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Influence of Dietary Cobalt on Fiber Digestibility and Serum Cobalt and Cobalamin Concentrations in Horses. The 2007 Horse NRC reduced cobalt (Co) requirements from 0.1 ppm to 0.05 ppm in dietary dry matter, though preliminary research suggested increasing dietary-Co enhanced fiber digestion in horses. This study aimed to evaluate fiber digestion with varying dietary Co amounts, as well as to compare serum Co concentrations with dietary Co content. Four geldings (mean body weight [BW] 503 ± 37 kg) were studied in a 4 × 4 Latin square design consisting of four 5-week periods, each comprising a 2-week washout phase followed by a 3-week treatment phase. Supplementing 0.0, 5.6, 16.8, or 28.0 mg of Co ...
Rising trends of inbreeding in Japanese Thoroughbred horses. We investigated the changes in inbreeding levels in Japanese Thoroughbred horses over the past 46 years. Our results show a significant increase in inbreeding over the past 30 years, primarily due to the influence of two sires, Northern Dancer and Sunday Silence. Northern Dancer's bloodline spread gradually through descendants like Northern Taste, leading to a slower increase in the inbreeding coefficient. In contrast, Sunday Silence was directly imported and became a leading sire, causing a rapid increase in his blood proportion and inbreeding coefficient. Our findings suggest that monitoring...
Mixed strongyle parasite infections vary across host age and space in a population of feral horses. Identifying factors that drive among-individual variation in mixed parasitic infections is fundamental to understanding the ecology and evolution of host–parasite interactions. However, a lack of non-invasive diagnostic tools to quantify mixed infections has restricted their investigation for host populations in the wild. This study applied DNA metabarcoding on parasite larvae cultured from faecal samples to characterize mixed strongyle infections of 320 feral horses on Sable Island, Nova Scotia, Canada, in 2014 to test for the influence of host (age, sex and reproductive/social status) and ...
Genetic composition of Kazakh horses of Zhabe type evaluated by SNP genotyping. Horses are animals traditionally playing prominent role as both food source and working animals for Kazakh people. Zhabe horses are traditional type of indigenous Kazakh horses characterized by versatility and adaptation to conditions of Central Asia. The present work focuses on examination of genetic structure of Zhabe horses using SNP genotyping with addition of previously published data. Total 1038 individuals including 403 new samples of Zhabe horses and 42 sample of white horses 'Zhetysu Asyly' have been considered. DNA was extracted from hair roots using commercial DNA isolation kit and ...
Distinct molecular epidemiology of resistances to extended-spectrum cephalosporins and carbapenems in Enterobacter hormaechei in cats and dogs versus horses in France. Enterobacter hormaechei is an important pathogen in humans and animals, which, in addition to its intrinsic AmpC, can acquire a wide variety of genes conferring resistances to extended-spectrum cephalosporins (ESCs) and carbapenems (CPs). In France, human clinical outbreaks of E. hormaechei resistant to ESC or carbapenem were reported. Objective: To study E. hormaechei isolates from cats and dogs (=59) as well as from horses (n = 55) presenting a non-susceptible phenotype to beta-lactams in order to determine which clones, resistance genes and plasmids are circulating in France. Methods: E. ho...
Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging. Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause a severe and often fatal illness. The zoonotic EEEV enzootic cycle involves a cycle of transmission between and avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans and horses. Interestingly, it has been described that the W132G mutation of the very low-density lipoprotein receptor (VLDLR), the receptor of EEEV, significantly enhanced the VLDLR-mediated cell attachment of EEEV. The patient's metabolism plays a pivotal role in shaping the complex lan...
Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse. Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties offering potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization is suitable for PL administration in horses. This pilot study characterized particle size and flow rate of pooled equine PL (single preparation) nebulized using an equine-specific nebulizer (Flexivent®). Unassigned: Protein composition and antimicrobial activity were compared before and after nebulization. Protein composition was evaluated according to growth factor, antimicrobial peptide and cytokine concen...
Anti-Pythium insidiosum activity of three novel triazole compounds: synthesis, pharmacokinetic and toxicological parameters. Pythiosis, caused by Pythium insidiosum, is an infectious and non-transmissible disease affecting horses, dogs, and humans, with no effective drug treatment available. Triazoles are compounds of interest for their potential pharmacological properties against fungi and bacteria. In this study, we synthesized three new triazole compounds (C1, C2, and C3) to assess their in vitro activities against P. insidiosum and their safety on human leukocytes. Susceptibility testing was performed against P. insidiosum isolates (n = 15) to determine the minimum inhibitory concentration (MIC) and minimum ...
