The demonstration of a non-estrogenic uterine stimulating and estrogen augmenting substance in pregnant mares’ urine. THE occurrence of substances, in the extracts of human urine and of testes, that are capable of augmenting the effects of estrogens or androgens has been postulated and demonstrated by various workers. Freud and co-workers (1933, 1935) obtained factors from extracts of testes and human urine that augmented the effects of androgens, although possessing no androgenic activity themselves. Emmens (1938) described the presence of substances in the phenolic fraction of normal human female urine which in themselves were non-estrogenic, but when given orally, increased the potency of estriol injected ...
Detection by tissue culture of an organism resembling Histoplasma capsulatum in an apparently healthy horse. Intracellular organisms resembling Histoplasma capsulatum have been observed in apparently normal amnio-allantoic membrane and adult horse spleen maintained in tissue culture.
The significance of this finding and comparison with another fungus Cryptococcus jarciminosus is discussed.
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