race reports produced by official stewards of the British Horseracing Authority, representing 1178 jockeys and their horses. We compared reports from 67 "Hands and Heels" races, where whips are held but not used (whipping-free, WF), with 59 reports from case-matched races where whipping was permitted (...
Medicine in the Sport of Horse Racing.
Current sports medicine reports    September 15, 2020   Volume 19, Issue 9 373-379 doi: 10.1249/JSR.0000000000000750
Ryan KD, Brodine J, Pothast J, McGoldrick A.Horseracing is among the most popular and increasingly lucrative industry sports in the nation. The average jockey must control a thoroughbred horse 10 times their weight that may act unpredictably whether at rest or full gallop resulting in falls, kicks, or even biting injuries. Despite the risks, jockeys do not have access to the same quality of medical care that is standard in similarly profitable sports organizations. Beyond the mental and physical demands of training and performance endured by any professional athlete, jockeys are confronted with health challenges unique to their sport. I...
Safety and efficacy of vermiculite as a feed additive for pigs, poultry, bovines, sheep, goats, rabbits and horses.
EFSA journal. European Food Safety Authority    June 30, 2020   Volume 18, Issue 6 e06160 doi: 10.2903/j.efsa.2020.6160
Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Kos Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A....Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on vermiculite as a feed additive for pigs, poultry, bovines, sheep, goats, rabbits and horses. Vermiculite, which is a magnesium aluminium iron silicate, is intended for use as a technological additive (functional groups: binders and anticaking agents) in premixtures and feedingstuffs for pigs, poultry, bovines, sheep, goats, rabbits and horses, with no proposed minimum or maximum concentration. The applicant reported a max...
Comparative Efficacy of the Prokinetic Effects of Cisapride and Tegaserod in Equines.
Journal of equine veterinary science    June 27, 2020   Volume 92 103179 doi: 10.1016/j.jevs.2020.103179
Ocampo L, Coello M, Aquino I.The aim of this study was to compare the effects of cisapride and tegaserod on intestinal smooth muscle activity in equines. Efficacy was evaluated through measurement of gastrointestinal transit time, bowel movements per day, stool weight, and bowel sounds. Drug safety was evaluated via heart rate, respiratory rate, and rectal temperature. Records were obtained throughout three periods: a control phase without treatment, a period of cisapride administration at a dose of 0.22 mg/kg, and a period of tegaserod treatment at a dose of 0.27 mg/kg. Gastrointestinal transit time, bowel movements pe...
Hippotherapy Practice and Safety Patterns in the United States: A Descriptive Survey Study.
Journal of alternative and complementary medicine (New York, N.Y.)    June 17, 2020   Volume 26, Issue 8 743-749 doi: 10.1089/acm.2020.0039
Peters BC, Fields BE, Erdman EA.Objective: The use of equine movement as a therapy tool in a plan of care, or hippotherapy, has grown considerably over the past three decades. However, there is little evidence of safety rates and related practice patterns to guide key stakeholders such as clients, therapists, the health care team, and third-party payers. The purpose of this article is to describe the safety and practice patterns of contemporary use of hippotherapy. Design: A survey was distributed to occupational therapy (OT), physical therapy (PT), and speech-language pathology clinicians who incorporate hippotherapy into t...
Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species.
EFSA journal. European Food Safety Authority    June 12, 2020   Volume 18, Issue 6 e06146 doi: 10.2903/j.efsa.2020.6146
Bampidis V, Azimonti G, Bastos ML, Christensen H, Kos Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M....Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from L. rhizome when used as sensory additives in feed and in water for drinking for all animal species. The FEEDAP Panel concludes that the additives under consideration are safe at the maximum proposed use levels: (i) turmeric extract at 15 mg/kg complete feed (or in water for drinking at comparable exposure) for a...
Safety and efficacy of essential oil, oleoresin and tincture from Zingiber officinale Roscoe when used as sensory additives in feed for all animal species.
EFSA journal. European Food Safety Authority    June 5, 2020   Volume 18, Issue 6 e06147 doi: 10.2903/j.efsa.2020.6147
Bampidis V, Azimonti G, Bastos ML, Christensen H, Kos Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M....Following a request from the European Commission, the EFSAPanel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of essential oil, oleoresin and tincture from Roscoe when used as sensory additives in feed for all animal species. The FEEDAPPanel concludes that the additives under consideration are safe for the target species at the following use levels: (i) ginger essential oil up to the maximum proposed use level of 80 mg/kg for veal calves (milk replacer) and 20 mg/kg complete feed (or 20 mg/L water...
Safety and efficacy of subcutaneous alpha-tocopherol in healthy adult horses.