Risk factors for fatality in jump racing Thoroughbreds in Great Britain (2010-2023). The British horseracing industry is committed to reducing equine fatalities in jump racing. Race-related fatalities are a major welfare concern and threaten the sport's social licence to operate. Objective: To describe the risk of, and determine risk factors for, fatality in British jump racing. Methods: Retrospective cohort. Methods: Analyses included all starts made in British jump races between January 2010 and April 2023. Available information for each horse, race, racecourse, trainer and jockey was collated and combined with details of all fatalities recorded by official veterinary office...
Expression and Analysis of TBX3 Gene in the Skin from Three Locations on Dun Mongolian Bider Horse. The Mongolian horse, one of the oldest and most genetically diverse breeds, exhibits a wide variety of coat colors and patterns, including both wild-type and unique features. A notable characteristic of dun Mongolian horses is the presence of Bider markings-symmetrical, black-mottled patterns observed on the shoulder blades. These markings are also seen in Przewalski's horses. The dun coat color, a common wild-type phenotype in domestic horses, is characterized by pigment dilution with distinct dark areas and is regulated by mutations in the gene. This study aimed to investigate the role of ...
Global distribution and gap analysis of equine housing research: The findings so far and where to go next. As a free-ranging, social species, the housing of horses () may limit their opportunity to display natural behaviour, compromising well-being. This review records and presents studies that have investigated horse housing design, evaluates the location and number of studies carried out to date, and reports the methods used to assess impact on equine well-being. A Boolean search was conducted in two databases: Web of Science and Scopus, filtered according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol, resulting in 60 peer-reviewed papers for evaluation. ...
Efficacy assessment of antiretroviral drugs against equine infectious anemia virus in vitro. Equine infectious anemia virus (EIAV) is an equine lentivirus related to human immunodeficiency virus type 1 (HIV-1). Both viruses are related among the Retroviridae family, but their clinical manifestations are different as EIAV causes a long persistent infection with no progressive immune dysfunction in most cases. Today, no treatment is approved against EIAV, contrary to HIV-1, manageable through antiretroviral therapy, known as HAART (highly active antiretroviral therapy) or cART (combination antiretroviral therapy). No information about the efficacy of antiretroviral drugs against EIAV is...
Evidence of Influenza A(H5N1) Spillover Infections in Horses, Mongolia. Recent outbreaks of influenza A(H5N1) have affected many mammal species. We report serologic evidence of H5N1 virus infection in horses in Mongolia. Because H3N8 equine influenza virus is endemic in many countries, horses should be monitored to prevent reassortment between equine and avian influenza viruses with unknown consequences.
Comparison of long and short rest periods during high-intensity interval exercise on transcriptomic responses in equine skeletal muscle. The purpose of this study was to elucidate the skeletal muscle transcriptomic response unique to rest duration during high-intensity interval exercise. Thoroughbred horses performed three 1-min bouts of exercise at their maximal oxygen uptake (10.7-12.5 m/s), separated by 15 min (long) or 2 min (short) walking at 1.7 m/s. Gluteus medius muscle was collected before and at 4 h after the exercise and used for RNA sequencing. We identified 1,756 and 1,421 differentially expressed genes in response to the long and short protocols, respectively using DEseq2 analysis [false discovery rate (FDR) cutof...
Preliminary Evidence of Human Plasmodium in Domestic Animals from a Malaria-Endemic Region in Indonesia. In Indonesia, malaria incidence is at a high rate despite maximum preventive efforts. Therefore, this study aims to determine the possibility of a reservoir among domestic animals in malaria-endemic areas. Animal blood was collected using EDTA tubes, then smeared and stained with Giemsa for microscopic identification. About 10 μl of blood was dropped on to a filter paper to capture DNA. Nested PCR was used for parasite molecular detection, while species were identified using the sequenced DNA. A total of 208 and 62 animal blood samples were collected from Gaura village, West Sumba and Fak...