Equine veterinary education    June 4, 2020   Volume 33, Issue 4 215-219 doi: 10.1111/eve.13308
Donnelly CG, Burns E, Easton-Jones CA, Katzman S, Stuart R, Cook SE, Finno CJ.Vitamin E is essential for neuromuscular function. The primary treatment, oral supplementation with natural ('RRR') α-tocopherol, is not effective in all horses. The objectives of this pilot study were to evaluate the safety and efficacy of a subcutaneously administered RRR-α-tocopherol preparation. Horses were randomly assigned in a cross-over design to initially receive RRR-α-tocopherol (5000 IU/450 kg of 600 IU/mL) subcutaneously (n = 3) or orally (n = 3) or were untreated sentinels (n = 2). Tissue reactions following injection in Phase I of the study necessitated adjustment of the prepa...
Concussion knowledge, attitudes and behaviour in equestrian athletes.
Journal of science and medicine in sport    May 17, 2020   Volume 23, Issue 11 1055-1061 doi: 10.1016/j.jsams.2020.05.008
Theadom A, Reid D, Hardaker N, Lough J, Hume PA.To determine knowledge, attitudes and behaviour towards concussion in adult equestrian athletes. Methods: Nationwide, cross-sectional, questionnaire. Methods: Participants were recruited via advertisements circulated through social media, community presentations and equestrian organisations. Participants were sent a web link to an online questionnaire previously designed for high school athletes and modified to ensure relevance to equestrian activities. The percentage of correct responses per item and a total knowledge score were calculated. Differences in concussion knowledge by age, sex, lev...
Safety and efficacy of propyl gallate for all animal species.
EFSA journal. European Food Safety Authority    April 30, 2020   Volume 18, Issue 4 e06069 doi: 10.2903/j.efsa.2020.6069
Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H, Dusemund B, Kos Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B....Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of propyl gallate as feed additive for all animal species. Propyl gallate is neither genotoxic nor carcinogenic. Propyl gallate a is safe for veal calves, cattle for fattening, dairy cows, sheep, goats, sows, horses and salmonids at the proposed maximum use level of 40 mg/kg and for ornamental fish at the proposed maximum use level of 100 mg/kg. The following concentrations (mg/kg complete feed) ...
Calcium Electroporation of Equine Sarcoids.
Animals : an open access journal from MDPI    March 19, 2020   Volume 10, Issue 3 doi: 10.3390/ani10030517
Frandsen SK, Gehl J, Tramm T, Thoefner MS.Sarcoids are common equine skin tumors where the risk of recurrence after treatment is high, and better treatment options are warranted. Calcium electroporation is a novel anti-cancer treatment where lethally high calcium concentrations are introduced into the cells by electroporation, a method where short high-voltage pulses induce transient permeabilization of the cell membrane. This study investigated the safety and long-term response of calcium electroporation on sarcoids. Thirty-two sarcoids in eight horses were included. The study suggested that calcium electroporation is a safe and feas...
Horse vision and obstacle visibility in horseracing.
Applied animal behaviour science    February 7, 2020   Volume 222 104882 doi: 10.1016/j.applanim.2019.104882
Paul SC, Stevens M.Visual information is key to how many animals interact with their environment, and much research has investigated how animals respond to colour and brightness information in the natural world. Understanding the visibility of features in anthropogenic environments, and how animals respond to these, is also important, not least for the welfare and safety of animals and the humans they co-exist with, but has received comparatively less attention. One area where this is particularly pertinent is animal sports such as horseracing. Here there is a need to understand how horses see and respond to obs...
Do riders who wear an air jacket in equestrian eventing have reduced injury risk in falls? A retrospective data analysis.
Journal of science and medicine in sport    January 2, 2020   Volume 23, Issue 5 428-429 doi: 10.1016/j.jsams.2019.12.028
Nylund LE, Sinclair PJ, Hitchens PL, Cobley S.No abstract available
Do riders who wear an air jacket in equestrian eventing have reduced injury risk in falls? A retrospective data analysis.
Journal of science and medicine in sport    January 2, 2020   Volume 23, Issue 5 428-429 doi: 10.1016/j.jsams.2019.12.028
Nylund LE, Sinclair PJ, Hitchens PL, Cobley S.No abstract available
Assessment of the application for renewal of authorisation of Yea-Sacc® (Saccharomyces cerevisiae) for horses.
EFSA journal. European Food Safety Authority    December 19, 2019   Volume 17, Issue 12 e05918 doi: 10.2903/j.efsa.2019.5918
Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H, Dusemund B, Kouba M, Kos Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B....Yea-Sacc is an additive based on a live preparation of a strain of intended for use as a zootechnical additive (digestibility enhancer). The current assessment is performed in the context of the renewal of the authorisation of the feed additive; however, the applicant proposed also to lower (6.5 × 10 colony forming unit (CFU)/kg of complete feedingstuff) the minimum dose of the additive when used in feed for horses. The additive is produced in a powder (Yea-Sacc) and in a prills (Yea-Sacc_TS) forms. The Panel considered that the additive currently on the market complies with the existing ...