Potential use of beet-pulp concentrate supplementation in athletic horse. The aim of this two-phase study was to evaluate the use of beet pulp concentrate (BPC) in athletic horses. On the first trial the effects of supplementation with 820g of BPC for 12 weeks were assessed and a crossover postprandial curves of blood biomarkers were determined in five adult Arabian mares. Differences were found in T-chol, HDL-chol, TPP and MCHC (p < 0.05). Postprandial curves varied among challenges (p < 0.05) for glucose, insulin, and hematocrit. These results confirmed that BPC supplementation led to changes in blood biomarkers, without inducing major metabolic disrupti...
Detection of Over 110 Anabolic-Androgenic Steroids, Corticosteroids and/or Their Esters in Horse Hair Using Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Gas Chromatography-Tandem Mass Spectrometry After Solid-Supported Liquid Extraction. Anabolic-androgenic steroids (AAS) are banned substances in both human and equine sports. They are often administered intramuscularly to horses in esterified forms for the purpose of extending their duration of action. As such, the detection of intact esters of endogenous steroids in hair is particularly advantageous, as it can provide unequivocal proof of their external origin. Compared with urine and blood matrices, hair in general allows a longer detection window as long as the administered drug can be incorporated into hair and has not degraded. This can be useful in doping control of equi...
Study of Variation of ACOX1 Gene Among Different Horse Breeds Maintained in Iran. The gene is vital for fatty acid metabolism and is linked to environmental stress and physical exertion adaptation. The p.Asp237Ser variant (rs782885985) in is associated with increased enzyme activity and reactive oxygen species (ROS) levels. This study examined the polymorphism across six horse breeds in Iran: Arabian, Thoroughbred, KWPN, Caspian, Kurdish, and Turkmen. The goal was to identify differences in genotype distribution, potentially serving as genetic markers under selection pressure related to breed-specific traits. In a sample of 324 horses, genomic DNA was analyzed using PCR...
Role of cannabidiolic acid or the combination of cannabigerol/cannabidiol in pain modulation and welfare improvement in horses with chronic osteoarthritis. Cannabidiol (CBD) is a non-psychotropic cannabinoid obtained from hemp (Cannabis sativa L.) used for pain management in companion animals including horses. The present study aimed to evaluate the efficacy of cannabidiolic acid (CBDA) and cannabigerol/cannabidiol oil (CBG/CBD) oral administration in alleviating pain in adult horses affected by chronic osteoarthritis (OA). Twenty-four horses (10 geldings and 14 mares), aged between 11 and 18 years old, were equally divided into two groups. One group received CBDA 15% oil and the other group received CBG/CBD oil (CBG20%-CBD10%) for 14 consecuti...
A consort-guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses. Fitness assessment of horses remains challenging. Heart rate variability (HRV) can be used to monitor human athlete's training, but its value is unknown in horses. Objective: The linear domain HRV variables are affected by fitness. Methods: Twelve healthy untrained thoroughbreds were randomly split into a training group (6 weeks of incremental racetrack training) and a control group (no training). Methods: Linear domain HRV variables were analyzed (high frequency [HF], low frequency [LF], their normalized units [Hf, Lf], root mean square of successive differences between beats [RMSSD], Poinc...
Immunodeficiencies in Foals. Knowledge of immunodeficiencies is crucial to neonatal medicine, in that they predispose to sepsis in the newborn and neonatal foal, as well as recurrent infections in older foals. The most common immunodeficiency in newborn and neonatal foals is failure of passive transfer, which is an example of an acquired immunodeficiency. Congenital or developmental immunodeficiencies may be transient or permanent, and can either affect the cell-mediated or humoral arms of immunity, and in some cases both. Affected foals often have chronic or recurrent respiratory or gastrointestinal infections, often wit...
Egg reappearance periods associated with anthelmintic treatments given to horses in winter and summer over two years. Shortened egg reappearance periods (ERP) have been seen as an early warning of anthelmintic resistance development in cyathostomins in horses. The hypothesis has been that in these instances, efficacy against egg laying adult cyathostomins remains high, but a decline in activity against later larval stages leads to the earlier resumption of egg shedding after treatment. In this study using a single herd of horses we investigated the ERP of a number of commonly used equine anthelmintics and examined whether ERP might show seasonal variation between winter and summer. Four main Faecal egg count ...
Promoting mental health in military veterans. Methodology and evaluation tools in a pilot study involving an Equine-Assisted Intervention. Military veterans exposed to stressful or traumatic events may experience adjustment difficulties in the post-deployment period, developing a high risk of mental health-related issues. Promising complementary practices such as Equine-Assisted Therapy (EAT) are now widely used, although standardized protocols are missing. The present study aimed to develop an EAT standardized intervention. Methods: A total of 16 veterans were enrolled for the study (11 veterans for the EAT group and 5 veterans for the control group). The EAT lasted 9 months and both a quantitative (State-Trait Anxiety Inventory...
How does the chemical composition of dung affect nitrous oxide and methane emissions in pasture soils? There is an important gap in how variations in herbivore dung composition affect GHG emissions on pastures, especially due to differences in dry matter (DM) and nitrogen contents. Oversimplifications can compromise the accuracy of mitigation strategies. This study aims to address this gap by investigating how the chemical composition of dung from different species influences GHG emissions in pasture systems. The results showed that drier dung led to higher cumulative N₂O emissions. The highest emissions were observed from goat at 9.47 mg N-N₂O g⁻ dry soil, followed by sheep at 5.95 mg ...
Effects of Porcine Zona Pellucida Immunocontraception on Mare Body Condition and Foaling Season Length in Two Western Wild Horse Populations. Wildlife managers and the public have expressed considerable interest in the use of contraception to help manage the populations of wild horses and burros (Equus caballus and E. asinus). Field testing has shown that two preparations of the porcine zona pellucida (PZP) vaccine, a simple emulsion (ZonaStat-H) and PZP-22 (which supplements ZonaStat-H with a controlled-release component) effectively prevent pregnancy in individual mares and can substantially reduce population foaling rates. To determine whether some PZP preparations might have secondary effects that harm treated mares or their foa...
Histopathological and diagnostic aspects of glanders based on a case series from Brazil. Glanders is a zoonotic disease of equids caused by the bacterium Burkholderia mallei, responsible for considerable economic loss. This study aimed to describe the clinical manifestations, pathological findings, and also bacteriological and molecular methods for agent detection in naturally infected animals (16 adult horses and one fetus) detected by serological survey from three glanders outbreaks. Of the 16 horses, 6 (37.5%) did not show clinical signs. After necropsy,samples of organs, lymph nodes, lesions and secretions were collectedfor histopathology, bacterial isolation, and PCR. The cli...
Traumatic Hemothorax With Rib Fixation in a Professional Jockey Following a Horse Stomping Incident. Traumatic hemothorax is a serious condition requiring immediate intervention. We present a case of a 48-year-old male professional jockey who suffered traumatic hemothorax, bilateral pulmonary contusions, and multiple rib fractures after being stomped by a horse. Management included intercostal drainage placement, costal fixation from the 5th to the 10th rib, and intensive care unit admission. Postoperative complications included, acute kidney injury, rhabdomyolysis, and severe acute respiratory distress syndrome. This case highlights the importance of a multidisciplinary approach in managing ...
Effectiveness of Equine-Assisted Activities and Therapies for Children with Autism Spectrum Disorder: An Update. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition requiring personalised therapeutic approaches. This study evaluated the effectiveness of Equine-Assisted Activities and Therapies (EAATs) in 86 children with varying ASD severity levels (levels 1-3). Methods: Vineland Adaptive Behaviour Scales and the Parenting Stress Index were used. Between May 2022 and October 2023, participants completed 20 weekly sessions of 45 min each, tailored to their individual needs. Results: Children with level 3 ASD demonstrated greater challenges in communication (level 1: 67.1 ± 29.0 vs. l...
Efficacy of 0.2% povidone-iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures. This retrospective study evaluates the efficacy of povidone-iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Methods: Horses that underwent routine ophthalmic surgery and procedures. Methods: Data were collected retrospectively from the medical records of equine patients undergoing ophthalmic procedures. Inclusion criteria were sampling for aerobic microbial culture at three different time points (T0: pre-irrigation, T1: post-irrigation, and T2: postoperatively) and T0 showing bacterial growth. Microbiological outcomes were assesse...
Mare milk and fermented mare milk alleviate dextran sulfate sodium salt-induced ulcerative colitis in mice by reducing inflammation and modulating intestinal flora. Mare milk (MM) and fermented mare milk (FM) are specialized animal milks with high nutritional value, containing a variety of functionally active substances that are capable of resisting inflammatory responses and oxidative stress. However, little relevant research on the maintenance of intestinal homeostasis has been performed. This study aimed to investigate the effects of MM and FM on the prevention of dextran sulfate sodium salt (DSS)-induced ulcerative colitis in a mouse model and to preliminarily elucidate the underlying mechanisms. The results showed that MM and FM had different degrees...
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