Assessment of the effect and safety of salacinol in horses.
Journal of equine science    December 18, 2019   Volume 30, Issue 4 105-111 doi: 10.1294/jes.30.105
Ueda F, Iida A, Saito H, Seki S, Amao A, Yamate H.We report a study that examined the effect and safety of salacinol from Salacia reticulata extract (SRE) for the intestinal microbiota of horses. We administered SRE to healthy horses and evaluated their intestinal microbiota before and after the test period for changes in composition. Horses that received the SRE showed notable differences in intestinal microbiota composition between before and after administration, with a substantial increase in bacteria of the order Lactobacillales at the end of the test period. Moreover, the Firmicutes-to-Bacteroidetes ratio was elevated. Salacinol was adm...
Clinical utility, dose determination, and safety of ocular contrast-enhanced ultrasonography in horses: A pilot study.
Veterinary ophthalmology    December 4, 2019   Volume 23, Issue 2 331-340 doi: 10.1111/vop.12730
Blohm KO, Tichy A, Nell B.To determine efficacy of contrast-enhanced ultrasonography (CEUS) using different sulfur hexafluoride (SF6) doses to assess blood flow and perfusion in equine eyes and to evaluate safety of SF6 in horses. Methods: Ocular B-mode and contrast-enhanced ultrasonography were performed bilaterally in nine sedated university-owned horses. Intravenous SonoVue® bolus injections of 5, 10, 15, 20, 25, and 30 mL were administered for 2/18, 5/18, 6/18, 3/18, 1/18, and 1/18 eyes, respectively. Doses were increased based on ascending bodyweight. Each eye within one horse was examined utilizing a different ...
Assessment of the application for renewal of authorisation of Biosprint® (Saccharomyces cerevisiae MUCL 39885) for dairy cows and horses.
EFSA journal. European Food Safety Authority    November 28, 2019   Volume 17, Issue 11 e05915 doi: 10.2903/j.efsa.2019.5915
Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Kouba M, Kos Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A....Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of the product Biosprint ( MUCL 39885) as a feed additive for dairy cows and horses. is considered by EFSA to have qualified presumption of safety (QPS) status. The applicant has provided data demonstrating that the additive currently in the market complies with the conditions of authorisation. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel confirms that the use of Biosprint under the current ...
What Do We Know About Clodronate Now? A Medical and Veterinary Perspective.
Journal of equine veterinary science    November 23, 2019   Volume 88 102874 doi: 10.1016/j.jevs.2019.102874
Markell R, Saviola G, Barker EA, Conway JD, Dujardin C.There has recently been some controversy over the use of bisphosphonates in horses and some confusion regarding the different classes of bisphosphonates and the differences between the mechanism of actions and effects of each class. This review article explores the different bisphosphonate classes and their different effects and mechanisms of action based on research from both the human and equine veterinary fields. This collaborative review between veterinary surgeons and medical doctors describes the latest use of bisphosphonates in humans and horses, including safety aspects, and allows com...
Horseback riding-related injuries treated in emergency departments: Risk factors and prevention strategies.
Journal of safety research    November 20, 2019   Volume 71 251-257 doi: 10.1016/j.jsr.2019.09.004
Asa N, Newton A, Sullivan L, Shi J, Wheeler K, Smith GA, Yang J.Despite inherit dangers of horseback riding (HBR), research on HBR-related injuries is sparse. This study used both quantitative and qualitative methods to (1) examine HBR-related injuries treated in emergency departments (EDs) and associated risk factors and (2) explore HBR-related injury experiences and recommendations for prevention strategies from the perspective of riders. We retrospectively analyzed data from the Nationwide Emergency Department Sample (NEDS), identifying HBR-related ED visits between 2010 and 2014. Additionally, we conducted 10 phone interviews with active horseback ride...
[Horse-related injuries – prevention very important].
Lakartidningen    November 14, 2019   Volume 116 FPT6 
Hall Angerås M.In Sweden equestrian sport activities are the sixth most popular sport and predominantly women and girls are engaged. Horses are prey animals and humans are predators, and the two species therefore act in completely different ways. It is well known that accidents can occur when horses and humans interact. Literature from different countries in the world reveals that most accidents happen to females and also children are at risk. The most common accident is when a rider falls from a horse, but also unmounted humans are at risk for injuries. Most of the injuries are uncomplicated, but there are...
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